Amino acid dipepetide frequency for Vagococcus zengguangii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.084AlaAla: 5.084 ± 0.147
0.512AlaCys: 0.512 ± 0.031
3.933AlaAsp: 3.933 ± 0.107
4.75AlaGlu: 4.75 ± 0.107
2.917AlaPhe: 2.917 ± 0.079
4.656AlaGly: 4.656 ± 0.085
1.246AlaHis: 1.246 ± 0.044
6.004AlaIle: 6.004 ± 0.108
5.052AlaLys: 5.052 ± 0.085
7.143AlaLeu: 7.143 ± 0.129
2.032AlaMet: 2.032 ± 0.068
3.31AlaAsn: 3.31 ± 0.076
2.045AlaPro: 2.045 ± 0.064
2.817AlaGln: 2.817 ± 0.067
2.51AlaArg: 2.51 ± 0.071
4.336AlaSer: 4.336 ± 0.094
4.437AlaThr: 4.437 ± 0.09
4.661AlaVal: 4.661 ± 0.101
0.55AlaTrp: 0.55 ± 0.033
2.498AlaTyr: 2.498 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.388CysAla: 0.388 ± 0.026
0.067CysCys: 0.067 ± 0.011
0.319CysAsp: 0.319 ± 0.02
0.404CysGlu: 0.404 ± 0.025
0.298CysPhe: 0.298 ± 0.026
0.594CysGly: 0.594 ± 0.034
0.171CysHis: 0.171 ± 0.019
0.371CysIle: 0.371 ± 0.026
0.236CysLys: 0.236 ± 0.022
0.715CysLeu: 0.715 ± 0.039
0.135CysMet: 0.135 ± 0.014
0.219CysAsn: 0.219 ± 0.019
0.282CysPro: 0.282 ± 0.023
0.309CysGln: 0.309 ± 0.027
0.225CysArg: 0.225 ± 0.019
0.401CysSer: 0.401 ± 0.025
0.293CysThr: 0.293 ± 0.023
0.395CysVal: 0.395 ± 0.028
0.054CysTrp: 0.054 ± 0.009
0.258CysTyr: 0.258 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.255AspAla: 3.255 ± 0.077
0.331AspCys: 0.331 ± 0.021
2.655AspAsp: 2.655 ± 0.083
4.924AspGlu: 4.924 ± 0.096
2.7AspPhe: 2.7 ± 0.065
3.347AspGly: 3.347 ± 0.074
0.916AspHis: 0.916 ± 0.04
4.179AspIle: 4.179 ± 0.093
3.692AspLys: 3.692 ± 0.096
5.16AspLeu: 5.16 ± 0.091
1.443AspMet: 1.443 ± 0.049
2.535AspAsn: 2.535 ± 0.066
1.611AspPro: 1.611 ± 0.066
1.931AspGln: 1.931 ± 0.07
1.712AspArg: 1.712 ± 0.055
2.758AspSer: 2.758 ± 0.072
2.793AspThr: 2.793 ± 0.079
4.047AspVal: 4.047 ± 0.089
0.579AspTrp: 0.579 ± 0.036
2.796AspTyr: 2.796 ± 0.08
0.0AspXaa: 0.0 ± 0.0
Glu
5.888GluAla: 5.888 ± 0.121
0.347GluCys: 0.347 ± 0.026
3.727GluAsp: 3.727 ± 0.083
6.633GluGlu: 6.633 ± 0.119
2.749GluPhe: 2.749 ± 0.061
4.201GluGly: 4.201 ± 0.092
1.451GluHis: 1.451 ± 0.046
5.653GluIle: 5.653 ± 0.099
5.823GluLys: 5.823 ± 0.109
7.74GluLeu: 7.74 ± 0.132
2.454GluMet: 2.454 ± 0.069
3.805GluAsn: 3.805 ± 0.071
2.009GluPro: 2.009 ± 0.064
3.664GluGln: 3.664 ± 0.087
3.217GluArg: 3.217 ± 0.082
3.592GluSer: 3.592 ± 0.08
4.426GluThr: 4.426 ± 0.084
5.574GluVal: 5.574 ± 0.111
0.705GluTrp: 0.705 ± 0.035
2.2GluTyr: 2.2 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
2.882PheAla: 2.882 ± 0.079
0.347PheCys: 0.347 ± 0.023
2.746PheAsp: 2.746 ± 0.064
3.141PheGlu: 3.141 ± 0.075
2.161PhePhe: 2.161 ± 0.071
3.313PheGly: 3.313 ± 0.079
0.723PheHis: 0.723 ± 0.034
3.486PheIle: 3.486 ± 0.087
2.595PheLys: 2.595 ± 0.068
3.865PheLeu: 3.865 ± 0.097
1.165PheMet: 1.165 ± 0.053
2.291PheAsn: 2.291 ± 0.062
1.511PhePro: 1.511 ± 0.051
1.298PheGln: 1.298 ± 0.044
1.306PheArg: 1.306 ± 0.046
3.147PheSer: 3.147 ± 0.08
2.31PheThr: 2.31 ± 0.062
3.167PheVal: 3.167 ± 0.08
0.393PheTrp: 0.393 ± 0.025
1.763PheTyr: 1.763 ± 0.06
0.0PheXaa: 0.0 ± 0.0
Gly
4.539GlyAla: 4.539 ± 0.109
0.507GlyCys: 0.507 ± 0.03
3.172GlyAsp: 3.172 ± 0.08
4.48GlyGlu: 4.48 ± 0.087
2.938GlyPhe: 2.938 ± 0.063
4.377GlyGly: 4.377 ± 0.119
1.213GlyHis: 1.213 ± 0.046
5.558GlyIle: 5.558 ± 0.099
4.578GlyLys: 4.578 ± 0.089
6.616GlyLeu: 6.616 ± 0.109
1.98GlyMet: 1.98 ± 0.064
2.744GlyAsn: 2.744 ± 0.066
1.454GlyPro: 1.454 ± 0.046
2.684GlyGln: 2.684 ± 0.066
2.349GlyArg: 2.349 ± 0.064
3.657GlySer: 3.657 ± 0.083
3.922GlyThr: 3.922 ± 0.087
4.845GlyVal: 4.845 ± 0.094
0.705GlyTrp: 0.705 ± 0.035
2.695GlyTyr: 2.695 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
1.179HisAla: 1.179 ± 0.046
0.141HisCys: 0.141 ± 0.017
1.018HisAsp: 1.018 ± 0.044
1.286HisGlu: 1.286 ± 0.042
0.953HisPhe: 0.953 ± 0.039
1.157HisGly: 1.157 ± 0.051
0.61HisHis: 0.61 ± 0.034
1.206HisIle: 1.206 ± 0.043
0.835HisLys: 0.835 ± 0.036
2.056HisLeu: 2.056 ± 0.059
0.479HisMet: 0.479 ± 0.026
0.685HisAsn: 0.685 ± 0.032
0.916HisPro: 0.916 ± 0.031
1.091HisGln: 1.091 ± 0.049
0.801HisArg: 0.801 ± 0.035
0.984HisSer: 0.984 ± 0.044
0.983HisThr: 0.983 ± 0.041
1.238HisVal: 1.238 ± 0.045
0.165HisTrp: 0.165 ± 0.016
0.969HisTyr: 0.969 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
5.869IleAla: 5.869 ± 0.107
0.601IleCys: 0.601 ± 0.037
4.602IleAsp: 4.602 ± 0.099
6.078IleGlu: 6.078 ± 0.106
3.152IlePhe: 3.152 ± 0.088
5.398IleGly: 5.398 ± 0.106
1.333IleHis: 1.333 ± 0.054
5.772IleIle: 5.772 ± 0.124
4.967IleLys: 4.967 ± 0.088
6.498IleLeu: 6.498 ± 0.132
1.961IleMet: 1.961 ± 0.056
3.954IleAsn: 3.954 ± 0.103
3.036IlePro: 3.036 ± 0.072
2.706IleGln: 2.706 ± 0.079
2.72IleArg: 2.72 ± 0.065
4.983IleSer: 4.983 ± 0.091
4.344IleThr: 4.344 ± 0.078
5.488IleVal: 5.488 ± 0.112
0.52IleTrp: 0.52 ± 0.028
2.511IleTyr: 2.511 ± 0.076
0.0IleXaa: 0.0 ± 0.0
Lys
4.455LysAla: 4.455 ± 0.091
0.244LysCys: 0.244 ± 0.022
3.399LysAsp: 3.399 ± 0.081
6.489LysGlu: 6.489 ± 0.116
2.223LysPhe: 2.223 ± 0.058
3.941LysGly: 3.941 ± 0.087
1.179LysHis: 1.179 ± 0.046
5.008LysIle: 5.008 ± 0.099
5.583LysLys: 5.583 ± 0.111
5.821LysLeu: 5.821 ± 0.103
2.224LysMet: 2.224 ± 0.061
3.6LysAsn: 3.6 ± 0.081
1.952LysPro: 1.952 ± 0.061
3.318LysGln: 3.318 ± 0.088
2.827LysArg: 2.827 ± 0.075
3.19LysSer: 3.19 ± 0.07
3.743LysThr: 3.743 ± 0.079
4.566LysVal: 4.566 ± 0.085
0.69LysTrp: 0.69 ± 0.033
2.329LysTyr: 2.329 ± 0.063
0.0LysXaa: 0.0 ± 0.0
Leu
8.25LeuAla: 8.25 ± 0.145
0.607LeuCys: 0.607 ± 0.035
5.201LeuAsp: 5.201 ± 0.105
6.879LeuGlu: 6.879 ± 0.112
4.428LeuPhe: 4.428 ± 0.099
6.189LeuGly: 6.189 ± 0.114
1.47LeuHis: 1.47 ± 0.047
7.386LeuIle: 7.386 ± 0.148
6.167LeuLys: 6.167 ± 0.084
9.75LeuLeu: 9.75 ± 0.17
2.888LeuMet: 2.888 ± 0.072
4.922LeuAsn: 4.922 ± 0.085
3.848LeuPro: 3.848 ± 0.088
3.044LeuGln: 3.044 ± 0.083
3.29LeuArg: 3.29 ± 0.077
7.037LeuSer: 7.037 ± 0.11
6.644LeuThr: 6.644 ± 0.116
7.088LeuVal: 7.088 ± 0.111
0.751LeuTrp: 0.751 ± 0.038
2.979LeuTyr: 2.979 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.104MetAla: 2.104 ± 0.067
0.14MetCys: 0.14 ± 0.015
1.419MetAsp: 1.419 ± 0.048
1.674MetGlu: 1.674 ± 0.051
1.116MetPhe: 1.116 ± 0.064
1.869MetGly: 1.869 ± 0.059
0.412MetHis: 0.412 ± 0.024
2.424MetIle: 2.424 ± 0.069
2.389MetLys: 2.389 ± 0.061
2.619MetLeu: 2.619 ± 0.061
1.067MetMet: 1.067 ± 0.04
1.576MetAsn: 1.576 ± 0.048
1.078MetPro: 1.078 ± 0.044
0.934MetGln: 0.934 ± 0.042
1.049MetArg: 1.049 ± 0.049
1.883MetSer: 1.883 ± 0.055
2.056MetThr: 2.056 ± 0.056
1.796MetVal: 1.796 ± 0.054
0.181MetTrp: 0.181 ± 0.018
0.82MetTyr: 0.82 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
2.758AsnAla: 2.758 ± 0.06
0.296AsnCys: 0.296 ± 0.023
2.609AsnAsp: 2.609 ± 0.067
3.646AsnGlu: 3.646 ± 0.081
1.997AsnPhe: 1.997 ± 0.062
3.304AsnGly: 3.304 ± 0.086
1.138AsnHis: 1.138 ± 0.048
3.608AsnIle: 3.608 ± 0.083
3.261AsnLys: 3.261 ± 0.086
4.323AsnLeu: 4.323 ± 0.091
1.379AsnMet: 1.379 ± 0.051
2.537AsnAsn: 2.537 ± 0.084
2.078AsnPro: 2.078 ± 0.062
2.809AsnGln: 2.809 ± 0.073
1.945AsnArg: 1.945 ± 0.054
2.44AsnSer: 2.44 ± 0.081
2.449AsnThr: 2.449 ± 0.072
3.263AsnVal: 3.263 ± 0.079
0.534AsnTrp: 0.534 ± 0.032
2.158AsnTyr: 2.158 ± 0.067
0.0AsnXaa: 0.0 ± 0.0
Pro
2.112ProAla: 2.112 ± 0.066
0.16ProCys: 0.16 ± 0.016
1.894ProAsp: 1.894 ± 0.054
3.041ProGlu: 3.041 ± 0.074
1.673ProPhe: 1.673 ± 0.056
1.988ProGly: 1.988 ± 0.052
0.677ProHis: 0.677 ± 0.035
2.673ProIle: 2.673 ± 0.071
2.099ProLys: 2.099 ± 0.066
3.083ProLeu: 3.083 ± 0.071
0.816ProMet: 0.816 ± 0.035
1.836ProAsn: 1.836 ± 0.047
0.64ProPro: 0.64 ± 0.031
1.2ProGln: 1.2 ± 0.042
0.945ProArg: 0.945 ± 0.039
2.096ProSer: 2.096 ± 0.065
2.308ProThr: 2.308 ± 0.062
2.608ProVal: 2.608 ± 0.068
0.308ProTrp: 0.308 ± 0.024
1.336ProTyr: 1.336 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
3.77GlnAla: 3.77 ± 0.116
0.173GlnCys: 0.173 ± 0.017
1.76GlnAsp: 1.76 ± 0.055
3.102GlnGlu: 3.102 ± 0.075
1.622GlnPhe: 1.622 ± 0.058
2.351GlnGly: 2.351 ± 0.058
0.832GlnHis: 0.832 ± 0.035
2.605GlnIle: 2.605 ± 0.062
2.682GlnLys: 2.682 ± 0.069
4.924GlnLeu: 4.924 ± 0.112
1.235GlnMet: 1.235 ± 0.043
1.836GlnAsn: 1.836 ± 0.051
1.422GlnPro: 1.422 ± 0.05
2.321GlnGln: 2.321 ± 0.083
1.666GlnArg: 1.666 ± 0.056
2.242GlnSer: 2.242 ± 0.064
2.647GlnThr: 2.647 ± 0.061
3.018GlnVal: 3.018 ± 0.079
0.306GlnTrp: 0.306 ± 0.024
1.36GlnTyr: 1.36 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
2.173ArgAla: 2.173 ± 0.064
0.209ArgCys: 0.209 ± 0.019
1.891ArgAsp: 1.891 ± 0.067
2.874ArgGlu: 2.874 ± 0.069
1.728ArgPhe: 1.728 ± 0.058
2.185ArgGly: 2.185 ± 0.066
0.839ArgHis: 0.839 ± 0.038
2.579ArgIle: 2.579 ± 0.071
2.519ArgLys: 2.519 ± 0.064
3.825ArgLeu: 3.825 ± 0.086
1.111ArgMet: 1.111 ± 0.042
1.652ArgAsn: 1.652 ± 0.056
1.195ArgPro: 1.195 ± 0.044
1.926ArgGln: 1.926 ± 0.067
1.685ArgArg: 1.685 ± 0.064
1.79ArgSer: 1.79 ± 0.053
1.822ArgThr: 1.822 ± 0.055
2.608ArgVal: 2.608 ± 0.068
0.339ArgTrp: 0.339 ± 0.027
1.558ArgTyr: 1.558 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
3.537SerAla: 3.537 ± 0.085
0.336SerCys: 0.336 ± 0.027
3.213SerAsp: 3.213 ± 0.061
4.314SerGlu: 4.314 ± 0.083
2.953SerPhe: 2.953 ± 0.065
4.114SerGly: 4.114 ± 0.082
1.153SerHis: 1.153 ± 0.044
4.388SerIle: 4.388 ± 0.088
3.745SerLys: 3.745 ± 0.091
6.56SerLeu: 6.56 ± 0.128
1.592SerMet: 1.592 ± 0.056
2.787SerAsn: 2.787 ± 0.09
1.858SerPro: 1.858 ± 0.054
2.548SerGln: 2.548 ± 0.063
2.093SerArg: 2.093 ± 0.052
3.776SerSer: 3.776 ± 0.099
3.394SerThr: 3.394 ± 0.07
4.038SerVal: 4.038 ± 0.088
0.59SerTrp: 0.59 ± 0.031
2.387SerTyr: 2.387 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
3.909ThrAla: 3.909 ± 0.078
0.315ThrCys: 0.315 ± 0.022
3.274ThrAsp: 3.274 ± 0.083
3.984ThrGlu: 3.984 ± 0.095
2.667ThrPhe: 2.667 ± 0.064
4.168ThrGly: 4.168 ± 0.094
1.141ThrHis: 1.141 ± 0.04
5.057ThrIle: 5.057 ± 0.098
3.643ThrLys: 3.643 ± 0.075
5.929ThrLeu: 5.929 ± 0.103
1.439ThrMet: 1.439 ± 0.047
2.923ThrAsn: 2.923 ± 0.084
2.478ThrPro: 2.478 ± 0.076
2.055ThrGln: 2.055 ± 0.068
1.853ThrArg: 1.853 ± 0.052
3.795ThrSer: 3.795 ± 0.122
3.741ThrThr: 3.741 ± 0.095
4.052ThrVal: 4.052 ± 0.085
0.518ThrTrp: 0.518 ± 0.037
2.289ThrTyr: 2.289 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
5.591ValAla: 5.591 ± 0.092
0.49ValCys: 0.49 ± 0.027
3.903ValAsp: 3.903 ± 0.079
5.114ValGlu: 5.114 ± 0.117
2.953ValPhe: 2.953 ± 0.08
4.758ValGly: 4.758 ± 0.086
1.099ValHis: 1.099 ± 0.041
5.625ValIle: 5.625 ± 0.098
4.605ValLys: 4.605 ± 0.092
6.782ValLeu: 6.782 ± 0.116
2.112ValMet: 2.112 ± 0.067
3.267ValAsn: 3.267 ± 0.077
2.414ValPro: 2.414 ± 0.07
2.169ValGln: 2.169 ± 0.057
2.257ValArg: 2.257 ± 0.072
4.629ValSer: 4.629 ± 0.098
4.656ValThr: 4.656 ± 0.095
5.423ValVal: 5.423 ± 0.108
0.549ValTrp: 0.549 ± 0.032
2.334ValTyr: 2.334 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.477TrpAla: 0.477 ± 0.031
0.055TrpCys: 0.055 ± 0.01
0.472TrpAsp: 0.472 ± 0.03
0.583TrpGlu: 0.583 ± 0.035
0.461TrpPhe: 0.461 ± 0.03
0.591TrpGly: 0.591 ± 0.035
0.209TrpHis: 0.209 ± 0.017
0.561TrpIle: 0.561 ± 0.031
0.507TrpLys: 0.507 ± 0.031
1.23TrpLeu: 1.23 ± 0.054
0.26TrpMet: 0.26 ± 0.022
0.422TrpAsn: 0.422 ± 0.025
0.224TrpPro: 0.224 ± 0.018
0.607TrpGln: 0.607 ± 0.034
0.328TrpArg: 0.328 ± 0.025
0.526TrpSer: 0.526 ± 0.035
0.457TrpThr: 0.457 ± 0.027
0.536TrpVal: 0.536 ± 0.031
0.089TrpTrp: 0.089 ± 0.014
0.344TrpTyr: 0.344 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.273TyrAla: 2.273 ± 0.064
0.255TyrCys: 0.255 ± 0.021
2.156TyrAsp: 2.156 ± 0.065
2.464TyrGlu: 2.464 ± 0.071
1.923TyrPhe: 1.923 ± 0.062
2.513TyrGly: 2.513 ± 0.067
0.94TyrHis: 0.94 ± 0.042
2.349TyrIle: 2.349 ± 0.066
1.799TyrLys: 1.799 ± 0.045
4.177TyrLeu: 4.177 ± 0.084
0.831TyrMet: 0.831 ± 0.039
1.634TyrAsn: 1.634 ± 0.063
1.443TyrPro: 1.443 ± 0.051
2.445TyrGln: 2.445 ± 0.083
1.731TyrArg: 1.731 ± 0.06
2.112TyrSer: 2.112 ± 0.059
1.806TyrThr: 1.806 ± 0.051
2.319TyrVal: 2.319 ± 0.063
0.415TyrTrp: 0.415 ± 0.027
1.799TyrTyr: 1.799 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1965 proteins (630790 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski