Amino acid dipepetide frequency for Magnetospirillum sp. UT-4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.765AlaAla: 22.765 ± 0.272	1.384AlaCys: 1.384 ± 0.039	7.74AlaAsp: 7.74 ± 0.105	9.47AlaGlu: 9.47 ± 0.112	4.347AlaPhe: 4.347 ± 0.059	12.653AlaGly: 12.653 ± 0.129	2.452AlaHis: 2.452 ± 0.05	5.393AlaIle: 5.393 ± 0.073	3.934AlaLys: 3.934 ± 0.073	14.448AlaLeu: 14.448 ± 0.137	3.751AlaMet: 3.751 ± 0.061	2.72AlaAsn: 2.72 ± 0.08	6.2AlaPro: 6.2 ± 0.102	3.725AlaGln: 3.725 ± 0.067	10.404AlaArg: 10.404 ± 0.141	5.392AlaSer: 5.392 ± 0.081	6.104AlaThr: 6.104 ± 0.182	10.869AlaVal: 10.869 ± 0.111	1.821AlaTrp: 1.821 ± 0.052	2.321AlaTyr: 2.321 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.057CysAla: 1.057 ± 0.032	0.135CysCys: 0.135 ± 0.012	0.582CysAsp: 0.582 ± 0.019	0.445CysGlu: 0.445 ± 0.02	0.323CysPhe: 0.323 ± 0.017	1.068CysGly: 1.068 ± 0.032	0.341CysHis: 0.341 ± 0.021	0.348CysIle: 0.348 ± 0.018	0.237CysLys: 0.237 ± 0.014	0.937CysLeu: 0.937 ± 0.03	0.158CysMet: 0.158 ± 0.011	0.23CysAsn: 0.23 ± 0.016	0.636CysPro: 0.636 ± 0.025	0.264CysGln: 0.264 ± 0.014	0.927CysArg: 0.927 ± 0.031	0.456CysSer: 0.456 ± 0.022	0.471CysThr: 0.471 ± 0.021	0.667CysVal: 0.667 ± 0.025	0.126CysTrp: 0.126 ± 0.011	0.21CysTyr: 0.21 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.634AspAla: 6.634 ± 0.102	0.572AspCys: 0.572 ± 0.025	3.331AspAsp: 3.331 ± 0.07	3.551AspGlu: 3.551 ± 0.058	2.089AspPhe: 2.089 ± 0.042	5.982AspGly: 5.982 ± 0.108	1.416AspHis: 1.416 ± 0.038	2.813AspIle: 2.813 ± 0.049	1.608AspLys: 1.608 ± 0.043	6.371AspLeu: 6.371 ± 0.08	1.344AspMet: 1.344 ± 0.037	1.207AspAsn: 1.207 ± 0.043	3.578AspPro: 3.578 ± 0.059	1.704AspGln: 1.704 ± 0.038	4.58AspArg: 4.58 ± 0.089	2.575AspSer: 2.575 ± 0.049	2.757AspThr: 2.757 ± 0.108	4.015AspVal: 4.015 ± 0.061	0.988AspTrp: 0.988 ± 0.03	1.322AspTyr: 1.322 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	8.544GluAla: 8.544 ± 0.097	0.484GluCys: 0.484 ± 0.021	2.887GluAsp: 2.887 ± 0.057	3.045GluGlu: 3.045 ± 0.059	1.688GluPhe: 1.688 ± 0.037	4.616GluGly: 4.616 ± 0.061	1.165GluHis: 1.165 ± 0.033	2.804GluIle: 2.804 ± 0.052	1.881GluLys: 1.881 ± 0.046	5.411GluLeu: 5.411 ± 0.091	1.755GluMet: 1.755 ± 0.039	1.098GluAsn: 1.098 ± 0.032	2.858GluPro: 2.858 ± 0.073	1.825GluGln: 1.825 ± 0.04	5.368GluArg: 5.368 ± 0.096	2.297GluSer: 2.297 ± 0.038	3.166GluThr: 3.166 ± 0.058	4.415GluVal: 4.415 ± 0.067	0.705GluTrp: 0.705 ± 0.025	1.017GluTyr: 1.017 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.595PheAla: 4.595 ± 0.062	0.397PheCys: 0.397 ± 0.017	2.424PheAsp: 2.424 ± 0.04	1.935PheGlu: 1.935 ± 0.045	1.183PhePhe: 1.183 ± 0.036	3.269PheGly: 3.269 ± 0.059	0.753PheHis: 0.753 ± 0.025	1.278PheIle: 1.278 ± 0.036	0.898PheLys: 0.898 ± 0.029	3.283PheLeu: 3.283 ± 0.062	0.653PheMet: 0.653 ± 0.021	0.892PheAsn: 0.892 ± 0.026	1.549PhePro: 1.549 ± 0.042	0.953PheGln: 0.953 ± 0.031	2.394PheArg: 2.394 ± 0.051	1.719PheSer: 1.719 ± 0.048	1.862PheThr: 1.862 ± 0.054	2.493PheVal: 2.493 ± 0.05	0.437PheTrp: 0.437 ± 0.021	0.705PheTyr: 0.705 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.161GlyAla: 10.161 ± 0.117	1.051GlyCys: 1.051 ± 0.034	4.994GlyAsp: 4.994 ± 0.075	4.983GlyGlu: 4.983 ± 0.072	3.244GlyPhe: 3.244 ± 0.056	8.505GlyGly: 8.505 ± 0.154	2.138GlyHis: 2.138 ± 0.047	4.485GlyIle: 4.485 ± 0.062	3.032GlyLys: 3.032 ± 0.061	9.399GlyLeu: 9.399 ± 0.112	2.542GlyMet: 2.542 ± 0.051	2.025GlyAsn: 2.025 ± 0.068	3.867GlyPro: 3.867 ± 0.067	2.739GlyGln: 2.739 ± 0.051	7.888GlyArg: 7.888 ± 0.117	4.304GlySer: 4.304 ± 0.104	4.824GlyThr: 4.824 ± 0.209	5.869GlyVal: 5.869 ± 0.07	1.481GlyTrp: 1.481 ± 0.036	2.01GlyTyr: 2.01 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.527HisAla: 2.527 ± 0.054	0.258HisCys: 0.258 ± 0.013	1.295HisAsp: 1.295 ± 0.036	0.986HisGlu: 0.986 ± 0.033	0.853HisPhe: 0.853 ± 0.028	2.122HisGly: 2.122 ± 0.045	0.751HisHis: 0.751 ± 0.029	0.801HisIle: 0.801 ± 0.027	0.512HisLys: 0.512 ± 0.021	2.44HisLeu: 2.44 ± 0.057	0.489HisMet: 0.489 ± 0.022	0.445HisAsn: 0.445 ± 0.018	1.616HisPro: 1.616 ± 0.044	0.643HisGln: 0.643 ± 0.023	1.894HisArg: 1.894 ± 0.046	0.93HisSer: 0.93 ± 0.029	0.875HisThr: 0.875 ± 0.025	1.584HisVal: 1.584 ± 0.038	0.343HisTrp: 0.343 ± 0.017	0.568HisTyr: 0.568 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.998IleAla: 5.998 ± 0.068	0.423IleCys: 0.423 ± 0.017	3.271IleAsp: 3.271 ± 0.048	3.011IleGlu: 3.011 ± 0.056	1.139IlePhe: 1.139 ± 0.034	4.172IleGly: 4.172 ± 0.068	0.878IleHis: 0.878 ± 0.027	1.598IleIle: 1.598 ± 0.037	1.296IleLys: 1.296 ± 0.04	3.696IleLeu: 3.696 ± 0.063	0.755IleMet: 0.755 ± 0.028	1.132IleAsn: 1.132 ± 0.035	2.007IlePro: 2.007 ± 0.048	1.044IleGln: 1.044 ± 0.03	3.084IleArg: 3.084 ± 0.06	1.999IleSer: 1.999 ± 0.045	2.181IleThr: 2.181 ± 0.054	3.19IleVal: 3.19 ± 0.053	0.401IleTrp: 0.401 ± 0.02	0.817IleTyr: 0.817 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	4.384LysAla: 4.384 ± 0.076	0.19LysCys: 0.19 ± 0.016	1.768LysAsp: 1.768 ± 0.048	1.396LysGlu: 1.396 ± 0.041	0.773LysPhe: 0.773 ± 0.026	2.808LysGly: 2.808 ± 0.055	0.56LysHis: 0.56 ± 0.022	1.167LysIle: 1.167 ± 0.032	1.087LysLys: 1.087 ± 0.035	2.744LysLeu: 2.744 ± 0.055	0.703LysMet: 0.703 ± 0.028	0.656LysAsn: 0.656 ± 0.024	1.916LysPro: 1.916 ± 0.042	0.837LysGln: 0.837 ± 0.028	2.151LysArg: 2.151 ± 0.051	1.495LysSer: 1.495 ± 0.039	1.558LysThr: 1.558 ± 0.041	2.718LysVal: 2.718 ± 0.054	0.315LysTrp: 0.315 ± 0.016	0.59LysTyr: 0.59 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	16.872LeuAla: 16.872 ± 0.189	0.875LeuCys: 0.875 ± 0.029	6.572LeuAsp: 6.572 ± 0.08	5.404LeuGlu: 5.404 ± 0.075	3.475LeuPhe: 3.475 ± 0.067	8.965LeuGly: 8.965 ± 0.108	2.063LeuHis: 2.063 ± 0.044	3.808LeuIle: 3.808 ± 0.075	3.679LeuLys: 3.679 ± 0.07	9.88LeuLeu: 9.88 ± 0.161	2.411LeuMet: 2.411 ± 0.051	2.111LeuAsn: 2.111 ± 0.055	6.028LeuPro: 6.028 ± 0.092	2.401LeuGln: 2.401 ± 0.052	7.198LeuArg: 7.198 ± 0.112	5.592LeuSer: 5.592 ± 0.067	5.058LeuThr: 5.058 ± 0.088	8.192LeuVal: 8.192 ± 0.096	1.261LeuTrp: 1.261 ± 0.036	1.873LeuTyr: 1.873 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	3.743MetAla: 3.743 ± 0.063	0.164MetCys: 0.164 ± 0.011	1.316MetAsp: 1.316 ± 0.037	1.209MetGlu: 1.209 ± 0.034	0.68MetPhe: 0.68 ± 0.024	1.962MetGly: 1.962 ± 0.041	0.423MetHis: 0.423 ± 0.021	1.039MetIle: 1.039 ± 0.029	0.87MetLys: 0.87 ± 0.027	2.434MetLeu: 2.434 ± 0.043	0.653MetMet: 0.653 ± 0.025	0.669MetAsn: 0.669 ± 0.023	1.496MetPro: 1.496 ± 0.042	0.652MetGln: 0.652 ± 0.022	1.802MetArg: 1.802 ± 0.04	1.429MetSer: 1.429 ± 0.032	1.7MetThr: 1.7 ± 0.043	2.208MetVal: 2.208 ± 0.051	0.223MetTrp: 0.223 ± 0.015	0.307MetTyr: 0.307 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.802AsnAla: 2.802 ± 0.087	0.245AsnCys: 0.245 ± 0.015	1.255AsnAsp: 1.255 ± 0.058	0.963AsnGlu: 0.963 ± 0.031	0.731AsnPhe: 0.731 ± 0.021	1.981AsnGly: 1.981 ± 0.075	0.514AsnHis: 0.514 ± 0.024	1.018AsnIle: 1.018 ± 0.033	0.553AsnLys: 0.553 ± 0.021	2.372AsnLeu: 2.372 ± 0.058	0.493AsnMet: 0.493 ± 0.023	0.519AsnAsn: 0.519 ± 0.031	1.604AsnPro: 1.604 ± 0.037	0.664AsnGln: 0.664 ± 0.027	1.723AsnArg: 1.723 ± 0.042	0.952AsnSer: 0.952 ± 0.037	1.101AsnThr: 1.101 ± 0.068	1.666AsnVal: 1.666 ± 0.044	0.295AsnTrp: 0.295 ± 0.021	0.501AsnTyr: 0.501 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	7.789ProAla: 7.789 ± 0.134	0.425ProCys: 0.425 ± 0.021	3.855ProAsp: 3.855 ± 0.066	3.933ProGlu: 3.933 ± 0.07	1.892ProPhe: 1.892 ± 0.045	5.328ProGly: 5.328 ± 0.083	1.202ProHis: 1.202 ± 0.034	1.792ProIle: 1.792 ± 0.037	1.509ProLys: 1.509 ± 0.041	5.174ProLeu: 5.174 ± 0.09	1.265ProMet: 1.265 ± 0.034	1.097ProAsn: 1.097 ± 0.029	3.971ProPro: 3.971 ± 0.115	1.43ProGln: 1.43 ± 0.044	3.422ProArg: 3.422 ± 0.07	2.354ProSer: 2.354 ± 0.053	2.247ProThr: 2.247 ± 0.05	4.672ProVal: 4.672 ± 0.074	0.749ProTrp: 0.749 ± 0.022	1.086ProTyr: 1.086 ± 0.031	0.001ProXaa: 0.001 ± 0.001
Gln	4.344GlnAla: 4.344 ± 0.078	0.246GlnCys: 0.246 ± 0.015	1.296GlnAsp: 1.296 ± 0.035	1.296GlnGlu: 1.296 ± 0.036	0.858GlnPhe: 0.858 ± 0.028	2.517GlnGly: 2.517 ± 0.05	0.582GlnHis: 0.582 ± 0.022	1.242GlnIle: 1.242 ± 0.033	0.733GlnLys: 0.733 ± 0.028	2.658GlnLeu: 2.658 ± 0.051	0.814GlnMet: 0.814 ± 0.027	0.566GlnAsn: 0.566 ± 0.022	1.718GlnPro: 1.718 ± 0.038	0.944GlnGln: 0.944 ± 0.034	2.272GlnArg: 2.272 ± 0.045	1.369GlnSer: 1.369 ± 0.035	1.395GlnThr: 1.395 ± 0.04	2.557GlnVal: 2.557 ± 0.051	0.384GlnTrp: 0.384 ± 0.018	0.535GlnTyr: 0.535 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	9.139ArgAla: 9.139 ± 0.136	0.68ArgCys: 0.68 ± 0.027	4.459ArgAsp: 4.459 ± 0.078	4.056ArgGlu: 4.056 ± 0.073	2.933ArgPhe: 2.933 ± 0.061	5.028ArgGly: 5.028 ± 0.08	2.277ArgHis: 2.277 ± 0.055	3.794ArgIle: 3.794 ± 0.059	2.284ArgLys: 2.284 ± 0.057	9.885ArgLeu: 9.885 ± 0.141	2.27ArgMet: 2.27 ± 0.05	1.649ArgAsn: 1.649 ± 0.038	4.681ArgPro: 4.681 ± 0.098	2.8ArgGln: 2.8 ± 0.048	7.689ArgArg: 7.689 ± 0.168	3.352ArgSer: 3.352 ± 0.065	3.423ArgThr: 3.423 ± 0.05	5.414ArgVal: 5.414 ± 0.081	1.087ArgTrp: 1.087 ± 0.034	1.551ArgTyr: 1.551 ± 0.035	0.001ArgXaa: 0.001 ± 0.001
Ser	5.734SerAla: 5.734 ± 0.107	0.484SerCys: 0.484 ± 0.024	2.485SerAsp: 2.485 ± 0.051	2.272SerGlu: 2.272 ± 0.041	1.777SerPhe: 1.777 ± 0.043	5.094SerGly: 5.094 ± 0.121	1.061SerHis: 1.061 ± 0.032	1.831SerIle: 1.831 ± 0.042	1.236SerLys: 1.236 ± 0.035	4.828SerLeu: 4.828 ± 0.069	1.087SerMet: 1.087 ± 0.032	1.024SerAsn: 1.024 ± 0.04	2.716SerPro: 2.716 ± 0.051	1.37SerGln: 1.37 ± 0.035	3.437SerArg: 3.437 ± 0.055	2.337SerSer: 2.337 ± 0.064	2.206SerThr: 2.206 ± 0.061	3.562SerVal: 3.562 ± 0.054	0.685SerTrp: 0.685 ± 0.027	1.015SerTyr: 1.015 ± 0.033	0.001SerXaa: 0.001 ± 0.001
Thr	6.182ThrAla: 6.182 ± 0.181	0.471ThrCys: 0.471 ± 0.021	2.663ThrAsp: 2.663 ± 0.099	2.529ThrGlu: 2.529 ± 0.049	1.791ThrPhe: 1.791 ± 0.052	4.956ThrGly: 4.956 ± 0.151	0.945ThrHis: 0.945 ± 0.027	2.401ThrIle: 2.401 ± 0.064	1.16ThrLys: 1.16 ± 0.034	5.709ThrLeu: 5.709 ± 0.112	1.115ThrMet: 1.115 ± 0.03	1.133ThrAsn: 1.133 ± 0.073	2.976ThrPro: 2.976 ± 0.052	1.226ThrGln: 1.226 ± 0.042	3.223ThrArg: 3.223 ± 0.054	2.094ThrSer: 2.094 ± 0.067	2.491ThrThr: 2.491 ± 0.127	4.605ThrVal: 4.605 ± 0.125	0.683ThrTrp: 0.683 ± 0.036	1.084ThrTyr: 1.084 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	11.088ValAla: 11.088 ± 0.105	0.73ValCys: 0.73 ± 0.027	4.233ValAsp: 4.233 ± 0.064	5.023ValGlu: 5.023 ± 0.07	2.647ValPhe: 2.647 ± 0.048	5.676ValGly: 5.676 ± 0.077	1.551ValHis: 1.551 ± 0.038	3.274ValIle: 3.274 ± 0.059	2.359ValLys: 2.359 ± 0.05	8.364ValLeu: 8.364 ± 0.111	1.974ValMet: 1.974 ± 0.042	1.921ValAsn: 1.921 ± 0.055	4.147ValPro: 4.147 ± 0.067	1.898ValGln: 1.898 ± 0.037	5.755ValArg: 5.755 ± 0.079	3.83ValSer: 3.83 ± 0.063	4.389ValThr: 4.389 ± 0.13	7.327ValVal: 7.327 ± 0.09	0.953ValTrp: 0.953 ± 0.027	1.381ValTyr: 1.381 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.391TrpAla: 1.391 ± 0.039	0.159TrpCys: 0.159 ± 0.012	0.704TrpAsp: 0.704 ± 0.025	0.566TrpGlu: 0.566 ± 0.024	0.476TrpPhe: 0.476 ± 0.019	0.967TrpGly: 0.967 ± 0.03	0.377TrpHis: 0.377 ± 0.019	0.522TrpIle: 0.522 ± 0.019	0.433TrpLys: 0.433 ± 0.021	1.64TrpLeu: 1.64 ± 0.048	0.365TrpMet: 0.365 ± 0.018	0.365TrpAsn: 0.365 ± 0.021	0.69TrpPro: 0.69 ± 0.026	0.552TrpGln: 0.552 ± 0.019	1.41TrpArg: 1.41 ± 0.034	0.74TrpSer: 0.74 ± 0.028	0.684TrpThr: 0.684 ± 0.033	0.936TrpVal: 0.936 ± 0.032	0.229TrpTrp: 0.229 ± 0.016	0.286TrpTyr: 0.286 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.142TyrAla: 2.142 ± 0.04	0.245TyrCys: 0.245 ± 0.014	1.305TyrAsp: 1.305 ± 0.032	0.953TyrGlu: 0.953 ± 0.026	0.772TyrPhe: 0.772 ± 0.027	1.869TyrGly: 1.869 ± 0.037	0.48TyrHis: 0.48 ± 0.02	0.684TyrIle: 0.684 ± 0.027	0.514TyrLys: 0.514 ± 0.023	2.044TyrLeu: 2.044 ± 0.04	0.384TyrMet: 0.384 ± 0.017	0.493TyrAsn: 0.493 ± 0.022	0.94TyrPro: 0.94 ± 0.03	0.657TyrGln: 0.657 ± 0.024	1.832TyrArg: 1.832 ± 0.042	1.03TyrSer: 1.03 ± 0.034	0.945TyrThr: 0.945 ± 0.034	1.559TyrVal: 1.559 ± 0.039	0.328TyrTrp: 0.328 ± 0.018	0.491TyrTyr: 0.491 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4085 proteins (1230408 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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