Amino acid dipepetide frequency for Aspergillus spelaeus tetramycovirus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.947AlaAla: 14.947 ± 3.224
3.375AlaCys: 3.375 ± 2.369
8.679AlaAsp: 8.679 ± 2.595
4.822AlaGlu: 4.822 ± 1.599
2.411AlaPhe: 2.411 ± 0.721
6.75AlaGly: 6.75 ± 1.793
2.411AlaHis: 2.411 ± 1.111
5.304AlaIle: 5.304 ± 2.597
3.857AlaLys: 3.857 ± 1.39
10.125AlaLeu: 10.125 ± 0.908
2.893AlaMet: 2.893 ± 0.547
2.411AlaAsn: 2.411 ± 0.803
6.268AlaPro: 6.268 ± 1.533
3.857AlaGln: 3.857 ± 1.37
10.125AlaArg: 10.125 ± 2.403
5.304AlaSer: 5.304 ± 1.751
6.268AlaThr: 6.268 ± 1.669
10.125AlaVal: 10.125 ± 1.517
0.482AlaTrp: 0.482 ± 0.443
3.857AlaTyr: 3.857 ± 0.551
0.0AlaXaa: 0.0 ± 0.0
Cys
1.446CysAla: 1.446 ± 1.177
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.482CysGly: 0.482 ± 0.392
0.0CysHis: 0.0 ± 0.0
0.964CysIle: 0.964 ± 0.785
0.0CysLys: 0.0 ± 0.0
1.446CysLeu: 1.446 ± 0.707
0.482CysMet: 0.482 ± 0.34
0.482CysAsn: 0.482 ± 0.392
1.446CysPro: 1.446 ± 1.177
0.0CysGln: 0.0 ± 0.0
2.411CysArg: 2.411 ± 0.721
1.446CysSer: 1.446 ± 0.778
0.482CysThr: 0.482 ± 0.443
1.446CysVal: 1.446 ± 1.177
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
9.643AspAla: 9.643 ± 1.634
0.0AspCys: 0.0 ± 0.0
4.339AspAsp: 4.339 ± 1.5
3.375AspGlu: 3.375 ± 0.994
0.482AspPhe: 0.482 ± 0.443
7.232AspGly: 7.232 ± 2.529
1.446AspHis: 1.446 ± 0.258
2.411AspIle: 2.411 ± 0.555
2.893AspLys: 2.893 ± 1.432
6.75AspLeu: 6.75 ± 2.681
1.446AspMet: 1.446 ± 0.489
0.964AspAsn: 0.964 ± 0.679
4.822AspPro: 4.822 ± 2.031
2.411AspGln: 2.411 ± 0.803
4.339AspArg: 4.339 ± 0.972
3.375AspSer: 3.375 ± 0.598
5.786AspThr: 5.786 ± 1.489
5.786AspVal: 5.786 ± 1.916
0.964AspTrp: 0.964 ± 0.441
3.375AspTyr: 3.375 ± 0.889
0.0AspXaa: 0.0 ± 0.0
Glu
4.339GluAla: 4.339 ± 1.12
0.482GluCys: 0.482 ± 0.392
3.857GluAsp: 3.857 ± 1.131
4.339GluGlu: 4.339 ± 1.514
2.893GluPhe: 2.893 ± 0.832
0.964GluGly: 0.964 ± 0.805
2.893GluHis: 2.893 ± 1.067
0.482GluIle: 0.482 ± 0.443
1.929GluLys: 1.929 ± 0.858
2.411GluLeu: 2.411 ± 0.71
1.446GluMet: 1.446 ± 0.625
0.964GluAsn: 0.964 ± 0.315
3.375GluPro: 3.375 ± 1.029
0.964GluGln: 0.964 ± 0.805
5.786GluArg: 5.786 ± 1.093
1.929GluSer: 1.929 ± 0.449
3.375GluThr: 3.375 ± 0.634
2.893GluVal: 2.893 ± 0.725
1.446GluTrp: 1.446 ± 0.625
2.411GluTyr: 2.411 ± 0.909
0.0GluXaa: 0.0 ± 0.0
Phe
1.929PheAla: 1.929 ± 1.307
0.964PheCys: 0.964 ± 0.489
2.411PheAsp: 2.411 ± 0.803
0.482PheGlu: 0.482 ± 0.34
0.964PhePhe: 0.964 ± 0.489
2.893PheGly: 2.893 ± 2.038
0.964PheHis: 0.964 ± 0.441
1.446PheIle: 1.446 ± 0.869
0.0PheLys: 0.0 ± 0.0
3.375PheLeu: 3.375 ± 2.378
0.0PheMet: 0.0 ± 0.0
0.482PheAsn: 0.482 ± 0.34
1.929PhePro: 1.929 ± 1.206
0.0PheGln: 0.0 ± 0.0
1.929PheArg: 1.929 ± 0.412
2.411PheSer: 2.411 ± 0.555
0.964PheThr: 0.964 ± 0.441
3.375PheVal: 3.375 ± 0.598
0.0PheTrp: 0.0 ± 0.0
1.929PheTyr: 1.929 ± 0.449
0.0PheXaa: 0.0 ± 0.0
Gly
4.822GlyAla: 4.822 ± 1.42
0.482GlyCys: 0.482 ± 0.34
7.232GlyAsp: 7.232 ± 1.508
2.893GlyGlu: 2.893 ± 0.516
0.482GlyPhe: 0.482 ± 0.34
6.268GlyGly: 6.268 ± 2.491
2.411GlyHis: 2.411 ± 0.637
1.929GlyIle: 1.929 ± 0.449
1.929GlyLys: 1.929 ± 0.412
8.197GlyLeu: 8.197 ± 2.311
1.446GlyMet: 1.446 ± 1.019
1.929GlyAsn: 1.929 ± 0.695
4.339GlyPro: 4.339 ± 1.1
1.929GlyGln: 1.929 ± 1.4
6.268GlyArg: 6.268 ± 1.446
7.232GlySer: 7.232 ± 3.52
2.411GlyThr: 2.411 ± 0.367
6.75GlyVal: 6.75 ± 2.022
0.482GlyTrp: 0.482 ± 0.34
2.893GlyTyr: 2.893 ± 1.049
0.0GlyXaa: 0.0 ± 0.0
His
2.411HisAla: 2.411 ± 0.367
0.0HisCys: 0.0 ± 0.0
0.964HisAsp: 0.964 ± 0.679
2.411HisGlu: 2.411 ± 1.337
1.446HisPhe: 1.446 ± 0.716
1.929HisGly: 1.929 ± 0.59
0.964HisHis: 0.964 ± 0.441
0.964HisIle: 0.964 ± 0.785
0.482HisLys: 0.482 ± 0.443
2.411HisLeu: 2.411 ± 1.086
0.964HisMet: 0.964 ± 0.315
0.964HisAsn: 0.964 ± 0.315
3.375HisPro: 3.375 ± 0.598
0.0HisGln: 0.0 ± 0.0
1.929HisArg: 1.929 ± 0.653
0.964HisSer: 0.964 ± 0.805
0.964HisThr: 0.964 ± 0.315
1.446HisVal: 1.446 ± 0.707
0.0HisTrp: 0.0 ± 0.0
1.446HisTyr: 1.446 ± 0.258
0.0HisXaa: 0.0 ± 0.0
Ile
5.786IleAla: 5.786 ± 1.916
0.482IleCys: 0.482 ± 0.761
3.857IleAsp: 3.857 ± 0.791
0.964IleGlu: 0.964 ± 0.315
0.964IlePhe: 0.964 ± 0.489
0.482IleGly: 0.482 ± 0.392
0.964IleHis: 0.964 ± 0.805
0.482IleIle: 0.482 ± 0.34
0.964IleLys: 0.964 ± 0.489
2.893IleLeu: 2.893 ± 1.414
0.482IleMet: 0.482 ± 0.34
1.446IleAsn: 1.446 ± 0.625
0.482IlePro: 0.482 ± 0.392
0.482IleGln: 0.482 ± 0.443
1.446IleArg: 1.446 ± 1.177
5.304IleSer: 5.304 ± 1.534
0.964IleThr: 0.964 ± 0.785
1.929IleVal: 1.929 ± 0.653
0.0IleTrp: 0.0 ± 0.0
1.446IleTyr: 1.446 ± 0.778
0.0IleXaa: 0.0 ± 0.0
Lys
2.411LysAla: 2.411 ± 1.36
0.482LysCys: 0.482 ± 0.443
1.929LysAsp: 1.929 ± 0.449
0.482LysGlu: 0.482 ± 0.34
0.482LysPhe: 0.482 ± 0.34
3.857LysGly: 3.857 ± 1.321
1.446LysHis: 1.446 ± 0.258
0.0LysIle: 0.0 ± 0.0
2.411LysLys: 2.411 ± 0.909
4.339LysLeu: 4.339 ± 1.11
0.482LysMet: 0.482 ± 0.609
0.482LysAsn: 0.482 ± 0.443
1.446LysPro: 1.446 ± 0.792
0.0LysGln: 0.0 ± 0.0
3.375LysArg: 3.375 ± 2.176
1.446LysSer: 1.446 ± 0.786
0.964LysThr: 0.964 ± 0.84
4.339LysVal: 4.339 ± 1.885
0.482LysTrp: 0.482 ± 0.34
1.446LysTyr: 1.446 ± 0.258
0.0LysXaa: 0.0 ± 0.0
Leu
8.679LeuAla: 8.679 ± 1.286
0.964LeuCys: 0.964 ± 0.315
6.75LeuAsp: 6.75 ± 1.02
4.822LeuGlu: 4.822 ± 0.261
2.893LeuPhe: 2.893 ± 1.034
10.608LeuGly: 10.608 ± 3.487
2.893LeuHis: 2.893 ± 0.784
4.339LeuIle: 4.339 ± 0.747
2.893LeuLys: 2.893 ± 1.467
9.643LeuLeu: 9.643 ± 0.997
3.375LeuMet: 3.375 ± 1.341
2.893LeuAsn: 2.893 ± 0.516
2.893LeuPro: 2.893 ± 1.001
1.446LeuGln: 1.446 ± 0.258
5.304LeuArg: 5.304 ± 1.105
9.643LeuSer: 9.643 ± 1.445
5.786LeuThr: 5.786 ± 1.853
7.232LeuVal: 7.232 ± 1.237
0.964LeuTrp: 0.964 ± 0.84
1.446LeuTyr: 1.446 ± 0.716
0.0LeuXaa: 0.0 ± 0.0
Met
3.857MetAla: 3.857 ± 2.543
0.482MetCys: 0.482 ± 0.392
0.964MetAsp: 0.964 ± 0.805
1.446MetGlu: 1.446 ± 1.019
1.446MetPhe: 1.446 ± 0.258
0.482MetGly: 0.482 ± 0.34
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.482MetLys: 0.482 ± 0.392
1.446MetLeu: 1.446 ± 0.525
0.964MetMet: 0.964 ± 0.315
0.482MetAsn: 0.482 ± 0.392
1.446MetPro: 1.446 ± 0.625
0.482MetGln: 0.482 ± 0.34
3.375MetArg: 3.375 ± 1.716
1.446MetSer: 1.446 ± 0.716
1.929MetThr: 1.929 ± 0.826
1.929MetVal: 1.929 ± 0.826
0.482MetTrp: 0.482 ± 0.34
0.964MetTyr: 0.964 ± 0.489
0.0MetXaa: 0.0 ± 0.0
Asn
3.857AsnAla: 3.857 ± 1.37
0.482AsnCys: 0.482 ± 0.392
0.482AsnAsp: 0.482 ± 0.34
0.964AsnGlu: 0.964 ± 0.785
1.929AsnPhe: 1.929 ± 1.055
0.482AsnGly: 0.482 ± 0.34
0.0AsnHis: 0.0 ± 0.0
0.482AsnIle: 0.482 ± 0.392
0.482AsnLys: 0.482 ± 0.392
2.411AsnLeu: 2.411 ± 0.676
0.482AsnMet: 0.482 ± 0.34
0.964AsnAsn: 0.964 ± 0.315
1.446AsnPro: 1.446 ± 0.525
1.446AsnGln: 1.446 ± 1.019
2.411AsnArg: 2.411 ± 1.378
0.964AsnSer: 0.964 ± 1.522
1.929AsnThr: 1.929 ± 0.449
1.929AsnVal: 1.929 ± 0.412
0.0AsnTrp: 0.0 ± 0.0
2.411AsnTyr: 2.411 ± 0.909
0.0AsnXaa: 0.0 ± 0.0
Pro
5.304ProAla: 5.304 ± 1.011
0.0ProCys: 0.0 ± 0.0
3.857ProAsp: 3.857 ± 0.901
3.375ProGlu: 3.375 ± 1.348
0.964ProPhe: 0.964 ± 0.315
4.822ProGly: 4.822 ± 0.261
1.929ProHis: 1.929 ± 0.811
2.411ProIle: 2.411 ± 0.676
1.929ProLys: 1.929 ± 0.412
5.304ProLeu: 5.304 ± 1.108
0.482ProMet: 0.482 ± 0.439
0.964ProAsn: 0.964 ± 0.785
3.857ProPro: 3.857 ± 0.839
0.482ProGln: 0.482 ± 0.34
5.304ProArg: 5.304 ± 0.779
4.339ProSer: 4.339 ± 1.157
5.786ProThr: 5.786 ± 1.575
4.822ProVal: 4.822 ± 1.522
0.482ProTrp: 0.482 ± 0.392
2.411ProTyr: 2.411 ± 1.053
0.0ProXaa: 0.0 ± 0.0
Gln
1.929GlnAla: 1.929 ± 1.4
0.0GlnCys: 0.0 ± 0.0
0.482GlnAsp: 0.482 ± 0.443
0.964GlnGlu: 0.964 ± 0.679
1.446GlnPhe: 1.446 ± 0.786
0.482GlnGly: 0.482 ± 0.34
0.964GlnHis: 0.964 ± 0.441
0.0GlnIle: 0.0 ± 0.0
0.0GlnLys: 0.0 ± 0.0
3.375GlnLeu: 3.375 ± 1.1
0.0GlnMet: 0.0 ± 0.0
0.482GlnAsn: 0.482 ± 0.34
0.964GlnPro: 0.964 ± 0.679
0.482GlnGln: 0.482 ± 0.392
0.964GlnArg: 0.964 ± 0.785
2.411GlnSer: 2.411 ± 1.644
1.446GlnThr: 1.446 ± 0.707
1.446GlnVal: 1.446 ± 0.792
0.482GlnTrp: 0.482 ± 0.34
0.964GlnTyr: 0.964 ± 0.489
0.0GlnXaa: 0.0 ± 0.0
Arg
11.572ArgAla: 11.572 ± 3.767
0.0ArgCys: 0.0 ± 0.0
4.339ArgAsp: 4.339 ± 1.11
3.857ArgGlu: 3.857 ± 0.934
3.375ArgPhe: 3.375 ± 1.366
3.375ArgGly: 3.375 ± 0.96
1.446ArgHis: 1.446 ± 0.671
2.893ArgIle: 2.893 ± 1.324
1.446ArgLys: 1.446 ± 0.671
11.09ArgLeu: 11.09 ± 0.435
1.446ArgMet: 1.446 ± 0.727
3.857ArgAsn: 3.857 ± 0.934
3.375ArgPro: 3.375 ± 2.312
1.446ArgGln: 1.446 ± 0.625
4.822ArgArg: 4.822 ± 1.402
6.75ArgSer: 6.75 ± 1.918
2.893ArgThr: 2.893 ± 0.832
7.715ArgVal: 7.715 ± 0.867
0.0ArgTrp: 0.0 ± 0.0
2.893ArgTyr: 2.893 ± 0.516
0.0ArgXaa: 0.0 ± 0.0
Ser
7.232SerAla: 7.232 ± 2.71
0.482SerCys: 0.482 ± 0.392
5.304SerAsp: 5.304 ± 2.214
3.857SerGlu: 3.857 ± 1.115
2.893SerPhe: 2.893 ± 1.034
9.161SerGly: 9.161 ± 2.286
1.929SerHis: 1.929 ± 1.008
1.929SerIle: 1.929 ± 1.055
2.411SerLys: 2.411 ± 0.631
8.679SerLeu: 8.679 ± 2.03
1.929SerMet: 1.929 ± 0.412
0.482SerAsn: 0.482 ± 0.392
3.375SerPro: 3.375 ± 1.619
0.964SerGln: 0.964 ± 0.489
4.822SerArg: 4.822 ± 1.622
7.232SerSer: 7.232 ± 2.211
1.929SerThr: 1.929 ± 1.008
6.75SerVal: 6.75 ± 1.7
0.482SerTrp: 0.482 ± 0.34
3.375SerTyr: 3.375 ± 0.857
0.0SerXaa: 0.0 ± 0.0
Thr
5.786ThrAla: 5.786 ± 1.916
0.482ThrCys: 0.482 ± 0.392
1.446ThrAsp: 1.446 ± 0.525
1.446ThrGlu: 1.446 ± 0.671
0.964ThrPhe: 0.964 ± 0.315
5.304ThrGly: 5.304 ± 0.994
1.929ThrHis: 1.929 ± 0.826
1.929ThrIle: 1.929 ± 0.412
1.446ThrLys: 1.446 ± 2.283
3.857ThrLeu: 3.857 ± 0.551
3.375ThrMet: 3.375 ± 0.634
0.482ThrAsn: 0.482 ± 0.392
8.197ThrPro: 8.197 ± 1.253
0.0ThrGln: 0.0 ± 0.0
4.822ThrArg: 4.822 ± 1.073
2.411ThrSer: 2.411 ± 0.637
5.304ThrThr: 5.304 ± 1.702
4.822ThrVal: 4.822 ± 1.632
0.482ThrTrp: 0.482 ± 0.392
0.0ThrTyr: 0.0 ± 0.0
0.0ThrXaa: 0.0 ± 0.0
Val
11.572ValAla: 11.572 ± 3.085
1.446ValCys: 1.446 ± 1.177
8.679ValAsp: 8.679 ± 0.877
7.715ValGlu: 7.715 ± 1.609
1.929ValPhe: 1.929 ± 1.29
1.929ValGly: 1.929 ± 1.008
1.446ValHis: 1.446 ± 0.869
2.411ValIle: 2.411 ± 0.676
5.304ValLys: 5.304 ± 1.487
5.304ValLeu: 5.304 ± 0.259
1.929ValMet: 1.929 ± 0.63
4.339ValAsn: 4.339 ± 0.931
4.822ValPro: 4.822 ± 1.632
1.446ValGln: 1.446 ± 1.33
4.822ValArg: 4.822 ± 1.287
8.679ValSer: 8.679 ± 2.253
1.929ValThr: 1.929 ± 0.412
7.232ValVal: 7.232 ± 2.815
0.964ValTrp: 0.964 ± 0.84
1.446ValTyr: 1.446 ± 0.786
0.0ValXaa: 0.0 ± 0.0
Trp
1.446TrpAla: 1.446 ± 1.465
0.964TrpCys: 0.964 ± 0.315
1.929TrpAsp: 1.929 ± 0.59
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
1.446TrpGly: 1.446 ± 0.625
0.0TrpHis: 0.0 ± 0.0
0.482TrpIle: 0.482 ± 0.443
0.0TrpLys: 0.0 ± 0.0
0.482TrpLeu: 0.482 ± 0.392
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.482TrpGln: 0.482 ± 0.443
0.482TrpArg: 0.482 ± 0.443
0.0TrpSer: 0.0 ± 0.0
0.0TrpThr: 0.0 ± 0.0
0.482TrpVal: 0.482 ± 0.34
0.0TrpTrp: 0.0 ± 0.0
0.482TrpTyr: 0.482 ± 0.34
0.0TrpXaa: 0.0 ± 0.0
Tyr
5.304TyrAla: 5.304 ± 0.778
0.964TyrCys: 0.964 ± 0.441
4.339TyrAsp: 4.339 ± 1.028
0.964TyrGlu: 0.964 ± 0.489
0.482TyrPhe: 0.482 ± 0.34
3.375TyrGly: 3.375 ± 0.888
0.0TyrHis: 0.0 ± 0.0
0.964TyrIle: 0.964 ± 0.805
1.446TyrLys: 1.446 ± 0.716
1.929TyrLeu: 1.929 ± 0.412
0.0TyrMet: 0.0 ± 0.0
0.482TyrAsn: 0.482 ± 0.392
1.446TyrPro: 1.446 ± 0.625
0.964TyrGln: 0.964 ± 0.743
3.857TyrArg: 3.857 ± 1.254
1.929TyrSer: 1.929 ± 1.206
3.375TyrThr: 3.375 ± 1.366
2.893TyrVal: 2.893 ± 0.516
0.482TyrTrp: 0.482 ± 0.761
0.482TyrTyr: 0.482 ± 0.761
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (2075 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski