Amino acid dipepetide frequency for Streptococcus phage phiARI0923

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.716AlaAla: 2.716 ± 0.949
0.313AlaCys: 0.313 ± 0.181
4.387AlaAsp: 4.387 ± 0.678
5.014AlaGlu: 5.014 ± 1.067
2.716AlaPhe: 2.716 ± 0.448
3.761AlaGly: 3.761 ± 0.772
0.522AlaHis: 0.522 ± 0.26
5.223AlaIle: 5.223 ± 1.588
6.581AlaLys: 6.581 ± 0.636
6.581AlaLeu: 6.581 ± 0.798
1.776AlaMet: 1.776 ± 0.483
3.447AlaAsn: 3.447 ± 0.705
2.089AlaPro: 2.089 ± 0.486
3.029AlaGln: 3.029 ± 0.611
2.716AlaArg: 2.716 ± 0.47
3.865AlaSer: 3.865 ± 0.597
4.074AlaThr: 4.074 ± 0.91
3.969AlaVal: 3.969 ± 0.648
1.149AlaTrp: 1.149 ± 0.385
2.194AlaTyr: 2.194 ± 0.415
0.0AlaXaa: 0.0 ± 0.0
Cys
0.209CysAla: 0.209 ± 0.116
0.0CysCys: 0.0 ± 0.0
0.104CysAsp: 0.104 ± 0.11
0.836CysGlu: 0.836 ± 0.383
0.522CysPhe: 0.522 ± 0.189
0.418CysGly: 0.418 ± 0.233
0.209CysHis: 0.209 ± 0.168
0.209CysIle: 0.209 ± 0.143
0.209CysLys: 0.209 ± 0.133
0.522CysLeu: 0.522 ± 0.276
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.209CysGln: 0.209 ± 0.174
0.418CysArg: 0.418 ± 0.239
0.418CysSer: 0.418 ± 0.267
0.209CysThr: 0.209 ± 0.162
0.313CysVal: 0.313 ± 0.168
0.209CysTrp: 0.209 ± 0.119
0.522CysTyr: 0.522 ± 0.212
0.0CysXaa: 0.0 ± 0.0
Asp
3.447AspAla: 3.447 ± 0.543
0.0AspCys: 0.0 ± 0.0
4.074AspAsp: 4.074 ± 0.901
3.552AspGlu: 3.552 ± 0.988
3.029AspPhe: 3.029 ± 0.663
4.805AspGly: 4.805 ± 0.772
1.149AspHis: 1.149 ± 0.417
4.701AspIle: 4.701 ± 0.812
5.85AspLys: 5.85 ± 1.022
3.761AspLeu: 3.761 ± 0.483
1.149AspMet: 1.149 ± 0.35
2.82AspAsn: 2.82 ± 0.497
1.88AspPro: 1.88 ± 0.404
1.149AspGln: 1.149 ± 0.311
1.671AspArg: 1.671 ± 0.328
3.238AspSer: 3.238 ± 0.564
3.343AspThr: 3.343 ± 0.537
4.074AspVal: 4.074 ± 0.562
0.94AspTrp: 0.94 ± 0.26
3.238AspTyr: 3.238 ± 0.646
0.0AspXaa: 0.0 ± 0.0
Glu
4.805GluAla: 4.805 ± 1.175
0.418GluCys: 0.418 ± 0.2
2.82GluAsp: 2.82 ± 0.447
7.417GluGlu: 7.417 ± 1.237
3.029GluPhe: 3.029 ± 0.578
3.029GluGly: 3.029 ± 0.53
0.731GluHis: 0.731 ± 0.322
6.894GluIle: 6.894 ± 0.807
7.73GluLys: 7.73 ± 1.156
9.924GluLeu: 9.924 ± 0.824
1.88GluMet: 1.88 ± 0.674
4.701GluAsn: 4.701 ± 0.808
1.88GluPro: 1.88 ± 0.575
3.238GluGln: 3.238 ± 0.834
2.925GluArg: 2.925 ± 0.718
4.074GluSer: 4.074 ± 0.572
4.805GluThr: 4.805 ± 0.631
3.865GluVal: 3.865 ± 0.516
1.358GluTrp: 1.358 ± 0.349
2.403GluTyr: 2.403 ± 0.441
0.0GluXaa: 0.0 ± 0.0
Phe
2.403PheAla: 2.403 ± 0.596
0.313PheCys: 0.313 ± 0.192
4.178PheAsp: 4.178 ± 0.671
3.238PheGlu: 3.238 ± 0.548
1.567PhePhe: 1.567 ± 0.498
2.194PheGly: 2.194 ± 0.501
0.627PheHis: 0.627 ± 0.297
2.82PheIle: 2.82 ± 0.678
3.238PheLys: 3.238 ± 0.684
2.194PheLeu: 2.194 ± 0.596
1.358PheMet: 1.358 ± 0.516
3.552PheAsn: 3.552 ± 0.586
0.731PhePro: 0.731 ± 0.356
1.358PheGln: 1.358 ± 0.349
1.567PheArg: 1.567 ± 0.374
2.82PheSer: 2.82 ± 0.517
3.343PheThr: 3.343 ± 0.492
1.462PheVal: 1.462 ± 0.384
0.418PheTrp: 0.418 ± 0.2
1.776PheTyr: 1.776 ± 0.393
0.0PheXaa: 0.0 ± 0.0
Gly
3.761GlyAla: 3.761 ± 1.203
0.209GlyCys: 0.209 ± 0.121
2.612GlyAsp: 2.612 ± 0.523
3.969GlyGlu: 3.969 ± 0.539
3.134GlyPhe: 3.134 ± 0.797
4.178GlyGly: 4.178 ± 0.668
1.149GlyHis: 1.149 ± 0.37
5.014GlyIle: 5.014 ± 0.667
4.805GlyLys: 4.805 ± 0.489
5.745GlyLeu: 5.745 ± 1.077
1.567GlyMet: 1.567 ± 0.455
3.656GlyAsn: 3.656 ± 0.554
0.522GlyPro: 0.522 ± 0.242
3.447GlyGln: 3.447 ± 0.739
3.029GlyArg: 3.029 ± 0.593
3.865GlySer: 3.865 ± 0.731
3.552GlyThr: 3.552 ± 0.594
3.969GlyVal: 3.969 ± 0.55
1.462GlyTrp: 1.462 ± 0.59
2.403GlyTyr: 2.403 ± 0.484
0.0GlyXaa: 0.0 ± 0.0
His
0.836HisAla: 0.836 ± 0.284
0.0HisCys: 0.0 ± 0.0
0.627HisAsp: 0.627 ± 0.255
1.358HisGlu: 1.358 ± 0.375
0.836HisPhe: 0.836 ± 0.284
0.731HisGly: 0.731 ± 0.259
0.209HisHis: 0.209 ± 0.18
1.462HisIle: 1.462 ± 0.3
0.836HisLys: 0.836 ± 0.262
1.776HisLeu: 1.776 ± 0.485
0.418HisMet: 0.418 ± 0.208
1.045HisAsn: 1.045 ± 0.307
0.209HisPro: 0.209 ± 0.19
0.313HisGln: 0.313 ± 0.189
0.104HisArg: 0.104 ± 0.133
0.94HisSer: 0.94 ± 0.45
1.254HisThr: 1.254 ± 0.415
0.94HisVal: 0.94 ± 0.302
0.0HisTrp: 0.0 ± 0.0
1.149HisTyr: 1.149 ± 0.292
0.0HisXaa: 0.0 ± 0.0
Ile
6.059IleAla: 6.059 ± 1.075
1.045IleCys: 1.045 ± 0.323
4.283IleAsp: 4.283 ± 0.765
6.059IleGlu: 6.059 ± 0.79
2.612IlePhe: 2.612 ± 0.575
4.283IleGly: 4.283 ± 0.735
1.045IleHis: 1.045 ± 0.339
4.074IleIle: 4.074 ± 0.795
5.223IleLys: 5.223 ± 0.681
5.536IleLeu: 5.536 ± 0.963
1.254IleMet: 1.254 ± 0.406
5.119IleAsn: 5.119 ± 0.598
1.776IlePro: 1.776 ± 0.336
3.029IleGln: 3.029 ± 0.388
3.447IleArg: 3.447 ± 0.768
6.268IleSer: 6.268 ± 1.122
3.865IleThr: 3.865 ± 0.421
3.134IleVal: 3.134 ± 0.664
1.045IleTrp: 1.045 ± 0.284
1.776IleTyr: 1.776 ± 0.421
0.0IleXaa: 0.0 ± 0.0
Lys
6.059LysAla: 6.059 ± 0.903
0.209LysCys: 0.209 ± 0.163
5.014LysAsp: 5.014 ± 0.728
7.417LysGlu: 7.417 ± 1.032
2.403LysPhe: 2.403 ± 0.426
5.014LysGly: 5.014 ± 0.869
1.567LysHis: 1.567 ± 0.326
5.745LysIle: 5.745 ± 0.813
5.432LysLys: 5.432 ± 0.974
6.268LysLeu: 6.268 ± 0.821
2.612LysMet: 2.612 ± 0.463
4.805LysAsn: 4.805 ± 0.658
1.567LysPro: 1.567 ± 0.445
3.552LysGln: 3.552 ± 0.449
3.552LysArg: 3.552 ± 0.643
5.641LysSer: 5.641 ± 0.643
6.059LysThr: 6.059 ± 0.56
4.596LysVal: 4.596 ± 0.75
0.94LysTrp: 0.94 ± 0.321
3.865LysTyr: 3.865 ± 0.529
0.0LysXaa: 0.0 ± 0.0
Leu
6.372LeuAla: 6.372 ± 0.672
0.313LeuCys: 0.313 ± 0.195
6.268LeuAsp: 6.268 ± 0.619
5.641LeuGlu: 5.641 ± 0.641
3.552LeuPhe: 3.552 ± 0.48
5.85LeuGly: 5.85 ± 0.624
1.254LeuHis: 1.254 ± 0.366
5.119LeuIle: 5.119 ± 0.558
7.73LeuLys: 7.73 ± 0.857
6.581LeuLeu: 6.581 ± 1.005
2.298LeuMet: 2.298 ± 0.704
5.536LeuAsn: 5.536 ± 0.76
3.029LeuPro: 3.029 ± 0.742
2.298LeuGln: 2.298 ± 0.757
4.074LeuArg: 4.074 ± 0.582
6.79LeuSer: 6.79 ± 0.892
5.536LeuThr: 5.536 ± 0.783
3.761LeuVal: 3.761 ± 0.59
0.522LeuTrp: 0.522 ± 0.419
2.716LeuTyr: 2.716 ± 0.478
0.0LeuXaa: 0.0 ± 0.0
Met
1.462MetAla: 1.462 ± 0.295
0.313MetCys: 0.313 ± 0.205
0.522MetAsp: 0.522 ± 0.265
2.194MetGlu: 2.194 ± 0.665
0.313MetPhe: 0.313 ± 0.293
1.358MetGly: 1.358 ± 0.294
0.104MetHis: 0.104 ± 0.118
1.671MetIle: 1.671 ± 0.484
2.925MetLys: 2.925 ± 0.639
1.462MetLeu: 1.462 ± 0.361
0.731MetMet: 0.731 ± 0.282
1.88MetAsn: 1.88 ± 0.56
0.731MetPro: 0.731 ± 0.347
0.522MetGln: 0.522 ± 0.189
0.627MetArg: 0.627 ± 0.316
1.567MetSer: 1.567 ± 0.524
1.985MetThr: 1.985 ± 0.643
1.776MetVal: 1.776 ± 0.345
0.104MetTrp: 0.104 ± 0.097
0.418MetTyr: 0.418 ± 0.182
0.0MetXaa: 0.0 ± 0.0
Asn
3.552AsnAla: 3.552 ± 0.653
0.104AsnCys: 0.104 ± 0.074
2.612AsnAsp: 2.612 ± 0.637
4.074AsnGlu: 4.074 ± 0.494
2.82AsnPhe: 2.82 ± 0.536
4.074AsnGly: 4.074 ± 0.831
1.671AsnHis: 1.671 ± 0.405
4.178AsnIle: 4.178 ± 0.803
4.492AsnLys: 4.492 ± 0.578
5.432AsnLeu: 5.432 ± 0.924
0.836AsnMet: 0.836 ± 0.339
3.029AsnAsn: 3.029 ± 0.568
2.925AsnPro: 2.925 ± 0.518
3.238AsnGln: 3.238 ± 0.718
3.761AsnArg: 3.761 ± 0.437
4.387AsnSer: 4.387 ± 0.731
3.447AsnThr: 3.447 ± 0.459
4.283AsnVal: 4.283 ± 0.604
1.045AsnTrp: 1.045 ± 0.339
1.254AsnTyr: 1.254 ± 0.265
0.0AsnXaa: 0.0 ± 0.0
Pro
1.776ProAla: 1.776 ± 0.478
0.313ProCys: 0.313 ± 0.217
2.403ProAsp: 2.403 ± 0.479
2.089ProGlu: 2.089 ± 0.634
0.627ProPhe: 0.627 ± 0.245
0.836ProGly: 0.836 ± 0.278
0.313ProHis: 0.313 ± 0.244
1.254ProIle: 1.254 ± 0.423
2.82ProLys: 2.82 ± 0.55
2.194ProLeu: 2.194 ± 0.539
0.522ProMet: 0.522 ± 0.222
1.462ProAsn: 1.462 ± 0.352
0.418ProPro: 0.418 ± 0.257
1.567ProGln: 1.567 ± 0.394
0.627ProArg: 0.627 ± 0.231
1.462ProSer: 1.462 ± 0.422
1.671ProThr: 1.671 ± 0.601
1.985ProVal: 1.985 ± 0.439
0.418ProTrp: 0.418 ± 0.247
0.731ProTyr: 0.731 ± 0.348
0.0ProXaa: 0.0 ± 0.0
Gln
3.656GlnAla: 3.656 ± 0.647
0.104GlnCys: 0.104 ± 0.103
1.358GlnAsp: 1.358 ± 0.336
4.178GlnGlu: 4.178 ± 0.749
1.776GlnPhe: 1.776 ± 0.333
1.985GlnGly: 1.985 ± 0.364
0.209GlnHis: 0.209 ± 0.108
2.403GlnIle: 2.403 ± 0.485
3.238GlnLys: 3.238 ± 0.499
3.343GlnLeu: 3.343 ± 0.559
0.627GlnMet: 0.627 ± 0.213
2.507GlnAsn: 2.507 ± 0.361
0.94GlnPro: 0.94 ± 0.373
1.149GlnGln: 1.149 ± 0.311
2.716GlnArg: 2.716 ± 0.57
4.178GlnSer: 4.178 ± 0.705
2.089GlnThr: 2.089 ± 0.408
2.925GlnVal: 2.925 ± 0.58
0.209GlnTrp: 0.209 ± 0.138
1.045GlnTyr: 1.045 ± 0.33
0.0GlnXaa: 0.0 ± 0.0
Arg
2.82ArgAla: 2.82 ± 0.45
0.418ArgCys: 0.418 ± 0.201
1.671ArgAsp: 1.671 ± 0.39
3.343ArgGlu: 3.343 ± 0.708
1.358ArgPhe: 1.358 ± 0.286
2.089ArgGly: 2.089 ± 0.466
0.836ArgHis: 0.836 ± 0.336
3.761ArgIle: 3.761 ± 0.763
3.656ArgLys: 3.656 ± 0.56
4.596ArgLeu: 4.596 ± 0.672
0.731ArgMet: 0.731 ± 0.215
3.134ArgAsn: 3.134 ± 0.625
1.567ArgPro: 1.567 ± 0.38
2.298ArgGln: 2.298 ± 0.612
2.716ArgArg: 2.716 ± 0.638
2.298ArgSer: 2.298 ± 0.385
2.194ArgThr: 2.194 ± 0.685
2.82ArgVal: 2.82 ± 0.542
0.627ArgTrp: 0.627 ± 0.219
1.985ArgTyr: 1.985 ± 0.553
0.0ArgXaa: 0.0 ± 0.0
Ser
4.387SerAla: 4.387 ± 0.821
0.313SerCys: 0.313 ± 0.178
3.552SerAsp: 3.552 ± 0.614
4.492SerGlu: 4.492 ± 0.675
2.82SerPhe: 2.82 ± 0.49
5.014SerGly: 5.014 ± 0.83
0.731SerHis: 0.731 ± 0.266
4.596SerIle: 4.596 ± 0.584
4.596SerLys: 4.596 ± 0.741
5.119SerLeu: 5.119 ± 0.763
0.94SerMet: 0.94 ± 0.379
4.701SerAsn: 4.701 ± 0.818
1.462SerPro: 1.462 ± 0.34
2.716SerGln: 2.716 ± 0.667
3.029SerArg: 3.029 ± 0.726
4.387SerSer: 4.387 ± 0.922
5.119SerThr: 5.119 ± 0.846
4.596SerVal: 4.596 ± 0.926
0.94SerTrp: 0.94 ± 0.319
2.403SerTyr: 2.403 ± 0.46
0.0SerXaa: 0.0 ± 0.0
Thr
5.327ThrAla: 5.327 ± 1.055
0.209ThrCys: 0.209 ± 0.182
5.119ThrAsp: 5.119 ± 0.844
4.074ThrGlu: 4.074 ± 0.646
2.925ThrPhe: 2.925 ± 0.849
5.327ThrGly: 5.327 ± 1.029
0.731ThrHis: 0.731 ± 0.232
5.536ThrIle: 5.536 ± 0.731
4.596ThrLys: 4.596 ± 0.437
5.432ThrLeu: 5.432 ± 0.853
0.836ThrMet: 0.836 ± 0.284
3.134ThrAsn: 3.134 ± 0.407
1.149ThrPro: 1.149 ± 0.414
2.089ThrGln: 2.089 ± 0.425
2.612ThrArg: 2.612 ± 0.565
3.656ThrSer: 3.656 ± 0.672
5.432ThrThr: 5.432 ± 1.043
3.969ThrVal: 3.969 ± 0.585
1.045ThrTrp: 1.045 ± 0.378
2.194ThrTyr: 2.194 ± 0.366
0.0ThrXaa: 0.0 ± 0.0
Val
3.343ValAla: 3.343 ± 0.602
0.522ValCys: 0.522 ± 0.207
4.178ValAsp: 4.178 ± 0.603
5.536ValGlu: 5.536 ± 0.605
2.82ValPhe: 2.82 ± 0.728
4.492ValGly: 4.492 ± 0.902
0.836ValHis: 0.836 ± 0.323
2.612ValIle: 2.612 ± 0.461
4.91ValLys: 4.91 ± 0.768
3.238ValLeu: 3.238 ± 0.588
1.462ValMet: 1.462 ± 0.343
3.552ValAsn: 3.552 ± 0.49
1.567ValPro: 1.567 ± 0.307
2.403ValGln: 2.403 ± 0.481
2.925ValArg: 2.925 ± 0.548
2.82ValSer: 2.82 ± 0.533
5.014ValThr: 5.014 ± 0.645
4.178ValVal: 4.178 ± 0.671
0.94ValTrp: 0.94 ± 0.287
1.462ValTyr: 1.462 ± 0.508
0.0ValXaa: 0.0 ± 0.0
Trp
0.94TrpAla: 0.94 ± 0.306
0.104TrpCys: 0.104 ± 0.133
0.313TrpAsp: 0.313 ± 0.179
0.731TrpGlu: 0.731 ± 0.234
0.731TrpPhe: 0.731 ± 0.315
1.149TrpGly: 1.149 ± 0.326
0.209TrpHis: 0.209 ± 0.133
1.462TrpIle: 1.462 ± 0.337
0.522TrpLys: 0.522 ± 0.246
1.149TrpLeu: 1.149 ± 0.413
0.627TrpMet: 0.627 ± 0.265
1.358TrpAsn: 1.358 ± 0.373
0.104TrpPro: 0.104 ± 0.107
0.836TrpGln: 0.836 ± 0.272
0.522TrpArg: 0.522 ± 0.238
1.045TrpSer: 1.045 ± 0.623
0.836TrpThr: 0.836 ± 0.25
0.627TrpVal: 0.627 ± 0.228
0.104TrpTrp: 0.104 ± 0.074
0.836TrpTyr: 0.836 ± 0.656
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.194TyrAla: 2.194 ± 0.414
0.313TyrCys: 0.313 ± 0.154
1.776TyrAsp: 1.776 ± 0.467
2.716TyrGlu: 2.716 ± 0.54
1.567TyrPhe: 1.567 ± 0.583
1.462TyrGly: 1.462 ± 0.465
0.94TyrHis: 0.94 ± 0.261
2.194TyrIle: 2.194 ± 0.408
2.925TyrLys: 2.925 ± 0.606
4.387TyrLeu: 4.387 ± 0.705
0.94TyrMet: 0.94 ± 0.331
1.776TyrAsn: 1.776 ± 0.504
0.94TyrPro: 0.94 ± 0.293
2.194TyrGln: 2.194 ± 0.516
1.985TyrArg: 1.985 ± 0.56
2.194TyrSer: 2.194 ± 0.315
1.567TyrThr: 1.567 ± 0.343
1.567TyrVal: 1.567 ± 0.381
0.731TyrTrp: 0.731 ± 0.259
2.194TyrTyr: 2.194 ± 0.852
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 35 proteins (9574 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski