Amino acid dipepetide frequency for Thalassobaculum litoreum DSM 18839

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.566AlaAla: 17.566 ± 0.154	1.12AlaCys: 1.12 ± 0.027	7.801AlaAsp: 7.801 ± 0.08	8.375AlaGlu: 8.375 ± 0.084	4.389AlaPhe: 4.389 ± 0.062	11.316AlaGly: 11.316 ± 0.116	2.126AlaHis: 2.126 ± 0.035	5.953AlaIle: 5.953 ± 0.068	3.618AlaLys: 3.618 ± 0.06	13.151AlaLeu: 13.151 ± 0.107	3.604AlaMet: 3.604 ± 0.054	2.678AlaAsn: 2.678 ± 0.044	5.69AlaPro: 5.69 ± 0.079	3.427AlaGln: 3.427 ± 0.049	8.751AlaArg: 8.751 ± 0.09	5.91AlaSer: 5.91 ± 0.066	6.19AlaThr: 6.19 ± 0.068	9.915AlaVal: 9.915 ± 0.1	1.597AlaTrp: 1.597 ± 0.031	2.537AlaTyr: 2.537 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.964CysAla: 0.964 ± 0.027	0.104CysCys: 0.104 ± 0.008	0.586CysAsp: 0.586 ± 0.019	0.435CysGlu: 0.435 ± 0.019	0.338CysPhe: 0.338 ± 0.016	0.975CysGly: 0.975 ± 0.025	0.259CysHis: 0.259 ± 0.016	0.34CysIle: 0.34 ± 0.016	0.18CysLys: 0.18 ± 0.01	0.874CysLeu: 0.874 ± 0.023	0.155CysMet: 0.155 ± 0.009	0.195CysAsn: 0.195 ± 0.012	0.469CysPro: 0.469 ± 0.018	0.212CysGln: 0.212 ± 0.012	0.656CysArg: 0.656 ± 0.023	0.425CysSer: 0.425 ± 0.018	0.417CysThr: 0.417 ± 0.016	0.61CysVal: 0.61 ± 0.023	0.115CysTrp: 0.115 ± 0.008	0.199CysTyr: 0.199 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.659AspAla: 7.659 ± 0.076	0.461AspCys: 0.461 ± 0.018	3.683AspAsp: 3.683 ± 0.067	3.443AspGlu: 3.443 ± 0.047	2.058AspPhe: 2.058 ± 0.038	6.306AspGly: 6.306 ± 0.076	1.364AspHis: 1.364 ± 0.033	3.032AspIle: 3.032 ± 0.05	1.546AspLys: 1.546 ± 0.036	6.759AspLeu: 6.759 ± 0.068	1.5AspMet: 1.5 ± 0.034	1.228AspAsn: 1.228 ± 0.031	4.199AspPro: 4.199 ± 0.056	1.686AspGln: 1.686 ± 0.035	5.303AspArg: 5.303 ± 0.068	2.469AspSer: 2.469 ± 0.045	3.27AspThr: 3.27 ± 0.064	4.474AspVal: 4.474 ± 0.057	1.152AspTrp: 1.152 ± 0.027	1.431AspTyr: 1.431 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	8.005GluAla: 8.005 ± 0.083	0.341GluCys: 0.341 ± 0.017	3.153GluAsp: 3.153 ± 0.053	3.51GluGlu: 3.51 ± 0.057	1.681GluPhe: 1.681 ± 0.033	4.544GluGly: 4.544 ± 0.058	1.244GluHis: 1.244 ± 0.028	3.671GluIle: 3.671 ± 0.051	1.933GluLys: 1.933 ± 0.039	5.195GluLeu: 5.195 ± 0.061	1.673GluMet: 1.673 ± 0.037	1.481GluAsn: 1.481 ± 0.032	2.872GluPro: 2.872 ± 0.055	2.043GluGln: 2.043 ± 0.041	5.196GluArg: 5.196 ± 0.064	2.523GluSer: 2.523 ± 0.035	3.939GluThr: 3.939 ± 0.048	4.298GluVal: 4.298 ± 0.05	0.628GluTrp: 0.628 ± 0.02	1.007GluTyr: 1.007 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.28PheAla: 4.28 ± 0.06	0.368PheCys: 0.368 ± 0.016	2.655PheAsp: 2.655 ± 0.046	2.186PheGlu: 2.186 ± 0.036	1.24PhePhe: 1.24 ± 0.032	3.467PheGly: 3.467 ± 0.047	0.755PheHis: 0.755 ± 0.021	1.381PheIle: 1.381 ± 0.032	0.911PheLys: 0.911 ± 0.026	3.256PheLeu: 3.256 ± 0.054	0.786PheMet: 0.786 ± 0.025	0.884PheAsn: 0.884 ± 0.028	1.541PhePro: 1.541 ± 0.031	1.002PheGln: 1.002 ± 0.027	2.228PheArg: 2.228 ± 0.037	1.96PheSer: 1.96 ± 0.037	1.926PheThr: 1.926 ± 0.031	2.649PheVal: 2.649 ± 0.047	0.552PheTrp: 0.552 ± 0.019	0.822PheTyr: 0.822 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	9.765GlyAla: 9.765 ± 0.103	0.888GlyCys: 0.888 ± 0.024	5.199GlyAsp: 5.199 ± 0.078	4.967GlyGlu: 4.967 ± 0.059	3.488GlyPhe: 3.488 ± 0.047	8.229GlyGly: 8.229 ± 0.141	1.936GlyHis: 1.936 ± 0.039	4.478GlyIle: 4.478 ± 0.066	2.85GlyLys: 2.85 ± 0.047	9.161GlyLeu: 9.161 ± 0.088	2.494GlyMet: 2.494 ± 0.043	2.135GlyAsn: 2.135 ± 0.058	3.92GlyPro: 3.92 ± 0.054	2.646GlyGln: 2.646 ± 0.037	6.579GlyArg: 6.579 ± 0.074	4.783GlySer: 4.783 ± 0.065	5.116GlyThr: 5.116 ± 0.079	6.576GlyVal: 6.576 ± 0.065	1.46GlyTrp: 1.46 ± 0.035	2.402GlyTyr: 2.402 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.292HisAla: 2.292 ± 0.042	0.233HisCys: 0.233 ± 0.012	1.255HisAsp: 1.255 ± 0.029	1.053HisGlu: 1.053 ± 0.028	0.731HisPhe: 0.731 ± 0.02	2.0HisGly: 2.0 ± 0.041	0.544HisHis: 0.544 ± 0.021	0.883HisIle: 0.883 ± 0.023	0.475HisLys: 0.475 ± 0.018	2.068HisLeu: 2.068 ± 0.036	0.485HisMet: 0.485 ± 0.018	0.462HisAsn: 0.462 ± 0.018	1.461HisPro: 1.461 ± 0.029	0.556HisGln: 0.556 ± 0.019	1.559HisArg: 1.559 ± 0.033	0.858HisSer: 0.858 ± 0.022	0.934HisThr: 0.934 ± 0.026	1.476HisVal: 1.476 ± 0.032	0.331HisTrp: 0.331 ± 0.016	0.518HisTyr: 0.518 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	6.914IleAla: 6.914 ± 0.079	0.497IleCys: 0.497 ± 0.019	3.866IleAsp: 3.866 ± 0.053	3.384IleGlu: 3.384 ± 0.044	1.489IlePhe: 1.489 ± 0.04	5.041IleGly: 5.041 ± 0.063	0.937IleHis: 0.937 ± 0.021	1.761IleIle: 1.761 ± 0.039	1.226IleLys: 1.226 ± 0.029	4.468IleLeu: 4.468 ± 0.063	0.87IleMet: 0.87 ± 0.026	1.254IleAsn: 1.254 ± 0.029	2.36IlePro: 2.36 ± 0.04	1.223IleGln: 1.223 ± 0.03	3.382IleArg: 3.382 ± 0.047	2.619IleSer: 2.619 ± 0.04	2.528IleThr: 2.528 ± 0.036	4.005IleVal: 4.005 ± 0.053	0.583IleTrp: 0.583 ± 0.021	0.983IleTyr: 0.983 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.74LysAla: 3.74 ± 0.059	0.148LysCys: 0.148 ± 0.01	1.611LysAsp: 1.611 ± 0.035	1.441LysGlu: 1.441 ± 0.034	0.768LysPhe: 0.768 ± 0.028	2.372LysGly: 2.372 ± 0.046	0.521LysHis: 0.521 ± 0.017	1.476LysIle: 1.476 ± 0.034	1.033LysLys: 1.033 ± 0.033	2.747LysLeu: 2.747 ± 0.048	0.663LysMet: 0.663 ± 0.023	0.647LysAsn: 0.647 ± 0.02	1.751LysPro: 1.751 ± 0.037	0.797LysGln: 0.797 ± 0.024	2.202LysArg: 2.202 ± 0.041	1.545LysSer: 1.545 ± 0.033	1.764LysThr: 1.764 ± 0.032	2.249LysVal: 2.249 ± 0.041	0.306LysTrp: 0.306 ± 0.012	0.565LysTyr: 0.565 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.512LeuAla: 13.512 ± 0.125	0.898LeuCys: 0.898 ± 0.022	6.629LeuAsp: 6.629 ± 0.073	5.664LeuGlu: 5.664 ± 0.072	3.415LeuPhe: 3.415 ± 0.05	8.352LeuGly: 8.352 ± 0.089	1.86LeuHis: 1.86 ± 0.036	4.967LeuIle: 4.967 ± 0.066	3.105LeuLys: 3.105 ± 0.046	9.0LeuLeu: 9.0 ± 0.106	2.339LeuMet: 2.339 ± 0.04	2.412LeuAsn: 2.412 ± 0.038	5.189LeuPro: 5.189 ± 0.06	2.501LeuGln: 2.501 ± 0.039	6.762LeuArg: 6.762 ± 0.069	6.354LeuSer: 6.354 ± 0.067	5.636LeuThr: 5.636 ± 0.058	7.499LeuVal: 7.499 ± 0.084	1.191LeuTrp: 1.191 ± 0.03	2.04LeuTyr: 2.04 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.424MetAla: 3.424 ± 0.059	0.154MetCys: 0.154 ± 0.009	1.323MetAsp: 1.323 ± 0.029	1.212MetGlu: 1.212 ± 0.029	0.707MetPhe: 0.707 ± 0.023	1.863MetGly: 1.863 ± 0.035	0.451MetHis: 0.451 ± 0.019	1.272MetIle: 1.272 ± 0.029	0.856MetLys: 0.856 ± 0.027	2.423MetLeu: 2.423 ± 0.04	0.64MetMet: 0.64 ± 0.025	0.69MetAsn: 0.69 ± 0.019	1.514MetPro: 1.514 ± 0.034	0.727MetGln: 0.727 ± 0.022	1.808MetArg: 1.808 ± 0.034	1.689MetSer: 1.689 ± 0.034	2.049MetThr: 2.049 ± 0.038	1.934MetVal: 1.934 ± 0.037	0.202MetTrp: 0.202 ± 0.012	0.347MetTyr: 0.347 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.871AsnAla: 2.871 ± 0.047	0.211AsnCys: 0.211 ± 0.012	1.392AsnAsp: 1.392 ± 0.043	1.137AsnGlu: 1.137 ± 0.027	0.838AsnPhe: 0.838 ± 0.024	2.106AsnGly: 2.106 ± 0.038	0.475AsnHis: 0.475 ± 0.018	1.121AsnIle: 1.121 ± 0.026	0.599AsnLys: 0.599 ± 0.022	2.454AsnLeu: 2.454 ± 0.045	0.575AsnMet: 0.575 ± 0.021	0.624AsnAsn: 0.624 ± 0.02	1.74AsnPro: 1.74 ± 0.033	0.697AsnGln: 0.697 ± 0.022	1.8AsnArg: 1.8 ± 0.032	1.028AsnSer: 1.028 ± 0.028	1.242AsnThr: 1.242 ± 0.029	1.751AsnVal: 1.751 ± 0.037	0.366AsnTrp: 0.366 ± 0.015	0.548AsnTyr: 0.548 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.315ProAla: 6.315 ± 0.075	0.318ProCys: 0.318 ± 0.015	3.991ProAsp: 3.991 ± 0.052	3.876ProGlu: 3.876 ± 0.051	1.882ProPhe: 1.882 ± 0.034	4.647ProGly: 4.647 ± 0.062	1.108ProHis: 1.108 ± 0.028	2.513ProIle: 2.513 ± 0.037	1.538ProLys: 1.538 ± 0.035	4.492ProLeu: 4.492 ± 0.059	1.306ProMet: 1.306 ± 0.03	1.232ProAsn: 1.232 ± 0.027	2.639ProPro: 2.639 ± 0.054	1.419ProGln: 1.419 ± 0.032	2.902ProArg: 2.902 ± 0.049	2.873ProSer: 2.873 ± 0.047	2.916ProThr: 2.916 ± 0.042	4.443ProVal: 4.443 ± 0.058	0.74ProTrp: 0.74 ± 0.025	1.179ProTyr: 1.179 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.711GlnAla: 3.711 ± 0.053	0.166GlnCys: 0.166 ± 0.009	1.506GlnAsp: 1.506 ± 0.029	1.563GlnGlu: 1.563 ± 0.036	0.893GlnPhe: 0.893 ± 0.024	2.275GlnGly: 2.275 ± 0.038	0.55GlnHis: 0.55 ± 0.019	1.686GlnIle: 1.686 ± 0.035	0.852GlnLys: 0.852 ± 0.023	2.341GlnLeu: 2.341 ± 0.038	0.779GlnMet: 0.779 ± 0.02	0.738GlnAsn: 0.738 ± 0.021	1.512GlnPro: 1.512 ± 0.031	0.977GlnGln: 0.977 ± 0.027	2.289GlnArg: 2.289 ± 0.044	1.56GlnSer: 1.56 ± 0.034	1.694GlnThr: 1.694 ± 0.032	2.238GlnVal: 2.238 ± 0.038	0.352GlnTrp: 0.352 ± 0.015	0.538GlnTyr: 0.538 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	8.229ArgAla: 8.229 ± 0.086	0.603ArgCys: 0.603 ± 0.02	4.543ArgAsp: 4.543 ± 0.053	4.226ArgGlu: 4.226 ± 0.059	2.863ArgPhe: 2.863 ± 0.043	5.001ArgGly: 5.001 ± 0.054	1.715ArgHis: 1.715 ± 0.037	4.053ArgIle: 4.053 ± 0.055	2.012ArgLys: 2.012 ± 0.034	8.065ArgLeu: 8.065 ± 0.086	1.97ArgMet: 1.97 ± 0.038	1.678ArgAsn: 1.678 ± 0.035	3.805ArgPro: 3.805 ± 0.061	2.387ArgGln: 2.387 ± 0.042	6.336ArgArg: 6.336 ± 0.082	3.708ArgSer: 3.708 ± 0.055	3.589ArgThr: 3.589 ± 0.045	5.219ArgVal: 5.219 ± 0.061	1.043ArgTrp: 1.043 ± 0.026	1.742ArgTyr: 1.742 ± 0.033	0.001ArgXaa: 0.001 ± 0.001
Ser	6.115SerAla: 6.115 ± 0.067	0.407SerCys: 0.407 ± 0.016	3.302SerAsp: 3.302 ± 0.049	2.8SerGlu: 2.8 ± 0.05	2.02SerPhe: 2.02 ± 0.036	5.617SerGly: 5.617 ± 0.09	1.026SerHis: 1.026 ± 0.025	2.592SerIle: 2.592 ± 0.037	1.347SerLys: 1.347 ± 0.033	5.152SerLeu: 5.152 ± 0.057	1.361SerMet: 1.361 ± 0.029	1.22SerAsn: 1.22 ± 0.032	2.564SerPro: 2.564 ± 0.038	1.468SerGln: 1.468 ± 0.032	3.415SerArg: 3.415 ± 0.047	2.707SerSer: 2.707 ± 0.053	2.731SerThr: 2.731 ± 0.044	4.144SerVal: 4.144 ± 0.054	0.691SerTrp: 0.691 ± 0.02	1.212SerTyr: 1.212 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	6.859ThrAla: 6.859 ± 0.072	0.468ThrCys: 0.468 ± 0.018	3.291ThrAsp: 3.291 ± 0.06	2.883ThrGlu: 2.883 ± 0.044	1.863ThrPhe: 1.863 ± 0.041	5.658ThrGly: 5.658 ± 0.079	1.035ThrHis: 1.035 ± 0.026	2.722ThrIle: 2.722 ± 0.045	1.318ThrLys: 1.318 ± 0.032	6.129ThrLeu: 6.129 ± 0.081	1.257ThrMet: 1.257 ± 0.033	1.21ThrAsn: 1.21 ± 0.029	3.359ThrPro: 3.359 ± 0.044	1.355ThrGln: 1.355 ± 0.032	3.475ThrArg: 3.475 ± 0.054	2.609ThrSer: 2.609 ± 0.046	2.926ThrThr: 2.926 ± 0.05	5.19ThrVal: 5.19 ± 0.065	0.712ThrTrp: 0.712 ± 0.02	1.275ThrTyr: 1.275 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.804ValAla: 9.804 ± 0.097	0.735ValCys: 0.735 ± 0.02	4.959ValAsp: 4.959 ± 0.062	4.917ValGlu: 4.917 ± 0.06	2.805ValPhe: 2.805 ± 0.045	6.151ValGly: 6.151 ± 0.07	1.442ValHis: 1.442 ± 0.031	3.911ValIle: 3.911 ± 0.061	1.988ValLys: 1.988 ± 0.042	7.722ValLeu: 7.722 ± 0.09	2.022ValMet: 2.022 ± 0.042	1.909ValAsn: 1.909 ± 0.038	3.953ValPro: 3.953 ± 0.048	1.988ValGln: 1.988 ± 0.037	5.083ValArg: 5.083 ± 0.056	4.327ValSer: 4.327 ± 0.057	4.8ValThr: 4.8 ± 0.07	6.497ValVal: 6.497 ± 0.071	1.017ValTrp: 1.017 ± 0.027	1.55ValTyr: 1.55 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.202TrpAla: 1.202 ± 0.027	0.145TrpCys: 0.145 ± 0.009	0.744TrpAsp: 0.744 ± 0.025	0.631TrpGlu: 0.631 ± 0.021	0.518TrpPhe: 0.518 ± 0.018	0.982TrpGly: 0.982 ± 0.027	0.343TrpHis: 0.343 ± 0.016	0.734TrpIle: 0.734 ± 0.023	0.414TrpLys: 0.414 ± 0.015	1.58TrpLeu: 1.58 ± 0.038	0.381TrpMet: 0.381 ± 0.016	0.373TrpAsn: 0.373 ± 0.017	0.716TrpPro: 0.716 ± 0.02	0.5TrpGln: 0.5 ± 0.017	1.272TrpArg: 1.272 ± 0.029	0.845TrpSer: 0.845 ± 0.026	0.824TrpThr: 0.824 ± 0.023	0.913TrpVal: 0.913 ± 0.027	0.239TrpTrp: 0.239 ± 0.015	0.291TrpTyr: 0.291 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.486TyrAla: 2.486 ± 0.033	0.243TyrCys: 0.243 ± 0.013	1.536TyrAsp: 1.536 ± 0.03	1.237TyrGlu: 1.237 ± 0.031	0.863TyrPhe: 0.863 ± 0.023	2.171TyrGly: 2.171 ± 0.043	0.485TyrHis: 0.485 ± 0.018	0.842TyrIle: 0.842 ± 0.024	0.545TyrLys: 0.545 ± 0.022	2.287TyrLeu: 2.287 ± 0.039	0.426TyrMet: 0.426 ± 0.018	0.524TyrAsn: 0.524 ± 0.021	1.076TyrPro: 1.076 ± 0.028	0.61TyrGln: 0.61 ± 0.019	1.79TyrArg: 1.79 ± 0.034	1.097TyrSer: 1.097 ± 0.025	1.103TyrThr: 1.103 ± 0.03	1.498TyrVal: 1.498 ± 0.027	0.368TyrTrp: 0.368 ± 0.018	0.573TyrTyr: 0.573 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 4959 proteins (1586320 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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