Amino acid dipepetide frequency for Yersinia phage Yepe2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.279AlaAla: 9.279 ± 1.255
0.994AlaCys: 0.994 ± 0.259
5.137AlaAsp: 5.137 ± 1.044
5.965AlaGlu: 5.965 ± 0.771
3.397AlaPhe: 3.397 ± 0.386
7.457AlaGly: 7.457 ± 0.862
1.74AlaHis: 1.74 ± 0.347
4.474AlaIle: 4.474 ± 0.593
7.539AlaLys: 7.539 ± 0.699
6.959AlaLeu: 6.959 ± 0.897
2.817AlaMet: 2.817 ± 0.529
4.64AlaAsn: 4.64 ± 0.65
2.817AlaPro: 2.817 ± 0.397
3.728AlaGln: 3.728 ± 0.497
4.557AlaArg: 4.557 ± 0.542
4.308AlaSer: 4.308 ± 0.759
3.397AlaThr: 3.397 ± 0.592
5.468AlaVal: 5.468 ± 0.598
1.243AlaTrp: 1.243 ± 0.299
2.983AlaTyr: 2.983 ± 0.519
0.0AlaXaa: 0.0 ± 0.0
Cys
0.994CysAla: 0.994 ± 0.338
0.0CysCys: 0.0 ± 0.0
0.663CysAsp: 0.663 ± 0.281
0.746CysGlu: 0.746 ± 0.252
0.414CysPhe: 0.414 ± 0.221
0.497CysGly: 0.497 ± 0.187
0.414CysHis: 0.414 ± 0.157
0.497CysIle: 0.497 ± 0.207
0.249CysLys: 0.249 ± 0.138
1.243CysLeu: 1.243 ± 0.315
0.166CysMet: 0.166 ± 0.109
0.497CysAsn: 0.497 ± 0.23
0.331CysPro: 0.331 ± 0.156
0.331CysGln: 0.331 ± 0.176
0.911CysArg: 0.911 ± 0.326
0.829CysSer: 0.829 ± 0.238
0.249CysThr: 0.249 ± 0.151
0.663CysVal: 0.663 ± 0.309
0.166CysTrp: 0.166 ± 0.123
0.331CysTyr: 0.331 ± 0.244
0.0CysXaa: 0.0 ± 0.0
Asp
4.888AspAla: 4.888 ± 0.662
0.497AspCys: 0.497 ± 0.231
4.308AspAsp: 4.308 ± 0.733
3.894AspGlu: 3.894 ± 0.623
2.486AspPhe: 2.486 ± 0.447
6.545AspGly: 6.545 ± 0.664
1.077AspHis: 1.077 ± 0.325
2.817AspIle: 2.817 ± 0.446
3.48AspLys: 3.48 ± 0.66
3.397AspLeu: 3.397 ± 0.471
2.9AspMet: 2.9 ± 0.558
2.817AspAsn: 2.817 ± 0.449
3.065AspPro: 3.065 ± 0.694
2.486AspGln: 2.486 ± 0.419
3.231AspArg: 3.231 ± 0.791
4.143AspSer: 4.143 ± 0.551
3.811AspThr: 3.811 ± 0.435
4.391AspVal: 4.391 ± 0.48
0.829AspTrp: 0.829 ± 0.306
1.657AspTyr: 1.657 ± 0.282
0.0AspXaa: 0.0 ± 0.0
Glu
7.125GluAla: 7.125 ± 0.934
0.829GluCys: 0.829 ± 0.306
4.474GluAsp: 4.474 ± 0.742
5.882GluGlu: 5.882 ± 1.165
2.734GluPhe: 2.734 ± 0.468
5.302GluGly: 5.302 ± 0.613
1.74GluHis: 1.74 ± 0.403
2.983GluIle: 2.983 ± 0.355
2.983GluLys: 2.983 ± 0.54
5.717GluLeu: 5.717 ± 0.605
3.231GluMet: 3.231 ± 0.537
3.314GluAsn: 3.314 ± 0.511
2.486GluPro: 2.486 ± 0.486
2.9GluGln: 2.9 ± 0.448
3.977GluArg: 3.977 ± 0.692
3.314GluSer: 3.314 ± 0.661
3.563GluThr: 3.563 ± 0.546
4.888GluVal: 4.888 ± 0.734
1.16GluTrp: 1.16 ± 0.311
3.065GluTyr: 3.065 ± 0.375
0.0GluXaa: 0.0 ± 0.0
Phe
2.568PheAla: 2.568 ± 0.623
0.497PheCys: 0.497 ± 0.206
2.237PheAsp: 2.237 ± 0.507
1.823PheGlu: 1.823 ± 0.374
1.077PhePhe: 1.077 ± 0.288
3.231PheGly: 3.231 ± 0.615
0.58PheHis: 0.58 ± 0.211
1.326PheIle: 1.326 ± 0.359
2.486PheLys: 2.486 ± 0.427
2.817PheLeu: 2.817 ± 0.409
1.16PheMet: 1.16 ± 0.324
2.071PheAsn: 2.071 ± 0.538
1.906PhePro: 1.906 ± 0.446
0.994PheGln: 0.994 ± 0.346
1.74PheArg: 1.74 ± 0.338
1.988PheSer: 1.988 ± 0.437
2.983PheThr: 2.983 ± 0.555
2.154PheVal: 2.154 ± 0.329
0.166PheTrp: 0.166 ± 0.103
1.326PheTyr: 1.326 ± 0.237
0.0PheXaa: 0.0 ± 0.0
Gly
6.297GlyAla: 6.297 ± 0.941
0.911GlyCys: 0.911 ± 0.382
6.131GlyAsp: 6.131 ± 0.624
5.468GlyGlu: 5.468 ± 0.699
2.486GlyPhe: 2.486 ± 0.426
5.965GlyGly: 5.965 ± 0.591
0.829GlyHis: 0.829 ± 0.273
4.225GlyIle: 4.225 ± 0.57
6.048GlyLys: 6.048 ± 0.809
6.959GlyLeu: 6.959 ± 0.942
2.651GlyMet: 2.651 ± 0.428
3.397GlyAsn: 3.397 ± 0.453
0.497GlyPro: 0.497 ± 0.213
2.983GlyGln: 2.983 ± 0.469
4.391GlyArg: 4.391 ± 0.514
5.634GlySer: 5.634 ± 0.686
3.314GlyThr: 3.314 ± 0.52
5.054GlyVal: 5.054 ± 0.504
2.154GlyTrp: 2.154 ± 0.518
2.651GlyTyr: 2.651 ± 0.421
0.0GlyXaa: 0.0 ± 0.0
His
1.16HisAla: 1.16 ± 0.314
0.331HisCys: 0.331 ± 0.159
1.077HisAsp: 1.077 ± 0.276
1.16HisGlu: 1.16 ± 0.313
1.077HisPhe: 1.077 ± 0.322
1.574HisGly: 1.574 ± 0.315
0.497HisHis: 0.497 ± 0.194
0.911HisIle: 0.911 ± 0.257
1.574HisLys: 1.574 ± 0.504
1.906HisLeu: 1.906 ± 0.468
0.497HisMet: 0.497 ± 0.185
0.911HisAsn: 0.911 ± 0.284
0.166HisPro: 0.166 ± 0.103
0.083HisGln: 0.083 ± 0.082
0.414HisArg: 0.414 ± 0.141
1.326HisSer: 1.326 ± 0.304
0.994HisThr: 0.994 ± 0.267
1.74HisVal: 1.74 ± 0.349
0.249HisTrp: 0.249 ± 0.154
0.414HisTyr: 0.414 ± 0.18
0.0HisXaa: 0.0 ± 0.0
Ile
4.06IleAla: 4.06 ± 0.453
0.746IleCys: 0.746 ± 0.258
3.728IleAsp: 3.728 ± 0.498
3.397IleGlu: 3.397 ± 0.529
0.911IlePhe: 0.911 ± 0.285
3.314IleGly: 3.314 ± 0.551
0.746IleHis: 0.746 ± 0.331
2.237IleIle: 2.237 ± 0.459
3.563IleLys: 3.563 ± 0.453
3.811IleLeu: 3.811 ± 0.571
0.911IleMet: 0.911 ± 0.237
2.32IleAsn: 2.32 ± 0.592
1.906IlePro: 1.906 ± 0.379
2.071IleGln: 2.071 ± 0.425
3.314IleArg: 3.314 ± 0.465
2.817IleSer: 2.817 ± 0.574
2.32IleThr: 2.32 ± 0.385
2.983IleVal: 2.983 ± 0.568
0.829IleTrp: 0.829 ± 0.232
1.574IleTyr: 1.574 ± 0.294
0.0IleXaa: 0.0 ± 0.0
Lys
8.699LysAla: 8.699 ± 0.885
0.746LysCys: 0.746 ± 0.284
3.48LysAsp: 3.48 ± 0.487
5.468LysGlu: 5.468 ± 0.58
1.988LysPhe: 1.988 ± 0.437
5.634LysGly: 5.634 ± 0.649
1.823LysHis: 1.823 ± 0.528
2.154LysIle: 2.154 ± 0.352
4.971LysLys: 4.971 ± 0.657
5.882LysLeu: 5.882 ± 0.79
2.403LysMet: 2.403 ± 0.369
2.32LysAsn: 2.32 ± 0.355
2.9LysPro: 2.9 ± 0.635
2.32LysGln: 2.32 ± 0.47
3.645LysArg: 3.645 ± 0.525
3.977LysSer: 3.977 ± 0.485
3.065LysThr: 3.065 ± 0.453
4.805LysVal: 4.805 ± 0.589
0.663LysTrp: 0.663 ± 0.214
2.154LysTyr: 2.154 ± 0.344
0.0LysXaa: 0.0 ± 0.0
Leu
7.954LeuAla: 7.954 ± 0.74
0.249LeuCys: 0.249 ± 0.134
4.474LeuAsp: 4.474 ± 0.6
6.048LeuGlu: 6.048 ± 0.788
2.817LeuPhe: 2.817 ± 0.543
4.391LeuGly: 4.391 ± 0.488
1.077LeuHis: 1.077 ± 0.298
3.811LeuIle: 3.811 ± 0.513
7.125LeuLys: 7.125 ± 0.874
5.385LeuLeu: 5.385 ± 0.763
3.314LeuMet: 3.314 ± 0.637
4.557LeuAsn: 4.557 ± 0.668
3.065LeuPro: 3.065 ± 0.551
3.397LeuGln: 3.397 ± 0.641
5.551LeuArg: 5.551 ± 0.579
5.054LeuSer: 5.054 ± 0.721
4.971LeuThr: 4.971 ± 0.682
5.468LeuVal: 5.468 ± 0.654
1.077LeuTrp: 1.077 ± 0.327
2.568LeuTyr: 2.568 ± 0.446
0.0LeuXaa: 0.0 ± 0.0
Met
2.817MetAla: 2.817 ± 0.457
0.331MetCys: 0.331 ± 0.131
1.823MetAsp: 1.823 ± 0.416
2.237MetGlu: 2.237 ± 0.457
1.326MetPhe: 1.326 ± 0.326
2.817MetGly: 2.817 ± 0.658
0.414MetHis: 0.414 ± 0.238
1.16MetIle: 1.16 ± 0.322
1.823MetLys: 1.823 ± 0.401
4.06MetLeu: 4.06 ± 0.618
0.497MetMet: 0.497 ± 0.185
1.988MetAsn: 1.988 ± 0.648
1.326MetPro: 1.326 ± 0.342
1.243MetGln: 1.243 ± 0.426
0.829MetArg: 0.829 ± 0.25
2.071MetSer: 2.071 ± 0.304
1.906MetThr: 1.906 ± 0.465
2.651MetVal: 2.651 ± 0.465
0.331MetTrp: 0.331 ± 0.181
1.16MetTyr: 1.16 ± 0.287
0.0MetXaa: 0.0 ± 0.0
Asn
3.065AsnAla: 3.065 ± 0.516
0.663AsnCys: 0.663 ± 0.232
2.568AsnAsp: 2.568 ± 0.393
2.9AsnGlu: 2.9 ± 0.429
1.74AsnPhe: 1.74 ± 0.246
4.557AsnGly: 4.557 ± 0.667
0.746AsnHis: 0.746 ± 0.261
2.734AsnIle: 2.734 ± 0.465
3.397AsnLys: 3.397 ± 0.639
3.811AsnLeu: 3.811 ± 0.469
1.326AsnMet: 1.326 ± 0.302
1.906AsnAsn: 1.906 ± 0.387
2.237AsnPro: 2.237 ± 0.345
1.906AsnGln: 1.906 ± 0.313
3.148AsnArg: 3.148 ± 0.651
3.065AsnSer: 3.065 ± 0.603
2.568AsnThr: 2.568 ± 0.594
2.486AsnVal: 2.486 ± 0.418
0.58AsnTrp: 0.58 ± 0.2
2.32AsnTyr: 2.32 ± 0.429
0.0AsnXaa: 0.0 ± 0.0
Pro
2.32ProAla: 2.32 ± 0.416
0.331ProCys: 0.331 ± 0.167
2.734ProAsp: 2.734 ± 0.471
4.391ProGlu: 4.391 ± 0.712
1.16ProPhe: 1.16 ± 0.275
1.243ProGly: 1.243 ± 0.267
0.911ProHis: 0.911 ± 0.258
1.243ProIle: 1.243 ± 0.262
2.568ProLys: 2.568 ± 0.506
2.983ProLeu: 2.983 ± 0.545
1.16ProMet: 1.16 ± 0.392
2.403ProAsn: 2.403 ± 0.522
0.911ProPro: 0.911 ± 0.253
1.077ProGln: 1.077 ± 0.276
1.243ProArg: 1.243 ± 0.335
2.568ProSer: 2.568 ± 0.356
1.988ProThr: 1.988 ± 0.301
3.148ProVal: 3.148 ± 0.575
0.663ProTrp: 0.663 ± 0.212
1.16ProTyr: 1.16 ± 0.341
0.0ProXaa: 0.0 ± 0.0
Gln
4.391GlnAla: 4.391 ± 0.566
0.166GlnCys: 0.166 ± 0.126
2.237GlnAsp: 2.237 ± 0.445
2.486GlnGlu: 2.486 ± 0.594
1.823GlnPhe: 1.823 ± 0.314
2.568GlnGly: 2.568 ± 0.452
0.414GlnHis: 0.414 ± 0.187
2.32GlnIle: 2.32 ± 0.454
1.823GlnLys: 1.823 ± 0.457
4.225GlnLeu: 4.225 ± 0.559
1.326GlnMet: 1.326 ± 0.269
0.829GlnAsn: 0.829 ± 0.187
1.574GlnPro: 1.574 ± 0.411
1.823GlnGln: 1.823 ± 0.338
1.823GlnArg: 1.823 ± 0.373
1.988GlnSer: 1.988 ± 0.385
1.823GlnThr: 1.823 ± 0.374
1.906GlnVal: 1.906 ± 0.355
0.994GlnTrp: 0.994 ± 0.215
1.326GlnTyr: 1.326 ± 0.317
0.0GlnXaa: 0.0 ± 0.0
Arg
4.805ArgAla: 4.805 ± 0.739
0.663ArgCys: 0.663 ± 0.269
3.314ArgAsp: 3.314 ± 0.438
3.894ArgGlu: 3.894 ± 0.732
1.823ArgPhe: 1.823 ± 0.318
3.894ArgGly: 3.894 ± 0.543
0.746ArgHis: 0.746 ± 0.235
1.988ArgIle: 1.988 ± 0.504
4.225ArgLys: 4.225 ± 0.78
4.64ArgLeu: 4.64 ± 0.577
1.408ArgMet: 1.408 ± 0.272
3.065ArgAsn: 3.065 ± 0.532
2.071ArgPro: 2.071 ± 0.347
2.071ArgGln: 2.071 ± 0.444
2.32ArgArg: 2.32 ± 0.374
3.728ArgSer: 3.728 ± 0.868
2.9ArgThr: 2.9 ± 0.433
3.894ArgVal: 3.894 ± 0.586
0.497ArgTrp: 0.497 ± 0.218
1.408ArgTyr: 1.408 ± 0.208
0.0ArgXaa: 0.0 ± 0.0
Ser
4.308SerAla: 4.308 ± 0.492
0.58SerCys: 0.58 ± 0.269
4.06SerAsp: 4.06 ± 0.566
3.314SerGlu: 3.314 ± 0.621
2.568SerPhe: 2.568 ± 0.418
5.634SerGly: 5.634 ± 0.643
1.823SerHis: 1.823 ± 0.408
3.397SerIle: 3.397 ± 0.531
3.811SerLys: 3.811 ± 0.581
4.722SerLeu: 4.722 ± 0.611
2.32SerMet: 2.32 ± 0.43
2.568SerAsn: 2.568 ± 0.521
2.154SerPro: 2.154 ± 0.364
2.403SerGln: 2.403 ± 0.45
3.728SerArg: 3.728 ± 0.58
3.065SerSer: 3.065 ± 0.528
3.231SerThr: 3.231 ± 0.376
3.563SerVal: 3.563 ± 0.406
0.746SerTrp: 0.746 ± 0.196
2.237SerTyr: 2.237 ± 0.677
0.0SerXaa: 0.0 ± 0.0
Thr
3.728ThrAla: 3.728 ± 0.851
0.663ThrCys: 0.663 ± 0.222
3.48ThrAsp: 3.48 ± 0.424
4.308ThrGlu: 4.308 ± 0.627
1.74ThrPhe: 1.74 ± 0.352
5.634ThrGly: 5.634 ± 0.687
0.911ThrHis: 0.911 ± 0.275
3.314ThrIle: 3.314 ± 0.519
4.474ThrLys: 4.474 ± 0.604
4.971ThrLeu: 4.971 ± 0.586
1.16ThrMet: 1.16 ± 0.278
1.74ThrAsn: 1.74 ± 0.402
2.568ThrPro: 2.568 ± 0.341
1.491ThrGln: 1.491 ± 0.42
1.906ThrArg: 1.906 ± 0.32
3.314ThrSer: 3.314 ± 0.505
3.065ThrThr: 3.065 ± 0.553
3.563ThrVal: 3.563 ± 0.604
0.58ThrTrp: 0.58 ± 0.273
1.326ThrTyr: 1.326 ± 0.262
0.0ThrXaa: 0.0 ± 0.0
Val
6.545ValAla: 6.545 ± 0.604
0.497ValCys: 0.497 ± 0.181
3.645ValAsp: 3.645 ± 0.463
5.22ValGlu: 5.22 ± 0.846
2.237ValPhe: 2.237 ± 0.562
4.06ValGly: 4.06 ± 0.568
0.911ValHis: 0.911 ± 0.287
3.811ValIle: 3.811 ± 0.609
4.64ValLys: 4.64 ± 0.703
4.722ValLeu: 4.722 ± 0.536
1.906ValMet: 1.906 ± 0.439
3.231ValAsn: 3.231 ± 0.654
2.651ValPro: 2.651 ± 0.47
2.486ValGln: 2.486 ± 0.579
4.391ValArg: 4.391 ± 0.631
4.474ValSer: 4.474 ± 0.597
4.722ValThr: 4.722 ± 0.487
4.225ValVal: 4.225 ± 0.791
0.994ValTrp: 0.994 ± 0.324
1.657ValTyr: 1.657 ± 0.451
0.0ValXaa: 0.0 ± 0.0
Trp
0.58TrpAla: 0.58 ± 0.154
0.249TrpCys: 0.249 ± 0.158
0.58TrpAsp: 0.58 ± 0.232
0.911TrpGlu: 0.911 ± 0.254
0.497TrpPhe: 0.497 ± 0.206
0.663TrpGly: 0.663 ± 0.168
0.331TrpHis: 0.331 ± 0.22
0.663TrpIle: 0.663 ± 0.249
1.491TrpLys: 1.491 ± 0.387
1.74TrpLeu: 1.74 ± 0.435
0.497TrpMet: 0.497 ± 0.173
1.16TrpAsn: 1.16 ± 0.392
0.331TrpPro: 0.331 ± 0.164
0.663TrpGln: 0.663 ± 0.229
0.58TrpArg: 0.58 ± 0.215
0.994TrpSer: 0.994 ± 0.328
1.077TrpThr: 1.077 ± 0.389
1.243TrpVal: 1.243 ± 0.302
0.166TrpTrp: 0.166 ± 0.112
0.331TrpTyr: 0.331 ± 0.132
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.314TyrAla: 3.314 ± 0.459
0.249TyrCys: 0.249 ± 0.17
2.568TyrAsp: 2.568 ± 0.377
2.154TyrGlu: 2.154 ± 0.416
0.829TyrPhe: 0.829 ± 0.198
3.065TyrGly: 3.065 ± 0.359
0.331TyrHis: 0.331 ± 0.19
1.491TyrIle: 1.491 ± 0.406
0.911TyrLys: 0.911 ± 0.262
2.403TyrLeu: 2.403 ± 0.459
1.077TyrMet: 1.077 ± 0.313
1.988TyrAsn: 1.988 ± 0.382
1.243TyrPro: 1.243 ± 0.277
1.408TyrGln: 1.408 ± 0.407
1.657TyrArg: 1.657 ± 0.317
1.574TyrSer: 1.574 ± 0.455
1.988TyrThr: 1.988 ± 0.58
2.734TyrVal: 2.734 ± 0.55
0.663TyrTrp: 0.663 ± 0.29
0.746TyrTyr: 0.746 ± 0.23
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 46 proteins (12071 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski