Amino acid dipepetide frequency for Ajellomyces capsulatus (strain H143) (Darling s disease fungus) (Histoplasma capsulatum)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.953AlaAla: 7.953 ± 0.061	0.989AlaCys: 0.989 ± 0.016	3.86AlaAsp: 3.86 ± 0.03	4.824AlaGlu: 4.824 ± 0.043	2.812AlaPhe: 2.812 ± 0.028	5.429AlaGly: 5.429 ± 0.044	1.728AlaHis: 1.728 ± 0.022	4.105AlaIle: 4.105 ± 0.037	3.938AlaLys: 3.938 ± 0.033	7.109AlaLeu: 7.109 ± 0.05	1.727AlaMet: 1.727 ± 0.02	2.92AlaAsn: 2.92 ± 0.032	4.185AlaPro: 4.185 ± 0.039	3.016AlaGln: 3.016 ± 0.034	4.844AlaArg: 4.844 ± 0.04	6.982AlaSer: 6.982 ± 0.046	4.953AlaThr: 4.953 ± 0.04	4.904AlaVal: 4.904 ± 0.037	0.948AlaTrp: 0.948 ± 0.015	1.866AlaTyr: 1.866 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	0.897CysAla: 0.897 ± 0.018	0.289CysCys: 0.289 ± 0.009	0.661CysAsp: 0.661 ± 0.014	0.657CysGlu: 0.657 ± 0.014	0.547CysPhe: 0.547 ± 0.011	0.974CysGly: 0.974 ± 0.018	0.371CysHis: 0.371 ± 0.011	0.722CysIle: 0.722 ± 0.015	0.57CysLys: 0.57 ± 0.015	1.301CysLeu: 1.301 ± 0.02	0.28CysMet: 0.28 ± 0.009	0.452CysAsn: 0.452 ± 0.012	0.749CysPro: 0.749 ± 0.016	0.504CysGln: 0.504 ± 0.013	0.848CysArg: 0.848 ± 0.015	1.043CysSer: 1.043 ± 0.021	0.677CysThr: 0.677 ± 0.012	0.764CysVal: 0.764 ± 0.016	0.221CysTrp: 0.221 ± 0.008	0.357CysTyr: 0.357 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	4.161AspAla: 4.161 ± 0.037	0.646AspCys: 0.646 ± 0.013	4.168AspAsp: 4.168 ± 0.054	4.255AspGlu: 4.255 ± 0.039	2.096AspPhe: 2.096 ± 0.026	4.131AspGly: 4.131 ± 0.039	1.217AspHis: 1.217 ± 0.017	3.388AspIle: 3.388 ± 0.028	2.347AspLys: 2.347 ± 0.026	4.802AspLeu: 4.802 ± 0.042	1.255AspMet: 1.255 ± 0.017	2.028AspAsn: 2.028 ± 0.025	3.234AspPro: 3.234 ± 0.027	1.787AspGln: 1.787 ± 0.023	3.101AspArg: 3.101 ± 0.027	4.226AspSer: 4.226 ± 0.039	2.81AspThr: 2.81 ± 0.029	3.513AspVal: 3.513 ± 0.031	0.795AspTrp: 0.795 ± 0.015	1.46AspTyr: 1.46 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	4.888GluAla: 4.888 ± 0.042	0.675GluCys: 0.675 ± 0.014	3.967GluAsp: 3.967 ± 0.038	5.251GluGlu: 5.251 ± 0.051	2.0GluPhe: 2.0 ± 0.024	3.701GluGly: 3.701 ± 0.034	1.359GluHis: 1.359 ± 0.017	3.245GluIle: 3.245 ± 0.031	3.824GluLys: 3.824 ± 0.042	5.256GluLeu: 5.256 ± 0.048	1.47GluMet: 1.47 ± 0.021	2.646GluAsn: 2.646 ± 0.025	2.785GluPro: 2.785 ± 0.035	2.423GluGln: 2.423 ± 0.029	4.134GluArg: 4.134 ± 0.038	4.505GluSer: 4.505 ± 0.038	3.392GluThr: 3.392 ± 0.03	3.307GluVal: 3.307 ± 0.035	0.841GluTrp: 0.841 ± 0.014	1.679GluTyr: 1.679 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	2.761PheAla: 2.761 ± 0.029	0.574PheCys: 0.574 ± 0.013	2.219PheAsp: 2.219 ± 0.027	2.158PheGlu: 2.158 ± 0.025	1.493PhePhe: 1.493 ± 0.026	2.632PheGly: 2.632 ± 0.034	0.964PheHis: 0.964 ± 0.017	1.755PheIle: 1.755 ± 0.024	1.513PheLys: 1.513 ± 0.018	3.481PheLeu: 3.481 ± 0.035	0.72PheMet: 0.72 ± 0.016	1.411PheAsn: 1.411 ± 0.021	2.147PhePro: 2.147 ± 0.026	1.414PheGln: 1.414 ± 0.02	2.099PheArg: 2.099 ± 0.023	3.235PheSer: 3.235 ± 0.03	2.034PheThr: 2.034 ± 0.023	2.268PheVal: 2.268 ± 0.026	0.566PheTrp: 0.566 ± 0.013	1.046PheTyr: 1.046 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	4.802GlyAla: 4.802 ± 0.042	0.913GlyCys: 0.913 ± 0.017	3.706GlyAsp: 3.706 ± 0.035	3.836GlyGlu: 3.836 ± 0.034	2.607GlyPhe: 2.607 ± 0.027	5.834GlyGly: 5.834 ± 0.06	1.629GlyHis: 1.629 ± 0.021	3.543GlyIle: 3.543 ± 0.037	3.623GlyLys: 3.623 ± 0.033	5.599GlyLeu: 5.599 ± 0.046	1.582GlyMet: 1.582 ± 0.021	2.804GlyAsn: 2.804 ± 0.025	3.221GlyPro: 3.221 ± 0.034	2.432GlyGln: 2.432 ± 0.03	4.303GlyArg: 4.303 ± 0.038	5.771GlySer: 5.771 ± 0.05	3.741GlyThr: 3.741 ± 0.038	4.159GlyVal: 4.159 ± 0.036	1.087GlyTrp: 1.087 ± 0.018	1.967GlyTyr: 1.967 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.807HisAla: 1.807 ± 0.022	0.369HisCys: 0.369 ± 0.012	1.333HisAsp: 1.333 ± 0.02	1.312HisGlu: 1.312 ± 0.02	0.966HisPhe: 0.966 ± 0.015	1.729HisGly: 1.729 ± 0.022	0.947HisHis: 0.947 ± 0.022	1.36HisIle: 1.36 ± 0.02	0.964HisLys: 0.964 ± 0.018	2.345HisLeu: 2.345 ± 0.025	0.489HisMet: 0.489 ± 0.011	0.936HisAsn: 0.936 ± 0.017	1.887HisPro: 1.887 ± 0.024	1.134HisGln: 1.134 ± 0.02	1.655HisArg: 1.655 ± 0.022	2.185HisSer: 2.185 ± 0.027	1.32HisThr: 1.32 ± 0.018	1.395HisVal: 1.395 ± 0.018	0.318HisTrp: 0.318 ± 0.009	0.658HisTyr: 0.658 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	3.929IleAla: 3.929 ± 0.036	0.839IleCys: 0.839 ± 0.016	2.943IleAsp: 2.943 ± 0.025	2.946IleGlu: 2.946 ± 0.028	2.095IlePhe: 2.095 ± 0.023	3.08IleGly: 3.08 ± 0.033	1.358IleHis: 1.358 ± 0.019	2.641IleIle: 2.641 ± 0.035	2.278IleLys: 2.278 ± 0.025	4.891IleLeu: 4.891 ± 0.037	1.019IleMet: 1.019 ± 0.016	1.901IleAsn: 1.901 ± 0.025	3.459IlePro: 3.459 ± 0.035	2.004IleGln: 2.004 ± 0.024	3.084IleArg: 3.084 ± 0.028	4.628IleSer: 4.628 ± 0.038	2.878IleThr: 2.878 ± 0.031	3.045IleVal: 3.045 ± 0.033	0.688IleTrp: 0.688 ± 0.014	1.486IleTyr: 1.486 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.944LysAla: 3.944 ± 0.037	0.587LysCys: 0.587 ± 0.013	2.646LysAsp: 2.646 ± 0.027	3.463LysGlu: 3.463 ± 0.037	1.615LysPhe: 1.615 ± 0.019	3.043LysGly: 3.043 ± 0.031	1.216LysHis: 1.216 ± 0.019	2.535LysIle: 2.535 ± 0.025	3.359LysLys: 3.359 ± 0.049	4.405LysLeu: 4.405 ± 0.038	1.068LysMet: 1.068 ± 0.017	1.914LysAsn: 1.914 ± 0.025	2.913LysPro: 2.913 ± 0.035	2.029LysGln: 2.029 ± 0.026	3.809LysArg: 3.809 ± 0.033	3.9LysSer: 3.9 ± 0.032	2.805LysThr: 2.805 ± 0.027	2.756LysVal: 2.756 ± 0.027	0.665LysTrp: 0.665 ± 0.015	1.44LysTyr: 1.44 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.249LeuAla: 7.249 ± 0.048	1.257LeuCys: 1.257 ± 0.02	5.015LeuAsp: 5.015 ± 0.04	5.571LeuGlu: 5.571 ± 0.043	3.264LeuPhe: 3.264 ± 0.033	5.702LeuGly: 5.702 ± 0.044	2.343LeuHis: 2.343 ± 0.023	4.028LeuIle: 4.028 ± 0.04	4.512LeuLys: 4.512 ± 0.037	8.471LeuLeu: 8.471 ± 0.064	1.698LeuMet: 1.698 ± 0.022	3.343LeuAsn: 3.343 ± 0.032	5.604LeuPro: 5.604 ± 0.043	3.871LeuGln: 3.871 ± 0.041	6.062LeuArg: 6.062 ± 0.043	7.844LeuSer: 7.844 ± 0.05	4.674LeuThr: 4.674 ± 0.036	5.119LeuVal: 5.119 ± 0.037	1.11LeuTrp: 1.11 ± 0.018	2.234LeuTyr: 2.234 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.119MetAla: 2.119 ± 0.027	0.246MetCys: 0.246 ± 0.008	1.251MetAsp: 1.251 ± 0.019	1.381MetGlu: 1.381 ± 0.019	0.711MetPhe: 0.711 ± 0.015	1.419MetGly: 1.419 ± 0.02	0.45MetHis: 0.45 ± 0.011	0.995MetIle: 0.995 ± 0.019	1.078MetLys: 1.078 ± 0.017	1.759MetLeu: 1.759 ± 0.024	0.501MetMet: 0.501 ± 0.013	0.813MetAsn: 0.813 ± 0.015	1.189MetPro: 1.189 ± 0.017	0.84MetGln: 0.84 ± 0.016	1.258MetArg: 1.258 ± 0.019	1.856MetSer: 1.856 ± 0.021	1.233MetThr: 1.233 ± 0.017	1.239MetVal: 1.239 ± 0.018	0.252MetTrp: 0.252 ± 0.008	0.479MetTyr: 0.479 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.033AsnAla: 3.033 ± 0.029	0.492AsnCys: 0.492 ± 0.013	2.139AsnAsp: 2.139 ± 0.024	2.228AsnGlu: 2.228 ± 0.025	1.428AsnPhe: 1.428 ± 0.019	3.118AsnGly: 3.118 ± 0.031	0.997AsnHis: 0.997 ± 0.019	2.333AsnIle: 2.333 ± 0.024	1.721AsnLys: 1.721 ± 0.023	3.397AsnLeu: 3.397 ± 0.032	0.857AsnMet: 0.857 ± 0.015	1.906AsnAsn: 1.906 ± 0.028	2.745AsnPro: 2.745 ± 0.03	1.45AsnGln: 1.45 ± 0.024	2.27AsnArg: 2.27 ± 0.03	3.284AsnSer: 3.284 ± 0.029	2.272AsnThr: 2.272 ± 0.024	2.316AsnVal: 2.316 ± 0.022	0.509AsnTrp: 0.509 ± 0.013	1.033AsnTyr: 1.033 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	4.905ProAla: 4.905 ± 0.04	0.612ProCys: 0.612 ± 0.012	3.163ProAsp: 3.163 ± 0.032	3.628ProGlu: 3.628 ± 0.036	2.152ProPhe: 2.152 ± 0.023	3.841ProGly: 3.841 ± 0.033	1.525ProHis: 1.525 ± 0.023	2.813ProIle: 2.813 ± 0.029	2.805ProLys: 2.805 ± 0.032	5.072ProLeu: 5.072 ± 0.043	1.046ProMet: 1.046 ± 0.016	2.467ProAsn: 2.467 ± 0.027	5.682ProPro: 5.682 ± 0.079	2.658ProGln: 2.658 ± 0.036	3.619ProArg: 3.619 ± 0.034	6.625ProSer: 6.625 ± 0.059	4.188ProThr: 4.188 ± 0.044	3.397ProVal: 3.397 ± 0.035	0.688ProTrp: 0.688 ± 0.015	1.48ProTyr: 1.48 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.057GlnAla: 3.057 ± 0.03	0.456GlnCys: 0.456 ± 0.013	1.918GlnAsp: 1.918 ± 0.023	2.389GlnGlu: 2.389 ± 0.029	1.316GlnPhe: 1.316 ± 0.017	2.315GlnGly: 2.315 ± 0.029	1.205GlnHis: 1.205 ± 0.024	1.987GlnIle: 1.987 ± 0.024	2.146GlnLys: 2.146 ± 0.023	3.563GlnLeu: 3.563 ± 0.038	0.854GlnMet: 0.854 ± 0.014	1.73GlnAsn: 1.73 ± 0.024	2.738GlnPro: 2.738 ± 0.032	2.689GlnGln: 2.689 ± 0.056	2.905GlnArg: 2.905 ± 0.03	3.298GlnSer: 3.298 ± 0.033	2.323GlnThr: 2.323 ± 0.03	2.027GlnVal: 2.027 ± 0.024	0.491GlnTrp: 0.491 ± 0.012	1.074GlnTyr: 1.074 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	4.635ArgAla: 4.635 ± 0.04	0.825ArgCys: 0.825 ± 0.015	3.46ArgAsp: 3.46 ± 0.033	4.037ArgGlu: 4.037 ± 0.041	2.185ArgPhe: 2.185 ± 0.02	4.039ArgGly: 4.039 ± 0.036	1.697ArgHis: 1.697 ± 0.026	3.225ArgIle: 3.225 ± 0.032	3.9ArgLys: 3.9 ± 0.035	5.646ArgLeu: 5.646 ± 0.041	1.413ArgMet: 1.413 ± 0.021	2.653ArgAsn: 2.653 ± 0.028	3.592ArgPro: 3.592 ± 0.034	2.803ArgGln: 2.803 ± 0.029	5.633ArgArg: 5.633 ± 0.055	5.345ArgSer: 5.345 ± 0.053	3.441ArgThr: 3.441 ± 0.028	3.444ArgVal: 3.444 ± 0.032	0.919ArgTrp: 0.919 ± 0.017	1.739ArgTyr: 1.739 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	6.577SerAla: 6.577 ± 0.041	1.011SerCys: 1.011 ± 0.019	4.259SerAsp: 4.259 ± 0.039	4.267SerGlu: 4.267 ± 0.037	3.162SerPhe: 3.162 ± 0.031	5.701SerGly: 5.701 ± 0.045	2.318SerHis: 2.318 ± 0.032	4.35SerIle: 4.35 ± 0.04	4.134SerLys: 4.134 ± 0.038	7.719SerLeu: 7.719 ± 0.049	1.801SerMet: 1.801 ± 0.02	3.555SerAsn: 3.555 ± 0.036	6.342SerPro: 6.342 ± 0.06	3.626SerGln: 3.626 ± 0.033	5.771SerArg: 5.771 ± 0.047	10.115SerSer: 10.115 ± 0.094	5.916SerThr: 5.916 ± 0.045	4.536SerVal: 4.536 ± 0.031	1.111SerTrp: 1.111 ± 0.017	2.014SerTyr: 2.014 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	4.832ThrAla: 4.832 ± 0.036	0.73ThrCys: 0.73 ± 0.015	2.761ThrAsp: 2.761 ± 0.031	3.04ThrGlu: 3.04 ± 0.028	2.164ThrPhe: 2.164 ± 0.023	3.956ThrGly: 3.956 ± 0.036	1.36ThrHis: 1.36 ± 0.017	3.094ThrIle: 3.094 ± 0.029	2.675ThrLys: 2.675 ± 0.027	5.112ThrLeu: 5.112 ± 0.043	1.124ThrMet: 1.124 ± 0.019	2.257ThrAsn: 2.257 ± 0.026	4.356ThrPro: 4.356 ± 0.044	2.07ThrGln: 2.07 ± 0.028	3.281ThrArg: 3.281 ± 0.034	5.749ThrSer: 5.749 ± 0.049	4.401ThrThr: 4.401 ± 0.047	3.382ThrVal: 3.382 ± 0.028	0.723ThrTrp: 0.723 ± 0.015	1.45ThrTyr: 1.45 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	4.703ValAla: 4.703 ± 0.044	0.794ValCys: 0.794 ± 0.016	3.63ValAsp: 3.63 ± 0.031	3.815ValGlu: 3.815 ± 0.035	2.254ValPhe: 2.254 ± 0.025	3.838ValGly: 3.838 ± 0.036	1.335ValHis: 1.335 ± 0.019	2.909ValIle: 2.909 ± 0.028	2.844ValLys: 2.844 ± 0.03	5.209ValLeu: 5.209 ± 0.04	1.232ValMet: 1.232 ± 0.019	2.165ValAsn: 2.165 ± 0.024	3.395ValPro: 3.395 ± 0.031	2.167ValGln: 2.167 ± 0.02	3.353ValArg: 3.353 ± 0.031	4.649ValSer: 4.649 ± 0.036	3.245ValThr: 3.245 ± 0.031	3.997ValVal: 3.997 ± 0.039	0.792ValTrp: 0.792 ± 0.014	1.513ValTyr: 1.513 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.018TrpAla: 1.018 ± 0.016	0.174TrpCys: 0.174 ± 0.007	0.804TrpAsp: 0.804 ± 0.018	0.85TrpGlu: 0.85 ± 0.016	0.46TrpPhe: 0.46 ± 0.012	0.808TrpGly: 0.808 ± 0.017	0.337TrpHis: 0.337 ± 0.009	0.703TrpIle: 0.703 ± 0.015	0.806TrpLys: 0.806 ± 0.016	1.259TrpLeu: 1.259 ± 0.021	0.342TrpMet: 0.342 ± 0.01	0.6TrpAsn: 0.6 ± 0.012	0.57TrpPro: 0.57 ± 0.013	0.5TrpGln: 0.5 ± 0.01	0.976TrpArg: 0.976 ± 0.017	0.975TrpSer: 0.975 ± 0.017	0.765TrpThr: 0.765 ± 0.014	0.793TrpVal: 0.793 ± 0.016	0.247TrpTrp: 0.247 ± 0.009	0.356TrpTyr: 0.356 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.824TyrAla: 1.824 ± 0.024	0.409TyrCys: 0.409 ± 0.011	1.514TyrAsp: 1.514 ± 0.023	1.441TyrGlu: 1.441 ± 0.02	1.161TyrPhe: 1.161 ± 0.017	1.868TyrGly: 1.868 ± 0.026	0.753TyrHis: 0.753 ± 0.014	1.457TyrIle: 1.457 ± 0.022	1.076TyrLys: 1.076 ± 0.017	2.577TyrLeu: 2.577 ± 0.03	0.586TyrMet: 0.586 ± 0.012	1.025TyrAsn: 1.025 ± 0.018	1.57TyrPro: 1.57 ± 0.025	1.064TyrGln: 1.064 ± 0.018	1.628TyrArg: 1.628 ± 0.022	2.073TyrSer: 2.073 ± 0.027	1.45TyrThr: 1.45 ± 0.022	1.479TyrVal: 1.479 ± 0.02	0.374TyrTrp: 0.374 ± 0.01	0.842TyrTyr: 0.842 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9545 proteins (3861477 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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