Amino acid dipepetide frequency for Elephant endotheliotropic herpesvirus 4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.7AlaAla: 9.7 ± 0.98
1.593AlaCys: 1.593 ± 0.158
3.275AlaAsp: 3.275 ± 0.321
2.971AlaGlu: 2.971 ± 0.207
2.828AlaPhe: 2.828 ± 0.233
4.975AlaGly: 4.975 ± 0.503
1.826AlaHis: 1.826 ± 0.221
2.935AlaIle: 2.935 ± 0.242
1.915AlaLys: 1.915 ± 0.222
6.121AlaLeu: 6.121 ± 0.44
1.575AlaMet: 1.575 ± 0.171
2.702AlaAsn: 2.702 ± 0.303
4.027AlaPro: 4.027 ± 0.504
2.166AlaGln: 2.166 ± 0.248
3.758AlaArg: 3.758 ± 0.282
5.62AlaSer: 5.62 ± 0.371
5.566AlaThr: 5.566 ± 0.485
5.924AlaVal: 5.924 ± 0.392
0.483AlaTrp: 0.483 ± 0.084
2.416AlaTyr: 2.416 ± 0.226
0.0AlaXaa: 0.0 ± 0.0
Cys
1.593CysAla: 1.593 ± 0.201
0.537CysCys: 0.537 ± 0.124
1.235CysAsp: 1.235 ± 0.161
0.859CysGlu: 0.859 ± 0.131
1.289CysPhe: 1.289 ± 0.177
1.414CysGly: 1.414 ± 0.195
0.68CysHis: 0.68 ± 0.099
1.539CysIle: 1.539 ± 0.201
0.966CysLys: 0.966 ± 0.139
2.219CysLeu: 2.219 ± 0.238
0.519CysMet: 0.519 ± 0.111
1.056CysAsn: 1.056 ± 0.131
1.056CysPro: 1.056 ± 0.114
0.412CysGln: 0.412 ± 0.089
1.45CysArg: 1.45 ± 0.186
1.378CysSer: 1.378 ± 0.194
1.736CysThr: 1.736 ± 0.212
2.076CysVal: 2.076 ± 0.199
0.161CysTrp: 0.161 ± 0.049
1.128CysTyr: 1.128 ± 0.133
0.0CysXaa: 0.0 ± 0.0
Asp
3.526AspAla: 3.526 ± 0.288
0.823AspCys: 0.823 ± 0.111
6.425AspAsp: 6.425 ± 0.937
4.045AspGlu: 4.045 ± 0.374
2.398AspPhe: 2.398 ± 0.235
4.26AspGly: 4.26 ± 0.419
1.163AspHis: 1.163 ± 0.148
2.452AspIle: 2.452 ± 0.222
1.772AspLys: 1.772 ± 0.172
5.494AspLeu: 5.494 ± 0.353
1.593AspMet: 1.593 ± 0.219
2.201AspAsn: 2.201 ± 0.217
3.025AspPro: 3.025 ± 0.298
1.074AspGln: 1.074 ± 0.157
3.132AspArg: 3.132 ± 0.262
3.114AspSer: 3.114 ± 0.251
2.899AspThr: 2.899 ± 0.286
4.456AspVal: 4.456 ± 0.261
0.483AspTrp: 0.483 ± 0.1
1.772AspTyr: 1.772 ± 0.199
0.0AspXaa: 0.0 ± 0.0
Glu
3.114GluAla: 3.114 ± 0.273
0.895GluCys: 0.895 ± 0.142
3.633GluAsp: 3.633 ± 0.307
4.295GluGlu: 4.295 ± 0.332
1.754GluPhe: 1.754 ± 0.208
2.702GluGly: 2.702 ± 0.353
1.128GluHis: 1.128 ± 0.162
2.166GluIle: 2.166 ± 0.207
2.166GluLys: 2.166 ± 0.211
3.687GluLeu: 3.687 ± 0.345
0.877GluMet: 0.877 ± 0.152
2.523GluAsn: 2.523 ± 0.236
1.933GluPro: 1.933 ± 0.199
1.593GluGln: 1.593 ± 0.194
2.881GluArg: 2.881 ± 0.26
3.221GluSer: 3.221 ± 0.235
3.544GluThr: 3.544 ± 0.251
2.667GluVal: 2.667 ± 0.252
0.322GluTrp: 0.322 ± 0.07
1.915GluTyr: 1.915 ± 0.209
0.0GluXaa: 0.0 ± 0.0
Phe
2.72PheAla: 2.72 ± 0.241
1.414PheCys: 1.414 ± 0.165
2.291PheAsp: 2.291 ± 0.176
1.611PheGlu: 1.611 ± 0.18
2.738PhePhe: 2.738 ± 0.341
1.933PheGly: 1.933 ± 0.192
1.11PheHis: 1.11 ± 0.154
2.183PheIle: 2.183 ± 0.269
1.647PheLys: 1.647 ± 0.188
5.244PheLeu: 5.244 ± 0.411
1.235PheMet: 1.235 ± 0.172
2.631PheAsn: 2.631 ± 0.25
2.13PhePro: 2.13 ± 0.261
1.128PheGln: 1.128 ± 0.136
1.879PheArg: 1.879 ± 0.205
3.221PheSer: 3.221 ± 0.291
2.631PheThr: 2.631 ± 0.282
3.83PheVal: 3.83 ± 0.37
0.34PheTrp: 0.34 ± 0.07
1.861PheTyr: 1.861 ± 0.236
0.0PheXaa: 0.0 ± 0.0
Gly
5.065GlyAla: 5.065 ± 0.486
0.913GlyCys: 0.913 ± 0.135
4.098GlyAsp: 4.098 ± 0.502
2.846GlyGlu: 2.846 ± 0.296
1.951GlyPhe: 1.951 ± 0.215
10.452GlyGly: 10.452 ± 1.276
1.468GlyHis: 1.468 ± 0.218
2.13GlyIle: 2.13 ± 0.208
2.076GlyLys: 2.076 ± 0.195
4.94GlyLeu: 4.94 ± 0.315
1.217GlyMet: 1.217 ± 0.146
2.72GlyAsn: 2.72 ± 0.229
3.293GlyPro: 3.293 ± 0.484
1.521GlyGln: 1.521 ± 0.159
4.277GlyArg: 4.277 ± 0.466
5.029GlySer: 5.029 ± 0.535
3.919GlyThr: 3.919 ± 0.309
4.081GlyVal: 4.081 ± 0.258
0.412GlyTrp: 0.412 ± 0.085
1.915GlyTyr: 1.915 ± 0.201
0.0GlyXaa: 0.0 ± 0.0
His
1.987HisAla: 1.987 ± 0.21
0.376HisCys: 0.376 ± 0.096
1.36HisAsp: 1.36 ± 0.138
1.074HisGlu: 1.074 ± 0.134
0.895HisPhe: 0.895 ± 0.11
2.04HisGly: 2.04 ± 0.268
1.897HisHis: 1.897 ± 0.358
1.056HisIle: 1.056 ± 0.146
1.253HisLys: 1.253 ± 0.154
2.38HisLeu: 2.38 ± 0.225
0.787HisMet: 0.787 ± 0.126
1.253HisAsn: 1.253 ± 0.141
1.718HisPro: 1.718 ± 0.174
0.913HisGln: 0.913 ± 0.133
2.058HisArg: 2.058 ± 0.165
1.271HisSer: 1.271 ± 0.161
1.647HisThr: 1.647 ± 0.238
2.094HisVal: 2.094 ± 0.227
0.286HisTrp: 0.286 ± 0.076
1.038HisTyr: 1.038 ± 0.139
0.0HisXaa: 0.0 ± 0.0
Ile
2.345IleAla: 2.345 ± 0.268
1.36IleCys: 1.36 ± 0.153
2.219IleAsp: 2.219 ± 0.202
2.094IleGlu: 2.094 ± 0.211
2.649IlePhe: 2.649 ± 0.267
1.915IleGly: 1.915 ± 0.21
0.984IleHis: 0.984 ± 0.165
2.398IleIle: 2.398 ± 0.286
2.273IleLys: 2.273 ± 0.18
5.101IleLeu: 5.101 ± 0.403
1.289IleMet: 1.289 ± 0.134
2.04IleAsn: 2.04 ± 0.259
2.38IlePro: 2.38 ± 0.246
1.217IleGln: 1.217 ± 0.133
2.792IleArg: 2.792 ± 0.234
3.257IleSer: 3.257 ± 0.341
2.881IleThr: 2.881 ± 0.205
3.848IleVal: 3.848 ± 0.312
0.537IleTrp: 0.537 ± 0.108
2.362IleTyr: 2.362 ± 0.288
0.0IleXaa: 0.0 ± 0.0
Lys
1.79LysAla: 1.79 ± 0.185
1.199LysCys: 1.199 ± 0.182
2.094LysAsp: 2.094 ± 0.205
1.79LysGlu: 1.79 ± 0.209
1.503LysPhe: 1.503 ± 0.156
1.503LysGly: 1.503 ± 0.192
1.468LysHis: 1.468 ± 0.182
2.47LysIle: 2.47 ± 0.217
3.544LysLys: 3.544 ± 0.303
3.472LysLeu: 3.472 ± 0.257
0.662LysMet: 0.662 ± 0.101
2.559LysAsn: 2.559 ± 0.258
1.826LysPro: 1.826 ± 0.214
1.539LysGln: 1.539 ± 0.183
3.007LysArg: 3.007 ± 0.225
2.434LysSer: 2.434 ± 0.21
2.613LysThr: 2.613 ± 0.209
1.897LysVal: 1.897 ± 0.222
0.34LysTrp: 0.34 ± 0.101
1.933LysTyr: 1.933 ± 0.234
0.0LysXaa: 0.0 ± 0.0
Leu
5.333LeuAla: 5.333 ± 0.37
3.007LeuCys: 3.007 ± 0.273
4.707LeuAsp: 4.707 ± 0.315
4.081LeuGlu: 4.081 ± 0.28
5.244LeuPhe: 5.244 ± 0.435
4.474LeuGly: 4.474 ± 0.238
2.094LeuHis: 2.094 ± 0.231
4.492LeuIle: 4.492 ± 0.422
3.669LeuLys: 3.669 ± 0.324
10.649LeuLeu: 10.649 ± 0.772
2.362LeuMet: 2.362 ± 0.249
4.027LeuAsn: 4.027 ± 0.372
4.206LeuPro: 4.206 ± 0.263
2.953LeuGln: 2.953 ± 0.259
4.796LeuArg: 4.796 ± 0.328
7.051LeuSer: 7.051 ± 0.364
5.924LeuThr: 5.924 ± 0.479
5.996LeuVal: 5.996 ± 0.434
1.002LeuTrp: 1.002 ± 0.143
4.671LeuTyr: 4.671 ± 0.39
0.0LeuXaa: 0.0 ± 0.0
Met
1.682MetAla: 1.682 ± 0.195
0.787MetCys: 0.787 ± 0.142
1.163MetAsp: 1.163 ± 0.159
0.913MetGlu: 0.913 ± 0.158
1.503MetPhe: 1.503 ± 0.177
1.092MetGly: 1.092 ± 0.127
0.644MetHis: 0.644 ± 0.114
1.217MetIle: 1.217 ± 0.137
0.805MetLys: 0.805 ± 0.156
2.631MetLeu: 2.631 ± 0.238
0.823MetMet: 0.823 ± 0.134
0.877MetAsn: 0.877 ± 0.112
0.805MetPro: 0.805 ± 0.107
0.662MetGln: 0.662 ± 0.117
1.324MetArg: 1.324 ± 0.166
1.647MetSer: 1.647 ± 0.157
1.664MetThr: 1.664 ± 0.173
1.342MetVal: 1.342 ± 0.162
0.43MetTrp: 0.43 ± 0.091
1.217MetTyr: 1.217 ± 0.162
0.0MetXaa: 0.0 ± 0.0
Asn
3.025AsnAla: 3.025 ± 0.286
0.859AsnCys: 0.859 ± 0.155
2.488AsnAsp: 2.488 ± 0.237
1.79AsnGlu: 1.79 ± 0.181
1.879AsnPhe: 1.879 ± 0.171
2.577AsnGly: 2.577 ± 0.256
1.324AsnHis: 1.324 ± 0.147
2.667AsnIle: 2.667 ± 0.25
2.04AsnLys: 2.04 ± 0.258
3.848AsnLeu: 3.848 ± 0.251
1.181AsnMet: 1.181 ± 0.138
3.776AsnAsn: 3.776 ± 0.49
2.148AsnPro: 2.148 ± 0.211
1.092AsnGln: 1.092 ± 0.157
2.595AsnArg: 2.595 ± 0.213
2.72AsnSer: 2.72 ± 0.218
3.329AsnThr: 3.329 ± 0.378
3.705AsnVal: 3.705 ± 0.279
0.43AsnTrp: 0.43 ± 0.087
1.468AsnTyr: 1.468 ± 0.194
0.0AsnXaa: 0.0 ± 0.0
Pro
4.456ProAla: 4.456 ± 0.513
1.056ProCys: 1.056 ± 0.162
2.649ProAsp: 2.649 ± 0.217
2.738ProGlu: 2.738 ± 0.222
1.879ProPhe: 1.879 ± 0.183
3.221ProGly: 3.221 ± 0.433
1.36ProHis: 1.36 ± 0.201
2.237ProIle: 2.237 ± 0.176
1.485ProLys: 1.485 ± 0.148
4.188ProLeu: 4.188 ± 0.291
1.074ProMet: 1.074 ± 0.142
1.629ProAsn: 1.629 ± 0.192
7.338ProPro: 7.338 ± 0.922
2.094ProGln: 2.094 ± 0.356
3.257ProArg: 3.257 ± 0.296
5.029ProSer: 5.029 ± 0.458
3.794ProThr: 3.794 ± 0.412
4.295ProVal: 4.295 ± 0.353
0.358ProTrp: 0.358 ± 0.106
1.987ProTyr: 1.987 ± 0.238
0.0ProXaa: 0.0 ± 0.0
Gln
1.933GlnAla: 1.933 ± 0.252
0.698GlnCys: 0.698 ± 0.129
1.074GlnAsp: 1.074 ± 0.178
1.521GlnGlu: 1.521 ± 0.191
0.984GlnPhe: 0.984 ± 0.156
1.414GlnGly: 1.414 ± 0.27
1.378GlnHis: 1.378 ± 0.148
1.36GlnIle: 1.36 ± 0.166
1.36GlnLys: 1.36 ± 0.13
2.702GlnLeu: 2.702 ± 0.214
0.662GlnMet: 0.662 ± 0.105
1.468GlnAsn: 1.468 ± 0.136
2.309GlnPro: 2.309 ± 0.499
5.047GlnGln: 5.047 ± 1.389
2.237GlnArg: 2.237 ± 0.242
1.897GlnSer: 1.897 ± 0.224
1.969GlnThr: 1.969 ± 0.206
1.736GlnVal: 1.736 ± 0.209
0.251GlnTrp: 0.251 ± 0.069
1.396GlnTyr: 1.396 ± 0.189
0.0GlnXaa: 0.0 ± 0.0
Arg
3.472ArgAla: 3.472 ± 0.282
1.181ArgCys: 1.181 ± 0.178
3.794ArgAsp: 3.794 ± 0.281
2.864ArgGlu: 2.864 ± 0.221
2.148ArgPhe: 2.148 ± 0.168
4.367ArgGly: 4.367 ± 0.496
1.933ArgHis: 1.933 ± 0.193
1.933ArgIle: 1.933 ± 0.185
2.738ArgLys: 2.738 ± 0.299
4.761ArgLeu: 4.761 ± 0.345
1.092ArgMet: 1.092 ± 0.132
2.935ArgAsn: 2.935 ± 0.297
3.597ArgPro: 3.597 ± 0.362
2.523ArgGln: 2.523 ± 0.297
5.834ArgArg: 5.834 ± 0.471
4.707ArgSer: 4.707 ± 0.399
3.436ArgThr: 3.436 ± 0.294
3.49ArgVal: 3.49 ± 0.267
0.573ArgTrp: 0.573 ± 0.111
2.47ArgTyr: 2.47 ± 0.278
0.0ArgXaa: 0.0 ± 0.0
Ser
6.228SerAla: 6.228 ± 0.518
1.79SerCys: 1.79 ± 0.182
3.705SerAsp: 3.705 ± 0.293
3.275SerGlu: 3.275 ± 0.239
2.81SerPhe: 2.81 ± 0.239
5.566SerGly: 5.566 ± 0.559
1.933SerHis: 1.933 ± 0.173
3.025SerIle: 3.025 ± 0.283
2.756SerLys: 2.756 ± 0.22
6.085SerLeu: 6.085 ± 0.391
1.593SerMet: 1.593 ± 0.183
2.756SerAsn: 2.756 ± 0.253
4.564SerPro: 4.564 ± 0.411
2.183SerGln: 2.183 ± 0.237
4.367SerArg: 4.367 ± 0.346
13.924SerSer: 13.924 ± 1.895
5.083SerThr: 5.083 ± 0.458
5.978SerVal: 5.978 ± 0.335
0.662SerTrp: 0.662 ± 0.118
2.183SerTyr: 2.183 ± 0.221
0.0SerXaa: 0.0 ± 0.0
Thr
6.103ThrAla: 6.103 ± 0.382
1.485ThrCys: 1.485 ± 0.194
3.311ThrAsp: 3.311 ± 0.204
3.132ThrGlu: 3.132 ± 0.241
3.078ThrPhe: 3.078 ± 0.278
3.919ThrGly: 3.919 ± 0.29
1.933ThrHis: 1.933 ± 0.222
2.702ThrIle: 2.702 ± 0.283
2.13ThrLys: 2.13 ± 0.233
5.745ThrLeu: 5.745 ± 0.424
1.289ThrMet: 1.289 ± 0.154
2.291ThrAsn: 2.291 ± 0.281
3.955ThrPro: 3.955 ± 0.459
1.987ThrGln: 1.987 ± 0.244
3.347ThrArg: 3.347 ± 0.271
5.244ThrSer: 5.244 ± 0.596
7.875ThrThr: 7.875 ± 1.072
6.282ThrVal: 6.282 ± 0.349
0.644ThrTrp: 0.644 ± 0.127
2.631ThrTyr: 2.631 ± 0.279
0.0ThrXaa: 0.0 ± 0.0
Val
5.387ValAla: 5.387 ± 0.3
2.076ValCys: 2.076 ± 0.258
3.579ValAsp: 3.579 ± 0.309
2.917ValGlu: 2.917 ± 0.258
4.063ValPhe: 4.063 ± 0.371
3.4ValGly: 3.4 ± 0.312
1.808ValHis: 1.808 ± 0.125
3.83ValIle: 3.83 ± 0.308
2.756ValLys: 2.756 ± 0.312
6.801ValLeu: 6.801 ± 0.556
1.987ValMet: 1.987 ± 0.231
3.114ValAsn: 3.114 ± 0.252
4.116ValPro: 4.116 ± 0.281
2.201ValGln: 2.201 ± 0.26
3.794ValArg: 3.794 ± 0.249
5.978ValSer: 5.978 ± 0.318
5.942ValThr: 5.942 ± 0.381
5.405ValVal: 5.405 ± 0.364
0.734ValTrp: 0.734 ± 0.12
3.293ValTyr: 3.293 ± 0.259
0.0ValXaa: 0.0 ± 0.0
Trp
0.412TrpAla: 0.412 ± 0.106
0.268TrpCys: 0.268 ± 0.075
0.447TrpAsp: 0.447 ± 0.087
0.376TrpGlu: 0.376 ± 0.067
0.555TrpPhe: 0.555 ± 0.127
0.573TrpGly: 0.573 ± 0.098
0.233TrpHis: 0.233 ± 0.063
0.537TrpIle: 0.537 ± 0.116
0.34TrpLys: 0.34 ± 0.099
1.002TrpLeu: 1.002 ± 0.155
0.179TrpMet: 0.179 ± 0.054
0.358TrpAsn: 0.358 ± 0.08
0.394TrpPro: 0.394 ± 0.084
0.215TrpGln: 0.215 ± 0.058
0.519TrpArg: 0.519 ± 0.107
0.823TrpSer: 0.823 ± 0.117
0.644TrpThr: 0.644 ± 0.149
0.537TrpVal: 0.537 ± 0.098
0.054TrpTrp: 0.054 ± 0.028
0.43TrpTyr: 0.43 ± 0.103
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.506TyrAla: 2.506 ± 0.224
0.984TyrCys: 0.984 ± 0.151
2.559TyrAsp: 2.559 ± 0.323
1.826TyrGlu: 1.826 ± 0.204
1.629TyrPhe: 1.629 ± 0.21
2.523TyrGly: 2.523 ± 0.238
1.02TyrHis: 1.02 ± 0.126
2.613TyrIle: 2.613 ± 0.294
1.951TyrLys: 1.951 ± 0.272
3.687TyrLeu: 3.687 ± 0.39
1.217TyrMet: 1.217 ± 0.169
2.022TyrAsn: 2.022 ± 0.204
1.306TyrPro: 1.306 ± 0.153
0.877TyrGln: 0.877 ± 0.156
2.541TyrArg: 2.541 ± 0.213
2.899TyrSer: 2.899 ± 0.247
1.987TyrThr: 1.987 ± 0.214
3.544TyrVal: 3.544 ± 0.304
0.394TyrTrp: 0.394 ± 0.084
2.148TyrTyr: 2.148 ± 0.244
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 120 proteins (55876 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski