Amino acid dipepetide frequency for Caloranaerobacter azorensis H53214

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.696AlaAla: 3.696 ± 0.099	0.565AlaCys: 0.565 ± 0.028	2.564AlaAsp: 2.564 ± 0.07	3.549AlaGlu: 3.549 ± 0.079	2.192AlaPhe: 2.192 ± 0.071	3.769AlaGly: 3.769 ± 0.097	0.835AlaHis: 0.835 ± 0.035	5.819AlaIle: 5.819 ± 0.121	4.912AlaLys: 4.912 ± 0.105	5.544AlaLeu: 5.544 ± 0.112	1.425AlaMet: 1.425 ± 0.05	2.372AlaAsn: 2.372 ± 0.062	1.346AlaPro: 1.346 ± 0.054	1.327AlaGln: 1.327 ± 0.053	2.222AlaArg: 2.222 ± 0.07	2.776AlaSer: 2.776 ± 0.077	2.432AlaThr: 2.432 ± 0.061	4.006AlaVal: 4.006 ± 0.092	0.315AlaTrp: 0.315 ± 0.023	1.936AlaTyr: 1.936 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.489CysAla: 0.489 ± 0.029	0.103CysCys: 0.103 ± 0.015	0.584CysAsp: 0.584 ± 0.031	0.607CysGlu: 0.607 ± 0.032	0.356CysPhe: 0.356 ± 0.024	0.906CysGly: 0.906 ± 0.042	0.165CysHis: 0.165 ± 0.017	0.948CysIle: 0.948 ± 0.041	0.793CysLys: 0.793 ± 0.043	0.704CysLeu: 0.704 ± 0.031	0.198CysMet: 0.198 ± 0.018	0.581CysAsn: 0.581 ± 0.029	0.5CysPro: 0.5 ± 0.036	0.176CysGln: 0.176 ± 0.019	0.381CysArg: 0.381 ± 0.025	0.532CysSer: 0.532 ± 0.034	0.425CysThr: 0.425 ± 0.03	0.554CysVal: 0.554 ± 0.033	0.064CysTrp: 0.064 ± 0.011	0.358CysTyr: 0.358 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	2.342AspAla: 2.342 ± 0.066	0.543AspCys: 0.543 ± 0.033	2.76AspAsp: 2.76 ± 0.071	5.007AspGlu: 5.007 ± 0.097	2.643AspPhe: 2.643 ± 0.067	3.288AspGly: 3.288 ± 0.088	0.476AspHis: 0.476 ± 0.031	7.333AspIle: 7.333 ± 0.119	5.764AspLys: 5.764 ± 0.099	4.843AspLeu: 4.843 ± 0.091	1.541AspMet: 1.541 ± 0.052	3.026AspAsn: 3.026 ± 0.076	1.26AspPro: 1.26 ± 0.048	0.679AspGln: 0.679 ± 0.035	2.325AspArg: 2.325 ± 0.057	2.665AspSer: 2.665 ± 0.064	2.269AspThr: 2.269 ± 0.068	3.889AspVal: 3.889 ± 0.072	0.368AspTrp: 0.368 ± 0.025	2.659AspTyr: 2.659 ± 0.075	0.0AspXaa: 0.0 ± 0.0
Glu	4.005GluAla: 4.005 ± 0.089	0.551GluCys: 0.551 ± 0.031	4.347GluAsp: 4.347 ± 0.093	7.013GluGlu: 7.013 ± 0.14	2.991GluPhe: 2.991 ± 0.066	4.267GluGly: 4.267 ± 0.091	0.949GluHis: 0.949 ± 0.043	8.842GluIle: 8.842 ± 0.131	8.323GluLys: 8.323 ± 0.137	7.24GluLeu: 7.24 ± 0.111	2.106GluMet: 2.106 ± 0.055	5.155GluAsn: 5.155 ± 0.095	1.622GluPro: 1.622 ± 0.053	1.721GluGln: 1.721 ± 0.053	3.155GluArg: 3.155 ± 0.077	3.163GluSer: 3.163 ± 0.072	2.79GluThr: 2.79 ± 0.057	5.229GluVal: 5.229 ± 0.094	0.454GluTrp: 0.454 ± 0.027	3.168GluTyr: 3.168 ± 0.072	0.0GluXaa: 0.0 ± 0.0
Phe	2.237PheAla: 2.237 ± 0.064	0.429PheCys: 0.429 ± 0.025	2.52PheAsp: 2.52 ± 0.066	2.856PheGlu: 2.856 ± 0.069	1.842PhePhe: 1.842 ± 0.065	2.81PheGly: 2.81 ± 0.079	0.536PheHis: 0.536 ± 0.03	5.01PheIle: 5.01 ± 0.106	3.742PheLys: 3.742 ± 0.069	3.808PheLeu: 3.808 ± 0.089	1.062PheMet: 1.062 ± 0.044	2.532PheAsn: 2.532 ± 0.065	1.212PhePro: 1.212 ± 0.046	0.84PheGln: 0.84 ± 0.04	1.494PheArg: 1.494 ± 0.054	2.774PheSer: 2.774 ± 0.062	2.217PheThr: 2.217 ± 0.064	2.64PheVal: 2.64 ± 0.057	0.272PheTrp: 0.272 ± 0.022	1.694PheTyr: 1.694 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	3.927GlyAla: 3.927 ± 0.114	0.821GlyCys: 0.821 ± 0.046	3.119GlyAsp: 3.119 ± 0.073	4.136GlyGlu: 4.136 ± 0.079	2.968GlyPhe: 2.968 ± 0.083	4.161GlyGly: 4.161 ± 0.109	1.043GlyHis: 1.043 ± 0.047	7.265GlyIle: 7.265 ± 0.117	5.835GlyLys: 5.835 ± 0.107	5.964GlyLeu: 5.964 ± 0.091	1.689GlyMet: 1.689 ± 0.059	3.099GlyAsn: 3.099 ± 0.073	1.386GlyPro: 1.386 ± 0.059	1.493GlyGln: 1.493 ± 0.048	2.606GlyArg: 2.606 ± 0.064	3.207GlySer: 3.207 ± 0.072	3.216GlyThr: 3.216 ± 0.081	4.604GlyVal: 4.604 ± 0.095	0.493GlyTrp: 0.493 ± 0.03	3.043GlyTyr: 3.043 ± 0.09	0.0GlyXaa: 0.0 ± 0.0
His	0.668HisAla: 0.668 ± 0.036	0.156HisCys: 0.156 ± 0.017	0.634HisAsp: 0.634 ± 0.034	0.793HisGlu: 0.793 ± 0.035	0.612HisPhe: 0.612 ± 0.033	0.952HisGly: 0.952 ± 0.042	0.27HisHis: 0.27 ± 0.02	1.419HisIle: 1.419 ± 0.04	1.074HisLys: 1.074 ± 0.05	1.224HisLeu: 1.224 ± 0.047	0.315HisMet: 0.315 ± 0.024	0.659HisAsn: 0.659 ± 0.031	0.724HisPro: 0.724 ± 0.038	0.35HisGln: 0.35 ± 0.023	0.609HisArg: 0.609 ± 0.026	0.774HisSer: 0.774 ± 0.035	0.678HisThr: 0.678 ± 0.035	0.803HisVal: 0.803 ± 0.035	0.105HisTrp: 0.105 ± 0.012	0.553HisTyr: 0.553 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.139IleAla: 6.139 ± 0.12	0.995IleCys: 0.995 ± 0.038	6.884IleAsp: 6.884 ± 0.109	8.792IleGlu: 8.792 ± 0.138	4.634IlePhe: 4.634 ± 0.101	6.767IleGly: 6.767 ± 0.131	1.313IleHis: 1.313 ± 0.045	11.413IleIle: 11.413 ± 0.173	10.429IleLys: 10.429 ± 0.149	10.253IleLeu: 10.253 ± 0.15	2.373IleMet: 2.373 ± 0.06	6.493IleAsn: 6.493 ± 0.104	3.589IlePro: 3.589 ± 0.076	2.373IleGln: 2.373 ± 0.068	4.092IleArg: 4.092 ± 0.09	6.804IleSer: 6.804 ± 0.127	5.048IleThr: 5.048 ± 0.102	7.049IleVal: 7.049 ± 0.127	0.562IleTrp: 0.562 ± 0.032	3.811IleTyr: 3.811 ± 0.087	0.0IleXaa: 0.0 ± 0.0
Lys	4.909LysAla: 4.909 ± 0.086	0.732LysCys: 0.732 ± 0.039	5.839LysAsp: 5.839 ± 0.096	9.173LysGlu: 9.173 ± 0.138	3.263LysPhe: 3.263 ± 0.072	5.547LysGly: 5.547 ± 0.093	1.194LysHis: 1.194 ± 0.046	9.955LysIle: 9.955 ± 0.14	8.94LysLys: 8.94 ± 0.153	8.442LysLeu: 8.442 ± 0.145	2.434LysMet: 2.434 ± 0.056	6.023LysAsn: 6.023 ± 0.126	2.414LysPro: 2.414 ± 0.065	2.262LysGln: 2.262 ± 0.055	3.988LysArg: 3.988 ± 0.074	4.606LysSer: 4.606 ± 0.083	4.036LysThr: 4.036 ± 0.08	6.389LysVal: 6.389 ± 0.101	0.637LysTrp: 0.637 ± 0.038	4.414LysTyr: 4.414 ± 0.092	0.0LysXaa: 0.0 ± 0.0
Leu	5.158LeuAla: 5.158 ± 0.103	0.768LeuCys: 0.768 ± 0.038	5.485LeuAsp: 5.485 ± 0.095	6.988LeuGlu: 6.988 ± 0.131	3.761LeuPhe: 3.761 ± 0.101	6.25LeuGly: 6.25 ± 0.109	1.104LeuHis: 1.104 ± 0.043	9.341LeuIle: 9.341 ± 0.15	9.313LeuLys: 9.313 ± 0.123	8.378LeuLeu: 8.378 ± 0.155	2.111LeuMet: 2.111 ± 0.056	5.869LeuAsn: 5.869 ± 0.105	3.01LeuPro: 3.01 ± 0.072	1.942LeuGln: 1.942 ± 0.063	3.294LeuArg: 3.294 ± 0.074	5.866LeuSer: 5.866 ± 0.099	4.329LeuThr: 4.329 ± 0.084	5.719LeuVal: 5.719 ± 0.104	0.457LeuTrp: 0.457 ± 0.03	3.224LeuTyr: 3.224 ± 0.076	0.0LeuXaa: 0.0 ± 0.0
Met	1.692MetAla: 1.692 ± 0.054	0.203MetCys: 0.203 ± 0.017	1.291MetAsp: 1.291 ± 0.044	1.788MetGlu: 1.788 ± 0.051	0.96MetPhe: 0.96 ± 0.035	1.691MetGly: 1.691 ± 0.054	0.303MetHis: 0.303 ± 0.024	2.408MetIle: 2.408 ± 0.067	2.429MetLys: 2.429 ± 0.063	2.215MetLeu: 2.215 ± 0.064	0.596MetMet: 0.596 ± 0.026	1.497MetAsn: 1.497 ± 0.05	0.835MetPro: 0.835 ± 0.033	0.604MetGln: 0.604 ± 0.032	1.041MetArg: 1.041 ± 0.04	1.413MetSer: 1.413 ± 0.044	1.096MetThr: 1.096 ± 0.043	1.471MetVal: 1.471 ± 0.043	0.116MetTrp: 0.116 ± 0.013	0.877MetTyr: 0.877 ± 0.045	0.0MetXaa: 0.0 ± 0.0
Asn	2.543AsnAla: 2.543 ± 0.066	0.564AsnCys: 0.564 ± 0.032	2.714AsnAsp: 2.714 ± 0.072	4.197AsnGlu: 4.197 ± 0.091	2.479AsnPhe: 2.479 ± 0.062	3.404AsnGly: 3.404 ± 0.083	0.689AsnHis: 0.689 ± 0.035	7.219AsnIle: 7.219 ± 0.123	5.984AsnLys: 5.984 ± 0.113	5.18AsnLeu: 5.18 ± 0.101	1.39AsnMet: 1.39 ± 0.043	3.621AsnAsn: 3.621 ± 0.083	2.215AsnPro: 2.215 ± 0.055	1.213AsnGln: 1.213 ± 0.045	2.462AsnArg: 2.462 ± 0.059	3.296AsnSer: 3.296 ± 0.089	2.523AsnThr: 2.523 ± 0.063	3.533AsnVal: 3.533 ± 0.068	0.4AsnTrp: 0.4 ± 0.028	2.351AsnTyr: 2.351 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	1.316ProAla: 1.316 ± 0.057	0.279ProCys: 0.279 ± 0.023	1.711ProAsp: 1.711 ± 0.057	2.443ProGlu: 2.443 ± 0.068	1.375ProPhe: 1.375 ± 0.047	1.891ProGly: 1.891 ± 0.063	0.517ProHis: 0.517 ± 0.025	3.199ProIle: 3.199 ± 0.08	2.406ProLys: 2.406 ± 0.067	2.537ProLeu: 2.537 ± 0.069	0.695ProMet: 0.695 ± 0.044	1.613ProAsn: 1.613 ± 0.053	0.754ProPro: 0.754 ± 0.037	0.749ProGln: 0.749 ± 0.037	1.015ProArg: 1.015 ± 0.039	1.566ProSer: 1.566 ± 0.042	1.544ProThr: 1.544 ± 0.056	2.264ProVal: 2.264 ± 0.063	0.206ProTrp: 0.206 ± 0.016	1.411ProTyr: 1.411 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	1.246GlnAla: 1.246 ± 0.045	0.167GlnCys: 0.167 ± 0.015	1.085GlnAsp: 1.085 ± 0.045	1.611GlnGlu: 1.611 ± 0.054	0.927GlnPhe: 0.927 ± 0.042	1.347GlnGly: 1.347 ± 0.053	0.322GlnHis: 0.322 ± 0.024	2.52GlnIle: 2.52 ± 0.063	2.211GlnLys: 2.211 ± 0.06	2.052GlnLeu: 2.052 ± 0.053	0.564GlnMet: 0.564 ± 0.029	1.335GlnAsn: 1.335 ± 0.046	0.553GlnPro: 0.553 ± 0.029	0.653GlnGln: 0.653 ± 0.039	1.055GlnArg: 1.055 ± 0.045	1.104GlnSer: 1.104 ± 0.049	0.98GlnThr: 0.98 ± 0.042	1.433GlnVal: 1.433 ± 0.05	0.114GlnTrp: 0.114 ± 0.014	0.893GlnTyr: 0.893 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.242ArgAla: 2.242 ± 0.058	0.404ArgCys: 0.404 ± 0.026	2.187ArgAsp: 2.187 ± 0.063	3.6ArgGlu: 3.6 ± 0.091	1.664ArgPhe: 1.664 ± 0.054	2.47ArgGly: 2.47 ± 0.07	0.609ArgHis: 0.609 ± 0.029	4.041ArgIle: 4.041 ± 0.09	3.73ArgLys: 3.73 ± 0.085	3.858ArgLeu: 3.858 ± 0.08	1.11ArgMet: 1.11 ± 0.037	2.131ArgAsn: 2.131 ± 0.058	1.113ArgPro: 1.113 ± 0.046	1.09ArgGln: 1.09 ± 0.04	1.855ArgArg: 1.855 ± 0.059	1.438ArgSer: 1.438 ± 0.05	1.71ArgThr: 1.71 ± 0.054	2.693ArgVal: 2.693 ± 0.075	0.261ArgTrp: 0.261 ± 0.022	1.63ArgTyr: 1.63 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	2.57SerAla: 2.57 ± 0.064	0.5SerCys: 0.5 ± 0.029	2.696SerAsp: 2.696 ± 0.065	3.446SerGlu: 3.446 ± 0.074	2.628SerPhe: 2.628 ± 0.07	3.636SerGly: 3.636 ± 0.09	0.831SerHis: 0.831 ± 0.039	6.292SerIle: 6.292 ± 0.111	5.365SerLys: 5.365 ± 0.089	5.279SerLeu: 5.279 ± 0.104	1.318SerMet: 1.318 ± 0.042	3.101SerAsn: 3.101 ± 0.074	1.571SerPro: 1.571 ± 0.047	1.418SerGln: 1.418 ± 0.044	2.228SerArg: 2.228 ± 0.062	3.349SerSer: 3.349 ± 0.08	2.496SerThr: 2.496 ± 0.062	3.258SerVal: 3.258 ± 0.076	0.337SerTrp: 0.337 ± 0.024	2.197SerTyr: 2.197 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	2.69ThrAla: 2.69 ± 0.077	0.406ThrCys: 0.406 ± 0.026	2.376ThrAsp: 2.376 ± 0.06	2.838ThrGlu: 2.838 ± 0.068	1.945ThrPhe: 1.945 ± 0.066	3.575ThrGly: 3.575 ± 0.075	0.66ThrHis: 0.66 ± 0.034	4.823ThrIle: 4.823 ± 0.093	3.585ThrLys: 3.585 ± 0.086	4.403ThrLeu: 4.403 ± 0.083	0.929ThrMet: 0.929 ± 0.043	2.372ThrAsn: 2.372 ± 0.061	1.764ThrPro: 1.764 ± 0.069	0.954ThrGln: 0.954 ± 0.042	1.678ThrArg: 1.678 ± 0.053	2.553ThrSer: 2.553 ± 0.071	2.373ThrThr: 2.373 ± 0.079	3.182ThrVal: 3.182 ± 0.086	0.301ThrTrp: 0.301 ± 0.023	1.811ThrTyr: 1.811 ± 0.065	0.0ThrXaa: 0.0 ± 0.0
Val	3.6ValAla: 3.6 ± 0.08	0.695ValCys: 0.695 ± 0.035	4.148ValAsp: 4.148 ± 0.072	4.896ValGlu: 4.896 ± 0.085	2.938ValPhe: 2.938 ± 0.073	4.297ValGly: 4.297 ± 0.103	0.803ValHis: 0.803 ± 0.033	6.951ValIle: 6.951 ± 0.103	6.044ValLys: 6.044 ± 0.096	6.078ValLeu: 6.078 ± 0.083	1.571ValMet: 1.571 ± 0.05	3.599ValAsn: 3.599 ± 0.078	2.137ValPro: 2.137 ± 0.069	1.288ValGln: 1.288 ± 0.042	2.401ValArg: 2.401 ± 0.061	3.969ValSer: 3.969 ± 0.082	2.97ValThr: 2.97 ± 0.091	4.793ValVal: 4.793 ± 0.101	0.392ValTrp: 0.392 ± 0.027	2.57ValTyr: 2.57 ± 0.068	0.0ValXaa: 0.0 ± 0.0
Trp	0.37TrpAla: 0.37 ± 0.025	0.062TrpCys: 0.062 ± 0.01	0.345TrpAsp: 0.345 ± 0.027	0.482TrpGlu: 0.482 ± 0.028	0.295TrpPhe: 0.295 ± 0.022	0.476TrpGly: 0.476 ± 0.029	0.111TrpHis: 0.111 ± 0.014	0.637TrpIle: 0.637 ± 0.037	0.5TrpLys: 0.5 ± 0.027	0.557TrpLeu: 0.557 ± 0.028	0.147TrpMet: 0.147 ± 0.015	0.365TrpAsn: 0.365 ± 0.027	0.164TrpPro: 0.164 ± 0.016	0.169TrpGln: 0.169 ± 0.018	0.24TrpArg: 0.24 ± 0.018	0.281TrpSer: 0.281 ± 0.022	0.27TrpThr: 0.27 ± 0.024	0.379TrpVal: 0.379 ± 0.025	0.084TrpTrp: 0.084 ± 0.011	0.265TrpTyr: 0.265 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.763TyrAla: 1.763 ± 0.051	0.479TyrCys: 0.479 ± 0.03	2.392TyrAsp: 2.392 ± 0.064	2.876TyrGlu: 2.876 ± 0.076	2.052TyrPhe: 2.052 ± 0.052	2.571TyrGly: 2.571 ± 0.071	0.643TyrHis: 0.643 ± 0.03	4.379TyrIle: 4.379 ± 0.085	3.817TyrLys: 3.817 ± 0.091	3.81TyrLeu: 3.81 ± 0.071	0.952TyrMet: 0.952 ± 0.036	2.536TyrAsn: 2.536 ± 0.067	1.322TyrPro: 1.322 ± 0.055	0.871TyrGln: 0.871 ± 0.041	1.694TyrArg: 1.694 ± 0.053	2.378TyrSer: 2.378 ± 0.064	1.817TyrThr: 1.817 ± 0.068	2.25TyrVal: 2.25 ± 0.061	0.262TyrTrp: 0.262 ± 0.018	1.903TyrTyr: 1.903 ± 0.065	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2148 proteins (640499 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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