Amino acid dipepetide frequency for Butyrivibrio proteoclasticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.054AlaAla: 6.054 ± 0.106	0.991AlaCys: 0.991 ± 0.031	4.729AlaAsp: 4.729 ± 0.064	4.851AlaGlu: 4.851 ± 0.075	3.247AlaPhe: 3.247 ± 0.055	5.293AlaGly: 5.293 ± 0.098	1.004AlaHis: 1.004 ± 0.033	5.532AlaIle: 5.532 ± 0.068	4.789AlaLys: 4.789 ± 0.073	6.452AlaLeu: 6.452 ± 0.077	2.236AlaMet: 2.236 ± 0.046	2.752AlaAsn: 2.752 ± 0.057	1.906AlaPro: 1.906 ± 0.063	1.969AlaGln: 1.969 ± 0.046	2.514AlaArg: 2.514 ± 0.046	4.28AlaSer: 4.28 ± 0.07	3.532AlaThr: 3.532 ± 0.065	5.413AlaVal: 5.413 ± 0.074	0.586AlaTrp: 0.586 ± 0.022	2.76AlaTyr: 2.76 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.935CysAla: 0.935 ± 0.027	0.245CysCys: 0.245 ± 0.015	0.967CysAsp: 0.967 ± 0.032	0.809CysGlu: 0.809 ± 0.023	0.675CysPhe: 0.675 ± 0.024	1.369CysGly: 1.369 ± 0.039	0.261CysHis: 0.261 ± 0.015	1.111CysIle: 1.111 ± 0.029	0.863CysLys: 0.863 ± 0.028	1.067CysLeu: 1.067 ± 0.03	0.404CysMet: 0.404 ± 0.018	0.634CysAsn: 0.634 ± 0.023	0.542CysPro: 0.542 ± 0.024	0.326CysGln: 0.326 ± 0.017	0.524CysArg: 0.524 ± 0.021	0.875CysSer: 0.875 ± 0.028	0.635CysThr: 0.635 ± 0.022	0.875CysVal: 0.875 ± 0.028	0.122CysTrp: 0.122 ± 0.011	0.605CysTyr: 0.605 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	4.374AspAla: 4.374 ± 0.066	0.744AspCys: 0.744 ± 0.027	3.988AspAsp: 3.988 ± 0.068	5.605AspGlu: 5.605 ± 0.078	3.045AspPhe: 3.045 ± 0.05	4.765AspGly: 4.765 ± 0.083	0.911AspHis: 0.911 ± 0.03	5.408AspIle: 5.408 ± 0.076	4.707AspLys: 4.707 ± 0.066	4.67AspLeu: 4.67 ± 0.069	2.015AspMet: 2.015 ± 0.044	3.111AspAsn: 3.111 ± 0.053	1.866AspPro: 1.866 ± 0.046	1.276AspGln: 1.276 ± 0.032	2.51AspArg: 2.51 ± 0.05	3.724AspSer: 3.724 ± 0.06	3.159AspThr: 3.159 ± 0.055	4.289AspVal: 4.289 ± 0.059	0.64AspTrp: 0.64 ± 0.028	3.43AspTyr: 3.43 ± 0.069	0.0AspXaa: 0.0 ± 0.0
Glu	5.143GluAla: 5.143 ± 0.078	0.822GluCys: 0.822 ± 0.028	4.579GluAsp: 4.579 ± 0.075	5.975GluGlu: 5.975 ± 0.089	2.814GluPhe: 2.814 ± 0.048	4.159GluGly: 4.159 ± 0.07	1.227GluHis: 1.227 ± 0.035	5.758GluIle: 5.758 ± 0.061	6.802GluLys: 6.802 ± 0.091	6.433GluLeu: 6.433 ± 0.084	2.257GluMet: 2.257 ± 0.046	4.373GluAsn: 4.373 ± 0.064	1.674GluPro: 1.674 ± 0.041	2.21GluGln: 2.21 ± 0.05	2.842GluArg: 2.842 ± 0.05	3.788GluSer: 3.788 ± 0.059	3.514GluThr: 3.514 ± 0.064	4.333GluVal: 4.333 ± 0.071	0.644GluTrp: 0.644 ± 0.024	3.449GluTyr: 3.449 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	3.011PheAla: 3.011 ± 0.048	0.752PheCys: 0.752 ± 0.027	3.125PheAsp: 3.125 ± 0.058	2.982PheGlu: 2.982 ± 0.051	2.327PhePhe: 2.327 ± 0.058	3.155PheGly: 3.155 ± 0.053	0.673PheHis: 0.673 ± 0.022	3.433PheIle: 3.433 ± 0.068	2.599PheLys: 2.599 ± 0.051	3.944PheLeu: 3.944 ± 0.07	1.33PheMet: 1.33 ± 0.034	2.001PheAsn: 2.001 ± 0.044	1.342PhePro: 1.342 ± 0.032	0.947PheGln: 0.947 ± 0.031	1.621PheArg: 1.621 ± 0.036	3.149PheSer: 3.149 ± 0.063	2.441PheThr: 2.441 ± 0.046	3.2PheVal: 3.2 ± 0.055	0.484PheTrp: 0.484 ± 0.025	1.996PheTyr: 1.996 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.697GlyAla: 4.697 ± 0.08	1.133GlyCys: 1.133 ± 0.029	3.816GlyAsp: 3.816 ± 0.059	4.236GlyGlu: 4.236 ± 0.063	3.291GlyPhe: 3.291 ± 0.059	4.24GlyGly: 4.24 ± 0.074	1.19GlyHis: 1.19 ± 0.033	6.14GlyIle: 6.14 ± 0.081	5.422GlyLys: 5.422 ± 0.074	5.422GlyLeu: 5.422 ± 0.08	2.203GlyMet: 2.203 ± 0.049	3.428GlyAsn: 3.428 ± 0.064	1.176GlyPro: 1.176 ± 0.037	1.815GlyGln: 1.815 ± 0.041	2.567GlyArg: 2.567 ± 0.045	4.072GlySer: 4.072 ± 0.071	3.871GlyThr: 3.871 ± 0.061	4.574GlyVal: 4.574 ± 0.062	0.667GlyTrp: 0.667 ± 0.027	3.416GlyTyr: 3.416 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	0.976HisAla: 0.976 ± 0.03	0.241HisCys: 0.241 ± 0.014	1.015HisAsp: 1.015 ± 0.032	1.094HisGlu: 1.094 ± 0.031	0.809HisPhe: 0.809 ± 0.026	1.163HisGly: 1.163 ± 0.03	0.361HisHis: 0.361 ± 0.028	1.3HisIle: 1.3 ± 0.036	0.966HisLys: 0.966 ± 0.031	1.288HisLeu: 1.288 ± 0.036	0.507HisMet: 0.507 ± 0.019	0.783HisAsn: 0.783 ± 0.024	0.693HisPro: 0.693 ± 0.026	0.42HisGln: 0.42 ± 0.017	0.662HisArg: 0.662 ± 0.025	0.939HisSer: 0.939 ± 0.031	0.816HisThr: 0.816 ± 0.029	1.082HisVal: 1.082 ± 0.033	0.159HisTrp: 0.159 ± 0.011	0.78HisTyr: 0.78 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.827IleAla: 5.827 ± 0.087	1.346IleCys: 1.346 ± 0.029	5.151IleAsp: 5.151 ± 0.074	5.242IleGlu: 5.242 ± 0.065	3.191IlePhe: 3.191 ± 0.054	5.078IleGly: 5.078 ± 0.067	1.237IleHis: 1.237 ± 0.033	6.158IleIle: 6.158 ± 0.102	5.213IleLys: 5.213 ± 0.068	6.673IleLeu: 6.673 ± 0.102	2.212IleMet: 2.212 ± 0.048	3.672IleAsn: 3.672 ± 0.062	3.119IlePro: 3.119 ± 0.057	1.896IleGln: 1.896 ± 0.041	3.222IleArg: 3.222 ± 0.054	5.814IleSer: 5.814 ± 0.084	4.547IleThr: 4.547 ± 0.063	5.404IleVal: 5.404 ± 0.071	0.646IleTrp: 0.646 ± 0.025	3.27IleTyr: 3.27 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	5.309LysAla: 5.309 ± 0.091	0.801LysCys: 0.801 ± 0.028	4.774LysAsp: 4.774 ± 0.063	6.834LysGlu: 6.834 ± 0.087	2.273LysPhe: 2.273 ± 0.038	4.093LysGly: 4.093 ± 0.062	1.103LysHis: 1.103 ± 0.033	5.104LysIle: 5.104 ± 0.062	6.593LysLys: 6.593 ± 0.085	5.812LysLeu: 5.812 ± 0.067	2.181LysMet: 2.181 ± 0.044	4.061LysAsn: 4.061 ± 0.062	1.936LysPro: 1.936 ± 0.04	1.939LysGln: 1.939 ± 0.045	3.198LysArg: 3.198 ± 0.056	3.831LysSer: 3.831 ± 0.065	3.734LysThr: 3.734 ± 0.057	4.493LysVal: 4.493 ± 0.06	0.679LysTrp: 0.679 ± 0.025	3.389LysTyr: 3.389 ± 0.054	0.0LysXaa: 0.0 ± 0.0
Leu	5.89LeuAla: 5.89 ± 0.075	1.331LeuCys: 1.331 ± 0.034	5.19LeuAsp: 5.19 ± 0.076	5.563LeuGlu: 5.563 ± 0.076	4.15LeuPhe: 4.15 ± 0.08	5.497LeuGly: 5.497 ± 0.067	1.327LeuHis: 1.327 ± 0.032	6.311LeuIle: 6.311 ± 0.095	6.101LeuLys: 6.101 ± 0.073	7.663LeuLeu: 7.663 ± 0.124	2.563LeuMet: 2.563 ± 0.051	4.021LeuAsn: 4.021 ± 0.062	2.968LeuPro: 2.968 ± 0.055	2.293LeuGln: 2.293 ± 0.048	3.263LeuArg: 3.263 ± 0.059	6.483LeuSer: 6.483 ± 0.085	4.579LeuThr: 4.579 ± 0.071	5.378LeuVal: 5.378 ± 0.079	0.731LeuTrp: 0.731 ± 0.026	3.484LeuTyr: 3.484 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.37MetAla: 2.37 ± 0.049	0.364MetCys: 0.364 ± 0.018	1.9MetAsp: 1.9 ± 0.04	2.035MetGlu: 2.035 ± 0.042	1.116MetPhe: 1.116 ± 0.032	1.957MetGly: 1.957 ± 0.048	0.518MetHis: 0.518 ± 0.024	2.356MetIle: 2.356 ± 0.047	2.224MetLys: 2.224 ± 0.037	2.667MetLeu: 2.667 ± 0.046	0.961MetMet: 0.961 ± 0.032	1.669MetAsn: 1.669 ± 0.035	1.134MetPro: 1.134 ± 0.042	0.954MetGln: 0.954 ± 0.031	1.19MetArg: 1.19 ± 0.034	1.996MetSer: 1.996 ± 0.041	1.712MetThr: 1.712 ± 0.037	1.936MetVal: 1.936 ± 0.038	0.245MetTrp: 0.245 ± 0.015	1.051MetTyr: 1.051 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.396AsnAla: 3.396 ± 0.064	0.643AsnCys: 0.643 ± 0.024	2.902AsnAsp: 2.902 ± 0.052	3.466AsnGlu: 3.466 ± 0.065	1.819AsnPhe: 1.819 ± 0.039	3.845AsnGly: 3.845 ± 0.059	0.809AsnHis: 0.809 ± 0.029	3.951AsnIle: 3.951 ± 0.076	3.141AsnLys: 3.141 ± 0.048	3.837AsnLeu: 3.837 ± 0.062	1.552AsnMet: 1.552 ± 0.034	2.495AsnAsn: 2.495 ± 0.056	1.992AsnPro: 1.992 ± 0.046	1.265AsnGln: 1.265 ± 0.032	2.004AsnArg: 2.004 ± 0.044	3.127AsnSer: 3.127 ± 0.06	2.589AsnThr: 2.589 ± 0.046	3.442AsnVal: 3.442 ± 0.058	0.484AsnTrp: 0.484 ± 0.02	2.269AsnTyr: 2.269 ± 0.056	0.0AsnXaa: 0.0 ± 0.0
Pro	2.08ProAla: 2.08 ± 0.055	0.371ProCys: 0.371 ± 0.017	2.36ProAsp: 2.36 ± 0.045	2.894ProGlu: 2.894 ± 0.056	1.519ProPhe: 1.519 ± 0.037	1.96ProGly: 1.96 ± 0.047	0.496ProHis: 0.496 ± 0.02	2.19ProIle: 2.19 ± 0.044	1.813ProLys: 1.813 ± 0.043	2.532ProLeu: 2.532 ± 0.045	0.863ProMet: 0.863 ± 0.026	1.228ProAsn: 1.228 ± 0.033	0.568ProPro: 0.568 ± 0.022	0.898ProGln: 0.898 ± 0.031	0.926ProArg: 0.926 ± 0.032	1.926ProSer: 1.926 ± 0.045	1.476ProThr: 1.476 ± 0.041	2.582ProVal: 2.582 ± 0.059	0.33ProTrp: 0.33 ± 0.016	1.427ProTyr: 1.427 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	1.794GlnAla: 1.794 ± 0.043	0.278GlnCys: 0.278 ± 0.014	1.454GlnAsp: 1.454 ± 0.036	1.948GlnGlu: 1.948 ± 0.042	1.091GlnPhe: 1.091 ± 0.032	1.603GlnGly: 1.603 ± 0.035	0.413GlnHis: 0.413 ± 0.018	2.272GlnIle: 2.272 ± 0.046	2.198GlnLys: 2.198 ± 0.049	2.262GlnLeu: 2.262 ± 0.046	0.965GlnMet: 0.965 ± 0.03	1.454GlnAsn: 1.454 ± 0.037	0.7GlnPro: 0.7 ± 0.023	0.884GlnGln: 0.884 ± 0.031	1.101GlnArg: 1.101 ± 0.031	1.526GlnSer: 1.526 ± 0.035	1.409GlnThr: 1.409 ± 0.034	1.635GlnVal: 1.635 ± 0.032	0.238GlnTrp: 0.238 ± 0.014	1.238GlnTyr: 1.238 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	2.551ArgAla: 2.551 ± 0.051	0.525ArgCys: 0.525 ± 0.023	2.302ArgAsp: 2.302 ± 0.044	2.987ArgGlu: 2.987 ± 0.056	1.819ArgPhe: 1.819 ± 0.042	2.204ArgGly: 2.204 ± 0.055	0.719ArgHis: 0.719 ± 0.026	3.352ArgIle: 3.352 ± 0.061	3.149ArgLys: 3.149 ± 0.055	3.309ArgLeu: 3.309 ± 0.061	1.326ArgMet: 1.326 ± 0.031	2.144ArgAsn: 2.144 ± 0.041	1.127ArgPro: 1.127 ± 0.036	1.228ArgGln: 1.228 ± 0.035	1.711ArgArg: 1.711 ± 0.043	2.044ArgSer: 2.044 ± 0.041	1.968ArgThr: 1.968 ± 0.04	2.419ArgVal: 2.419 ± 0.041	0.37ArgTrp: 0.37 ± 0.019	1.794ArgTyr: 1.794 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.37SerAla: 4.37 ± 0.074	0.775SerCys: 0.775 ± 0.022	4.33SerAsp: 4.33 ± 0.067	4.608SerGlu: 4.608 ± 0.061	3.378SerPhe: 3.378 ± 0.057	4.927SerGly: 4.927 ± 0.073	0.979SerHis: 0.979 ± 0.029	4.777SerIle: 4.777 ± 0.07	4.139SerLys: 4.139 ± 0.059	5.285SerLeu: 5.285 ± 0.076	1.829SerMet: 1.829 ± 0.043	2.826SerAsn: 2.826 ± 0.062	1.7SerPro: 1.7 ± 0.039	1.715SerGln: 1.715 ± 0.038	2.477SerArg: 2.477 ± 0.044	4.445SerSer: 4.445 ± 0.111	3.224SerThr: 3.224 ± 0.065	4.477SerVal: 4.477 ± 0.076	0.602SerTrp: 0.602 ± 0.022	2.803SerTyr: 2.803 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	3.9ThrAla: 3.9 ± 0.074	0.617ThrCys: 0.617 ± 0.022	3.607ThrAsp: 3.607 ± 0.063	3.507ThrGlu: 3.507 ± 0.055	2.32ThrPhe: 2.32 ± 0.05	4.234ThrGly: 4.234 ± 0.066	0.793ThrHis: 0.793 ± 0.028	4.23ThrIle: 4.23 ± 0.071	3.221ThrLys: 3.221 ± 0.056	4.516ThrLeu: 4.516 ± 0.064	1.343ThrMet: 1.343 ± 0.036	2.306ThrAsn: 2.306 ± 0.053	1.902ThrPro: 1.902 ± 0.053	1.382ThrGln: 1.382 ± 0.033	1.847ThrArg: 1.847 ± 0.044	3.314ThrSer: 3.314 ± 0.065	2.931ThrThr: 2.931 ± 0.063	4.189ThrVal: 4.189 ± 0.067	0.511ThrTrp: 0.511 ± 0.021	2.259ThrTyr: 2.259 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	4.85ValAla: 4.85 ± 0.085	1.095ValCys: 1.095 ± 0.033	4.224ValAsp: 4.224 ± 0.064	4.286ValGlu: 4.286 ± 0.068	3.152ValPhe: 3.152 ± 0.061	4.045ValGly: 4.045 ± 0.07	1.001ValHis: 1.001 ± 0.026	5.472ValIle: 5.472 ± 0.074	4.658ValLys: 4.658 ± 0.065	6.366ValLeu: 6.366 ± 0.084	2.044ValMet: 2.044 ± 0.044	3.213ValAsn: 3.213 ± 0.051	2.38ValPro: 2.38 ± 0.047	1.539ValGln: 1.539 ± 0.032	2.563ValArg: 2.563 ± 0.045	4.854ValSer: 4.854 ± 0.075	4.003ValThr: 4.003 ± 0.082	4.99ValVal: 4.99 ± 0.07	0.603ValTrp: 0.603 ± 0.021	2.826ValTyr: 2.826 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.544TrpAla: 0.544 ± 0.027	0.17TrpCys: 0.17 ± 0.013	0.585TrpAsp: 0.585 ± 0.025	0.6TrpGlu: 0.6 ± 0.022	0.417TrpPhe: 0.417 ± 0.02	0.652TrpGly: 0.652 ± 0.026	0.222TrpHis: 0.222 ± 0.015	0.705TrpIle: 0.705 ± 0.024	0.654TrpLys: 0.654 ± 0.026	0.819TrpLeu: 0.819 ± 0.027	0.305TrpMet: 0.305 ± 0.015	0.625TrpAsn: 0.625 ± 0.024	0.235TrpPro: 0.235 ± 0.016	0.323TrpGln: 0.323 ± 0.016	0.356TrpArg: 0.356 ± 0.018	0.523TrpSer: 0.523 ± 0.022	0.464TrpThr: 0.464 ± 0.026	0.555TrpVal: 0.555 ± 0.02	0.13TrpTrp: 0.13 ± 0.011	0.431TrpTyr: 0.431 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.821TyrAla: 2.821 ± 0.051	0.602TyrCys: 0.602 ± 0.022	3.24TyrAsp: 3.24 ± 0.055	3.273TyrGlu: 3.273 ± 0.057	2.056TyrPhe: 2.056 ± 0.046	3.137TyrGly: 3.137 ± 0.057	0.809TyrHis: 0.809 ± 0.024	3.359TyrIle: 3.359 ± 0.057	2.884TyrLys: 2.884 ± 0.053	3.768TyrLeu: 3.768 ± 0.061	1.259TyrMet: 1.259 ± 0.035	2.229TyrAsn: 2.229 ± 0.041	1.48TyrPro: 1.48 ± 0.039	1.183TyrGln: 1.183 ± 0.035	1.952TyrArg: 1.952 ± 0.04	2.957TyrSer: 2.957 ± 0.054	2.325TyrThr: 2.325 ± 0.049	2.898TyrVal: 2.898 ± 0.046	0.445TyrTrp: 0.445 ± 0.019	2.362TyrTyr: 2.362 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3761 proteins (1231681 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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