Amino acid dipepetide frequency for Ketobacter sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.558AlaAla: 8.558 ± 0.101	0.961AlaCys: 0.961 ± 0.029	5.206AlaAsp: 5.206 ± 0.069	5.586AlaGlu: 5.586 ± 0.073	3.389AlaPhe: 3.389 ± 0.047	6.816AlaGly: 6.816 ± 0.077	1.787AlaHis: 1.787 ± 0.033	5.44AlaIle: 5.44 ± 0.067	3.878AlaLys: 3.878 ± 0.058	10.005AlaLeu: 10.005 ± 0.094	2.543AlaMet: 2.543 ± 0.042	3.239AlaAsn: 3.239 ± 0.053	3.332AlaPro: 3.332 ± 0.053	3.866AlaGln: 3.866 ± 0.059	4.602AlaArg: 4.602 ± 0.055	5.336AlaSer: 5.336 ± 0.065	4.547AlaThr: 4.547 ± 0.063	6.341AlaVal: 6.341 ± 0.07	1.098AlaTrp: 1.098 ± 0.028	2.383AlaTyr: 2.383 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.906CysAla: 0.906 ± 0.025	0.165CysCys: 0.165 ± 0.011	0.629CysAsp: 0.629 ± 0.019	0.63CysGlu: 0.63 ± 0.021	0.433CysPhe: 0.433 ± 0.015	0.908CysGly: 0.908 ± 0.029	0.312CysHis: 0.312 ± 0.016	0.606CysIle: 0.606 ± 0.021	0.369CysLys: 0.369 ± 0.016	1.092CysLeu: 1.092 ± 0.028	0.206CysMet: 0.206 ± 0.012	0.367CysAsn: 0.367 ± 0.016	0.442CysPro: 0.442 ± 0.02	0.406CysGln: 0.406 ± 0.018	0.576CysArg: 0.576 ± 0.018	0.702CysSer: 0.702 ± 0.021	0.489CysThr: 0.489 ± 0.018	0.677CysVal: 0.677 ± 0.024	0.131CysTrp: 0.131 ± 0.011	0.315CysTyr: 0.315 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.977AspAla: 4.977 ± 0.074	0.612AspCys: 0.612 ± 0.022	3.273AspAsp: 3.273 ± 0.061	3.64AspGlu: 3.64 ± 0.052	2.498AspPhe: 2.498 ± 0.049	4.101AspGly: 4.101 ± 0.104	1.307AspHis: 1.307 ± 0.033	3.616AspIle: 3.616 ± 0.05	2.439AspLys: 2.439 ± 0.043	5.778AspLeu: 5.778 ± 0.062	1.439AspMet: 1.439 ± 0.03	2.193AspAsn: 2.193 ± 0.053	2.732AspPro: 2.732 ± 0.053	2.783AspGln: 2.783 ± 0.048	3.087AspArg: 3.087 ± 0.049	3.742AspSer: 3.742 ± 0.065	2.94AspThr: 2.94 ± 0.051	3.961AspVal: 3.961 ± 0.062	0.882AspTrp: 0.882 ± 0.026	1.915AspTyr: 1.915 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	5.327GluAla: 5.327 ± 0.069	0.527GluCys: 0.527 ± 0.018	2.999GluAsp: 2.999 ± 0.051	3.546GluGlu: 3.546 ± 0.06	2.447GluPhe: 2.447 ± 0.043	3.688GluGly: 3.688 ± 0.053	1.46GluHis: 1.46 ± 0.034	3.667GluIle: 3.667 ± 0.051	3.25GluLys: 3.25 ± 0.054	6.691GluLeu: 6.691 ± 0.077	1.603GluMet: 1.603 ± 0.034	2.442GluAsn: 2.442 ± 0.042	2.276GluPro: 2.276 ± 0.044	3.613GluGln: 3.613 ± 0.058	3.614GluArg: 3.614 ± 0.056	3.832GluSer: 3.832 ± 0.049	3.143GluThr: 3.143 ± 0.046	3.931GluVal: 3.931 ± 0.055	0.799GluTrp: 0.799 ± 0.023	1.826GluTyr: 1.826 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.25PheAla: 3.25 ± 0.049	0.515PheCys: 0.515 ± 0.018	2.689PheAsp: 2.689 ± 0.047	2.491PheGlu: 2.491 ± 0.043	1.7PhePhe: 1.7 ± 0.038	3.088PheGly: 3.088 ± 0.049	0.89PheHis: 0.89 ± 0.024	2.35PheIle: 2.35 ± 0.043	1.677PheLys: 1.677 ± 0.033	3.637PheLeu: 3.637 ± 0.052	0.998PheMet: 0.998 ± 0.026	1.79PheAsn: 1.79 ± 0.034	1.55PhePro: 1.55 ± 0.036	1.462PheGln: 1.462 ± 0.032	2.004PheArg: 2.004 ± 0.036	3.201PheSer: 3.201 ± 0.048	2.182PheThr: 2.182 ± 0.04	2.779PheVal: 2.779 ± 0.049	0.559PheTrp: 0.559 ± 0.024	1.33PheTyr: 1.33 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	5.958GlyAla: 5.958 ± 0.067	0.889GlyCys: 0.889 ± 0.023	4.076GlyAsp: 4.076 ± 0.065	4.254GlyGlu: 4.254 ± 0.062	3.299GlyPhe: 3.299 ± 0.048	5.248GlyGly: 5.248 ± 0.072	1.576GlyHis: 1.576 ± 0.035	4.522GlyIle: 4.522 ± 0.061	3.594GlyLys: 3.594 ± 0.062	7.313GlyLeu: 7.313 ± 0.08	2.104GlyMet: 2.104 ± 0.042	2.743GlyAsn: 2.743 ± 0.05	2.164GlyPro: 2.164 ± 0.042	2.8GlyGln: 2.8 ± 0.05	3.656GlyArg: 3.656 ± 0.052	4.67GlySer: 4.67 ± 0.074	3.683GlyThr: 3.683 ± 0.062	5.475GlyVal: 5.475 ± 0.069	1.077GlyTrp: 1.077 ± 0.025	2.456GlyTyr: 2.456 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.624HisAla: 1.624 ± 0.032	0.338HisCys: 0.338 ± 0.015	1.082HisAsp: 1.082 ± 0.03	1.121HisGlu: 1.121 ± 0.028	1.168HisPhe: 1.168 ± 0.029	1.59HisGly: 1.59 ± 0.032	0.758HisHis: 0.758 ± 0.024	1.304HisIle: 1.304 ± 0.029	0.874HisLys: 0.874 ± 0.022	2.395HisLeu: 2.395 ± 0.045	0.506HisMet: 0.506 ± 0.02	0.811HisAsn: 0.811 ± 0.025	1.281HisPro: 1.281 ± 0.032	1.168HisGln: 1.168 ± 0.031	1.311HisArg: 1.311 ± 0.029	1.535HisSer: 1.535 ± 0.031	1.02HisThr: 1.02 ± 0.027	1.223HisVal: 1.223 ± 0.028	0.407HisTrp: 0.407 ± 0.016	0.855HisTyr: 0.855 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.73IleAla: 5.73 ± 0.067	0.603IleCys: 0.603 ± 0.02	3.83IleAsp: 3.83 ± 0.065	4.179IleGlu: 4.179 ± 0.052	1.898IlePhe: 1.898 ± 0.037	4.223IleGly: 4.223 ± 0.058	1.224IleHis: 1.224 ± 0.027	2.969IleIle: 2.969 ± 0.053	2.822IleLys: 2.822 ± 0.044	5.197IleLeu: 5.197 ± 0.066	1.219IleMet: 1.219 ± 0.028	2.615IleAsn: 2.615 ± 0.044	2.805IlePro: 2.805 ± 0.035	2.253IleGln: 2.253 ± 0.039	3.26IleArg: 3.26 ± 0.053	4.043IleSer: 4.043 ± 0.053	3.383IleThr: 3.383 ± 0.049	3.808IleVal: 3.808 ± 0.05	0.66IleTrp: 0.66 ± 0.022	1.56IleTyr: 1.56 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.272LysAla: 4.272 ± 0.062	0.286LysCys: 0.286 ± 0.014	2.278LysAsp: 2.278 ± 0.041	2.645LysGlu: 2.645 ± 0.048	1.221LysPhe: 1.221 ± 0.031	2.909LysGly: 2.909 ± 0.052	0.994LysHis: 0.994 ± 0.025	2.574LysIle: 2.574 ± 0.039	2.372LysLys: 2.372 ± 0.051	4.707LysLeu: 4.707 ± 0.058	1.14LysMet: 1.14 ± 0.028	1.792LysAsn: 1.792 ± 0.04	2.349LysPro: 2.349 ± 0.045	2.444LysGln: 2.444 ± 0.045	2.639LysArg: 2.639 ± 0.046	2.899LysSer: 2.899 ± 0.051	2.534LysThr: 2.534 ± 0.038	3.094LysVal: 3.094 ± 0.044	0.457LysTrp: 0.457 ± 0.018	1.124LysTyr: 1.124 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	9.649LeuAla: 9.649 ± 0.108	1.153LeuCys: 1.153 ± 0.026	6.178LeuAsp: 6.178 ± 0.076	6.179LeuGlu: 6.179 ± 0.068	4.191LeuPhe: 4.191 ± 0.064	7.073LeuGly: 7.073 ± 0.078	2.169LeuHis: 2.169 ± 0.042	5.957LeuIle: 5.957 ± 0.08	4.901LeuLys: 4.901 ± 0.062	10.838LeuLeu: 10.838 ± 0.117	2.692LeuMet: 2.692 ± 0.042	4.395LeuAsn: 4.395 ± 0.063	5.08LeuPro: 5.08 ± 0.054	4.841LeuGln: 4.841 ± 0.069	5.565LeuArg: 5.565 ± 0.066	7.689LeuSer: 7.689 ± 0.064	5.554LeuThr: 5.554 ± 0.068	7.194LeuVal: 7.194 ± 0.075	1.242LeuTrp: 1.242 ± 0.032	2.698LeuTyr: 2.698 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.472MetAla: 2.472 ± 0.045	0.199MetCys: 0.199 ± 0.011	1.464MetAsp: 1.464 ± 0.029	1.407MetGlu: 1.407 ± 0.033	0.793MetPhe: 0.793 ± 0.026	1.807MetGly: 1.807 ± 0.035	0.506MetHis: 0.506 ± 0.018	1.328MetIle: 1.328 ± 0.031	1.273MetLys: 1.273 ± 0.031	2.722MetLeu: 2.722 ± 0.041	0.744MetMet: 0.744 ± 0.024	1.12MetAsn: 1.12 ± 0.026	1.301MetPro: 1.301 ± 0.027	1.126MetGln: 1.126 ± 0.027	1.29MetArg: 1.29 ± 0.029	1.844MetSer: 1.844 ± 0.033	1.473MetThr: 1.473 ± 0.032	1.806MetVal: 1.806 ± 0.033	0.227MetTrp: 0.227 ± 0.013	0.482MetTyr: 0.482 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.37AsnAla: 3.37 ± 0.05	0.363AsnCys: 0.363 ± 0.017	2.142AsnAsp: 2.142 ± 0.056	2.163AsnGlu: 2.163 ± 0.04	1.392AsnPhe: 1.392 ± 0.032	3.036AsnGly: 3.036 ± 0.057	0.896AsnHis: 0.896 ± 0.024	2.295AsnIle: 2.295 ± 0.038	1.721AsnLys: 1.721 ± 0.037	3.967AsnLeu: 3.967 ± 0.051	0.924AsnMet: 0.924 ± 0.025	1.673AsnAsn: 1.673 ± 0.042	2.288AsnPro: 2.288 ± 0.044	1.929AsnGln: 1.929 ± 0.036	2.268AsnArg: 2.268 ± 0.038	2.438AsnSer: 2.438 ± 0.044	2.208AsnThr: 2.208 ± 0.04	2.537AsnVal: 2.537 ± 0.042	0.562AsnTrp: 0.562 ± 0.02	1.133AsnTyr: 1.133 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	3.91ProAla: 3.91 ± 0.051	0.327ProCys: 0.327 ± 0.014	3.217ProAsp: 3.217 ± 0.053	3.377ProGlu: 3.377 ± 0.057	1.826ProPhe: 1.826 ± 0.037	3.454ProGly: 3.454 ± 0.05	0.964ProHis: 0.964 ± 0.027	2.385ProIle: 2.385 ± 0.039	1.739ProLys: 1.739 ± 0.039	4.482ProLeu: 4.482 ± 0.053	1.088ProMet: 1.088 ± 0.025	1.503ProAsn: 1.503 ± 0.029	1.694ProPro: 1.694 ± 0.033	1.888ProGln: 1.888 ± 0.038	1.813ProArg: 1.813 ± 0.039	2.437ProSer: 2.437 ± 0.036	2.109ProThr: 2.109 ± 0.041	3.778ProVal: 3.778 ± 0.058	0.57ProTrp: 0.57 ± 0.022	1.249ProTyr: 1.249 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.392GlnAla: 4.392 ± 0.056	0.454GlnCys: 0.454 ± 0.02	2.148GlnAsp: 2.148 ± 0.039	2.4GlnGlu: 2.4 ± 0.042	1.867GlnPhe: 1.867 ± 0.036	2.907GlnGly: 2.907 ± 0.041	1.169GlnHis: 1.169 ± 0.029	2.508GlnIle: 2.508 ± 0.042	1.903GlnLys: 1.903 ± 0.038	5.135GlnLeu: 5.135 ± 0.072	1.058GlnMet: 1.058 ± 0.025	1.628GlnAsn: 1.628 ± 0.032	2.023GlnPro: 2.023 ± 0.037	3.085GlnGln: 3.085 ± 0.057	2.869GlnArg: 2.869 ± 0.043	3.041GlnSer: 3.041 ± 0.053	2.228GlnThr: 2.228 ± 0.044	3.122GlnVal: 3.122 ± 0.047	0.747GlnTrp: 0.747 ± 0.024	1.36GlnTyr: 1.36 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	4.149ArgAla: 4.149 ± 0.058	0.557ArgCys: 0.557 ± 0.018	2.904ArgAsp: 2.904 ± 0.04	3.329ArgGlu: 3.329 ± 0.05	2.694ArgPhe: 2.694 ± 0.043	3.028ArgGly: 3.028 ± 0.043	1.364ArgHis: 1.364 ± 0.032	3.49ArgIle: 3.49 ± 0.053	2.54ArgLys: 2.54 ± 0.042	5.995ArgLeu: 5.995 ± 0.067	1.432ArgMet: 1.432 ± 0.031	2.259ArgAsn: 2.259 ± 0.041	2.029ArgPro: 2.029 ± 0.032	2.566ArgGln: 2.566 ± 0.041	3.084ArgArg: 3.084 ± 0.054	3.401ArgSer: 3.401 ± 0.054	2.511ArgThr: 2.511 ± 0.042	3.874ArgVal: 3.874 ± 0.051	0.877ArgTrp: 0.877 ± 0.025	2.067ArgTyr: 2.067 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.1SerAla: 6.1 ± 0.074	0.6SerCys: 0.6 ± 0.025	3.983SerAsp: 3.983 ± 0.067	4.032SerGlu: 4.032 ± 0.056	2.518SerPhe: 2.518 ± 0.044	5.723SerGly: 5.723 ± 0.071	1.44SerHis: 1.44 ± 0.032	3.776SerIle: 3.776 ± 0.059	2.786SerLys: 2.786 ± 0.04	6.892SerLeu: 6.892 ± 0.065	1.663SerMet: 1.663 ± 0.034	2.523SerAsn: 2.523 ± 0.049	2.732SerPro: 2.732 ± 0.045	2.687SerGln: 2.687 ± 0.039	3.516SerArg: 3.516 ± 0.046	4.223SerSer: 4.223 ± 0.054	3.336SerThr: 3.336 ± 0.047	4.802SerVal: 4.802 ± 0.056	0.862SerTrp: 0.862 ± 0.026	1.773SerTyr: 1.773 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.697ThrAla: 4.697 ± 0.06	0.502ThrCys: 0.502 ± 0.018	3.018ThrAsp: 3.018 ± 0.057	3.051ThrGlu: 3.051 ± 0.042	1.967ThrPhe: 1.967 ± 0.033	4.321ThrGly: 4.321 ± 0.06	1.183ThrHis: 1.183 ± 0.024	2.983ThrIle: 2.983 ± 0.046	1.831ThrLys: 1.831 ± 0.033	6.303ThrLeu: 6.303 ± 0.066	1.087ThrMet: 1.087 ± 0.026	1.679ThrAsn: 1.679 ± 0.039	2.836ThrPro: 2.836 ± 0.045	2.178ThrGln: 2.178 ± 0.043	2.72ThrArg: 2.72 ± 0.047	3.114ThrSer: 3.114 ± 0.05	2.828ThrThr: 2.828 ± 0.052	3.816ThrVal: 3.816 ± 0.052	0.61ThrTrp: 0.61 ± 0.022	1.422ThrTyr: 1.422 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	6.551ValAla: 6.551 ± 0.072	0.764ValCys: 0.764 ± 0.024	4.405ValAsp: 4.405 ± 0.058	4.429ValGlu: 4.429 ± 0.061	2.867ValPhe: 2.867 ± 0.045	4.639ValGly: 4.639 ± 0.068	1.304ValHis: 1.304 ± 0.031	4.305ValIle: 4.305 ± 0.062	3.077ValLys: 3.077 ± 0.052	7.131ValLeu: 7.131 ± 0.072	1.914ValMet: 1.914 ± 0.035	2.94ValAsn: 2.94 ± 0.057	2.981ValPro: 2.981 ± 0.041	2.542ValGln: 2.542 ± 0.037	3.563ValArg: 3.563 ± 0.05	4.899ValSer: 4.899 ± 0.054	4.023ValThr: 4.023 ± 0.049	5.561ValVal: 5.561 ± 0.071	0.794ValTrp: 0.794 ± 0.025	1.884ValTyr: 1.884 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.894TrpAla: 0.894 ± 0.025	0.169TrpCys: 0.169 ± 0.011	0.672TrpAsp: 0.672 ± 0.024	0.647TrpGlu: 0.647 ± 0.018	0.572TrpPhe: 0.572 ± 0.023	0.902TrpGly: 0.902 ± 0.028	0.343TrpHis: 0.343 ± 0.013	0.753TrpIle: 0.753 ± 0.027	0.569TrpLys: 0.569 ± 0.021	1.659TrpLeu: 1.659 ± 0.033	0.398TrpMet: 0.398 ± 0.017	0.535TrpAsn: 0.535 ± 0.018	0.54TrpPro: 0.54 ± 0.018	0.826TrpGln: 0.826 ± 0.025	0.732TrpArg: 0.732 ± 0.021	0.857TrpSer: 0.857 ± 0.024	0.57TrpThr: 0.57 ± 0.022	0.98TrpVal: 0.98 ± 0.026	0.215TrpTrp: 0.215 ± 0.012	0.397TrpTyr: 0.397 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.13TyrAla: 2.13 ± 0.042	0.377TyrCys: 0.377 ± 0.016	1.722TyrAsp: 1.722 ± 0.044	1.574TyrGlu: 1.574 ± 0.035	1.399TyrPhe: 1.399 ± 0.033	2.097TyrGly: 2.097 ± 0.04	0.727TyrHis: 0.727 ± 0.023	1.453TyrIle: 1.453 ± 0.032	1.117TyrLys: 1.117 ± 0.032	3.299TyrLeu: 3.299 ± 0.046	0.621TyrMet: 0.621 ± 0.022	1.056TyrAsn: 1.056 ± 0.028	1.375TyrPro: 1.375 ± 0.032	1.58TyrGln: 1.58 ± 0.033	1.98TyrArg: 1.98 ± 0.037	2.064TyrSer: 2.064 ± 0.039	1.384TyrThr: 1.384 ± 0.035	1.813TyrVal: 1.813 ± 0.039	0.457TyrTrp: 0.457 ± 0.019	0.975TyrTyr: 0.975 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4352 proteins (1530567 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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