Amino acid dipepetide frequency for Sodalis-like symbiont of Philaenus spumarius

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.006AlaAla: 11.006 ± 0.226
1.256AlaCys: 1.256 ± 0.061
5.28AlaAsp: 5.28 ± 0.15
5.96AlaGlu: 5.96 ± 0.155
3.517AlaPhe: 3.517 ± 0.103
7.568AlaGly: 7.568 ± 0.154
1.946AlaHis: 1.946 ± 0.076
5.479AlaIle: 5.479 ± 0.117
3.592AlaLys: 3.592 ± 0.105
12.336AlaLeu: 12.336 ± 0.225
2.769AlaMet: 2.769 ± 0.087
2.713AlaAsn: 2.713 ± 0.097
3.831AlaPro: 3.831 ± 0.11
4.537AlaGln: 4.537 ± 0.131
6.881AlaArg: 6.881 ± 0.152
5.15AlaSer: 5.15 ± 0.127
4.545AlaThr: 4.545 ± 0.121
6.836AlaVal: 6.836 ± 0.158
1.285AlaTrp: 1.285 ± 0.054
2.275AlaTyr: 2.275 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
1.046CysAla: 1.046 ± 0.05
0.295CysCys: 0.295 ± 0.028
0.706CysAsp: 0.706 ± 0.047
0.64CysGlu: 0.64 ± 0.044
0.703CysPhe: 0.703 ± 0.05
1.099CysGly: 1.099 ± 0.056
0.688CysHis: 0.688 ± 0.053
0.634CysIle: 0.634 ± 0.038
0.401CysLys: 0.401 ± 0.034
1.128CysLeu: 1.128 ± 0.054
0.427CysMet: 0.427 ± 0.035
0.313CysAsn: 0.313 ± 0.027
0.834CysPro: 0.834 ± 0.048
0.613CysGln: 0.613 ± 0.041
0.948CysArg: 0.948 ± 0.051
0.68CysSer: 0.68 ± 0.041
0.552CysThr: 0.552 ± 0.038
0.804CysVal: 0.804 ± 0.043
0.173CysTrp: 0.173 ± 0.025
0.398CysTyr: 0.398 ± 0.031
0.0CysXaa: 0.0 ± 0.0
Asp
5.466AspAla: 5.466 ± 0.125
0.611AspCys: 0.611 ± 0.042
3.021AspAsp: 3.021 ± 0.113
3.772AspGlu: 3.772 ± 0.102
2.097AspPhe: 2.097 ± 0.077
4.07AspGly: 4.07 ± 0.123
1.099AspHis: 1.099 ± 0.06
3.472AspIle: 3.472 ± 0.081
2.501AspLys: 2.501 ± 0.092
4.67AspLeu: 4.67 ± 0.123
1.457AspMet: 1.457 ± 0.074
2.222AspAsn: 2.222 ± 0.084
2.217AspPro: 2.217 ± 0.082
1.614AspGln: 1.614 ± 0.058
3.204AspArg: 3.204 ± 0.091
2.774AspSer: 2.774 ± 0.092
2.705AspThr: 2.705 ± 0.099
4.101AspVal: 4.101 ± 0.106
0.823AspTrp: 0.823 ± 0.047
1.845AspTyr: 1.845 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
5.742GluAla: 5.742 ± 0.131
0.526GluCys: 0.526 ± 0.039
2.525GluAsp: 2.525 ± 0.095
3.125GluGlu: 3.125 ± 0.131
1.651GluPhe: 1.651 ± 0.066
3.568GluGly: 3.568 ± 0.108
1.447GluHis: 1.447 ± 0.067
3.772GluIle: 3.772 ± 0.109
3.456GluLys: 3.456 ± 0.111
5.737GluLeu: 5.737 ± 0.142
1.63GluMet: 1.63 ± 0.064
1.895GluAsn: 1.895 ± 0.066
1.861GluPro: 1.861 ± 0.071
3.355GluGln: 3.355 ± 0.092
4.813GluArg: 4.813 ± 0.119
2.525GluSer: 2.525 ± 0.097
2.981GluThr: 2.981 ± 0.09
4.032GluVal: 4.032 ± 0.102
0.56GluTrp: 0.56 ± 0.036
1.423GluTyr: 1.423 ± 0.065
0.0GluXaa: 0.0 ± 0.0
Phe
3.196PheAla: 3.196 ± 0.092
0.608PheCys: 0.608 ± 0.043
2.222PheAsp: 2.222 ± 0.095
1.617PheGlu: 1.617 ± 0.067
1.479PhePhe: 1.479 ± 0.075
2.79PheGly: 2.79 ± 0.084
0.884PheHis: 0.884 ± 0.05
2.639PheIle: 2.639 ± 0.105
1.176PheLys: 1.176 ± 0.054
3.002PheLeu: 3.002 ± 0.081
0.892PheMet: 0.892 ± 0.048
1.569PheAsn: 1.569 ± 0.064
1.423PhePro: 1.423 ± 0.052
1.197PheGln: 1.197 ± 0.048
2.174PheArg: 2.174 ± 0.081
2.88PheSer: 2.88 ± 0.091
2.225PheThr: 2.225 ± 0.078
2.275PheVal: 2.275 ± 0.083
0.478PheTrp: 0.478 ± 0.036
1.428PheTyr: 1.428 ± 0.064
0.0PheXaa: 0.0 ± 0.0
Gly
6.562GlyAla: 6.562 ± 0.17
1.03GlyCys: 1.03 ± 0.054
4.064GlyAsp: 4.064 ± 0.116
4.691GlyGlu: 4.691 ± 0.118
2.83GlyPhe: 2.83 ± 0.1
5.36GlyGly: 5.36 ± 0.142
1.861GlyHis: 1.861 ± 0.074
4.648GlyIle: 4.648 ± 0.117
4.062GlyLys: 4.062 ± 0.116
7.181GlyLeu: 7.181 ± 0.15
2.256GlyMet: 2.256 ± 0.081
2.331GlyAsn: 2.331 ± 0.086
2.206GlyPro: 2.206 ± 0.076
3.135GlyGln: 3.135 ± 0.093
4.6GlyArg: 4.6 ± 0.12
3.945GlySer: 3.945 ± 0.097
3.547GlyThr: 3.547 ± 0.105
5.567GlyVal: 5.567 ± 0.118
1.059GlyTrp: 1.059 ± 0.056
2.254GlyTyr: 2.254 ± 0.077
0.0GlyXaa: 0.0 ± 0.0
His
1.903HisAla: 1.903 ± 0.072
0.648HisCys: 0.648 ± 0.047
1.218HisAsp: 1.218 ± 0.061
1.343HisGlu: 1.343 ± 0.07
1.067HisPhe: 1.067 ± 0.051
2.044HisGly: 2.044 ± 0.072
0.863HisHis: 0.863 ± 0.05
1.431HisIle: 1.431 ± 0.065
0.855HisLys: 0.855 ± 0.047
2.62HisLeu: 2.62 ± 0.084
0.746HisMet: 0.746 ± 0.043
0.871HisAsn: 0.871 ± 0.047
1.487HisPro: 1.487 ± 0.068
1.237HisGln: 1.237 ± 0.056
1.572HisArg: 1.572 ± 0.072
1.518HisSer: 1.518 ± 0.065
1.213HisThr: 1.213 ± 0.054
1.396HisVal: 1.396 ± 0.066
0.409HisTrp: 0.409 ± 0.036
0.924HisTyr: 0.924 ± 0.05
0.0HisXaa: 0.0 ± 0.0
Ile
5.875IleAla: 5.875 ± 0.128
0.884IleCys: 0.884 ± 0.051
3.624IleAsp: 3.624 ± 0.096
3.711IleGlu: 3.711 ± 0.109
1.903IlePhe: 1.903 ± 0.075
4.744IleGly: 4.744 ± 0.129
1.505IleHis: 1.505 ± 0.061
3.194IleIle: 3.194 ± 0.094
2.57IleLys: 2.57 ± 0.084
4.606IleLeu: 4.606 ± 0.125
1.226IleMet: 1.226 ± 0.057
2.195IleAsn: 2.195 ± 0.083
2.402IlePro: 2.402 ± 0.079
1.853IleGln: 1.853 ± 0.066
3.175IleArg: 3.175 ± 0.097
3.451IleSer: 3.451 ± 0.091
3.924IleThr: 3.924 ± 0.101
3.6IleVal: 3.6 ± 0.098
0.589IleTrp: 0.589 ± 0.041
1.768IleTyr: 1.768 ± 0.073
0.0IleXaa: 0.0 ± 0.0
Lys
3.977LysAla: 3.977 ± 0.119
0.265LysCys: 0.265 ± 0.025
1.887LysAsp: 1.887 ± 0.073
2.36LysGlu: 2.36 ± 0.078
0.988LysPhe: 0.988 ± 0.056
2.846LysGly: 2.846 ± 0.111
1.25LysHis: 1.25 ± 0.062
2.421LysIle: 2.421 ± 0.091
2.126LysLys: 2.126 ± 0.079
4.009LysLeu: 4.009 ± 0.114
1.195LysMet: 1.195 ± 0.058
1.58LysAsn: 1.58 ± 0.058
1.898LysPro: 1.898 ± 0.065
2.148LysGln: 2.148 ± 0.083
3.045LysArg: 3.045 ± 0.103
2.222LysSer: 2.222 ± 0.075
2.525LysThr: 2.525 ± 0.086
3.215LysVal: 3.215 ± 0.103
0.327LysTrp: 0.327 ± 0.027
1.049LysTyr: 1.049 ± 0.056
0.0LysXaa: 0.0 ± 0.0
Leu
11.845LeuAla: 11.845 ± 0.203
1.471LeuCys: 1.471 ± 0.063
5.904LeuAsp: 5.904 ± 0.143
5.569LeuGlu: 5.569 ± 0.133
3.698LeuPhe: 3.698 ± 0.121
7.292LeuGly: 7.292 ± 0.158
2.456LeuHis: 2.456 ± 0.077
5.179LeuIle: 5.179 ± 0.122
4.131LeuLys: 4.131 ± 0.103
11.5LeuLeu: 11.5 ± 0.286
2.888LeuMet: 2.888 ± 0.101
3.573LeuAsn: 3.573 ± 0.112
5.93LeuPro: 5.93 ± 0.167
4.293LeuGln: 4.293 ± 0.111
6.923LeuArg: 6.923 ± 0.143
7.0LeuSer: 7.0 ± 0.156
6.56LeuThr: 6.56 ± 0.148
7.165LeuVal: 7.165 ± 0.143
1.383LeuTrp: 1.383 ± 0.079
2.769LeuTyr: 2.769 ± 0.09
0.0LeuXaa: 0.0 ± 0.0
Met
2.864MetAla: 2.864 ± 0.069
0.236MetCys: 0.236 ± 0.031
1.208MetAsp: 1.208 ± 0.054
1.24MetGlu: 1.24 ± 0.058
0.908MetPhe: 0.908 ± 0.05
1.731MetGly: 1.731 ± 0.069
0.552MetHis: 0.552 ± 0.039
1.691MetIle: 1.691 ± 0.076
1.258MetLys: 1.258 ± 0.059
3.053MetLeu: 3.053 ± 0.087
0.842MetMet: 0.842 ± 0.059
1.059MetAsn: 1.059 ± 0.057
1.274MetPro: 1.274 ± 0.064
1.102MetGln: 1.102 ± 0.061
1.603MetArg: 1.603 ± 0.068
1.656MetSer: 1.656 ± 0.062
1.678MetThr: 1.678 ± 0.063
1.922MetVal: 1.922 ± 0.072
0.204MetTrp: 0.204 ± 0.026
0.534MetTyr: 0.534 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
3.101AsnAla: 3.101 ± 0.097
0.265AsnCys: 0.265 ± 0.025
1.842AsnAsp: 1.842 ± 0.059
1.577AsnGlu: 1.577 ± 0.058
1.165AsnPhe: 1.165 ± 0.057
2.655AsnGly: 2.655 ± 0.097
0.765AsnHis: 0.765 ± 0.045
2.161AsnIle: 2.161 ± 0.087
1.333AsnLys: 1.333 ± 0.07
3.252AsnLeu: 3.252 ± 0.099
0.826AsnMet: 0.826 ± 0.042
1.346AsnAsn: 1.346 ± 0.07
1.829AsnPro: 1.829 ± 0.066
1.418AsnGln: 1.418 ± 0.061
2.222AsnArg: 2.222 ± 0.08
1.622AsnSer: 1.622 ± 0.061
1.712AsnThr: 1.712 ± 0.068
2.304AsnVal: 2.304 ± 0.071
0.547AsnTrp: 0.547 ± 0.038
1.003AsnTyr: 1.003 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
4.831ProAla: 4.831 ± 0.125
0.462ProCys: 0.462 ± 0.035
2.697ProAsp: 2.697 ± 0.081
2.955ProGlu: 2.955 ± 0.094
1.649ProPhe: 1.649 ± 0.065
3.409ProGly: 3.409 ± 0.097
1.006ProHis: 1.006 ± 0.05
1.98ProIle: 1.98 ± 0.073
1.492ProLys: 1.492 ± 0.073
5.137ProLeu: 5.137 ± 0.136
1.189ProMet: 1.189 ± 0.057
1.134ProAsn: 1.134 ± 0.054
1.861ProPro: 1.861 ± 0.078
1.925ProGln: 1.925 ± 0.073
2.389ProArg: 2.389 ± 0.078
2.275ProSer: 2.275 ± 0.093
2.307ProThr: 2.307 ± 0.076
3.716ProVal: 3.716 ± 0.1
0.626ProTrp: 0.626 ± 0.046
1.303ProTyr: 1.303 ± 0.059
0.0ProXaa: 0.0 ± 0.0
Gln
4.914GlnAla: 4.914 ± 0.127
0.523GlnCys: 0.523 ± 0.038
1.986GlnAsp: 1.986 ± 0.086
2.299GlnGlu: 2.299 ± 0.089
1.452GlnPhe: 1.452 ± 0.057
3.271GlnGly: 3.271 ± 0.093
1.171GlnHis: 1.171 ± 0.06
2.14GlnIle: 2.14 ± 0.082
1.633GlnLys: 1.633 ± 0.072
5.139GlnLeu: 5.139 ± 0.139
1.126GlnMet: 1.126 ± 0.054
1.245GlnAsn: 1.245 ± 0.061
2.158GlnPro: 2.158 ± 0.089
3.297GlnGln: 3.297 ± 0.121
3.608GlnArg: 3.608 ± 0.109
2.095GlnSer: 2.095 ± 0.069
2.126GlnThr: 2.126 ± 0.077
3.239GlnVal: 3.239 ± 0.1
0.672GlnTrp: 0.672 ± 0.045
1.072GlnTyr: 1.072 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
5.811ArgAla: 5.811 ± 0.115
1.203ArgCys: 1.203 ± 0.06
3.483ArgAsp: 3.483 ± 0.097
4.168ArgGlu: 4.168 ± 0.11
3.032ArgPhe: 3.032 ± 0.086
3.892ArgGly: 3.892 ± 0.107
2.171ArgHis: 2.171 ± 0.081
3.897ArgIle: 3.897 ± 0.093
2.702ArgLys: 2.702 ± 0.09
7.566ArgLeu: 7.566 ± 0.16
1.654ArgMet: 1.654 ± 0.076
2.007ArgAsn: 2.007 ± 0.085
2.718ArgPro: 2.718 ± 0.092
3.809ArgGln: 3.809 ± 0.109
4.715ArgArg: 4.715 ± 0.138
3.233ArgSer: 3.233 ± 0.092
3.095ArgThr: 3.095 ± 0.082
4.717ArgVal: 4.717 ± 0.115
0.887ArgTrp: 0.887 ± 0.053
2.394ArgTyr: 2.394 ± 0.078
0.0ArgXaa: 0.0 ± 0.0
Ser
5.206SerAla: 5.206 ± 0.135
0.624SerCys: 0.624 ± 0.043
3.31SerAsp: 3.31 ± 0.091
3.071SerGlu: 3.071 ± 0.083
2.018SerPhe: 2.018 ± 0.083
4.699SerGly: 4.699 ± 0.106
1.404SerHis: 1.404 ± 0.058
2.633SerIle: 2.633 ± 0.085
1.89SerLys: 1.89 ± 0.069
6.002SerLeu: 6.002 ± 0.126
1.274SerMet: 1.274 ± 0.053
1.656SerAsn: 1.656 ± 0.072
2.461SerPro: 2.461 ± 0.088
2.495SerGln: 2.495 ± 0.089
3.958SerArg: 3.958 ± 0.099
2.941SerSer: 2.941 ± 0.105
2.825SerThr: 2.825 ± 0.095
4.38SerVal: 4.38 ± 0.11
0.778SerTrp: 0.778 ± 0.043
1.67SerTyr: 1.67 ± 0.069
0.0SerXaa: 0.0 ± 0.0
Thr
5.068ThrAla: 5.068 ± 0.115
0.653ThrCys: 0.653 ± 0.047
2.742ThrAsp: 2.742 ± 0.101
2.525ThrGlu: 2.525 ± 0.085
1.951ThrPhe: 1.951 ± 0.079
4.51ThrGly: 4.51 ± 0.106
1.237ThrHis: 1.237 ± 0.057
2.697ThrIle: 2.697 ± 0.085
1.691ThrLys: 1.691 ± 0.079
7.714ThrLeu: 7.714 ± 0.171
1.006ThrMet: 1.006 ± 0.056
1.367ThrAsn: 1.367 ± 0.062
3.024ThrPro: 3.024 ± 0.095
1.988ThrGln: 1.988 ± 0.07
3.647ThrArg: 3.647 ± 0.101
2.562ThrSer: 2.562 ± 0.079
2.689ThrThr: 2.689 ± 0.09
4.316ThrVal: 4.316 ± 0.108
0.557ThrTrp: 0.557 ± 0.042
1.144ThrTyr: 1.144 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
7.099ValAla: 7.099 ± 0.164
0.855ValCys: 0.855 ± 0.048
3.939ValAsp: 3.939 ± 0.111
4.327ValGlu: 4.327 ± 0.126
2.458ValPhe: 2.458 ± 0.083
4.746ValGly: 4.746 ± 0.112
1.683ValHis: 1.683 ± 0.069
4.741ValIle: 4.741 ± 0.113
3.167ValLys: 3.167 ± 0.098
7.552ValLeu: 7.552 ± 0.164
2.089ValMet: 2.089 ± 0.086
2.628ValAsn: 2.628 ± 0.083
3.071ValPro: 3.071 ± 0.09
2.479ValGln: 2.479 ± 0.077
4.16ValArg: 4.16 ± 0.116
4.579ValSer: 4.579 ± 0.107
4.051ValThr: 4.051 ± 0.109
5.609ValVal: 5.609 ± 0.152
0.836ValTrp: 0.836 ± 0.052
1.733ValTyr: 1.733 ± 0.081
0.0ValXaa: 0.0 ± 0.0
Trp
0.844TrpAla: 0.844 ± 0.046
0.175TrpCys: 0.175 ± 0.022
0.518TrpAsp: 0.518 ± 0.036
0.467TrpGlu: 0.467 ± 0.037
0.528TrpPhe: 0.528 ± 0.043
0.786TrpGly: 0.786 ± 0.046
0.39TrpHis: 0.39 ± 0.034
0.661TrpIle: 0.661 ± 0.05
0.377TrpLys: 0.377 ± 0.029
2.164TrpLeu: 2.164 ± 0.093
0.3TrpMet: 0.3 ± 0.029
0.3TrpAsn: 0.3 ± 0.032
0.605TrpPro: 0.605 ± 0.042
1.033TrpGln: 1.033 ± 0.064
1.144TrpArg: 1.144 ± 0.053
0.619TrpSer: 0.619 ± 0.039
0.417TrpThr: 0.417 ± 0.033
0.903TrpVal: 0.903 ± 0.053
0.188TrpTrp: 0.188 ± 0.023
0.374TrpTyr: 0.374 ± 0.035
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.405TyrAla: 2.405 ± 0.079
0.494TyrCys: 0.494 ± 0.033
1.564TyrAsp: 1.564 ± 0.071
1.208TyrGlu: 1.208 ± 0.063
1.059TyrPhe: 1.059 ± 0.055
2.11TyrGly: 2.11 ± 0.077
0.988TyrHis: 0.988 ± 0.057
1.327TyrIle: 1.327 ± 0.059
0.919TyrLys: 0.919 ± 0.053
3.162TyrLeu: 3.162 ± 0.091
0.82TyrMet: 0.82 ± 0.052
0.94TyrAsn: 0.94 ± 0.048
1.253TyrPro: 1.253 ± 0.064
1.635TyrGln: 1.635 ± 0.057
2.373TyrArg: 2.373 ± 0.084
1.569TyrSer: 1.569 ± 0.071
1.415TyrThr: 1.415 ± 0.066
1.707TyrVal: 1.707 ± 0.07
0.411TyrTrp: 0.411 ± 0.038
0.865TyrTyr: 0.865 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1600 proteins (376700 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski