Amino acid dipepetide frequency for Flexistipes sinusarabici (strain ATCC 49648 / DSM 4947 / MAS 10)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.01AlaAla: 5.01 ± 0.102
0.802AlaCys: 0.802 ± 0.038
3.652AlaAsp: 3.652 ± 0.08
5.126AlaGlu: 5.126 ± 0.104
3.06AlaPhe: 3.06 ± 0.077
5.35AlaGly: 5.35 ± 0.107
0.951AlaHis: 0.951 ± 0.042
3.907AlaIle: 3.907 ± 0.095
4.529AlaLys: 4.529 ± 0.084
5.738AlaLeu: 5.738 ± 0.111
1.465AlaMet: 1.465 ± 0.054
2.336AlaAsn: 2.336 ± 0.05
1.647AlaPro: 1.647 ± 0.048
1.33AlaGln: 1.33 ± 0.049
2.316AlaArg: 2.316 ± 0.054
3.623AlaSer: 3.623 ± 0.073
2.556AlaThr: 2.556 ± 0.061
5.221AlaVal: 5.221 ± 0.091
0.362AlaTrp: 0.362 ± 0.027
2.312AlaTyr: 2.312 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.662CysAla: 0.662 ± 0.038
0.181CysCys: 0.181 ± 0.02
0.579CysAsp: 0.579 ± 0.031
0.735CysGlu: 0.735 ± 0.033
0.562CysPhe: 0.562 ± 0.031
1.019CysGly: 1.019 ± 0.049
0.436CysHis: 0.436 ± 0.059
0.776CysIle: 0.776 ± 0.035
0.796CysLys: 0.796 ± 0.041
0.792CysLeu: 0.792 ± 0.035
0.271CysMet: 0.271 ± 0.019
0.508CysAsn: 0.508 ± 0.032
0.55CysPro: 0.55 ± 0.031
0.182CysGln: 0.182 ± 0.016
0.523CysArg: 0.523 ± 0.031
0.861CysSer: 0.861 ± 0.036
0.498CysThr: 0.498 ± 0.025
0.667CysVal: 0.667 ± 0.034
0.077CysTrp: 0.077 ± 0.009
0.415CysTyr: 0.415 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
3.04AspAla: 3.04 ± 0.068
0.566AspCys: 0.566 ± 0.028
2.8AspAsp: 2.8 ± 0.071
4.577AspGlu: 4.577 ± 0.093
3.6AspPhe: 3.6 ± 0.075
2.965AspGly: 2.965 ± 0.075
0.764AspHis: 0.764 ± 0.038
5.968AspIle: 5.968 ± 0.103
5.291AspLys: 5.291 ± 0.096
4.71AspLeu: 4.71 ± 0.086
1.558AspMet: 1.558 ± 0.053
3.023AspAsn: 3.023 ± 0.079
1.728AspPro: 1.728 ± 0.053
0.841AspGln: 0.841 ± 0.036
2.118AspArg: 2.118 ± 0.066
3.324AspSer: 3.324 ± 0.066
2.541AspThr: 2.541 ± 0.059
3.742AspVal: 3.742 ± 0.075
0.431AspTrp: 0.431 ± 0.029
2.703AspTyr: 2.703 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
4.029GluAla: 4.029 ± 0.077
0.669GluCys: 0.669 ± 0.032
3.875GluAsp: 3.875 ± 0.085
5.689GluGlu: 5.689 ± 0.131
2.902GluPhe: 2.902 ± 0.064
3.885GluGly: 3.885 ± 0.077
1.199GluHis: 1.199 ± 0.046
6.873GluIle: 6.873 ± 0.112
8.341GluLys: 8.341 ± 0.131
6.197GluLeu: 6.197 ± 0.113
1.948GluMet: 1.948 ± 0.05
5.201GluAsn: 5.201 ± 0.097
1.662GluPro: 1.662 ± 0.047
1.812GluGln: 1.812 ± 0.055
2.884GluArg: 2.884 ± 0.075
4.227GluSer: 4.227 ± 0.096
3.358GluThr: 3.358 ± 0.082
4.208GluVal: 4.208 ± 0.088
0.455GluTrp: 0.455 ± 0.025
2.998GluTyr: 2.998 ± 0.07
0.0GluXaa: 0.0 ± 0.0
Phe
3.325PheAla: 3.325 ± 0.087
0.599PheCys: 0.599 ± 0.026
3.231PheAsp: 3.231 ± 0.074
3.342PheGlu: 3.342 ± 0.067
3.127PhePhe: 3.127 ± 0.096
3.581PheGly: 3.581 ± 0.082
0.879PheHis: 0.879 ± 0.032
4.396PheIle: 4.396 ± 0.093
3.532PheLys: 3.532 ± 0.071
5.284PheLeu: 5.284 ± 0.117
1.254PheMet: 1.254 ± 0.04
2.572PheAsn: 2.572 ± 0.065
1.602PhePro: 1.602 ± 0.053
1.223PheGln: 1.223 ± 0.045
2.154PheArg: 2.154 ± 0.058
3.913PheSer: 3.913 ± 0.08
2.567PheThr: 2.567 ± 0.07
3.49PheVal: 3.49 ± 0.081
0.417PheTrp: 0.417 ± 0.029
2.318PheTyr: 2.318 ± 0.066
0.0PheXaa: 0.0 ± 0.0
Gly
4.078GlyAla: 4.078 ± 0.103
0.887GlyCys: 0.887 ± 0.041
3.38GlyAsp: 3.38 ± 0.075
4.393GlyGlu: 4.393 ± 0.081
3.729GlyPhe: 3.729 ± 0.078
4.723GlyGly: 4.723 ± 0.114
1.206GlyHis: 1.206 ± 0.046
6.175GlyIle: 6.175 ± 0.099
5.575GlyLys: 5.575 ± 0.094
5.698GlyLeu: 5.698 ± 0.115
1.915GlyMet: 1.915 ± 0.057
3.001GlyAsn: 3.001 ± 0.065
1.313GlyPro: 1.313 ± 0.049
1.338GlyGln: 1.338 ± 0.048
2.753GlyArg: 2.753 ± 0.067
3.961GlySer: 3.961 ± 0.086
3.17GlyThr: 3.17 ± 0.073
4.894GlyVal: 4.894 ± 0.085
0.57GlyTrp: 0.57 ± 0.029
3.16GlyTyr: 3.16 ± 0.084
0.0GlyXaa: 0.0 ± 0.0
His
0.85HisAla: 0.85 ± 0.037
0.272HisCys: 0.272 ± 0.021
0.793HisAsp: 0.793 ± 0.037
1.057HisGlu: 1.057 ± 0.043
0.994HisPhe: 0.994 ± 0.036
1.115HisGly: 1.115 ± 0.042
0.333HisHis: 0.333 ± 0.025
1.455HisIle: 1.455 ± 0.055
1.265HisLys: 1.265 ± 0.044
1.595HisLeu: 1.595 ± 0.052
0.372HisMet: 0.372 ± 0.023
0.925HisAsn: 0.925 ± 0.043
0.837HisPro: 0.837 ± 0.045
0.379HisGln: 0.379 ± 0.024
0.688HisArg: 0.688 ± 0.031
1.135HisSer: 1.135 ± 0.043
0.895HisThr: 0.895 ± 0.034
0.948HisVal: 0.948 ± 0.035
0.142HisTrp: 0.142 ± 0.017
0.67HisTyr: 0.67 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
5.294IleAla: 5.294 ± 0.094
0.973IleCys: 0.973 ± 0.039
4.899IleAsp: 4.899 ± 0.089
5.224IleGlu: 5.224 ± 0.101
4.651IlePhe: 4.651 ± 0.099
5.056IleGly: 5.056 ± 0.1
1.343IleHis: 1.343 ± 0.043
6.789IleIle: 6.789 ± 0.135
6.824IleLys: 6.824 ± 0.109
8.037IleLeu: 8.037 ± 0.132
1.812IleMet: 1.812 ± 0.057
4.668IleAsn: 4.668 ± 0.075
3.351IlePro: 3.351 ± 0.075
1.818IleGln: 1.818 ± 0.056
3.107IleArg: 3.107 ± 0.067
6.33IleSer: 6.33 ± 0.103
4.118IleThr: 4.118 ± 0.09
5.382IleVal: 5.382 ± 0.102
0.447IleTrp: 0.447 ± 0.028
3.296IleTyr: 3.296 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
4.731LysAla: 4.731 ± 0.102
0.744LysCys: 0.744 ± 0.039
4.783LysAsp: 4.783 ± 0.092
6.817LysGlu: 6.817 ± 0.118
3.486LysPhe: 3.486 ± 0.059
5.153LysGly: 5.153 ± 0.083
1.401LysHis: 1.401 ± 0.048
7.682LysIle: 7.682 ± 0.104
8.234LysLys: 8.234 ± 0.128
7.384LysLeu: 7.384 ± 0.118
2.357LysMet: 2.357 ± 0.057
6.039LysAsn: 6.039 ± 0.115
2.554LysPro: 2.554 ± 0.063
2.242LysGln: 2.242 ± 0.057
3.701LysArg: 3.701 ± 0.071
5.426LysSer: 5.426 ± 0.099
4.315LysThr: 4.315 ± 0.091
4.974LysVal: 4.974 ± 0.097
0.602LysTrp: 0.602 ± 0.031
3.962LysTyr: 3.962 ± 0.074
0.0LysXaa: 0.0 ± 0.0
Leu
5.715LeuAla: 5.715 ± 0.109
0.944LeuCys: 0.944 ± 0.041
4.987LeuAsp: 4.987 ± 0.103
6.099LeuGlu: 6.099 ± 0.094
4.482LeuPhe: 4.482 ± 0.109
5.863LeuGly: 5.863 ± 0.111
1.411LeuHis: 1.411 ± 0.045
7.084LeuIle: 7.084 ± 0.141
9.02LeuLys: 9.02 ± 0.132
8.667LeuLeu: 8.667 ± 0.165
2.237LeuMet: 2.237 ± 0.054
5.226LeuAsn: 5.226 ± 0.094
3.274LeuPro: 3.274 ± 0.07
2.527LeuGln: 2.527 ± 0.068
3.704LeuArg: 3.704 ± 0.077
7.106LeuSer: 7.106 ± 0.109
4.538LeuThr: 4.538 ± 0.082
5.194LeuVal: 5.194 ± 0.092
0.631LeuTrp: 0.631 ± 0.03
3.279LeuTyr: 3.279 ± 0.075
0.0LeuXaa: 0.0 ± 0.0
Met
1.678MetAla: 1.678 ± 0.051
0.239MetCys: 0.239 ± 0.019
1.462MetAsp: 1.462 ± 0.04
1.639MetGlu: 1.639 ± 0.049
1.122MetPhe: 1.122 ± 0.044
1.779MetGly: 1.779 ± 0.053
0.473MetHis: 0.473 ± 0.024
1.909MetIle: 1.909 ± 0.045
2.4MetLys: 2.4 ± 0.055
2.403MetLeu: 2.403 ± 0.061
0.56MetMet: 0.56 ± 0.034
1.332MetAsn: 1.332 ± 0.048
1.0MetPro: 1.0 ± 0.036
0.802MetGln: 0.802 ± 0.039
0.96MetArg: 0.96 ± 0.035
1.63MetSer: 1.63 ± 0.05
1.219MetThr: 1.219 ± 0.044
1.462MetVal: 1.462 ± 0.041
0.153MetTrp: 0.153 ± 0.017
0.78MetTyr: 0.78 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
2.956AsnAla: 2.956 ± 0.065
0.547AsnCys: 0.547 ± 0.031
2.752AsnAsp: 2.752 ± 0.062
3.476AsnGlu: 3.476 ± 0.067
3.057AsnPhe: 3.057 ± 0.071
3.023AsnGly: 3.023 ± 0.07
0.718AsnHis: 0.718 ± 0.031
5.634AsnIle: 5.634 ± 0.101
4.525AsnLys: 4.525 ± 0.077
5.113AsnLeu: 5.113 ± 0.093
1.424AsnMet: 1.424 ± 0.045
3.06AsnAsn: 3.06 ± 0.088
2.202AsnPro: 2.202 ± 0.049
1.091AsnGln: 1.091 ± 0.042
2.184AsnArg: 2.184 ± 0.057
3.156AsnSer: 3.156 ± 0.072
2.471AsnThr: 2.471 ± 0.059
3.657AsnVal: 3.657 ± 0.071
0.33AsnTrp: 0.33 ± 0.024
2.36AsnTyr: 2.36 ± 0.067
0.0AsnXaa: 0.0 ± 0.0
Pro
2.109ProAla: 2.109 ± 0.061
0.288ProCys: 0.288 ± 0.022
2.218ProAsp: 2.218 ± 0.055
3.286ProGlu: 3.286 ± 0.071
1.938ProPhe: 1.938 ± 0.052
2.274ProGly: 2.274 ± 0.059
0.633ProHis: 0.633 ± 0.036
1.909ProIle: 1.909 ± 0.053
2.018ProLys: 2.018 ± 0.061
3.023ProLeu: 3.023 ± 0.073
0.677ProMet: 0.677 ± 0.03
1.149ProAsn: 1.149 ± 0.038
0.999ProPro: 0.999 ± 0.041
0.801ProGln: 0.801 ± 0.041
0.96ProArg: 0.96 ± 0.039
2.006ProSer: 2.006 ± 0.051
1.403ProThr: 1.403 ± 0.045
3.133ProVal: 3.133 ± 0.067
0.246ProTrp: 0.246 ± 0.017
1.404ProTyr: 1.404 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
1.472GlnAla: 1.472 ± 0.049
0.243GlnCys: 0.243 ± 0.02
1.078GlnAsp: 1.078 ± 0.038
1.673GlnGlu: 1.673 ± 0.058
1.047GlnPhe: 1.047 ± 0.038
1.259GlnGly: 1.259 ± 0.048
0.402GlnHis: 0.402 ± 0.024
1.983GlnIle: 1.983 ± 0.056
2.37GlnLys: 2.37 ± 0.06
2.347GlnLeu: 2.347 ± 0.058
0.803GlnMet: 0.803 ± 0.038
1.507GlnAsn: 1.507 ± 0.047
0.695GlnPro: 0.695 ± 0.034
0.737GlnGln: 0.737 ± 0.033
0.987GlnArg: 0.987 ± 0.034
1.394GlnSer: 1.394 ± 0.051
1.155GlnThr: 1.155 ± 0.042
1.374GlnVal: 1.374 ± 0.055
0.207GlnTrp: 0.207 ± 0.02
0.908GlnTyr: 0.908 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
2.035ArgAla: 2.035 ± 0.059
0.417ArgCys: 0.417 ± 0.027
2.174ArgAsp: 2.174 ± 0.059
3.086ArgGlu: 3.086 ± 0.07
2.19ArgPhe: 2.19 ± 0.053
2.329ArgGly: 2.329 ± 0.06
0.685ArgHis: 0.685 ± 0.034
3.406ArgIle: 3.406 ± 0.067
3.775ArgLys: 3.775 ± 0.081
3.842ArgLeu: 3.842 ± 0.079
1.091ArgMet: 1.091 ± 0.036
2.205ArgAsn: 2.205 ± 0.059
1.1ArgPro: 1.1 ± 0.041
1.246ArgGln: 1.246 ± 0.04
1.699ArgArg: 1.699 ± 0.052
2.179ArgSer: 2.179 ± 0.066
1.565ArgThr: 1.565 ± 0.042
2.403ArgVal: 2.403 ± 0.066
0.352ArgTrp: 0.352 ± 0.023
1.731ArgTyr: 1.731 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
3.901SerAla: 3.901 ± 0.077
0.851SerCys: 0.851 ± 0.036
3.898SerAsp: 3.898 ± 0.074
5.077SerGlu: 5.077 ± 0.097
3.745SerPhe: 3.745 ± 0.081
5.289SerGly: 5.289 ± 0.09
1.115SerHis: 1.115 ± 0.042
4.952SerIle: 4.952 ± 0.089
5.062SerLys: 5.062 ± 0.1
6.042SerLeu: 6.042 ± 0.089
1.597SerMet: 1.597 ± 0.049
2.743SerAsn: 2.743 ± 0.064
2.038SerPro: 2.038 ± 0.055
1.553SerGln: 1.553 ± 0.049
2.717SerArg: 2.717 ± 0.059
4.263SerSer: 4.263 ± 0.103
2.766SerThr: 2.766 ± 0.069
4.686SerVal: 4.686 ± 0.079
0.546SerTrp: 0.546 ± 0.029
2.617SerTyr: 2.617 ± 0.068
0.0SerXaa: 0.0 ± 0.0
Thr
3.573ThrAla: 3.573 ± 0.076
0.459ThrCys: 0.459 ± 0.028
2.842ThrAsp: 2.842 ± 0.068
3.091ThrGlu: 3.091 ± 0.073
2.459ThrPhe: 2.459 ± 0.062
4.301ThrGly: 4.301 ± 0.083
0.801ThrHis: 0.801 ± 0.03
3.474ThrIle: 3.474 ± 0.062
3.312ThrLys: 3.312 ± 0.068
4.405ThrLeu: 4.405 ± 0.075
0.937ThrMet: 0.937 ± 0.038
2.005ThrAsn: 2.005 ± 0.058
1.931ThrPro: 1.931 ± 0.058
0.964ThrGln: 0.964 ± 0.033
1.469ThrArg: 1.469 ± 0.047
2.836ThrSer: 2.836 ± 0.07
2.166ThrThr: 2.166 ± 0.06
3.618ThrVal: 3.618 ± 0.08
0.282ThrTrp: 0.282 ± 0.024
1.73ThrTyr: 1.73 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
4.124ValAla: 4.124 ± 0.087
0.845ValCys: 0.845 ± 0.037
4.134ValAsp: 4.134 ± 0.089
4.573ValGlu: 4.573 ± 0.091
3.761ValPhe: 3.761 ± 0.086
3.871ValGly: 3.871 ± 0.081
1.028ValHis: 1.028 ± 0.033
5.473ValIle: 5.473 ± 0.092
5.753ValLys: 5.753 ± 0.102
5.928ValLeu: 5.928 ± 0.104
1.689ValMet: 1.689 ± 0.048
3.599ValAsn: 3.599 ± 0.075
2.274ValPro: 2.274 ± 0.057
1.533ValGln: 1.533 ± 0.046
2.439ValArg: 2.439 ± 0.067
4.689ValSer: 4.689 ± 0.089
3.176ValThr: 3.176 ± 0.057
4.868ValVal: 4.868 ± 0.098
0.41ValTrp: 0.41 ± 0.022
2.497ValTyr: 2.497 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.411TrpAla: 0.411 ± 0.028
0.074TrpCys: 0.074 ± 0.011
0.392TrpAsp: 0.392 ± 0.026
0.537TrpGlu: 0.537 ± 0.03
0.421TrpPhe: 0.421 ± 0.029
0.486TrpGly: 0.486 ± 0.027
0.165TrpHis: 0.165 ± 0.016
0.51TrpIle: 0.51 ± 0.027
0.56TrpLys: 0.56 ± 0.033
0.76TrpLeu: 0.76 ± 0.037
0.198TrpMet: 0.198 ± 0.02
0.358TrpAsn: 0.358 ± 0.023
0.227TrpPro: 0.227 ± 0.018
0.281TrpGln: 0.281 ± 0.018
0.29TrpArg: 0.29 ± 0.019
0.321TrpSer: 0.321 ± 0.02
0.253TrpThr: 0.253 ± 0.02
0.427TrpVal: 0.427 ± 0.027
0.098TrpTrp: 0.098 ± 0.013
0.295TrpTyr: 0.295 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.305TyrAla: 2.305 ± 0.052
0.489TyrCys: 0.489 ± 0.032
2.36TyrAsp: 2.36 ± 0.057
2.917TyrGlu: 2.917 ± 0.072
2.472TyrPhe: 2.472 ± 0.067
2.597TyrGly: 2.597 ± 0.062
0.777TyrHis: 0.777 ± 0.033
3.063TyrIle: 3.063 ± 0.067
3.405TyrLys: 3.405 ± 0.076
4.024TyrLeu: 4.024 ± 0.083
0.835TyrMet: 0.835 ± 0.039
2.278TyrAsn: 2.278 ± 0.068
1.488TyrPro: 1.488 ± 0.052
0.939TyrGln: 0.939 ± 0.041
1.859TyrArg: 1.859 ± 0.054
3.08TyrSer: 3.08 ± 0.075
1.922TyrThr: 1.922 ± 0.053
2.316TyrVal: 2.316 ± 0.058
0.307TyrTrp: 0.307 ± 0.02
1.827TyrTyr: 1.827 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2185 proteins (690808 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski