Amino acid dipepetide frequency for Hubei picorna-like virus 56

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.602AlaAla: 2.602 ± 1.432
0.325AlaCys: 0.325 ± 0.142
1.626AlaAsp: 1.626 ± 0.146
2.602AlaGlu: 2.602 ± 0.576
2.276AlaPhe: 2.276 ± 0.139
3.902AlaGly: 3.902 ± 0.007
1.301AlaHis: 1.301 ± 0.569
6.179AlaIle: 6.179 ± 0.989
3.902AlaLys: 3.902 ± 1.707
7.154AlaLeu: 7.154 ± 1.415
1.626AlaMet: 1.626 ± 1.002
4.878AlaAsn: 4.878 ± 1.277
0.325AlaPro: 0.325 ± 0.714
1.301AlaGln: 1.301 ± 1.144
2.276AlaArg: 2.276 ± 0.139
4.878AlaSer: 4.878 ± 2.133
2.276AlaThr: 2.276 ± 0.718
4.228AlaVal: 4.228 ± 0.721
0.325AlaTrp: 0.325 ± 0.714
2.276AlaTyr: 2.276 ± 0.139
0.0AlaXaa: 0.0 ± 0.0
Cys
0.65CysAla: 0.65 ± 0.284
0.0CysCys: 0.0 ± 0.0
1.626CysAsp: 1.626 ± 0.711
1.951CysGlu: 1.951 ± 0.853
0.325CysPhe: 0.325 ± 0.142
1.301CysGly: 1.301 ± 0.288
0.0CysHis: 0.0 ± 0.0
0.976CysIle: 0.976 ± 0.427
0.976CysLys: 0.976 ± 0.427
1.301CysLeu: 1.301 ± 0.288
0.325CysMet: 0.325 ± 0.142
0.65CysAsn: 0.65 ± 0.284
0.65CysPro: 0.65 ± 0.572
0.325CysGln: 0.325 ± 0.142
0.0CysArg: 0.0 ± 0.0
2.927CysSer: 2.927 ± 0.423
0.65CysThr: 0.65 ± 0.284
0.976CysVal: 0.976 ± 0.427
0.325CysTrp: 0.325 ± 0.142
1.301CysTyr: 1.301 ± 0.569
0.0CysXaa: 0.0 ± 0.0
Asp
1.951AspAla: 1.951 ± 0.86
1.626AspCys: 1.626 ± 0.711
1.301AspAsp: 1.301 ± 0.288
2.276AspGlu: 2.276 ± 2.431
5.203AspPhe: 5.203 ± 2.864
3.252AspGly: 3.252 ± 0.291
0.976AspHis: 0.976 ± 0.427
5.854AspIle: 5.854 ± 0.01
3.577AspLys: 3.577 ± 0.149
5.528AspLeu: 5.528 ± 0.704
0.976AspMet: 0.976 ± 0.43
3.252AspAsn: 3.252 ± 0.566
3.577AspPro: 3.577 ± 1.564
1.626AspGln: 1.626 ± 0.711
2.602AspArg: 2.602 ± 1.138
2.927AspSer: 2.927 ± 1.28
1.626AspThr: 1.626 ± 0.711
3.252AspVal: 3.252 ± 0.566
0.65AspTrp: 0.65 ± 0.284
1.951AspTyr: 1.951 ± 0.003
0.0AspXaa: 0.0 ± 0.0
Glu
3.577GluAla: 3.577 ± 1.564
0.976GluCys: 0.976 ± 0.427
3.577GluAsp: 3.577 ± 1.006
3.252GluGlu: 3.252 ± 0.566
3.902GluPhe: 3.902 ± 0.007
4.228GluGly: 4.228 ± 0.992
2.276GluHis: 2.276 ± 0.996
4.228GluIle: 4.228 ± 0.992
4.228GluLys: 4.228 ± 0.136
6.504GluLeu: 6.504 ± 2.296
1.951GluMet: 1.951 ± 0.003
1.626GluAsn: 1.626 ± 0.711
0.976GluPro: 0.976 ± 0.43
1.626GluGln: 1.626 ± 1.002
1.951GluArg: 1.951 ± 0.853
3.577GluSer: 3.577 ± 0.708
2.927GluThr: 2.927 ± 0.433
3.577GluVal: 3.577 ± 0.149
0.0GluTrp: 0.0 ± 0.0
5.203GluTyr: 5.203 ± 0.562
0.0GluXaa: 0.0 ± 0.0
Phe
2.602PheAla: 2.602 ± 0.281
0.976PheCys: 0.976 ± 0.427
3.577PheAsp: 3.577 ± 0.708
1.951PheGlu: 1.951 ± 0.853
0.65PhePhe: 0.65 ± 0.284
4.228PheGly: 4.228 ± 0.721
1.951PheHis: 1.951 ± 0.003
4.553PheIle: 4.553 ± 0.579
4.228PheLys: 4.228 ± 0.136
2.927PheLeu: 2.927 ± 0.423
0.65PheMet: 0.65 ± 0.144
3.252PheAsn: 3.252 ± 0.566
2.602PhePro: 2.602 ± 0.576
2.276PheGln: 2.276 ± 3.288
2.276PheArg: 2.276 ± 0.718
3.902PheSer: 3.902 ± 0.85
3.902PheThr: 3.902 ± 0.007
2.276PheVal: 2.276 ± 0.718
0.325PheTrp: 0.325 ± 0.142
1.951PheTyr: 1.951 ± 0.86
0.0PheXaa: 0.0 ± 0.0
Gly
1.951GlyAla: 1.951 ± 1.717
0.976GlyCys: 0.976 ± 0.427
2.276GlyAsp: 2.276 ± 0.139
1.951GlyGlu: 1.951 ± 0.003
3.902GlyPhe: 3.902 ± 0.863
3.252GlyGly: 3.252 ± 1.148
0.976GlyHis: 0.976 ± 0.43
4.228GlyIle: 4.228 ± 0.992
3.902GlyLys: 3.902 ± 1.707
5.528GlyLeu: 5.528 ± 3.579
0.65GlyMet: 0.65 ± 0.284
2.276GlyAsn: 2.276 ± 0.718
3.577GlyPro: 3.577 ± 1.006
2.602GlyGln: 2.602 ± 0.576
1.951GlyArg: 1.951 ± 0.86
2.602GlySer: 2.602 ± 0.576
4.228GlyThr: 4.228 ± 3.291
1.626GlyVal: 1.626 ± 0.711
0.325GlyTrp: 0.325 ± 0.714
2.602GlyTyr: 2.602 ± 0.576
0.0GlyXaa: 0.0 ± 0.0
His
0.976HisAla: 0.976 ± 0.427
1.301HisCys: 1.301 ± 0.569
1.626HisAsp: 1.626 ± 0.711
1.951HisGlu: 1.951 ± 0.003
1.301HisPhe: 1.301 ± 0.288
0.65HisGly: 0.65 ± 0.572
0.325HisHis: 0.325 ± 0.142
1.951HisIle: 1.951 ± 0.853
1.951HisLys: 1.951 ± 0.853
1.301HisLeu: 1.301 ± 0.569
0.65HisMet: 0.65 ± 0.284
2.276HisAsn: 2.276 ± 0.996
0.976HisPro: 0.976 ± 0.43
0.325HisGln: 0.325 ± 0.142
0.976HisArg: 0.976 ± 0.427
1.626HisSer: 1.626 ± 0.711
0.976HisThr: 0.976 ± 0.427
0.325HisVal: 0.325 ± 0.142
0.325HisTrp: 0.325 ± 0.142
0.65HisTyr: 0.65 ± 0.284
0.0HisXaa: 0.0 ± 0.0
Ile
4.553IleAla: 4.553 ± 1.134
1.626IleCys: 1.626 ± 0.146
3.252IleAsp: 3.252 ± 0.566
3.252IleGlu: 3.252 ± 0.291
3.902IlePhe: 3.902 ± 0.85
4.228IleGly: 4.228 ± 0.136
1.626IleHis: 1.626 ± 0.711
4.878IleIle: 4.878 ± 0.437
7.48IleLys: 7.48 ± 1.558
7.805IleLeu: 7.805 ± 2.557
1.626IleMet: 1.626 ± 0.711
5.528IleAsn: 5.528 ± 0.704
2.602IlePro: 2.602 ± 1.138
1.301IleGln: 1.301 ± 0.288
3.577IleArg: 3.577 ± 1.006
5.528IleSer: 5.528 ± 0.704
4.228IleThr: 4.228 ± 0.992
5.203IleVal: 5.203 ± 0.562
0.65IleTrp: 0.65 ± 0.284
3.902IleTyr: 3.902 ± 0.863
0.0IleXaa: 0.0 ± 0.0
Lys
4.228LysAla: 4.228 ± 0.721
0.976LysCys: 0.976 ± 0.427
4.228LysAsp: 4.228 ± 0.992
7.154LysGlu: 7.154 ± 1.415
2.276LysPhe: 2.276 ± 0.996
3.252LysGly: 3.252 ± 0.566
1.951LysHis: 1.951 ± 0.853
4.228LysIle: 4.228 ± 1.849
5.203LysLys: 5.203 ± 1.419
5.203LysLeu: 5.203 ± 0.562
1.301LysMet: 1.301 ± 0.569
4.228LysAsn: 4.228 ± 0.721
2.602LysPro: 2.602 ± 0.281
4.228LysGln: 4.228 ± 1.578
2.927LysArg: 2.927 ± 0.423
5.203LysSer: 5.203 ± 1.419
3.902LysThr: 3.902 ± 0.85
6.179LysVal: 6.179 ± 0.724
0.976LysTrp: 0.976 ± 0.427
4.228LysTyr: 4.228 ± 0.136
0.0LysXaa: 0.0 ± 0.0
Leu
7.48LeuAla: 7.48 ± 0.701
0.976LeuCys: 0.976 ± 1.287
4.553LeuAsp: 4.553 ± 0.579
5.203LeuGlu: 5.203 ± 0.294
5.203LeuPhe: 5.203 ± 0.294
3.577LeuGly: 3.577 ± 0.149
2.276LeuHis: 2.276 ± 0.139
7.805LeuIle: 7.805 ± 1.7
7.48LeuLys: 7.48 ± 1.558
9.431LeuLeu: 9.431 ± 1.554
1.626LeuMet: 1.626 ± 1.002
4.878LeuAsn: 4.878 ± 0.42
0.976LeuPro: 0.976 ± 0.43
3.577LeuGln: 3.577 ± 1.006
7.805LeuArg: 7.805 ± 0.843
5.854LeuSer: 5.854 ± 0.847
5.203LeuThr: 5.203 ± 1.151
4.878LeuVal: 4.878 ± 0.437
0.65LeuTrp: 0.65 ± 0.572
3.902LeuTyr: 3.902 ± 0.863
0.0LeuXaa: 0.0 ± 0.0
Met
1.301MetAla: 1.301 ± 1.144
0.0MetCys: 0.0 ± 0.0
0.976MetAsp: 0.976 ± 0.43
1.626MetGlu: 1.626 ± 1.002
0.325MetPhe: 0.325 ± 0.714
0.65MetGly: 0.65 ± 0.284
0.65MetHis: 0.65 ± 0.284
1.301MetIle: 1.301 ± 0.288
0.976MetLys: 0.976 ± 0.427
1.626MetLeu: 1.626 ± 0.711
0.0MetMet: 0.0 ± 0.0
1.951MetAsn: 1.951 ± 0.853
1.626MetPro: 1.626 ± 0.146
0.65MetGln: 0.65 ± 0.572
0.65MetArg: 0.65 ± 0.284
2.602MetSer: 2.602 ± 0.281
2.276MetThr: 2.276 ± 0.139
0.976MetVal: 0.976 ± 0.427
0.0MetTrp: 0.0 ± 0.0
0.65MetTyr: 0.65 ± 0.284
0.0MetXaa: 0.0 ± 0.0
Asn
6.179AsnAla: 6.179 ± 0.989
0.65AsnCys: 0.65 ± 0.284
1.626AsnAsp: 1.626 ± 0.711
3.252AsnGlu: 3.252 ± 0.566
3.252AsnPhe: 3.252 ± 0.291
2.927AsnGly: 2.927 ± 0.423
0.976AsnHis: 0.976 ± 0.427
6.179AsnIle: 6.179 ± 1.845
5.203AsnLys: 5.203 ± 2.008
4.553AsnLeu: 4.553 ± 1.134
0.976AsnMet: 0.976 ± 0.427
3.577AsnAsn: 3.577 ± 1.006
3.577AsnPro: 3.577 ± 1.564
3.902AsnGln: 3.902 ± 0.863
1.951AsnArg: 1.951 ± 0.003
4.553AsnSer: 4.553 ± 0.579
2.927AsnThr: 2.927 ± 2.147
2.602AsnVal: 2.602 ± 1.432
0.0AsnTrp: 0.0 ± 0.0
2.276AsnTyr: 2.276 ± 0.139
0.0AsnXaa: 0.0 ± 0.0
Pro
1.626ProAla: 1.626 ± 0.146
0.325ProCys: 0.325 ± 0.142
3.252ProAsp: 3.252 ± 0.291
1.626ProGlu: 1.626 ± 0.711
2.927ProPhe: 2.927 ± 0.433
1.301ProGly: 1.301 ± 0.288
1.301ProHis: 1.301 ± 0.569
3.577ProIle: 3.577 ± 0.149
1.626ProLys: 1.626 ± 0.711
2.927ProLeu: 2.927 ± 0.423
0.976ProMet: 0.976 ± 0.43
2.927ProAsn: 2.927 ± 0.433
1.951ProPro: 1.951 ± 0.853
0.325ProGln: 0.325 ± 0.714
1.626ProArg: 1.626 ± 0.146
3.902ProSer: 3.902 ± 1.707
4.228ProThr: 4.228 ± 0.721
1.301ProVal: 1.301 ± 0.569
0.0ProTrp: 0.0 ± 0.0
1.626ProTyr: 1.626 ± 0.146
0.0ProXaa: 0.0 ± 0.0
Gln
1.951GlnAla: 1.951 ± 0.003
0.976GlnCys: 0.976 ± 0.427
3.577GlnAsp: 3.577 ± 1.006
1.626GlnGlu: 1.626 ± 0.711
2.276GlnPhe: 2.276 ± 2.431
2.276GlnGly: 2.276 ± 2.431
0.325GlnHis: 0.325 ± 0.142
3.577GlnIle: 3.577 ± 1.006
1.626GlnLys: 1.626 ± 0.146
3.252GlnLeu: 3.252 ± 2.004
0.325GlnMet: 0.325 ± 0.714
1.951GlnAsn: 1.951 ± 0.86
1.626GlnPro: 1.626 ± 0.146
4.553GlnGln: 4.553 ± 8.289
1.301GlnArg: 1.301 ± 1.144
3.902GlnSer: 3.902 ± 5.147
1.301GlnThr: 1.301 ± 0.288
1.626GlnVal: 1.626 ± 0.146
0.0GlnTrp: 0.0 ± 0.0
2.276GlnTyr: 2.276 ± 0.139
0.0GlnXaa: 0.0 ± 0.0
Arg
2.602ArgAla: 2.602 ± 0.281
1.301ArgCys: 1.301 ± 0.569
1.626ArgAsp: 1.626 ± 0.711
2.927ArgGlu: 2.927 ± 0.433
2.602ArgPhe: 2.602 ± 0.281
1.626ArgGly: 1.626 ± 1.002
0.0ArgHis: 0.0 ± 0.0
2.602ArgIle: 2.602 ± 1.138
2.602ArgLys: 2.602 ± 0.281
2.927ArgLeu: 2.927 ± 0.423
0.976ArgMet: 0.976 ± 0.43
1.626ArgAsn: 1.626 ± 0.711
1.951ArgPro: 1.951 ± 0.003
2.927ArgGln: 2.927 ± 2.147
1.626ArgArg: 1.626 ± 0.711
2.276ArgSer: 2.276 ± 0.139
3.252ArgThr: 3.252 ± 0.566
0.976ArgVal: 0.976 ± 0.427
0.65ArgTrp: 0.65 ± 0.284
1.951ArgTyr: 1.951 ± 0.86
0.0ArgXaa: 0.0 ± 0.0
Ser
3.252SerAla: 3.252 ± 1.422
0.976SerCys: 0.976 ± 0.427
3.902SerAsp: 3.902 ± 0.85
5.203SerGlu: 5.203 ± 1.419
2.602SerPhe: 2.602 ± 1.138
3.577SerGly: 3.577 ± 1.006
1.301SerHis: 1.301 ± 0.569
4.228SerIle: 4.228 ± 1.849
7.154SerLys: 7.154 ± 2.272
8.13SerLeu: 8.13 ± 0.129
2.927SerMet: 2.927 ± 0.423
5.203SerAsn: 5.203 ± 2.864
3.252SerPro: 3.252 ± 0.566
3.577SerGln: 3.577 ± 1.862
0.976SerArg: 0.976 ± 0.427
6.504SerSer: 6.504 ± 1.131
5.203SerThr: 5.203 ± 1.419
3.252SerVal: 3.252 ± 1.148
1.301SerTrp: 1.301 ± 0.569
2.927SerTyr: 2.927 ± 0.433
0.0SerXaa: 0.0 ± 0.0
Thr
1.951ThrAla: 1.951 ± 0.853
0.325ThrCys: 0.325 ± 0.142
3.902ThrAsp: 3.902 ± 1.72
6.504ThrGlu: 6.504 ± 1.131
2.927ThrPhe: 2.927 ± 0.423
2.602ThrGly: 2.602 ± 0.576
1.626ThrHis: 1.626 ± 0.711
3.577ThrIle: 3.577 ± 0.149
5.528ThrLys: 5.528 ± 1.866
7.805ThrLeu: 7.805 ± 1.727
1.951ThrMet: 1.951 ± 0.853
3.577ThrAsn: 3.577 ± 0.149
1.951ThrPro: 1.951 ± 0.853
1.301ThrGln: 1.301 ± 0.288
1.951ThrArg: 1.951 ± 0.003
4.228ThrSer: 4.228 ± 0.136
5.528ThrThr: 5.528 ± 0.152
2.276ThrVal: 2.276 ± 0.139
0.0ThrTrp: 0.0 ± 0.0
1.626ThrTyr: 1.626 ± 0.146
0.0ThrXaa: 0.0 ± 0.0
Val
2.927ValAla: 2.927 ± 0.423
1.951ValCys: 1.951 ± 0.003
2.927ValAsp: 2.927 ± 0.423
3.252ValGlu: 3.252 ± 0.291
1.626ValPhe: 1.626 ± 0.146
1.301ValGly: 1.301 ± 0.288
0.65ValHis: 0.65 ± 0.284
3.902ValIle: 3.902 ± 1.72
2.927ValLys: 2.927 ± 0.423
5.854ValLeu: 5.854 ± 0.847
0.65ValMet: 0.65 ± 0.284
4.228ValAsn: 4.228 ± 1.578
1.951ValPro: 1.951 ± 0.003
1.301ValGln: 1.301 ± 0.288
1.951ValArg: 1.951 ± 0.853
4.228ValSer: 4.228 ± 0.136
3.577ValThr: 3.577 ± 1.564
2.927ValVal: 2.927 ± 0.423
0.325ValTrp: 0.325 ± 0.714
2.927ValTyr: 2.927 ± 2.147
0.0ValXaa: 0.0 ± 0.0
Trp
0.325TrpAla: 0.325 ± 0.142
0.325TrpCys: 0.325 ± 0.142
0.325TrpAsp: 0.325 ± 0.142
0.0TrpGlu: 0.0 ± 0.0
0.976TrpPhe: 0.976 ± 0.427
0.976TrpGly: 0.976 ± 2.143
0.325TrpHis: 0.325 ± 0.142
0.65TrpIle: 0.65 ± 0.284
0.325TrpLys: 0.325 ± 0.142
0.976TrpLeu: 0.976 ± 0.43
0.0TrpMet: 0.0 ± 0.0
0.65TrpAsn: 0.65 ± 0.284
0.0TrpPro: 0.0 ± 0.0
0.65TrpGln: 0.65 ± 0.284
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
0.325TrpThr: 0.325 ± 0.142
0.325TrpVal: 0.325 ± 0.142
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.577TyrAla: 3.577 ± 1.006
0.65TyrCys: 0.65 ± 0.284
4.228TyrAsp: 4.228 ± 0.136
2.602TyrGlu: 2.602 ± 0.281
2.927TyrPhe: 2.927 ± 0.423
2.276TyrGly: 2.276 ± 3.288
1.626TyrHis: 1.626 ± 0.146
2.276TyrIle: 2.276 ± 0.996
3.577TyrLys: 3.577 ± 0.149
2.602TyrLeu: 2.602 ± 1.432
0.325TyrMet: 0.325 ± 0.142
2.602TyrAsn: 2.602 ± 1.138
2.602TyrPro: 2.602 ± 0.576
1.951TyrGln: 1.951 ± 1.717
0.65TyrArg: 0.65 ± 0.572
4.228TyrSer: 4.228 ± 0.992
2.602TyrThr: 2.602 ± 0.281
2.602TyrVal: 2.602 ± 0.576
0.325TyrTrp: 0.325 ± 0.142
2.927TyrTyr: 2.927 ± 1.28
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (3076 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski