Amino acid dipepetide frequency for Candidatus Mycoplasma haemobos

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.193AlaAla: 2.193 ± 0.11
0.667AlaCys: 0.667 ± 0.053
2.292AlaAsp: 2.292 ± 0.093
3.141AlaGlu: 3.141 ± 0.117
2.587AlaPhe: 2.587 ± 0.099
4.205AlaGly: 4.205 ± 0.127
0.732AlaHis: 0.732 ± 0.053
4.733AlaIle: 4.733 ± 0.143
5.895AlaLys: 5.895 ± 0.162
6.252AlaLeu: 6.252 ± 0.167
0.947AlaMet: 0.947 ± 0.057
3.024AlaAsn: 3.024 ± 0.106
1.669AlaPro: 1.669 ± 0.081
1.647AlaGln: 1.647 ± 0.072
1.938AlaArg: 1.938 ± 0.089
4.172AlaSer: 4.172 ± 0.114
3.822AlaThr: 3.822 ± 0.128
2.911AlaVal: 2.911 ± 0.113
1.02AlaTrp: 1.02 ± 0.067
2.146AlaTyr: 2.146 ± 0.08
0.0AlaXaa: 0.0 ± 0.0
Cys
0.893CysAla: 0.893 ± 0.065
0.157CysCys: 0.157 ± 0.034
0.488CysAsp: 0.488 ± 0.042
1.071CysGlu: 1.071 ± 0.065
0.496CysPhe: 0.496 ± 0.047
0.598CysGly: 0.598 ± 0.046
0.149CysHis: 0.149 ± 0.027
0.787CysIle: 0.787 ± 0.053
1.494CysLys: 1.494 ± 0.076
1.049CysLeu: 1.049 ± 0.066
0.142CysMet: 0.142 ± 0.025
0.718CysAsn: 0.718 ± 0.049
0.251CysPro: 0.251 ± 0.033
0.368CysGln: 0.368 ± 0.041
0.437CysArg: 0.437 ± 0.043
1.115CysSer: 1.115 ± 0.07
1.45CysThr: 1.45 ± 0.087
1.017CysVal: 1.017 ± 0.053
0.084CysTrp: 0.084 ± 0.019
0.412CysTyr: 0.412 ± 0.039
0.0CysXaa: 0.0 ± 0.0
Asp
3.082AspAla: 3.082 ± 0.108
0.434AspCys: 0.434 ± 0.041
3.111AspAsp: 3.111 ± 0.126
4.266AspGlu: 4.266 ± 0.131
3.02AspPhe: 3.02 ± 0.12
2.565AspGly: 2.565 ± 0.117
0.707AspHis: 0.707 ± 0.05
4.052AspIle: 4.052 ± 0.13
6.114AspLys: 6.114 ± 0.16
5.749AspLeu: 5.749 ± 0.139
0.776AspMet: 0.776 ± 0.052
3.869AspAsn: 3.869 ± 0.126
1.909AspPro: 1.909 ± 0.09
1.607AspGln: 1.607 ± 0.085
1.508AspArg: 1.508 ± 0.069
4.522AspSer: 4.522 ± 0.139
3.122AspThr: 3.122 ± 0.108
2.361AspVal: 2.361 ± 0.092
1.261AspTrp: 1.261 ± 0.067
2.448AspTyr: 2.448 ± 0.108
0.0AspXaa: 0.0 ± 0.0
Glu
4.372GluAla: 4.372 ± 0.152
0.616GluCys: 0.616 ± 0.05
4.54GluAsp: 4.54 ± 0.155
7.327GluGlu: 7.327 ± 0.209
2.98GluPhe: 2.98 ± 0.104
4.048GluGly: 4.048 ± 0.129
1.213GluHis: 1.213 ± 0.085
6.351GluIle: 6.351 ± 0.158
9.382GluLys: 9.382 ± 0.187
7.538GluLeu: 7.538 ± 0.185
1.093GluMet: 1.093 ± 0.07
5.487GluAsn: 5.487 ± 0.141
1.636GluPro: 1.636 ± 0.094
2.532GluGln: 2.532 ± 0.096
2.722GluArg: 2.722 ± 0.111
4.146GluSer: 4.146 ± 0.124
3.512GluThr: 3.512 ± 0.125
3.775GluVal: 3.775 ± 0.121
1.417GluTrp: 1.417 ± 0.075
2.565GluTyr: 2.565 ± 0.106
0.0GluXaa: 0.0 ± 0.0
Phe
2.255PheAla: 2.255 ± 0.1
0.74PheCys: 0.74 ± 0.054
2.569PheAsp: 2.569 ± 0.096
3.643PheGlu: 3.643 ± 0.135
2.452PhePhe: 2.452 ± 0.119
2.241PheGly: 2.241 ± 0.086
0.594PheHis: 0.594 ± 0.051
2.966PheIle: 2.966 ± 0.122
5.378PheLys: 5.378 ± 0.124
4.798PheLeu: 4.798 ± 0.192
0.619PheMet: 0.619 ± 0.055
2.944PheAsn: 2.944 ± 0.128
1.352PhePro: 1.352 ± 0.074
1.221PheGln: 1.221 ± 0.079
1.559PheArg: 1.559 ± 0.08
3.742PheSer: 3.742 ± 0.124
2.252PheThr: 2.252 ± 0.099
2.241PheVal: 2.241 ± 0.092
0.776PheTrp: 0.776 ± 0.066
1.374PheTyr: 1.374 ± 0.073
0.0PheXaa: 0.0 ± 0.0
Gly
3.829GlyAla: 3.829 ± 0.119
0.659GlyCys: 0.659 ± 0.048
3.214GlyAsp: 3.214 ± 0.11
3.487GlyGlu: 3.487 ± 0.123
2.445GlyPhe: 2.445 ± 0.097
5.09GlyGly: 5.09 ± 0.176
0.758GlyHis: 0.758 ± 0.054
4.492GlyIle: 4.492 ± 0.143
5.254GlyLys: 5.254 ± 0.132
4.605GlyLeu: 4.605 ± 0.113
0.842GlyMet: 0.842 ± 0.052
2.867GlyAsn: 2.867 ± 0.11
0.652GlyPro: 0.652 ± 0.054
1.483GlyGln: 1.483 ± 0.082
1.618GlyArg: 1.618 ± 0.075
3.917GlySer: 3.917 ± 0.134
3.622GlyThr: 3.622 ± 0.124
3.749GlyVal: 3.749 ± 0.135
1.049GlyTrp: 1.049 ± 0.069
2.175GlyTyr: 2.175 ± 0.099
0.0GlyXaa: 0.0 ± 0.0
His
0.681HisAla: 0.681 ± 0.05
0.204HisCys: 0.204 ± 0.028
0.576HisAsp: 0.576 ± 0.046
0.834HisGlu: 0.834 ± 0.06
0.761HisPhe: 0.761 ± 0.05
0.67HisGly: 0.67 ± 0.053
0.24HisHis: 0.24 ± 0.031
1.013HisIle: 1.013 ± 0.061
1.545HisLys: 1.545 ± 0.075
1.479HisLeu: 1.479 ± 0.083
0.2HisMet: 0.2 ± 0.027
0.856HisAsn: 0.856 ± 0.061
0.419HisPro: 0.419 ± 0.041
0.404HisGln: 0.404 ± 0.035
0.485HisArg: 0.485 ± 0.043
0.995HisSer: 0.995 ± 0.068
0.729HisThr: 0.729 ± 0.055
0.521HisVal: 0.521 ± 0.043
0.291HisTrp: 0.291 ± 0.035
0.638HisTyr: 0.638 ± 0.05
0.0HisXaa: 0.0 ± 0.0
Ile
4.787IleAla: 4.787 ± 0.129
0.78IleCys: 0.78 ± 0.055
4.019IleAsp: 4.019 ± 0.139
5.385IleGlu: 5.385 ± 0.172
3.563IlePhe: 3.563 ± 0.134
4.325IleGly: 4.325 ± 0.128
0.889IleHis: 0.889 ± 0.06
4.47IleIle: 4.47 ± 0.166
8.183IleLys: 8.183 ± 0.153
6.11IleLeu: 6.11 ± 0.187
0.925IleMet: 0.925 ± 0.062
4.904IleAsn: 4.904 ± 0.156
2.671IlePro: 2.671 ± 0.094
2.117IleGln: 2.117 ± 0.092
2.335IleArg: 2.335 ± 0.088
6.219IleSer: 6.219 ± 0.149
4.277IleThr: 4.277 ± 0.119
3.6IleVal: 3.6 ± 0.135
0.878IleTrp: 0.878 ± 0.052
2.696IleTyr: 2.696 ± 0.104
0.0IleXaa: 0.0 ± 0.0
Lys
5.975LysAla: 5.975 ± 0.148
1.151LysCys: 1.151 ± 0.077
8.063LysAsp: 8.063 ± 0.228
11.473LysGlu: 11.473 ± 0.229
4.175LysPhe: 4.175 ± 0.133
4.645LysGly: 4.645 ± 0.146
1.807LysHis: 1.807 ± 0.092
7.462LysIle: 7.462 ± 0.171
11.251LysLys: 11.251 ± 0.232
10.198LysLeu: 10.198 ± 0.194
1.647LysMet: 1.647 ± 0.071
6.959LysAsn: 6.959 ± 0.171
2.729LysPro: 2.729 ± 0.1
4.004LysGln: 4.004 ± 0.146
3.152LysArg: 3.152 ± 0.107
6.303LysSer: 6.303 ± 0.149
5.837LysThr: 5.837 ± 0.151
5.727LysVal: 5.727 ± 0.157
2.069LysTrp: 2.069 ± 0.089
4.671LysTyr: 4.671 ± 0.135
0.0LysXaa: 0.0 ± 0.0
Leu
5.254LeuAla: 5.254 ± 0.13
0.838LeuCys: 0.838 ± 0.057
5.185LeuAsp: 5.185 ± 0.141
6.649LeuGlu: 6.649 ± 0.181
4.882LeuPhe: 4.882 ± 0.173
5.447LeuGly: 5.447 ± 0.151
1.071LeuHis: 1.071 ± 0.072
7.713LeuIle: 7.713 ± 0.202
10.599LeuLys: 10.599 ± 0.196
9.32LeuLeu: 9.32 ± 0.234
1.148LeuMet: 1.148 ± 0.072
6.533LeuAsn: 6.533 ± 0.171
2.74LeuPro: 2.74 ± 0.114
2.645LeuGln: 2.645 ± 0.11
3.563LeuArg: 3.563 ± 0.117
7.979LeuSer: 7.979 ± 0.209
5.666LeuThr: 5.666 ± 0.158
4.747LeuVal: 4.747 ± 0.12
1.093LeuTrp: 1.093 ± 0.065
2.222LeuTyr: 2.222 ± 0.118
0.0LeuXaa: 0.0 ± 0.0
Met
1.144MetAla: 1.144 ± 0.062
0.135MetCys: 0.135 ± 0.022
0.656MetAsp: 0.656 ± 0.048
0.962MetGlu: 0.962 ± 0.058
0.689MetPhe: 0.689 ± 0.049
0.831MetGly: 0.831 ± 0.066
0.288MetHis: 0.288 ± 0.036
0.791MetIle: 0.791 ± 0.054
1.272MetLys: 1.272 ± 0.063
1.119MetLeu: 1.119 ± 0.061
0.182MetMet: 0.182 ± 0.029
1.002MetAsn: 1.002 ± 0.071
0.463MetPro: 0.463 ± 0.042
0.547MetGln: 0.547 ± 0.041
0.499MetArg: 0.499 ± 0.041
1.341MetSer: 1.341 ± 0.058
0.82MetThr: 0.82 ± 0.05
0.685MetVal: 0.685 ± 0.054
0.128MetTrp: 0.128 ± 0.021
0.375MetTyr: 0.375 ± 0.038
0.0MetXaa: 0.0 ± 0.0
Asn
3.057AsnAla: 3.057 ± 0.117
0.514AsnCys: 0.514 ± 0.051
3.312AsnAsp: 3.312 ± 0.103
4.205AsnGlu: 4.205 ± 0.134
2.827AsnPhe: 2.827 ± 0.131
2.915AsnGly: 2.915 ± 0.117
0.791AsnHis: 0.791 ± 0.055
5.035AsnIle: 5.035 ± 0.158
8.125AsnLys: 8.125 ± 0.184
5.964AsnLeu: 5.964 ± 0.158
0.947AsnMet: 0.947 ± 0.067
4.849AsnAsn: 4.849 ± 0.158
2.139AsnPro: 2.139 ± 0.085
1.924AsnGln: 1.924 ± 0.073
1.855AsnArg: 1.855 ± 0.083
4.977AsnSer: 4.977 ± 0.161
3.888AsnThr: 3.888 ± 0.134
2.652AsnVal: 2.652 ± 0.112
1.399AsnTrp: 1.399 ± 0.078
2.871AsnTyr: 2.871 ± 0.108
0.0AsnXaa: 0.0 ± 0.0
Pro
1.508ProAla: 1.508 ± 0.076
0.248ProCys: 0.248 ± 0.032
1.567ProAsp: 1.567 ± 0.078
2.569ProGlu: 2.569 ± 0.095
1.173ProPhe: 1.173 ± 0.076
0.718ProGly: 0.718 ± 0.056
0.517ProHis: 0.517 ± 0.044
2.252ProIle: 2.252 ± 0.102
3.228ProLys: 3.228 ± 0.106
2.623ProLeu: 2.623 ± 0.102
0.299ProMet: 0.299 ± 0.028
1.829ProAsn: 1.829 ± 0.088
1.013ProPro: 1.013 ± 0.061
0.973ProGln: 0.973 ± 0.055
0.853ProArg: 0.853 ± 0.058
2.397ProSer: 2.397 ± 0.1
1.902ProThr: 1.902 ± 0.098
1.476ProVal: 1.476 ± 0.083
0.259ProTrp: 0.259 ± 0.032
0.845ProTyr: 0.845 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
1.698GlnAla: 1.698 ± 0.078
0.197GlnCys: 0.197 ± 0.026
1.96GlnAsp: 1.96 ± 0.09
3.265GlnGlu: 3.265 ± 0.119
1.071GlnPhe: 1.071 ± 0.066
1.516GlnGly: 1.516 ± 0.081
0.39GlnHis: 0.39 ± 0.035
2.346GlnIle: 2.346 ± 0.093
3.829GlnLys: 3.829 ± 0.107
2.773GlnLeu: 2.773 ± 0.109
0.554GlnMet: 0.554 ± 0.042
2.095GlnAsn: 2.095 ± 0.076
0.805GlnPro: 0.805 ± 0.052
1.632GlnGln: 1.632 ± 0.132
1.035GlnArg: 1.035 ± 0.065
1.712GlnSer: 1.712 ± 0.08
1.592GlnThr: 1.592 ± 0.072
1.261GlnVal: 1.261 ± 0.069
0.565GlnTrp: 0.565 ± 0.045
1.068GlnTyr: 1.068 ± 0.065
0.0GlnXaa: 0.0 ± 0.0
Arg
1.712ArgAla: 1.712 ± 0.077
0.419ArgCys: 0.419 ± 0.036
2.113ArgAsp: 2.113 ± 0.095
2.641ArgGlu: 2.641 ± 0.115
1.446ArgPhe: 1.446 ± 0.075
1.578ArgGly: 1.578 ± 0.081
0.481ArgHis: 0.481 ± 0.041
2.39ArgIle: 2.39 ± 0.098
3.108ArgLys: 3.108 ± 0.112
2.7ArgLeu: 2.7 ± 0.098
0.554ArgMet: 0.554 ± 0.045
2.022ArgAsn: 2.022 ± 0.088
0.809ArgPro: 0.809 ± 0.058
1.155ArgGln: 1.155 ± 0.074
1.385ArgArg: 1.385 ± 0.095
1.909ArgSer: 1.909 ± 0.095
1.709ArgThr: 1.709 ± 0.076
1.694ArgVal: 1.694 ± 0.09
0.554ArgTrp: 0.554 ± 0.042
1.363ArgTyr: 1.363 ± 0.082
0.0ArgXaa: 0.0 ± 0.0
Ser
3.953SerAla: 3.953 ± 0.126
0.506SerCys: 0.506 ± 0.047
4.099SerAsp: 4.099 ± 0.13
5.604SerGlu: 5.604 ± 0.153
3.669SerPhe: 3.669 ± 0.138
4.376SerGly: 4.376 ± 0.135
0.944SerHis: 0.944 ± 0.07
4.999SerIle: 4.999 ± 0.133
7.983SerLys: 7.983 ± 0.16
7.309SerLeu: 7.309 ± 0.158
1.086SerMet: 1.086 ± 0.063
4.933SerAsn: 4.933 ± 0.12
2.062SerPro: 2.062 ± 0.095
2.27SerGln: 2.27 ± 0.093
2.048SerArg: 2.048 ± 0.095
6.78SerSer: 6.78 ± 0.195
4.23SerThr: 4.23 ± 0.124
3.52SerVal: 3.52 ± 0.111
1.151SerTrp: 1.151 ± 0.07
2.758SerTyr: 2.758 ± 0.098
0.0SerXaa: 0.0 ± 0.0
Thr
3.312ThrAla: 3.312 ± 0.138
0.393ThrCys: 0.393 ± 0.041
3.265ThrAsp: 3.265 ± 0.123
3.556ThrGlu: 3.556 ± 0.126
2.335ThrPhe: 2.335 ± 0.101
3.691ThrGly: 3.691 ± 0.131
0.732ThrHis: 0.732 ± 0.057
4.587ThrIle: 4.587 ± 0.143
6.38ThrLys: 6.38 ± 0.182
5.611ThrLeu: 5.611 ± 0.155
0.547ThrMet: 0.547 ± 0.041
3.837ThrAsn: 3.837 ± 0.114
2.08ThrPro: 2.08 ± 0.09
1.712ThrGln: 1.712 ± 0.076
1.523ThrArg: 1.523 ± 0.074
4.365ThrSer: 4.365 ± 0.137
4.157ThrThr: 4.157 ± 0.159
3.071ThrVal: 3.071 ± 0.102
0.893ThrTrp: 0.893 ± 0.053
1.964ThrTyr: 1.964 ± 0.091
0.0ThrXaa: 0.0 ± 0.0
Val
3.811ValAla: 3.811 ± 0.12
0.568ValCys: 0.568 ± 0.049
2.718ValAsp: 2.718 ± 0.101
3.268ValGlu: 3.268 ± 0.12
2.478ValPhe: 2.478 ± 0.102
3.538ValGly: 3.538 ± 0.113
0.649ValHis: 0.649 ± 0.048
3.545ValIle: 3.545 ± 0.145
4.828ValLys: 4.828 ± 0.14
4.514ValLeu: 4.514 ± 0.145
0.78ValMet: 0.78 ± 0.052
2.988ValAsn: 2.988 ± 0.106
1.676ValPro: 1.676 ± 0.076
1.308ValGln: 1.308 ± 0.058
1.312ValArg: 1.312 ± 0.075
3.906ValSer: 3.906 ± 0.131
3.013ValThr: 3.013 ± 0.099
2.995ValVal: 2.995 ± 0.108
0.685ValTrp: 0.685 ± 0.047
1.53ValTyr: 1.53 ± 0.077
0.0ValXaa: 0.0 ± 0.0
Trp
0.71TrpAla: 0.71 ± 0.046
2.693TrpCys: 2.693 ± 0.14
1.064TrpAsp: 1.064 ± 0.062
1.082TrpGlu: 1.082 ± 0.067
0.619TrpPhe: 0.619 ± 0.041
0.842TrpGly: 0.842 ± 0.062
0.131TrpHis: 0.131 ± 0.021
0.842TrpIle: 0.842 ± 0.053
2.135TrpLys: 2.135 ± 0.092
1.053TrpLeu: 1.053 ± 0.067
0.233TrpMet: 0.233 ± 0.027
1.104TrpAsn: 1.104 ± 0.062
0.164TrpPro: 0.164 ± 0.023
0.444TrpGln: 0.444 ± 0.045
0.459TrpArg: 0.459 ± 0.044
0.659TrpSer: 0.659 ± 0.048
0.907TrpThr: 0.907 ± 0.059
0.561TrpVal: 0.561 ± 0.045
0.131TrpTrp: 0.131 ± 0.021
0.404TrpTyr: 0.404 ± 0.04
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.763TyrAla: 1.763 ± 0.083
1.257TyrCys: 1.257 ± 0.069
1.676TyrAsp: 1.676 ± 0.08
2.824TyrGlu: 2.824 ± 0.104
2.044TyrPhe: 2.044 ± 0.087
1.971TyrGly: 1.971 ± 0.092
0.459TyrHis: 0.459 ± 0.038
2.31TyrIle: 2.31 ± 0.082
3.319TyrLys: 3.319 ± 0.11
4.529TyrLeu: 4.529 ± 0.165
0.401TyrMet: 0.401 ± 0.044
1.425TyrAsn: 1.425 ± 0.082
1.009TyrPro: 1.009 ± 0.064
1.37TyrGln: 1.37 ± 0.069
1.457TyrArg: 1.457 ± 0.082
3.122TyrSer: 3.122 ± 0.122
1.505TyrThr: 1.505 ± 0.08
1.548TyrVal: 1.548 ± 0.075
0.536TyrTrp: 0.536 ± 0.04
1.621TyrTyr: 1.621 ± 0.093
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1109 proteins (274467 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski