Amino acid dipepetide frequency for Thiohalospira halophila DSM 15071

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.668AlaAla: 17.668 ± 0.26
0.894AlaCys: 0.894 ± 0.034
7.791AlaAsp: 7.791 ± 0.094
10.626AlaGlu: 10.626 ± 0.128
3.663AlaPhe: 3.663 ± 0.077
12.462AlaGly: 12.462 ± 0.153
2.45AlaHis: 2.45 ± 0.062
5.009AlaIle: 5.009 ± 0.094
1.848AlaLys: 1.848 ± 0.049
13.854AlaLeu: 13.854 ± 0.182
2.79AlaMet: 2.79 ± 0.064
2.229AlaAsn: 2.229 ± 0.057
5.177AlaPro: 5.177 ± 0.097
2.765AlaGln: 2.765 ± 0.062
10.066AlaArg: 10.066 ± 0.138
4.962AlaSer: 4.962 ± 0.082
6.178AlaThr: 6.178 ± 0.082
9.612AlaVal: 9.612 ± 0.125
2.038AlaTrp: 2.038 ± 0.052
2.207AlaTyr: 2.207 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.67CysAla: 0.67 ± 0.025
0.097CysCys: 0.097 ± 0.012
0.446CysAsp: 0.446 ± 0.023
0.425CysGlu: 0.425 ± 0.027
0.201CysPhe: 0.201 ± 0.018
0.777CysGly: 0.777 ± 0.037
0.292CysHis: 0.292 ± 0.022
0.256CysIle: 0.256 ± 0.019
0.124CysLys: 0.124 ± 0.012
0.649CysLeu: 0.649 ± 0.027
0.108CysMet: 0.108 ± 0.012
0.189CysAsn: 0.189 ± 0.015
0.533CysPro: 0.533 ± 0.036
0.227CysGln: 0.227 ± 0.017
0.659CysArg: 0.659 ± 0.031
0.325CysSer: 0.325 ± 0.023
0.323CysThr: 0.323 ± 0.025
0.419CysVal: 0.419 ± 0.022
0.072CysTrp: 0.072 ± 0.009
0.177CysTyr: 0.177 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
6.427AspAla: 6.427 ± 0.097
0.44AspCys: 0.44 ± 0.026
3.532AspAsp: 3.532 ± 0.091
4.676AspGlu: 4.676 ± 0.092
2.164AspPhe: 2.164 ± 0.053
5.485AspGly: 5.485 ± 0.103
1.681AspHis: 1.681 ± 0.046
2.409AspIle: 2.409 ± 0.06
1.12AspLys: 1.12 ± 0.044
6.646AspLeu: 6.646 ± 0.1
1.106AspMet: 1.106 ± 0.037
1.273AspAsn: 1.273 ± 0.041
4.369AspPro: 4.369 ± 0.076
1.821AspGln: 1.821 ± 0.051
5.084AspArg: 5.084 ± 0.083
2.478AspSer: 2.478 ± 0.064
2.767AspThr: 2.767 ± 0.066
3.389AspVal: 3.389 ± 0.066
1.082AspTrp: 1.082 ± 0.034
1.857AspTyr: 1.857 ± 0.051
0.0AspXaa: 0.0 ± 0.0
Glu
11.507GluAla: 11.507 ± 0.152
0.427GluCys: 0.427 ± 0.025
3.661GluAsp: 3.661 ± 0.067
6.334GluGlu: 6.334 ± 0.121
1.851GluPhe: 1.851 ± 0.052
7.036GluGly: 7.036 ± 0.096
1.665GluHis: 1.665 ± 0.049
2.653GluIle: 2.653 ± 0.065
1.85GluLys: 1.85 ± 0.065
7.82GluLeu: 7.82 ± 0.106
1.671GluMet: 1.671 ± 0.046
1.593GluAsn: 1.593 ± 0.045
4.533GluPro: 4.533 ± 0.092
3.282GluGln: 3.282 ± 0.076
7.449GluArg: 7.449 ± 0.122
3.416GluSer: 3.416 ± 0.064
3.985GluThr: 3.985 ± 0.068
5.801GluVal: 5.801 ± 0.082
1.064GluTrp: 1.064 ± 0.037
1.549GluTyr: 1.549 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.179PheAla: 3.179 ± 0.079
0.269PheCys: 0.269 ± 0.019
2.197PheAsp: 2.197 ± 0.054
2.075PheGlu: 2.075 ± 0.056
1.207PhePhe: 1.207 ± 0.044
2.865PheGly: 2.865 ± 0.061
0.877PheHis: 0.877 ± 0.031
1.24PheIle: 1.24 ± 0.051
0.587PheLys: 0.587 ± 0.027
3.158PheLeu: 3.158 ± 0.078
0.625PheMet: 0.625 ± 0.027
0.884PheAsn: 0.884 ± 0.037
1.497PhePro: 1.497 ± 0.043
1.078PheGln: 1.078 ± 0.036
2.487PheArg: 2.487 ± 0.059
1.485PheSer: 1.485 ± 0.05
1.682PheThr: 1.682 ± 0.053
2.041PheVal: 2.041 ± 0.051
0.434PheTrp: 0.434 ± 0.026
0.789PheTyr: 0.789 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
8.883GlyAla: 8.883 ± 0.123
0.794GlyCys: 0.794 ± 0.038
5.33GlyAsp: 5.33 ± 0.085
7.936GlyGlu: 7.936 ± 0.107
2.93GlyPhe: 2.93 ± 0.066
8.275GlyGly: 8.275 ± 0.129
2.28GlyHis: 2.28 ± 0.059
3.962GlyIle: 3.962 ± 0.073
2.086GlyLys: 2.086 ± 0.054
9.971GlyLeu: 9.971 ± 0.131
2.355GlyMet: 2.355 ± 0.052
2.063GlyAsn: 2.063 ± 0.056
3.989GlyPro: 3.989 ± 0.067
2.938GlyGln: 2.938 ± 0.065
7.573GlyArg: 7.573 ± 0.094
4.459GlySer: 4.459 ± 0.087
4.459GlyThr: 4.459 ± 0.09
6.574GlyVal: 6.574 ± 0.102
1.547GlyTrp: 1.547 ± 0.047
2.269GlyTyr: 2.269 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
2.627HisAla: 2.627 ± 0.057
0.248HisCys: 0.248 ± 0.019
1.331HisAsp: 1.331 ± 0.043
1.325HisGlu: 1.325 ± 0.045
0.844HisPhe: 0.844 ± 0.034
2.326HisGly: 2.326 ± 0.045
0.812HisHis: 0.812 ± 0.035
0.856HisIle: 0.856 ± 0.036
0.398HisLys: 0.398 ± 0.024
2.74HisLeu: 2.74 ± 0.066
0.387HisMet: 0.387 ± 0.022
0.503HisAsn: 0.503 ± 0.027
1.777HisPro: 1.777 ± 0.046
0.827HisGln: 0.827 ± 0.03
2.215HisArg: 2.215 ± 0.051
0.804HisSer: 0.804 ± 0.026
1.114HisThr: 1.114 ± 0.038
1.359HisVal: 1.359 ± 0.038
0.469HisTrp: 0.469 ± 0.024
0.739HisTyr: 0.739 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
4.749IleAla: 4.749 ± 0.085
0.275IleCys: 0.275 ± 0.019
2.553IleAsp: 2.553 ± 0.066
2.804IleGlu: 2.804 ± 0.072
1.136IlePhe: 1.136 ± 0.034
3.499IleGly: 3.499 ± 0.077
1.113IleHis: 1.113 ± 0.031
1.552IleIle: 1.552 ± 0.048
0.859IleLys: 0.859 ± 0.035
4.025IleLeu: 4.025 ± 0.082
0.587IleMet: 0.587 ± 0.026
1.12IleAsn: 1.12 ± 0.036
2.254IlePro: 2.254 ± 0.051
1.468IleGln: 1.468 ± 0.05
3.431IleArg: 3.431 ± 0.07
1.756IleSer: 1.756 ± 0.052
2.405IleThr: 2.405 ± 0.054
2.285IleVal: 2.285 ± 0.056
0.404IleTrp: 0.404 ± 0.023
0.804IleTyr: 0.804 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
2.376LysAla: 2.376 ± 0.064
0.099LysCys: 0.099 ± 0.012
1.083LysAsp: 1.083 ± 0.043
1.53LysGlu: 1.53 ± 0.053
0.491LysPhe: 0.491 ± 0.028
1.832LysGly: 1.832 ± 0.057
0.415LysHis: 0.415 ± 0.023
0.775LysIle: 0.775 ± 0.035
0.799LysLys: 0.799 ± 0.041
1.759LysLeu: 1.759 ± 0.05
0.448LysMet: 0.448 ± 0.025
0.522LysAsn: 0.522 ± 0.027
1.077LysPro: 1.077 ± 0.042
0.732LysGln: 0.732 ± 0.026
1.605LysArg: 1.605 ± 0.051
0.984LysSer: 0.984 ± 0.041
1.19LysThr: 1.19 ± 0.043
1.643LysVal: 1.643 ± 0.058
0.244LysTrp: 0.244 ± 0.018
0.473LysTyr: 0.473 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
15.343LeuAla: 15.343 ± 0.188
0.658LeuCys: 0.658 ± 0.029
6.635LeuAsp: 6.635 ± 0.096
8.614LeuGlu: 8.614 ± 0.11
3.431LeuPhe: 3.431 ± 0.084
9.014LeuGly: 9.014 ± 0.114
2.528LeuHis: 2.528 ± 0.063
3.55LeuIle: 3.55 ± 0.067
2.253LeuLys: 2.253 ± 0.058
11.01LeuLeu: 11.01 ± 0.175
2.053LeuMet: 2.053 ± 0.055
2.154LeuAsn: 2.154 ± 0.048
5.939LeuPro: 5.939 ± 0.106
3.246LeuGln: 3.246 ± 0.067
8.646LeuArg: 8.646 ± 0.117
4.499LeuSer: 4.499 ± 0.078
5.686LeuThr: 5.686 ± 0.082
8.049LeuVal: 8.049 ± 0.118
1.302LeuTrp: 1.302 ± 0.043
2.178LeuTyr: 2.178 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
3.107MetAla: 3.107 ± 0.059
0.096MetCys: 0.096 ± 0.011
1.419MetAsp: 1.419 ± 0.039
1.659MetGlu: 1.659 ± 0.051
0.459MetPhe: 0.459 ± 0.025
1.862MetGly: 1.862 ± 0.049
0.382MetHis: 0.382 ± 0.022
0.705MetIle: 0.705 ± 0.03
0.604MetLys: 0.604 ± 0.03
1.754MetLeu: 1.754 ± 0.047
0.447MetMet: 0.447 ± 0.026
0.663MetAsn: 0.663 ± 0.028
1.118MetPro: 1.118 ± 0.035
0.659MetGln: 0.659 ± 0.028
1.408MetArg: 1.408 ± 0.04
1.268MetSer: 1.268 ± 0.042
1.246MetThr: 1.246 ± 0.038
1.571MetVal: 1.571 ± 0.04
0.139MetTrp: 0.139 ± 0.012
0.281MetTyr: 0.281 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
2.362AsnAla: 2.362 ± 0.061
0.184AsnCys: 0.184 ± 0.016
1.218AsnAsp: 1.218 ± 0.037
1.387AsnGlu: 1.387 ± 0.043
0.665AsnPhe: 0.665 ± 0.027
1.882AsnGly: 1.882 ± 0.057
0.543AsnHis: 0.543 ± 0.027
1.092AsnIle: 1.092 ± 0.037
0.499AsnLys: 0.499 ± 0.029
2.382AsnLeu: 2.382 ± 0.052
0.44AsnMet: 0.44 ± 0.024
0.581AsnAsn: 0.581 ± 0.028
1.664AsnPro: 1.664 ± 0.046
0.803AsnGln: 0.803 ± 0.038
2.025AsnArg: 2.025 ± 0.041
0.895AsnSer: 0.895 ± 0.032
1.161AsnThr: 1.161 ± 0.041
1.373AsnVal: 1.373 ± 0.041
0.279AsnTrp: 0.279 ± 0.019
0.529AsnTyr: 0.529 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
7.272ProAla: 7.272 ± 0.117
0.324ProCys: 0.324 ± 0.02
3.903ProAsp: 3.903 ± 0.071
5.674ProGlu: 5.674 ± 0.1
1.712ProPhe: 1.712 ± 0.046
5.423ProGly: 5.423 ± 0.104
1.015ProHis: 1.015 ± 0.034
1.507ProIle: 1.507 ± 0.046
0.856ProLys: 0.856 ± 0.038
5.162ProLeu: 5.162 ± 0.083
1.072ProMet: 1.072 ± 0.038
0.904ProAsn: 0.904 ± 0.037
2.869ProPro: 2.869 ± 0.076
1.342ProGln: 1.342 ± 0.047
3.611ProArg: 3.611 ± 0.079
2.07ProSer: 2.07 ± 0.056
2.309ProThr: 2.309 ± 0.058
4.777ProVal: 4.777 ± 0.085
0.957ProTrp: 0.957 ± 0.038
1.021ProTyr: 1.021 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
4.098GlnAla: 4.098 ± 0.068
0.186GlnCys: 0.186 ± 0.02
1.414GlnAsp: 1.414 ± 0.046
2.306GlnGlu: 2.306 ± 0.054
0.803GlnPhe: 0.803 ± 0.028
2.933GlnGly: 2.933 ± 0.057
0.645GlnHis: 0.645 ± 0.031
1.021GlnIle: 1.021 ± 0.034
0.695GlnLys: 0.695 ± 0.03
3.063GlnLeu: 3.063 ± 0.067
0.704GlnMet: 0.704 ± 0.035
0.577GlnAsn: 0.577 ± 0.029
1.778GlnPro: 1.778 ± 0.044
1.53GlnGln: 1.53 ± 0.052
3.644GlnArg: 3.644 ± 0.076
1.481GlnSer: 1.481 ± 0.047
1.464GlnThr: 1.464 ± 0.044
2.514GlnVal: 2.514 ± 0.055
0.509GlnTrp: 0.509 ± 0.026
0.641GlnTyr: 0.641 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
9.425ArgAla: 9.425 ± 0.139
0.516ArgCys: 0.516 ± 0.025
4.79ArgAsp: 4.79 ± 0.078
6.815ArgGlu: 6.815 ± 0.1
2.732ArgPhe: 2.732 ± 0.055
5.924ArgGly: 5.924 ± 0.09
2.288ArgHis: 2.288 ± 0.062
3.746ArgIle: 3.746 ± 0.073
1.756ArgLys: 1.756 ± 0.062
10.325ArgLeu: 10.325 ± 0.135
1.873ArgMet: 1.873 ± 0.051
1.807ArgAsn: 1.807 ± 0.053
4.304ArgPro: 4.304 ± 0.088
3.28ArgGln: 3.28 ± 0.063
8.127ArgArg: 8.127 ± 0.128
3.421ArgSer: 3.421 ± 0.068
3.762ArgThr: 3.762 ± 0.067
6.203ArgVal: 6.203 ± 0.108
1.298ArgTrp: 1.298 ± 0.039
2.221ArgTyr: 2.221 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
4.945SerAla: 4.945 ± 0.083
0.281SerCys: 0.281 ± 0.02
2.583SerAsp: 2.583 ± 0.062
3.157SerGlu: 3.157 ± 0.068
1.301SerPhe: 1.301 ± 0.038
4.869SerGly: 4.869 ± 0.084
0.979SerHis: 0.979 ± 0.033
1.737SerIle: 1.737 ± 0.047
0.866SerLys: 0.866 ± 0.036
4.654SerLeu: 4.654 ± 0.079
1.034SerMet: 1.034 ± 0.04
1.01SerAsn: 1.01 ± 0.045
2.388SerPro: 2.388 ± 0.053
1.364SerGln: 1.364 ± 0.042
3.634SerArg: 3.634 ± 0.068
2.23SerSer: 2.23 ± 0.071
2.258SerThr: 2.258 ± 0.054
3.125SerVal: 3.125 ± 0.074
0.613SerTrp: 0.613 ± 0.028
0.881SerTyr: 0.881 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
6.258ThrAla: 6.258 ± 0.096
0.332ThrCys: 0.332 ± 0.021
3.017ThrAsp: 3.017 ± 0.061
3.487ThrGlu: 3.487 ± 0.064
1.597ThrPhe: 1.597 ± 0.042
5.423ThrGly: 5.423 ± 0.091
1.004ThrHis: 1.004 ± 0.033
2.26ThrIle: 2.26 ± 0.045
0.751ThrLys: 0.751 ± 0.032
6.143ThrLeu: 6.143 ± 0.101
0.896ThrMet: 0.896 ± 0.034
1.057ThrAsn: 1.057 ± 0.035
3.107ThrPro: 3.107 ± 0.063
1.197ThrGln: 1.197 ± 0.032
3.578ThrArg: 3.578 ± 0.063
2.202ThrSer: 2.202 ± 0.053
2.789ThrThr: 2.789 ± 0.06
4.243ThrVal: 4.243 ± 0.074
0.684ThrTrp: 0.684 ± 0.027
1.044ThrTyr: 1.044 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
9.81ValAla: 9.81 ± 0.127
0.508ValCys: 0.508 ± 0.028
5.045ValAsp: 5.045 ± 0.082
6.081ValGlu: 6.081 ± 0.097
2.116ValPhe: 2.116 ± 0.051
5.881ValGly: 5.881 ± 0.106
1.755ValHis: 1.755 ± 0.046
3.357ValIle: 3.357 ± 0.068
1.387ValLys: 1.387 ± 0.051
6.935ValLeu: 6.935 ± 0.094
1.541ValMet: 1.541 ± 0.049
1.879ValAsn: 1.879 ± 0.052
3.442ValPro: 3.442 ± 0.06
1.829ValGln: 1.829 ± 0.048
5.696ValArg: 5.696 ± 0.078
3.467ValSer: 3.467 ± 0.078
4.454ValThr: 4.454 ± 0.079
6.507ValVal: 6.507 ± 0.102
0.794ValTrp: 0.794 ± 0.032
1.447ValTyr: 1.447 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.336TrpAla: 1.336 ± 0.04
0.123TrpCys: 0.123 ± 0.012
0.678TrpAsp: 0.678 ± 0.026
0.963TrpGlu: 0.963 ± 0.031
0.549TrpPhe: 0.549 ± 0.031
1.011TrpGly: 1.011 ± 0.036
0.345TrpHis: 0.345 ± 0.019
0.533TrpIle: 0.533 ± 0.027
0.276TrpLys: 0.276 ± 0.019
2.151TrpLeu: 2.151 ± 0.059
0.337TrpMet: 0.337 ± 0.023
0.313TrpAsn: 0.313 ± 0.019
0.782TrpPro: 0.782 ± 0.035
0.703TrpGln: 0.703 ± 0.034
1.376TrpArg: 1.376 ± 0.049
0.703TrpSer: 0.703 ± 0.031
0.642TrpThr: 0.642 ± 0.029
1.083TrpVal: 1.083 ± 0.038
0.295TrpTrp: 0.295 ± 0.022
0.37TrpTyr: 0.37 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.247TyrAla: 2.247 ± 0.051
0.216TyrCys: 0.216 ± 0.017
1.18TyrAsp: 1.18 ± 0.04
1.274TyrGlu: 1.274 ± 0.043
0.803TyrPhe: 0.803 ± 0.033
1.894TyrGly: 1.894 ± 0.051
0.633TyrHis: 0.633 ± 0.031
0.86TyrIle: 0.86 ± 0.038
0.458TyrLys: 0.458 ± 0.025
2.588TyrLeu: 2.588 ± 0.059
0.37TyrMet: 0.37 ± 0.023
0.641TyrAsn: 0.641 ± 0.028
1.184TyrPro: 1.184 ± 0.037
0.917TyrGln: 0.917 ± 0.035
2.302TyrArg: 2.302 ± 0.054
1.004TyrSer: 1.004 ± 0.036
1.196TyrThr: 1.196 ± 0.04
1.363TyrVal: 1.363 ± 0.042
0.347TyrTrp: 0.347 ± 0.021
0.644TyrTyr: 0.644 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2641 proteins (821077 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski