Amino acid dipepetide frequency for Burkholderiales bacterium PBB2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.311AlaAla: 19.311 ± 0.178	1.366AlaCys: 1.366 ± 0.035	6.134AlaAsp: 6.134 ± 0.062	7.906AlaGlu: 7.906 ± 0.088	3.785AlaPhe: 3.785 ± 0.052	10.966AlaGly: 10.966 ± 0.115	2.595AlaHis: 2.595 ± 0.047	4.241AlaIle: 4.241 ± 0.052	3.755AlaLys: 3.755 ± 0.065	16.876AlaLeu: 16.876 ± 0.172	3.159AlaMet: 3.159 ± 0.044	2.728AlaAsn: 2.728 ± 0.05	6.737AlaPro: 6.737 ± 0.092	7.429AlaGln: 7.429 ± 0.087	9.252AlaArg: 9.252 ± 0.108	7.962AlaSer: 7.962 ± 0.084	5.284AlaThr: 5.284 ± 0.068	8.262AlaVal: 8.262 ± 0.074	2.327AlaTrp: 2.327 ± 0.043	2.463AlaTyr: 2.463 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	1.109CysAla: 1.109 ± 0.027	0.113CysCys: 0.113 ± 0.007	0.449CysAsp: 0.449 ± 0.018	0.522CysGlu: 0.522 ± 0.019	0.314CysPhe: 0.314 ± 0.015	0.938CysGly: 0.938 ± 0.028	0.241CysHis: 0.241 ± 0.012	0.339CysIle: 0.339 ± 0.016	0.222CysLys: 0.222 ± 0.012	0.988CysLeu: 0.988 ± 0.026	0.182CysMet: 0.182 ± 0.011	0.227CysAsn: 0.227 ± 0.012	0.479CysPro: 0.479 ± 0.022	0.327CysGln: 0.327 ± 0.016	0.61CysArg: 0.61 ± 0.021	0.598CysSer: 0.598 ± 0.021	0.414CysThr: 0.414 ± 0.018	0.643CysVal: 0.643 ± 0.023	0.125CysTrp: 0.125 ± 0.009	0.184CysTyr: 0.184 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.547AspAla: 6.547 ± 0.064	0.463AspCys: 0.463 ± 0.021	2.144AspAsp: 2.144 ± 0.043	3.084AspGlu: 3.084 ± 0.045	1.969AspPhe: 1.969 ± 0.038	4.42AspGly: 4.42 ± 0.06	1.013AspHis: 1.013 ± 0.027	2.025AspIle: 2.025 ± 0.036	1.522AspLys: 1.522 ± 0.039	5.619AspLeu: 5.619 ± 0.067	1.031AspMet: 1.031 ± 0.025	1.077AspAsn: 1.077 ± 0.025	2.654AspPro: 2.654 ± 0.041	1.87AspGln: 1.87 ± 0.045	3.011AspArg: 3.011 ± 0.049	2.564AspSer: 2.564 ± 0.044	2.075AspThr: 2.075 ± 0.042	3.157AspVal: 3.157 ± 0.051	1.051AspTrp: 1.051 ± 0.026	1.257AspTyr: 1.257 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	7.935GluAla: 7.935 ± 0.089	0.357GluCys: 0.357 ± 0.015	2.304GluAsp: 2.304 ± 0.039	2.381GluGlu: 2.381 ± 0.039	1.853GluPhe: 1.853 ± 0.034	4.146GluGly: 4.146 ± 0.056	1.341GluHis: 1.341 ± 0.027	2.374GluIle: 2.374 ± 0.047	1.477GluLys: 1.477 ± 0.04	7.287GluLeu: 7.287 ± 0.091	1.102GluMet: 1.102 ± 0.025	1.086GluAsn: 1.086 ± 0.025	2.727GluPro: 2.727 ± 0.043	3.202GluGln: 3.202 ± 0.06	4.991GluArg: 4.991 ± 0.068	2.526GluSer: 2.526 ± 0.044	2.186GluThr: 2.186 ± 0.039	3.898GluVal: 3.898 ± 0.053	0.703GluTrp: 0.703 ± 0.021	0.891GluTyr: 0.891 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.968PheAla: 3.968 ± 0.052	0.374PheCys: 0.374 ± 0.016	2.249PheAsp: 2.249 ± 0.037	2.274PheGlu: 2.274 ± 0.044	1.277PhePhe: 1.277 ± 0.031	3.101PheGly: 3.101 ± 0.05	0.705PheHis: 0.705 ± 0.023	1.295PheIle: 1.295 ± 0.031	1.283PheLys: 1.283 ± 0.028	2.75PheLeu: 2.75 ± 0.046	0.728PheMet: 0.728 ± 0.023	1.13PheAsn: 1.13 ± 0.029	1.285PhePro: 1.285 ± 0.029	1.183PheGln: 1.183 ± 0.028	1.758PheArg: 1.758 ± 0.035	2.385PheSer: 2.385 ± 0.046	1.589PheThr: 1.589 ± 0.033	2.417PheVal: 2.417 ± 0.04	0.538PheTrp: 0.538 ± 0.018	0.806PheTyr: 0.806 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.252GlyAla: 9.252 ± 0.099	0.857GlyCys: 0.857 ± 0.025	3.851GlyAsp: 3.851 ± 0.058	4.658GlyGlu: 4.658 ± 0.055	3.164GlyPhe: 3.164 ± 0.042	7.16GlyGly: 7.16 ± 0.221	1.889GlyHis: 1.889 ± 0.04	3.112GlyIle: 3.112 ± 0.049	2.768GlyLys: 2.768 ± 0.054	10.874GlyLeu: 10.874 ± 0.098	1.973GlyMet: 1.973 ± 0.035	2.089GlyAsn: 2.089 ± 0.046	3.29GlyPro: 3.29 ± 0.048	4.324GlyGln: 4.324 ± 0.052	6.012GlyArg: 6.012 ± 0.065	5.403GlySer: 5.403 ± 0.097	3.707GlyThr: 3.707 ± 0.062	5.786GlyVal: 5.786 ± 0.065	1.506GlyTrp: 1.506 ± 0.03	2.086GlyTyr: 2.086 ± 0.044	0.002GlyXaa: 0.002 ± 0.001
His	2.71HisAla: 2.71 ± 0.047	0.295HisCys: 0.295 ± 0.014	0.964HisAsp: 0.964 ± 0.024	1.252HisGlu: 1.252 ± 0.032	0.848HisPhe: 0.848 ± 0.024	2.056HisGly: 2.056 ± 0.041	0.568HisHis: 0.568 ± 0.023	0.826HisIle: 0.826 ± 0.025	0.582HisLys: 0.582 ± 0.018	2.431HisLeu: 2.431 ± 0.043	0.393HisMet: 0.393 ± 0.015	0.455HisAsn: 0.455 ± 0.015	1.365HisPro: 1.365 ± 0.032	0.884HisGln: 0.884 ± 0.025	1.46HisArg: 1.46 ± 0.034	1.274HisSer: 1.274 ± 0.03	0.883HisThr: 0.883 ± 0.025	1.352HisVal: 1.352 ± 0.034	0.409HisTrp: 0.409 ± 0.016	0.575HisTyr: 0.575 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	4.968IleAla: 4.968 ± 0.065	0.4IleCys: 0.4 ± 0.017	2.477IleAsp: 2.477 ± 0.042	2.817IleGlu: 2.817 ± 0.048	1.066IlePhe: 1.066 ± 0.027	3.538IleGly: 3.538 ± 0.052	0.809IleHis: 0.809 ± 0.021	1.252IleIle: 1.252 ± 0.033	1.453IleLys: 1.453 ± 0.034	2.833IleLeu: 2.833 ± 0.048	0.571IleMet: 0.571 ± 0.018	1.341IleAsn: 1.341 ± 0.027	1.663IlePro: 1.663 ± 0.038	1.45IleGln: 1.45 ± 0.035	2.164IleArg: 2.164 ± 0.038	2.59IleSer: 2.59 ± 0.046	2.086IleThr: 2.086 ± 0.04	2.549IleVal: 2.549 ± 0.043	0.486IleTrp: 0.486 ± 0.02	0.827IleTyr: 0.827 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.836LysAla: 3.836 ± 0.069	0.125LysCys: 0.125 ± 0.009	1.493LysAsp: 1.493 ± 0.038	1.269LysGlu: 1.269 ± 0.03	0.878LysPhe: 0.878 ± 0.025	2.176LysGly: 2.176 ± 0.048	0.602LysHis: 0.602 ± 0.021	1.258LysIle: 1.258 ± 0.03	1.246LysLys: 1.246 ± 0.04	3.526LysLeu: 3.526 ± 0.058	0.598LysMet: 0.598 ± 0.024	0.953LysAsn: 0.953 ± 0.025	2.224LysPro: 2.224 ± 0.044	1.243LysGln: 1.243 ± 0.032	2.069LysArg: 2.069 ± 0.041	1.782LysSer: 1.782 ± 0.037	1.769LysThr: 1.769 ± 0.033	2.069LysVal: 2.069 ± 0.038	0.27LysTrp: 0.27 ± 0.012	0.54LysTyr: 0.54 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	16.638LeuAla: 16.638 ± 0.133	1.078LeuCys: 1.078 ± 0.027	6.297LeuAsp: 6.297 ± 0.067	5.433LeuGlu: 5.433 ± 0.066	3.311LeuPhe: 3.311 ± 0.051	9.747LeuGly: 9.747 ± 0.101	2.499LeuHis: 2.499 ± 0.047	4.36LeuIle: 4.36 ± 0.053	3.812LeuLys: 3.812 ± 0.051	13.703LeuLeu: 13.703 ± 0.144	2.709LeuMet: 2.709 ± 0.044	3.287LeuAsn: 3.287 ± 0.057	6.991LeuPro: 6.991 ± 0.088	6.127LeuGln: 6.127 ± 0.07	9.333LeuArg: 9.333 ± 0.101	8.54LeuSer: 8.54 ± 0.108	4.789LeuThr: 4.789 ± 0.059	7.142LeuVal: 7.142 ± 0.078	1.559LeuTrp: 1.559 ± 0.036	1.973LeuTyr: 1.973 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.879MetAla: 2.879 ± 0.041	0.152MetCys: 0.152 ± 0.01	1.08MetAsp: 1.08 ± 0.028	0.94MetGlu: 0.94 ± 0.028	0.631MetPhe: 0.631 ± 0.022	1.701MetGly: 1.701 ± 0.034	0.456MetHis: 0.456 ± 0.016	0.738MetIle: 0.738 ± 0.022	0.875MetLys: 0.875 ± 0.018	2.449MetLeu: 2.449 ± 0.043	0.468MetMet: 0.468 ± 0.018	0.803MetAsn: 0.803 ± 0.021	1.355MetPro: 1.355 ± 0.03	1.049MetGln: 1.049 ± 0.027	1.543MetArg: 1.543 ± 0.03	1.736MetSer: 1.736 ± 0.032	1.171MetThr: 1.171 ± 0.028	1.465MetVal: 1.465 ± 0.034	0.198MetTrp: 0.198 ± 0.01	0.296MetTyr: 0.296 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.132AsnAla: 3.132 ± 0.047	0.23AsnCys: 0.23 ± 0.013	1.144AsnAsp: 1.144 ± 0.029	1.308AsnGlu: 1.308 ± 0.03	0.942AsnPhe: 0.942 ± 0.026	2.269AsnGly: 2.269 ± 0.047	0.504AsnHis: 0.504 ± 0.016	1.025AsnIle: 1.025 ± 0.026	0.795AsnLys: 0.795 ± 0.023	2.784AsnLeu: 2.784 ± 0.046	0.459AsnMet: 0.459 ± 0.018	0.803AsnAsn: 0.803 ± 0.03	1.718AsnPro: 1.718 ± 0.035	1.0AsnGln: 1.0 ± 0.029	1.511AsnArg: 1.511 ± 0.031	1.55AsnSer: 1.55 ± 0.043	1.409AsnThr: 1.409 ± 0.035	1.571AsnVal: 1.571 ± 0.036	0.413AsnTrp: 0.413 ± 0.019	0.663AsnTyr: 0.663 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	8.022ProAla: 8.022 ± 0.1	0.385ProCys: 0.385 ± 0.016	2.727ProAsp: 2.727 ± 0.048	3.811ProGlu: 3.811 ± 0.058	1.608ProPhe: 1.608 ± 0.034	4.887ProGly: 4.887 ± 0.06	1.026ProHis: 1.026 ± 0.026	1.646ProIle: 1.646 ± 0.029	1.492ProLys: 1.492 ± 0.036	5.734ProLeu: 5.734 ± 0.067	1.246ProMet: 1.246 ± 0.027	1.19ProAsn: 1.19 ± 0.029	2.789ProPro: 2.789 ± 0.055	2.423ProGln: 2.423 ± 0.04	3.113ProArg: 3.113 ± 0.053	3.302ProSer: 3.302 ± 0.051	2.286ProThr: 2.286 ± 0.038	3.968ProVal: 3.968 ± 0.054	0.851ProTrp: 0.851 ± 0.024	0.953ProTyr: 0.953 ± 0.023	0.001ProXaa: 0.001 ± 0.001
Gln	7.947GlnAla: 7.947 ± 0.093	0.283GlnCys: 0.283 ± 0.013	1.963GlnAsp: 1.963 ± 0.034	1.919GlnGlu: 1.919 ± 0.039	1.398GlnPhe: 1.398 ± 0.031	4.056GlnGly: 4.056 ± 0.054	1.08GlnHis: 1.08 ± 0.027	2.018GlnIle: 2.018 ± 0.052	0.978GlnLys: 0.978 ± 0.028	5.914GlnLeu: 5.914 ± 0.082	1.007GlnMet: 1.007 ± 0.026	0.882GlnAsn: 0.882 ± 0.027	2.685GlnPro: 2.685 ± 0.045	2.589GlnGln: 2.589 ± 0.048	4.3GlnArg: 4.3 ± 0.059	2.378GlnSer: 2.378 ± 0.05	2.185GlnThr: 2.185 ± 0.036	3.409GlnVal: 3.409 ± 0.062	0.73GlnTrp: 0.73 ± 0.022	0.684GlnTyr: 0.684 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.313ArgAla: 8.313 ± 0.083	0.678ArgCys: 0.678 ± 0.022	3.28ArgAsp: 3.28 ± 0.05	4.475ArgGlu: 4.475 ± 0.059	2.71ArgPhe: 2.71 ± 0.044	4.745ArgGly: 4.745 ± 0.061	1.878ArgHis: 1.878 ± 0.035	3.046ArgIle: 3.046 ± 0.043	1.741ArgLys: 1.741 ± 0.034	9.198ArgLeu: 9.198 ± 0.096	1.799ArgMet: 1.799 ± 0.035	1.63ArgAsn: 1.63 ± 0.032	3.558ArgPro: 3.558 ± 0.063	3.575ArgGln: 3.575 ± 0.053	5.428ArgArg: 5.428 ± 0.083	4.285ArgSer: 4.285 ± 0.058	2.505ArgThr: 2.505 ± 0.042	4.874ArgVal: 4.874 ± 0.067	1.4ArgTrp: 1.4 ± 0.031	1.808ArgTyr: 1.808 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	7.897SerAla: 7.897 ± 0.083	0.54SerCys: 0.54 ± 0.019	2.842SerAsp: 2.842 ± 0.054	3.149SerGlu: 3.149 ± 0.045	2.287SerPhe: 2.287 ± 0.044	5.809SerGly: 5.809 ± 0.089	1.286SerHis: 1.286 ± 0.031	2.235SerIle: 2.235 ± 0.047	1.782SerLys: 1.782 ± 0.042	7.478SerLeu: 7.478 ± 0.078	1.256SerMet: 1.256 ± 0.031	1.667SerAsn: 1.667 ± 0.039	3.395SerPro: 3.395 ± 0.05	2.543SerGln: 2.543 ± 0.043	4.004SerArg: 4.004 ± 0.047	4.465SerSer: 4.465 ± 0.095	3.052SerThr: 3.052 ± 0.065	3.811SerVal: 3.811 ± 0.054	1.046SerTrp: 1.046 ± 0.03	1.411SerTyr: 1.411 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.498ThrAla: 5.498 ± 0.074	0.296ThrCys: 0.296 ± 0.014	1.935ThrAsp: 1.935 ± 0.039	2.296ThrGlu: 2.296 ± 0.041	1.237ThrPhe: 1.237 ± 0.032	4.091ThrGly: 4.091 ± 0.065	0.929ThrHis: 0.929 ± 0.025	1.564ThrIle: 1.564 ± 0.035	1.002ThrLys: 1.002 ± 0.03	5.813ThrLeu: 5.813 ± 0.07	0.854ThrMet: 0.854 ± 0.027	0.996ThrAsn: 0.996 ± 0.031	3.356ThrPro: 3.356 ± 0.051	2.019ThrGln: 2.019 ± 0.044	2.871ThrArg: 2.871 ± 0.042	2.367ThrSer: 2.367 ± 0.053	2.137ThrThr: 2.137 ± 0.057	3.788ThrVal: 3.788 ± 0.055	0.587ThrTrp: 0.587 ± 0.02	0.81ThrTyr: 0.81 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	8.385ValAla: 8.385 ± 0.076	0.662ValCys: 0.662 ± 0.02	3.612ValAsp: 3.612 ± 0.051	3.763ValGlu: 3.763 ± 0.05	2.463ValPhe: 2.463 ± 0.041	4.984ValGly: 4.984 ± 0.057	1.441ValHis: 1.441 ± 0.033	2.725ValIle: 2.725 ± 0.041	2.096ValLys: 2.096 ± 0.041	8.307ValLeu: 8.307 ± 0.084	1.643ValMet: 1.643 ± 0.032	1.899ValAsn: 1.899 ± 0.041	3.42ValPro: 3.42 ± 0.048	3.21ValGln: 3.21 ± 0.05	4.424ValArg: 4.424 ± 0.057	4.101ValSer: 4.101 ± 0.059	3.083ValThr: 3.083 ± 0.052	4.834ValVal: 4.834 ± 0.069	1.004ValTrp: 1.004 ± 0.027	1.402ValTyr: 1.402 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.767TrpAla: 1.767 ± 0.038	0.168TrpCys: 0.168 ± 0.011	0.629TrpAsp: 0.629 ± 0.023	0.5TrpGlu: 0.5 ± 0.02	0.492TrpPhe: 0.492 ± 0.017	1.118TrpGly: 1.118 ± 0.027	0.351TrpHis: 0.351 ± 0.015	0.559TrpIle: 0.559 ± 0.021	0.406TrpLys: 0.406 ± 0.017	2.41TrpLeu: 2.41 ± 0.05	0.449TrpMet: 0.449 ± 0.018	0.397TrpAsn: 0.397 ± 0.015	0.813TrpPro: 0.813 ± 0.024	0.999TrpGln: 0.999 ± 0.027	1.444TrpArg: 1.444 ± 0.034	0.937TrpSer: 0.937 ± 0.027	0.728TrpThr: 0.728 ± 0.025	1.107TrpVal: 1.107 ± 0.029	0.298TrpTrp: 0.298 ± 0.013	0.268TrpTyr: 0.268 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.423TyrAla: 2.423 ± 0.041	0.203TyrCys: 0.203 ± 0.012	0.981TyrAsp: 0.981 ± 0.027	1.012TyrGlu: 1.012 ± 0.022	0.86TyrPhe: 0.86 ± 0.023	1.857TyrGly: 1.857 ± 0.037	0.366TyrHis: 0.366 ± 0.018	0.702TyrIle: 0.702 ± 0.02	0.637TyrLys: 0.637 ± 0.022	2.355TyrLeu: 2.355 ± 0.04	0.361TyrMet: 0.361 ± 0.016	0.589TyrAsn: 0.589 ± 0.023	0.954TyrPro: 0.954 ± 0.026	0.963TyrGln: 0.963 ± 0.029	1.624TyrArg: 1.624 ± 0.034	1.207TyrSer: 1.207 ± 0.032	1.107TyrThr: 1.107 ± 0.029	1.358TyrVal: 1.358 ± 0.028	0.335TyrTrp: 0.335 ± 0.016	0.484TyrTyr: 0.484 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.005XaaXaa: 0.005 ± 0.002

Statistics based on 4553 proteins (1629190 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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