Amino acid dipepetide frequency for Lactobacillus capillatus DSM 19910

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.908AlaAla: 7.908 ± 0.135
0.514AlaCys: 0.514 ± 0.031
4.206AlaAsp: 4.206 ± 0.099
4.698AlaGlu: 4.698 ± 0.102
3.253AlaPhe: 3.253 ± 0.082
5.878AlaGly: 5.878 ± 0.118
1.392AlaHis: 1.392 ± 0.053
5.719AlaIle: 5.719 ± 0.111
5.451AlaLys: 5.451 ± 0.111
7.76AlaLeu: 7.76 ± 0.107
1.844AlaMet: 1.844 ± 0.055
3.335AlaAsn: 3.335 ± 0.082
2.126AlaPro: 2.126 ± 0.065
3.68AlaGln: 3.68 ± 0.101
2.9AlaArg: 2.9 ± 0.068
4.284AlaSer: 4.284 ± 0.096
4.644AlaThr: 4.644 ± 0.087
5.768AlaVal: 5.768 ± 0.1
0.597AlaTrp: 0.597 ± 0.038
2.546AlaTyr: 2.546 ± 0.065
0.002AlaXaa: 0.002 ± 0.002
Cys
0.424CysAla: 0.424 ± 0.026
0.065CysCys: 0.065 ± 0.011
0.29CysAsp: 0.29 ± 0.023
0.291CysGlu: 0.291 ± 0.025
0.312CysPhe: 0.312 ± 0.023
0.527CysGly: 0.527 ± 0.032
0.166CysHis: 0.166 ± 0.015
0.39CysIle: 0.39 ± 0.025
0.207CysLys: 0.207 ± 0.019
0.672CysLeu: 0.672 ± 0.035
0.123CysMet: 0.123 ± 0.014
0.22CysAsn: 0.22 ± 0.02
0.256CysPro: 0.256 ± 0.023
0.266CysGln: 0.266 ± 0.024
0.261CysArg: 0.261 ± 0.021
0.475CysSer: 0.475 ± 0.026
0.285CysThr: 0.285 ± 0.026
0.369CysVal: 0.369 ± 0.027
0.086CysTrp: 0.086 ± 0.011
0.26CysTyr: 0.26 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.403AspAla: 3.403 ± 0.085
0.283AspCys: 0.283 ± 0.021
2.733AspAsp: 2.733 ± 0.07
3.653AspGlu: 3.653 ± 0.093
2.489AspPhe: 2.489 ± 0.064
3.238AspGly: 3.238 ± 0.08
1.029AspHis: 1.029 ± 0.04
3.709AspIle: 3.709 ± 0.078
3.755AspLys: 3.755 ± 0.084
5.18AspLeu: 5.18 ± 0.098
1.21AspMet: 1.21 ± 0.046
2.467AspAsn: 2.467 ± 0.078
1.951AspPro: 1.951 ± 0.06
2.206AspGln: 2.206 ± 0.067
1.909AspArg: 1.909 ± 0.067
2.801AspSer: 2.801 ± 0.079
2.54AspThr: 2.54 ± 0.07
3.609AspVal: 3.609 ± 0.073
0.559AspTrp: 0.559 ± 0.032
2.215AspTyr: 2.215 ± 0.057
0.0AspXaa: 0.0 ± 0.0
Glu
4.088GluAla: 4.088 ± 0.087
0.285GluCys: 0.285 ± 0.019
2.744GluAsp: 2.744 ± 0.07
3.73GluGlu: 3.73 ± 0.087
2.086GluPhe: 2.086 ± 0.057
2.862GluGly: 2.862 ± 0.08
1.282GluHis: 1.282 ± 0.053
4.304GluIle: 4.304 ± 0.088
5.408GluLys: 5.408 ± 0.105
6.458GluLeu: 6.458 ± 0.119
1.712GluMet: 1.712 ± 0.056
2.975GluAsn: 2.975 ± 0.062
1.581GluPro: 1.581 ± 0.049
3.179GluGln: 3.179 ± 0.093
2.859GluArg: 2.859 ± 0.081
2.608GluSer: 2.608 ± 0.065
3.333GluThr: 3.333 ± 0.075
3.983GluVal: 3.983 ± 0.088
0.554GluTrp: 0.554 ± 0.03
1.916GluTyr: 1.916 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
3.152PheAla: 3.152 ± 0.076
0.323PheCys: 0.323 ± 0.021
2.553PheAsp: 2.553 ± 0.076
2.429PheGlu: 2.429 ± 0.068
2.357PhePhe: 2.357 ± 0.081
3.107PheGly: 3.107 ± 0.074
0.736PheHis: 0.736 ± 0.035
3.653PheIle: 3.653 ± 0.099
3.195PheLys: 3.195 ± 0.069
4.338PheLeu: 4.338 ± 0.114
1.07PheMet: 1.07 ± 0.039
2.298PheAsn: 2.298 ± 0.057
1.408PhePro: 1.408 ± 0.048
1.398PheGln: 1.398 ± 0.049
1.325PheArg: 1.325 ± 0.051
3.15PheSer: 3.15 ± 0.074
2.529PheThr: 2.529 ± 0.062
2.924PheVal: 2.924 ± 0.087
0.465PheTrp: 0.465 ± 0.031
1.733PheTyr: 1.733 ± 0.058
0.0PheXaa: 0.0 ± 0.0
Gly
4.908GlyAla: 4.908 ± 0.109
0.455GlyCys: 0.455 ± 0.029
2.919GlyAsp: 2.919 ± 0.074
3.281GlyGlu: 3.281 ± 0.078
3.183GlyPhe: 3.183 ± 0.089
4.258GlyGly: 4.258 ± 0.112
1.303GlyHis: 1.303 ± 0.045
5.827GlyIle: 5.827 ± 0.105
4.956GlyLys: 4.956 ± 0.097
6.571GlyLeu: 6.571 ± 0.107
1.886GlyMet: 1.886 ± 0.064
2.803GlyAsn: 2.803 ± 0.075
1.503GlyPro: 1.503 ± 0.057
2.895GlyGln: 2.895 ± 0.082
2.64GlyArg: 2.64 ± 0.065
3.997GlySer: 3.997 ± 0.082
4.171GlyThr: 4.171 ± 0.081
4.693GlyVal: 4.693 ± 0.107
0.701GlyTrp: 0.701 ± 0.038
2.629GlyTyr: 2.629 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
1.341HisAla: 1.341 ± 0.043
0.15HisCys: 0.15 ± 0.016
0.948HisAsp: 0.948 ± 0.042
1.08HisGlu: 1.08 ± 0.043
1.155HisPhe: 1.155 ± 0.039
1.401HisGly: 1.401 ± 0.045
0.572HisHis: 0.572 ± 0.027
1.315HisIle: 1.315 ± 0.044
1.151HisLys: 1.151 ± 0.045
2.013HisLeu: 2.013 ± 0.065
0.438HisMet: 0.438 ± 0.026
0.927HisAsn: 0.927 ± 0.036
0.944HisPro: 0.944 ± 0.035
0.979HisGln: 0.979 ± 0.041
0.76HisArg: 0.76 ± 0.034
1.091HisSer: 1.091 ± 0.041
0.962HisThr: 0.962 ± 0.035
1.237HisVal: 1.237 ± 0.043
0.194HisTrp: 0.194 ± 0.02
0.862HisTyr: 0.862 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
6.281IleAla: 6.281 ± 0.09
0.583IleCys: 0.583 ± 0.031
4.125IleAsp: 4.125 ± 0.102
3.89IleGlu: 3.89 ± 0.092
3.374IlePhe: 3.374 ± 0.09
5.279IleGly: 5.279 ± 0.112
1.231IleHis: 1.231 ± 0.049
6.249IleIle: 6.249 ± 0.138
5.292IleLys: 5.292 ± 0.092
7.058IleLeu: 7.058 ± 0.148
1.827IleMet: 1.827 ± 0.054
3.486IleAsn: 3.486 ± 0.081
2.925IlePro: 2.925 ± 0.07
2.608IleGln: 2.608 ± 0.064
2.679IleArg: 2.679 ± 0.063
5.066IleSer: 5.066 ± 0.096
4.615IleThr: 4.615 ± 0.084
5.08IleVal: 5.08 ± 0.103
0.64IleTrp: 0.64 ± 0.035
2.495IleTyr: 2.495 ± 0.068
0.0IleXaa: 0.0 ± 0.0
Lys
5.027LysAla: 5.027 ± 0.094
0.245LysCys: 0.245 ± 0.02
3.776LysAsp: 3.776 ± 0.089
4.997LysGlu: 4.997 ± 0.1
2.244LysPhe: 2.244 ± 0.058
3.822LysGly: 3.822 ± 0.093
1.365LysHis: 1.365 ± 0.044
5.68LysIle: 5.68 ± 0.091
7.134LysLys: 7.134 ± 0.136
7.024LysLeu: 7.024 ± 0.128
2.521LysMet: 2.521 ± 0.055
4.185LysAsn: 4.185 ± 0.085
2.056LysPro: 2.056 ± 0.062
3.93LysGln: 3.93 ± 0.086
3.566LysArg: 3.566 ± 0.091
3.539LysSer: 3.539 ± 0.077
4.519LysThr: 4.519 ± 0.093
4.927LysVal: 4.927 ± 0.089
0.678LysTrp: 0.678 ± 0.038
2.825LysTyr: 2.825 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
8.935LeuAla: 8.935 ± 0.134
0.675LeuCys: 0.675 ± 0.04
5.088LeuAsp: 5.088 ± 0.094
5.526LeuGlu: 5.526 ± 0.104
4.707LeuPhe: 4.707 ± 0.108
6.868LeuGly: 6.868 ± 0.111
1.86LeuHis: 1.86 ± 0.056
7.281LeuIle: 7.281 ± 0.146
7.483LeuLys: 7.483 ± 0.132
10.697LeuLeu: 10.697 ± 0.19
2.416LeuMet: 2.416 ± 0.066
4.894LeuAsn: 4.894 ± 0.087
3.897LeuPro: 3.897 ± 0.085
4.104LeuGln: 4.104 ± 0.094
3.991LeuArg: 3.991 ± 0.095
6.531LeuSer: 6.531 ± 0.106
6.669LeuThr: 6.669 ± 0.108
6.91LeuVal: 6.91 ± 0.121
0.761LeuTrp: 0.761 ± 0.038
2.828LeuTyr: 2.828 ± 0.078
0.0LeuXaa: 0.0 ± 0.0
Met
1.984MetAla: 1.984 ± 0.053
0.154MetCys: 0.154 ± 0.017
1.213MetAsp: 1.213 ± 0.046
1.244MetGlu: 1.244 ± 0.041
0.884MetPhe: 0.884 ± 0.039
1.712MetGly: 1.712 ± 0.056
0.486MetHis: 0.486 ± 0.025
2.008MetIle: 2.008 ± 0.064
1.858MetLys: 1.858 ± 0.056
2.515MetLeu: 2.515 ± 0.07
0.685MetMet: 0.685 ± 0.034
1.314MetAsn: 1.314 ± 0.048
0.997MetPro: 0.997 ± 0.042
1.213MetGln: 1.213 ± 0.057
1.069MetArg: 1.069 ± 0.042
1.58MetSer: 1.58 ± 0.046
1.624MetThr: 1.624 ± 0.048
1.696MetVal: 1.696 ± 0.056
0.154MetTrp: 0.154 ± 0.016
0.669MetTyr: 0.669 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
3.215AsnAla: 3.215 ± 0.079
0.268AsnCys: 0.268 ± 0.023
2.644AsnAsp: 2.644 ± 0.069
3.031AsnGlu: 3.031 ± 0.074
2.016AsnPhe: 2.016 ± 0.059
3.472AsnGly: 3.472 ± 0.092
0.946AsnHis: 0.946 ± 0.036
3.617AsnIle: 3.617 ± 0.08
3.72AsnLys: 3.72 ± 0.084
4.433AsnLeu: 4.433 ± 0.082
1.263AsnMet: 1.263 ± 0.045
2.82AsnAsn: 2.82 ± 0.078
1.769AsnPro: 1.769 ± 0.051
2.054AsnGln: 2.054 ± 0.061
1.8AsnArg: 1.8 ± 0.053
2.909AsnSer: 2.909 ± 0.081
2.664AsnThr: 2.664 ± 0.067
2.991AsnVal: 2.991 ± 0.072
0.605AsnTrp: 0.605 ± 0.029
2.198AsnTyr: 2.198 ± 0.074
0.0AsnXaa: 0.0 ± 0.0
Pro
2.819ProAla: 2.819 ± 0.067
0.143ProCys: 0.143 ± 0.016
1.774ProAsp: 1.774 ± 0.05
2.472ProGlu: 2.472 ± 0.062
1.671ProPhe: 1.671 ± 0.054
1.881ProGly: 1.881 ± 0.051
0.705ProHis: 0.705 ± 0.032
2.185ProIle: 2.185 ± 0.062
2.037ProLys: 2.037 ± 0.06
3.653ProLeu: 3.653 ± 0.091
0.618ProMet: 0.618 ± 0.03
1.581ProAsn: 1.581 ± 0.056
0.627ProPro: 0.627 ± 0.034
1.801ProGln: 1.801 ± 0.058
1.156ProArg: 1.156 ± 0.042
1.82ProSer: 1.82 ± 0.044
2.172ProThr: 2.172 ± 0.058
2.562ProVal: 2.562 ± 0.072
0.323ProTrp: 0.323 ± 0.024
1.229ProTyr: 1.229 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
3.637GlnAla: 3.637 ± 0.092
0.153GlnCys: 0.153 ± 0.015
1.879GlnAsp: 1.879 ± 0.056
2.593GlnGlu: 2.593 ± 0.076
1.492GlnPhe: 1.492 ± 0.05
2.382GlnGly: 2.382 ± 0.068
1.024GlnHis: 1.024 ± 0.043
3.089GlnIle: 3.089 ± 0.088
3.991GlnLys: 3.991 ± 0.085
5.032GlnLeu: 5.032 ± 0.104
1.174GlnMet: 1.174 ± 0.049
2.242GlnAsn: 2.242 ± 0.074
1.424GlnPro: 1.424 ± 0.041
2.843GlnGln: 2.843 ± 0.097
2.131GlnArg: 2.131 ± 0.071
2.206GlnSer: 2.206 ± 0.072
2.935GlnThr: 2.935 ± 0.085
3.077GlnVal: 3.077 ± 0.08
0.381GlnTrp: 0.381 ± 0.026
1.454GlnTyr: 1.454 ± 0.054
0.0GlnXaa: 0.0 ± 0.0
Arg
2.714ArgAla: 2.714 ± 0.067
0.215ArgCys: 0.215 ± 0.019
1.893ArgAsp: 1.893 ± 0.06
2.459ArgGlu: 2.459 ± 0.077
1.835ArgPhe: 1.835 ± 0.06
2.287ArgGly: 2.287 ± 0.06
0.898ArgHis: 0.898 ± 0.044
2.965ArgIle: 2.965 ± 0.076
3.191ArgLys: 3.191 ± 0.09
4.18ArgLeu: 4.18 ± 0.102
1.01ArgMet: 1.01 ± 0.042
1.903ArgAsn: 1.903 ± 0.058
1.328ArgPro: 1.328 ± 0.047
2.129ArgGln: 2.129 ± 0.056
2.126ArgArg: 2.126 ± 0.063
2.183ArgSer: 2.183 ± 0.048
2.054ArgThr: 2.054 ± 0.055
2.784ArgVal: 2.784 ± 0.075
0.365ArgTrp: 0.365 ± 0.025
1.696ArgTyr: 1.696 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
4.29SerAla: 4.29 ± 0.082
0.295SerCys: 0.295 ± 0.021
3.016SerAsp: 3.016 ± 0.08
3.394SerGlu: 3.394 ± 0.094
3.218SerPhe: 3.218 ± 0.083
4.362SerGly: 4.362 ± 0.106
1.04SerHis: 1.04 ± 0.037
4.056SerIle: 4.056 ± 0.082
3.991SerLys: 3.991 ± 0.083
6.564SerLeu: 6.564 ± 0.125
1.349SerMet: 1.349 ± 0.046
2.897SerAsn: 2.897 ± 0.081
1.731SerPro: 1.731 ± 0.05
2.588SerGln: 2.588 ± 0.076
2.255SerArg: 2.255 ± 0.058
4.612SerSer: 4.612 ± 0.176
3.535SerThr: 3.535 ± 0.101
3.954SerVal: 3.954 ± 0.092
0.675SerTrp: 0.675 ± 0.036
2.201SerTyr: 2.201 ± 0.07
0.002SerXaa: 0.002 ± 0.002
Thr
5.558ThrAla: 5.558 ± 0.113
0.29ThrCys: 0.29 ± 0.023
3.228ThrAsp: 3.228 ± 0.079
3.293ThrGlu: 3.293 ± 0.072
2.593ThrPhe: 2.593 ± 0.062
4.462ThrGly: 4.462 ± 0.086
1.104ThrHis: 1.104 ± 0.039
4.453ThrIle: 4.453 ± 0.089
3.949ThrLys: 3.949 ± 0.074
5.704ThrLeu: 5.704 ± 0.116
1.311ThrMet: 1.311 ± 0.05
2.833ThrAsn: 2.833 ± 0.07
2.422ThrPro: 2.422 ± 0.071
2.237ThrGln: 2.237 ± 0.073
2.156ThrArg: 2.156 ± 0.062
3.86ThrSer: 3.86 ± 0.118
3.991ThrThr: 3.991 ± 0.091
4.376ThrVal: 4.376 ± 0.089
0.514ThrTrp: 0.514 ± 0.03
1.921ThrTyr: 1.921 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
5.798ValAla: 5.798 ± 0.122
0.51ValCys: 0.51 ± 0.025
3.658ValAsp: 3.658 ± 0.072
3.768ValGlu: 3.768 ± 0.081
2.841ValPhe: 2.841 ± 0.068
4.734ValGly: 4.734 ± 0.089
1.226ValHis: 1.226 ± 0.044
5.437ValIle: 5.437 ± 0.098
4.871ValLys: 4.871 ± 0.09
6.746ValLeu: 6.746 ± 0.116
1.623ValMet: 1.623 ± 0.053
3.128ValAsn: 3.128 ± 0.078
2.58ValPro: 2.58 ± 0.063
2.433ValGln: 2.433 ± 0.069
2.443ValArg: 2.443 ± 0.07
4.539ValSer: 4.539 ± 0.091
4.497ValThr: 4.497 ± 0.083
5.093ValVal: 5.093 ± 0.1
0.521ValTrp: 0.521 ± 0.035
2.29ValTyr: 2.29 ± 0.07
0.0ValXaa: 0.0 ± 0.0
Trp
0.564TrpAla: 0.564 ± 0.03
0.057TrpCys: 0.057 ± 0.009
0.454TrpAsp: 0.454 ± 0.029
0.43TrpGlu: 0.43 ± 0.024
0.467TrpPhe: 0.467 ± 0.032
0.592TrpGly: 0.592 ± 0.034
0.228TrpHis: 0.228 ± 0.019
0.655TrpIle: 0.655 ± 0.042
0.538TrpLys: 0.538 ± 0.03
1.26TrpLeu: 1.26 ± 0.051
0.229TrpMet: 0.229 ± 0.019
0.508TrpAsn: 0.508 ± 0.035
0.272TrpPro: 0.272 ± 0.022
0.545TrpGln: 0.545 ± 0.029
0.393TrpArg: 0.393 ± 0.025
0.616TrpSer: 0.616 ± 0.032
0.425TrpThr: 0.425 ± 0.025
0.565TrpVal: 0.565 ± 0.029
0.119TrpTrp: 0.119 ± 0.015
0.412TrpTyr: 0.412 ± 0.039
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.459TyrAla: 2.459 ± 0.065
0.28TyrCys: 0.28 ± 0.022
1.8TyrAsp: 1.8 ± 0.056
1.69TyrGlu: 1.69 ± 0.058
1.964TyrPhe: 1.964 ± 0.058
2.456TyrGly: 2.456 ± 0.054
0.928TyrHis: 0.928 ± 0.041
2.191TyrIle: 2.191 ± 0.058
1.882TyrLys: 1.882 ± 0.059
4.261TyrLeu: 4.261 ± 0.089
0.752TyrMet: 0.752 ± 0.04
1.62TyrAsn: 1.62 ± 0.061
1.432TyrPro: 1.432 ± 0.048
2.048TyrGln: 2.048 ± 0.064
1.798TyrArg: 1.798 ± 0.059
2.156TyrSer: 2.156 ± 0.071
2.089TyrThr: 2.089 ± 0.062
2.137TyrVal: 2.137 ± 0.06
0.436TyrTrp: 0.436 ± 0.028
1.624TyrTyr: 1.624 ± 0.068
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.002XaaLeu: 0.002 ± 0.002
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.002XaaSer: 0.002 ± 0.002
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.035XaaXaa: 0.035 ± 0.03
Statistics based on 2051 proteins (627950 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski