Amino acid dipepetide frequency for Mycolicibacterium wolinskyi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.158AlaAla: 20.158 ± 0.132	0.978AlaCys: 0.978 ± 0.022	8.591AlaAsp: 8.591 ± 0.063	8.042AlaGlu: 8.042 ± 0.06	3.58AlaPhe: 3.58 ± 0.045	11.779AlaGly: 11.779 ± 0.066	2.561AlaHis: 2.561 ± 0.037	5.592AlaIle: 5.592 ± 0.054	3.043AlaLys: 3.043 ± 0.045	13.043AlaLeu: 13.043 ± 0.085	2.947AlaMet: 2.947 ± 0.034	2.627AlaAsn: 2.627 ± 0.038	6.237AlaPro: 6.237 ± 0.077	4.023AlaGln: 4.023 ± 0.04	8.378AlaArg: 8.378 ± 0.068	5.885AlaSer: 5.885 ± 0.053	7.3AlaThr: 7.3 ± 0.062	12.186AlaVal: 12.186 ± 0.092	1.626AlaTrp: 1.626 ± 0.03	2.382AlaTyr: 2.382 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.054CysAla: 1.054 ± 0.022	0.087CysCys: 0.087 ± 0.007	0.513CysAsp: 0.513 ± 0.015	0.394CysGlu: 0.394 ± 0.013	0.23CysPhe: 0.23 ± 0.012	0.909CysGly: 0.909 ± 0.021	0.174CysHis: 0.174 ± 0.009	0.265CysIle: 0.265 ± 0.012	0.105CysLys: 0.105 ± 0.007	0.655CysLeu: 0.655 ± 0.018	0.129CysMet: 0.129 ± 0.008	0.167CysAsn: 0.167 ± 0.01	0.486CysPro: 0.486 ± 0.016	0.199CysGln: 0.199 ± 0.01	0.58CysArg: 0.58 ± 0.016	0.451CysSer: 0.451 ± 0.013	0.497CysThr: 0.497 ± 0.014	0.674CysVal: 0.674 ± 0.019	0.135CysTrp: 0.135 ± 0.007	0.175CysTyr: 0.175 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.799AspAla: 7.799 ± 0.071	0.431AspCys: 0.431 ± 0.014	4.316AspAsp: 4.316 ± 0.058	4.27AspGlu: 4.27 ± 0.046	1.767AspPhe: 1.767 ± 0.026	6.018AspGly: 6.018 ± 0.063	1.435AspHis: 1.435 ± 0.028	2.743AspIle: 2.743 ± 0.041	1.389AspLys: 1.389 ± 0.029	6.053AspLeu: 6.053 ± 0.059	1.084AspMet: 1.084 ± 0.025	1.328AspAsn: 1.328 ± 0.028	4.234AspPro: 4.234 ± 0.043	1.71AspGln: 1.71 ± 0.032	4.622AspArg: 4.622 ± 0.05	2.823AspSer: 2.823 ± 0.037	3.264AspThr: 3.264 ± 0.043	5.392AspVal: 5.392 ± 0.057	0.982AspTrp: 0.982 ± 0.022	1.454AspTyr: 1.454 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	6.089GluAla: 6.089 ± 0.06	0.344GluCys: 0.344 ± 0.012	2.437GluAsp: 2.437 ± 0.036	2.352GluGlu: 2.352 ± 0.036	1.946GluPhe: 1.946 ± 0.029	3.225GluGly: 3.225 ± 0.044	1.555GluHis: 1.555 ± 0.027	2.69GluIle: 2.69 ± 0.036	1.343GluLys: 1.343 ± 0.029	6.762GluLeu: 6.762 ± 0.063	1.076GluMet: 1.076 ± 0.022	1.186GluAsn: 1.186 ± 0.024	3.253GluPro: 3.253 ± 0.048	2.308GluGln: 2.308 ± 0.031	4.443GluArg: 4.443 ± 0.05	2.812GluSer: 2.812 ± 0.038	2.815GluThr: 2.815 ± 0.039	4.321GluVal: 4.321 ± 0.049	0.752GluTrp: 0.752 ± 0.015	1.179GluTyr: 1.179 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.058PheAla: 4.058 ± 0.049	0.315PheCys: 0.315 ± 0.012	2.538PheAsp: 2.538 ± 0.035	1.625PheGlu: 1.625 ± 0.03	1.048PhePhe: 1.048 ± 0.025	3.583PheGly: 3.583 ± 0.043	0.645PheHis: 0.645 ± 0.015	1.174PheIle: 1.174 ± 0.024	0.546PheLys: 0.546 ± 0.018	2.578PheLeu: 2.578 ± 0.038	0.526PheMet: 0.526 ± 0.015	0.761PheAsn: 0.761 ± 0.022	1.391PhePro: 1.391 ± 0.024	0.693PheGln: 0.693 ± 0.016	1.643PheArg: 1.643 ± 0.026	1.706PheSer: 1.706 ± 0.031	2.159PheThr: 2.159 ± 0.031	2.675PheVal: 2.675 ± 0.036	0.451PheTrp: 0.451 ± 0.016	0.725PheTyr: 0.725 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	10.064GlyAla: 10.064 ± 0.069	0.757GlyCys: 0.757 ± 0.02	4.939GlyAsp: 4.939 ± 0.048	4.394GlyGlu: 4.394 ± 0.043	3.152GlyPhe: 3.152 ± 0.043	7.505GlyGly: 7.505 ± 0.075	1.972GlyHis: 1.972 ± 0.034	4.277GlyIle: 4.277 ± 0.047	2.288GlyLys: 2.288 ± 0.035	8.806GlyLeu: 8.806 ± 0.069	2.177GlyMet: 2.177 ± 0.029	1.943GlyAsn: 1.943 ± 0.032	4.392GlyPro: 4.392 ± 0.048	2.753GlyGln: 2.753 ± 0.041	6.168GlyArg: 6.168 ± 0.054	5.09GlySer: 5.09 ± 0.041	5.21GlyThr: 5.21 ± 0.062	7.68GlyVal: 7.68 ± 0.065	1.635GlyTrp: 1.635 ± 0.029	2.417GlyTyr: 2.417 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.449HisAla: 2.449 ± 0.038	0.209HisCys: 0.209 ± 0.011	1.416HisAsp: 1.416 ± 0.026	1.114HisGlu: 1.114 ± 0.021	0.653HisPhe: 0.653 ± 0.018	2.054HisGly: 2.054 ± 0.035	0.7HisHis: 0.7 ± 0.021	0.894HisIle: 0.894 ± 0.021	0.366HisLys: 0.366 ± 0.014	2.126HisLeu: 2.126 ± 0.029	0.385HisMet: 0.385 ± 0.013	0.487HisAsn: 0.487 ± 0.017	1.617HisPro: 1.617 ± 0.029	0.627HisGln: 0.627 ± 0.019	1.83HisArg: 1.83 ± 0.028	1.028HisSer: 1.028 ± 0.022	1.28HisThr: 1.28 ± 0.025	1.714HisVal: 1.714 ± 0.029	0.371HisTrp: 0.371 ± 0.014	0.555HisTyr: 0.555 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	6.774IleAla: 6.774 ± 0.059	0.396IleCys: 0.396 ± 0.015	3.502IleAsp: 3.502 ± 0.05	2.702IleGlu: 2.702 ± 0.044	1.103IlePhe: 1.103 ± 0.025	4.741IleGly: 4.741 ± 0.056	0.783IleHis: 0.783 ± 0.018	1.517IleIle: 1.517 ± 0.031	0.889IleLys: 0.889 ± 0.021	3.195IleLeu: 3.195 ± 0.038	0.631IleMet: 0.631 ± 0.016	1.118IleAsn: 1.118 ± 0.023	2.382IlePro: 2.382 ± 0.035	0.944IleGln: 0.944 ± 0.021	2.776IleArg: 2.776 ± 0.038	2.378IleSer: 2.378 ± 0.033	2.848IleThr: 2.848 ± 0.038	4.012IleVal: 4.012 ± 0.05	0.495IleTrp: 0.495 ± 0.014	0.851IleTyr: 0.851 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	2.753LysAla: 2.753 ± 0.047	0.118LysCys: 0.118 ± 0.007	1.139LysAsp: 1.139 ± 0.027	0.985LysGlu: 0.985 ± 0.022	0.673LysPhe: 0.673 ± 0.021	1.533LysGly: 1.533 ± 0.027	0.493LysHis: 0.493 ± 0.013	1.014LysIle: 1.014 ± 0.021	0.661LysLys: 0.661 ± 0.021	2.328LysLeu: 2.328 ± 0.037	0.495LysMet: 0.495 ± 0.016	0.539LysAsn: 0.539 ± 0.019	1.565LysPro: 1.565 ± 0.031	0.768LysGln: 0.768 ± 0.017	1.637LysArg: 1.637 ± 0.026	1.25LysSer: 1.25 ± 0.025	1.4LysThr: 1.4 ± 0.03	1.943LysVal: 1.943 ± 0.031	0.322LysTrp: 0.322 ± 0.013	0.464LysTyr: 0.464 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	14.261LeuAla: 14.261 ± 0.095	0.816LeuCys: 0.816 ± 0.019	6.598LeuAsp: 6.598 ± 0.058	4.367LeuGlu: 4.367 ± 0.043	2.743LeuPhe: 2.743 ± 0.039	8.738LeuGly: 8.738 ± 0.067	2.052LeuHis: 2.052 ± 0.031	4.389LeuIle: 4.389 ± 0.054	1.913LeuLys: 1.913 ± 0.033	9.656LeuLeu: 9.656 ± 0.087	1.786LeuMet: 1.786 ± 0.028	2.139LeuAsn: 2.139 ± 0.029	5.772LeuPro: 5.772 ± 0.055	2.562LeuGln: 2.562 ± 0.033	7.476LeuArg: 7.476 ± 0.067	5.617LeuSer: 5.617 ± 0.053	6.536LeuThr: 6.536 ± 0.06	8.541LeuVal: 8.541 ± 0.084	1.207LeuTrp: 1.207 ± 0.031	1.722LeuTyr: 1.722 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.656MetAla: 2.656 ± 0.037	0.194MetCys: 0.194 ± 0.009	0.915MetAsp: 0.915 ± 0.023	0.682MetGlu: 0.682 ± 0.02	0.659MetPhe: 0.659 ± 0.019	1.521MetGly: 1.521 ± 0.027	0.4MetHis: 0.4 ± 0.015	0.93MetIle: 0.93 ± 0.02	0.487MetLys: 0.487 ± 0.014	2.107MetLeu: 2.107 ± 0.03	0.438MetMet: 0.438 ± 0.015	0.511MetAsn: 0.511 ± 0.015	1.227MetPro: 1.227 ± 0.023	0.556MetGln: 0.556 ± 0.016	1.576MetArg: 1.576 ± 0.026	1.605MetSer: 1.605 ± 0.026	1.897MetThr: 1.897 ± 0.029	1.649MetVal: 1.649 ± 0.028	0.263MetTrp: 0.263 ± 0.012	0.347MetTyr: 0.347 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.734AsnAla: 2.734 ± 0.037	0.192AsnCys: 0.192 ± 0.01	1.246AsnAsp: 1.246 ± 0.025	1.026AsnGlu: 1.026 ± 0.023	0.661AsnPhe: 0.661 ± 0.018	2.057AsnGly: 2.057 ± 0.038	0.482AsnHis: 0.482 ± 0.016	0.996AsnIle: 0.996 ± 0.023	0.49AsnLys: 0.49 ± 0.014	2.119AsnLeu: 2.119 ± 0.029	0.419AsnMet: 0.419 ± 0.013	0.593AsnAsn: 0.593 ± 0.017	1.778AsnPro: 1.778 ± 0.033	0.651AsnGln: 0.651 ± 0.019	1.626AsnArg: 1.626 ± 0.028	1.179AsnSer: 1.179 ± 0.023	1.351AsnThr: 1.351 ± 0.027	1.863AsnVal: 1.863 ± 0.03	0.383AsnTrp: 0.383 ± 0.012	0.568AsnTyr: 0.568 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	7.469ProAla: 7.469 ± 0.074	0.289ProCys: 0.289 ± 0.013	4.502ProAsp: 4.502 ± 0.054	3.721ProGlu: 3.721 ± 0.046	1.636ProPhe: 1.636 ± 0.03	5.443ProGly: 5.443 ± 0.051	1.227ProHis: 1.227 ± 0.024	2.218ProIle: 2.218 ± 0.032	1.307ProLys: 1.307 ± 0.024	4.851ProLeu: 4.851 ± 0.046	1.207ProMet: 1.207 ± 0.025	1.272ProAsn: 1.272 ± 0.022	3.528ProPro: 3.528 ± 0.081	1.86ProGln: 1.86 ± 0.033	3.29ProArg: 3.29 ± 0.044	2.9ProSer: 2.9 ± 0.038	3.342ProThr: 3.342 ± 0.042	5.086ProVal: 5.086 ± 0.051	0.85ProTrp: 0.85 ± 0.02	1.214ProTyr: 1.214 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.712GlnAla: 3.712 ± 0.043	0.205GlnCys: 0.205 ± 0.009	1.2GlnAsp: 1.2 ± 0.021	1.14GlnGlu: 1.14 ± 0.027	1.007GlnPhe: 1.007 ± 0.021	1.907GlnGly: 1.907 ± 0.029	0.749GlnHis: 0.749 ± 0.017	1.567GlnIle: 1.567 ± 0.028	0.627GlnLys: 0.627 ± 0.019	3.518GlnLeu: 3.518 ± 0.04	0.696GlnMet: 0.696 ± 0.017	0.619GlnAsn: 0.619 ± 0.018	1.842GlnPro: 1.842 ± 0.033	1.308GlnGln: 1.308 ± 0.029	2.818GlnArg: 2.818 ± 0.034	1.473GlnSer: 1.473 ± 0.029	1.634GlnThr: 1.634 ± 0.028	2.464GlnVal: 2.464 ± 0.037	0.575GlnTrp: 0.575 ± 0.015	0.68GlnTyr: 0.68 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	8.159ArgAla: 8.159 ± 0.073	0.554ArgCys: 0.554 ± 0.019	4.278ArgAsp: 4.278 ± 0.044	3.868ArgGlu: 3.868 ± 0.045	2.382ArgPhe: 2.382 ± 0.03	5.015ArgGly: 5.015 ± 0.048	1.748ArgHis: 1.748 ± 0.029	3.557ArgIle: 3.557 ± 0.041	1.661ArgLys: 1.661 ± 0.028	7.333ArgLeu: 7.333 ± 0.067	1.789ArgMet: 1.789 ± 0.028	1.729ArgAsn: 1.729 ± 0.025	3.844ArgPro: 3.844 ± 0.044	2.321ArgGln: 2.321 ± 0.034	6.358ArgArg: 6.358 ± 0.066	3.884ArgSer: 3.884 ± 0.04	4.221ArgThr: 4.221 ± 0.042	5.501ArgVal: 5.501 ± 0.043	1.299ArgTrp: 1.299 ± 0.026	1.861ArgTyr: 1.861 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.981SerAla: 6.981 ± 0.063	0.418SerCys: 0.418 ± 0.013	3.223SerAsp: 3.223 ± 0.037	2.553SerGlu: 2.553 ± 0.034	1.665SerPhe: 1.665 ± 0.028	5.605SerGly: 5.605 ± 0.055	1.071SerHis: 1.071 ± 0.024	2.242SerIle: 2.242 ± 0.029	1.155SerLys: 1.155 ± 0.023	4.749SerLeu: 4.749 ± 0.048	1.327SerMet: 1.327 ± 0.026	1.124SerAsn: 1.124 ± 0.021	2.992SerPro: 2.992 ± 0.032	1.45SerGln: 1.45 ± 0.026	3.568SerArg: 3.568 ± 0.039	3.043SerSer: 3.043 ± 0.043	3.313SerThr: 3.313 ± 0.038	4.534SerVal: 4.534 ± 0.052	0.897SerTrp: 0.897 ± 0.019	1.252SerTyr: 1.252 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	8.099ThrAla: 8.099 ± 0.066	0.422ThrCys: 0.422 ± 0.016	3.834ThrAsp: 3.834 ± 0.035	3.301ThrGlu: 3.301 ± 0.038	1.898ThrPhe: 1.898 ± 0.028	5.765ThrGly: 5.765 ± 0.057	1.181ThrHis: 1.181 ± 0.023	2.495ThrIle: 2.495 ± 0.036	1.312ThrLys: 1.312 ± 0.027	5.709ThrLeu: 5.709 ± 0.051	1.244ThrMet: 1.244 ± 0.026	1.249ThrAsn: 1.249 ± 0.023	3.884ThrPro: 3.884 ± 0.043	1.508ThrGln: 1.508 ± 0.027	3.61ThrArg: 3.61 ± 0.041	3.115ThrSer: 3.115 ± 0.038	3.965ThrThr: 3.965 ± 0.062	6.078ThrVal: 6.078 ± 0.053	0.854ThrTrp: 0.854 ± 0.021	1.348ThrTyr: 1.348 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	11.667ValAla: 11.667 ± 0.077	0.777ValCys: 0.777 ± 0.021	5.705ValAsp: 5.705 ± 0.05	4.637ValGlu: 4.637 ± 0.05	2.697ValPhe: 2.697 ± 0.037	7.112ValGly: 7.112 ± 0.059	1.81ValHis: 1.81 ± 0.029	4.123ValIle: 4.123 ± 0.042	1.79ValLys: 1.79 ± 0.034	9.175ValLeu: 9.175 ± 0.071	1.632ValMet: 1.632 ± 0.029	2.106ValAsn: 2.106 ± 0.036	4.679ValPro: 4.679 ± 0.048	2.182ValGln: 2.182 ± 0.036	5.852ValArg: 5.852 ± 0.053	4.844ValSer: 4.844 ± 0.051	5.649ValThr: 5.649 ± 0.046	8.692ValVal: 8.692 ± 0.073	1.084ValTrp: 1.084 ± 0.021	1.64ValTyr: 1.64 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.56TrpAla: 1.56 ± 0.028	0.145TrpCys: 0.145 ± 0.009	0.788TrpAsp: 0.788 ± 0.019	0.629TrpGlu: 0.629 ± 0.017	0.543TrpPhe: 0.543 ± 0.015	1.03TrpGly: 1.03 ± 0.021	0.37TrpHis: 0.37 ± 0.014	0.659TrpIle: 0.659 ± 0.016	0.337TrpLys: 0.337 ± 0.012	1.722TrpLeu: 1.722 ± 0.033	0.33TrpMet: 0.33 ± 0.013	0.41TrpAsn: 0.41 ± 0.012	0.833TrpPro: 0.833 ± 0.02	0.646TrpGln: 0.646 ± 0.019	1.223TrpArg: 1.223 ± 0.026	0.933TrpSer: 0.933 ± 0.023	0.927TrpThr: 0.927 ± 0.022	1.125TrpVal: 1.125 ± 0.022	0.332TrpTrp: 0.332 ± 0.013	0.341TrpTyr: 0.341 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.46TyrAla: 2.46 ± 0.033	0.233TyrCys: 0.233 ± 0.01	1.436TyrAsp: 1.436 ± 0.029	1.091TyrGlu: 1.091 ± 0.025	0.796TyrPhe: 0.796 ± 0.016	2.08TyrGly: 2.08 ± 0.034	0.467TyrHis: 0.467 ± 0.015	0.694TyrIle: 0.694 ± 0.018	0.369TyrLys: 0.369 ± 0.014	2.406TyrLeu: 2.406 ± 0.037	0.303TyrMet: 0.303 ± 0.012	0.505TyrAsn: 0.505 ± 0.016	1.278TyrPro: 1.278 ± 0.021	0.67TyrGln: 0.67 ± 0.016	1.887TyrArg: 1.887 ± 0.031	1.148TyrSer: 1.148 ± 0.023	1.261TyrThr: 1.261 ± 0.024	1.721TyrVal: 1.721 ± 0.031	0.368TyrTrp: 0.368 ± 0.012	0.526TyrTyr: 0.526 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6894 proteins (2192979 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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