Amino acid dipepetide frequency for Paenibacillus ferrarius

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.286AlaAla: 8.286 ± 0.087
0.685AlaCys: 0.685 ± 0.018
4.008AlaAsp: 4.008 ± 0.041
4.882AlaGlu: 4.882 ± 0.05
3.383AlaPhe: 3.383 ± 0.035
6.078AlaGly: 6.078 ± 0.073
1.415AlaHis: 1.415 ± 0.028
5.688AlaIle: 5.688 ± 0.059
4.534AlaLys: 4.534 ± 0.048
7.897AlaLeu: 7.897 ± 0.066
2.171AlaMet: 2.171 ± 0.032
3.115AlaAsn: 3.115 ± 0.043
2.665AlaPro: 2.665 ± 0.034
2.883AlaGln: 2.883 ± 0.035
3.033AlaArg: 3.033 ± 0.038
5.433AlaSer: 5.433 ± 0.063
4.091AlaThr: 4.091 ± 0.072
5.912AlaVal: 5.912 ± 0.07
0.973AlaTrp: 0.973 ± 0.017
2.735AlaTyr: 2.735 ± 0.037
0.0AlaXaa: 0.0 ± 0.0
Cys
0.47CysAla: 0.47 ± 0.014
0.105CysCys: 0.105 ± 0.007
0.365CysAsp: 0.365 ± 0.012
0.43CysGlu: 0.43 ± 0.013
0.342CysPhe: 0.342 ± 0.013
0.665CysGly: 0.665 ± 0.017
0.181CysHis: 0.181 ± 0.008
0.489CysIle: 0.489 ± 0.014
0.338CysLys: 0.338 ± 0.011
0.795CysLeu: 0.795 ± 0.019
0.217CysMet: 0.217 ± 0.01
0.26CysAsn: 0.26 ± 0.011
0.294CysPro: 0.294 ± 0.011
0.23CysGln: 0.23 ± 0.01
0.366CysArg: 0.366 ± 0.012
0.594CysSer: 0.594 ± 0.015
0.399CysThr: 0.399 ± 0.012
0.451CysVal: 0.451 ± 0.012
0.099CysTrp: 0.099 ± 0.007
0.273CysTyr: 0.273 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
3.885AspAla: 3.885 ± 0.044
0.366AspCys: 0.366 ± 0.012
2.364AspAsp: 2.364 ± 0.037
3.521AspGlu: 3.521 ± 0.045
2.204AspPhe: 2.204 ± 0.033
3.888AspGly: 3.888 ± 0.045
1.171AspHis: 1.171 ± 0.023
3.612AspIle: 3.612 ± 0.039
2.894AspLys: 2.894 ± 0.037
4.855AspLeu: 4.855 ± 0.048
1.374AspMet: 1.374 ± 0.022
2.014AspAsn: 2.014 ± 0.03
2.138AspPro: 2.138 ± 0.033
2.125AspGln: 2.125 ± 0.028
2.353AspArg: 2.353 ± 0.027
2.942AspSer: 2.942 ± 0.035
2.587AspThr: 2.587 ± 0.034
3.437AspVal: 3.437 ± 0.037
0.866AspTrp: 0.866 ± 0.019
2.149AspTyr: 2.149 ± 0.028
0.0AspXaa: 0.0 ± 0.0
Glu
5.438GluAla: 5.438 ± 0.054
0.348GluCys: 0.348 ± 0.013
2.906GluAsp: 2.906 ± 0.04
4.424GluGlu: 4.424 ± 0.064
2.201GluPhe: 2.201 ± 0.036
3.842GluGly: 3.842 ± 0.045
1.461GluHis: 1.461 ± 0.025
4.277GluIle: 4.277 ± 0.045
3.931GluLys: 3.931 ± 0.05
6.722GluLeu: 6.722 ± 0.063
1.846GluMet: 1.846 ± 0.027
2.445GluAsn: 2.445 ± 0.037
1.953GluPro: 1.953 ± 0.033
3.432GluGln: 3.432 ± 0.039
3.252GluArg: 3.252 ± 0.045
3.421GluSer: 3.421 ± 0.041
3.227GluThr: 3.227 ± 0.039
4.132GluVal: 4.132 ± 0.054
0.863GluTrp: 0.863 ± 0.019
1.807GluTyr: 1.807 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
3.26PheAla: 3.26 ± 0.038
0.343PheCys: 0.343 ± 0.011
2.314PheAsp: 2.314 ± 0.033
2.383PheGlu: 2.383 ± 0.031
1.93PhePhe: 1.93 ± 0.033
3.105PheGly: 3.105 ± 0.046
0.992PheHis: 0.992 ± 0.02
3.218PheIle: 3.218 ± 0.042
2.219PheLys: 2.219 ± 0.032
4.094PheLeu: 4.094 ± 0.053
1.157PheMet: 1.157 ± 0.023
1.797PheAsn: 1.797 ± 0.029
1.665PhePro: 1.665 ± 0.027
1.677PheGln: 1.677 ± 0.026
1.867PheArg: 1.867 ± 0.026
3.015PheSer: 3.015 ± 0.038
2.639PheThr: 2.639 ± 0.033
3.025PheVal: 3.025 ± 0.04
0.531PheTrp: 0.531 ± 0.015
1.584PheTyr: 1.584 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
5.272GlyAla: 5.272 ± 0.086
0.673GlyCys: 0.673 ± 0.016
3.314GlyAsp: 3.314 ± 0.037
3.827GlyGlu: 3.827 ± 0.049
3.198GlyPhe: 3.198 ± 0.042
4.9GlyGly: 4.9 ± 0.063
1.454GlyHis: 1.454 ± 0.024
5.583GlyIle: 5.583 ± 0.051
4.531GlyLys: 4.531 ± 0.042
6.94GlyLeu: 6.94 ± 0.057
2.067GlyMet: 2.067 ± 0.03
2.984GlyAsn: 2.984 ± 0.052
1.724GlyPro: 1.724 ± 0.033
2.565GlyGln: 2.565 ± 0.034
2.855GlyArg: 2.855 ± 0.04
4.826GlySer: 4.826 ± 0.057
4.599GlyThr: 4.599 ± 0.062
4.952GlyVal: 4.952 ± 0.059
1.059GlyTrp: 1.059 ± 0.021
2.903GlyTyr: 2.903 ± 0.032
0.0GlyXaa: 0.0 ± 0.0
His
1.592HisAla: 1.592 ± 0.024
0.176HisCys: 0.176 ± 0.009
1.028HisAsp: 1.028 ± 0.022
1.218HisGlu: 1.218 ± 0.021
1.116HisPhe: 1.116 ± 0.02
1.381HisGly: 1.381 ± 0.025
0.607HisHis: 0.607 ± 0.019
1.544HisIle: 1.544 ± 0.025
0.964HisLys: 0.964 ± 0.02
2.211HisLeu: 2.211 ± 0.032
0.608HisMet: 0.608 ± 0.017
0.756HisAsn: 0.756 ± 0.018
1.133HisPro: 1.133 ± 0.021
0.878HisGln: 0.878 ± 0.02
1.011HisArg: 1.011 ± 0.023
1.233HisSer: 1.233 ± 0.022
1.122HisThr: 1.122 ± 0.023
1.489HisVal: 1.489 ± 0.026
0.341HisTrp: 0.341 ± 0.013
0.926HisTyr: 0.926 ± 0.016
0.0HisXaa: 0.0 ± 0.0
Ile
5.889IleAla: 5.889 ± 0.061
0.657IleCys: 0.657 ± 0.017
3.786IleAsp: 3.786 ± 0.041
4.367IleGlu: 4.367 ± 0.048
2.609IlePhe: 2.609 ± 0.038
5.325IleGly: 5.325 ± 0.054
1.651IleHis: 1.651 ± 0.025
4.6IleIle: 4.6 ± 0.058
3.428IleLys: 3.428 ± 0.038
6.275IleLeu: 6.275 ± 0.066
1.743IleMet: 1.743 ± 0.023
2.74IleAsn: 2.74 ± 0.041
3.22IlePro: 3.22 ± 0.038
2.995IleGln: 2.995 ± 0.036
3.561IleArg: 3.561 ± 0.041
5.074IleSer: 5.074 ± 0.045
4.231IleThr: 4.231 ± 0.043
5.254IleVal: 5.254 ± 0.053
0.81IleTrp: 0.81 ± 0.017
2.258IleTyr: 2.258 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
4.49LysAla: 4.49 ± 0.043
0.24LysCys: 0.24 ± 0.011
3.278LysAsp: 3.278 ± 0.038
4.345LysGlu: 4.345 ± 0.05
1.864LysPhe: 1.864 ± 0.028
3.714LysGly: 3.714 ± 0.039
1.194LysHis: 1.194 ± 0.024
3.495LysIle: 3.495 ± 0.041
3.73LysLys: 3.73 ± 0.054
5.823LysLeu: 5.823 ± 0.057
1.812LysMet: 1.812 ± 0.025
2.397LysAsn: 2.397 ± 0.04
2.338LysPro: 2.338 ± 0.031
2.883LysGln: 2.883 ± 0.04
2.571LysArg: 2.571 ± 0.038
3.434LysSer: 3.434 ± 0.037
3.029LysThr: 3.029 ± 0.031
3.965LysVal: 3.965 ± 0.042
0.784LysTrp: 0.784 ± 0.018
1.893LysTyr: 1.893 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
8.043LeuAla: 8.043 ± 0.07
0.823LeuCys: 0.823 ± 0.019
5.037LeuAsp: 5.037 ± 0.05
5.852LeuGlu: 5.852 ± 0.054
4.677LeuPhe: 4.677 ± 0.06
6.488LeuGly: 6.488 ± 0.057
2.221LeuHis: 2.221 ± 0.027
6.961LeuIle: 6.961 ± 0.068
5.603LeuLys: 5.603 ± 0.052
11.049LeuLeu: 11.049 ± 0.098
2.584LeuMet: 2.584 ± 0.035
4.275LeuAsn: 4.275 ± 0.048
4.427LeuPro: 4.427 ± 0.046
4.45LeuGln: 4.45 ± 0.042
4.534LeuArg: 4.534 ± 0.046
7.301LeuSer: 7.301 ± 0.05
6.013LeuThr: 6.013 ± 0.05
6.35LeuVal: 6.35 ± 0.06
1.084LeuTrp: 1.084 ± 0.022
3.232LeuTyr: 3.232 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
2.075MetAla: 2.075 ± 0.03
0.158MetCys: 0.158 ± 0.008
1.506MetAsp: 1.506 ± 0.022
1.678MetGlu: 1.678 ± 0.025
1.073MetPhe: 1.073 ± 0.023
1.714MetGly: 1.714 ± 0.026
0.5MetHis: 0.5 ± 0.016
1.998MetIle: 1.998 ± 0.026
2.154MetLys: 2.154 ± 0.031
2.889MetLeu: 2.889 ± 0.038
0.887MetMet: 0.887 ± 0.019
1.574MetAsn: 1.574 ± 0.026
1.161MetPro: 1.161 ± 0.022
1.074MetGln: 1.074 ± 0.023
1.218MetArg: 1.218 ± 0.019
1.812MetSer: 1.812 ± 0.026
1.707MetThr: 1.707 ± 0.027
1.701MetVal: 1.701 ± 0.026
0.256MetTrp: 0.256 ± 0.009
0.777MetTyr: 0.777 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.976AsnAla: 2.976 ± 0.039
0.28AsnCys: 0.28 ± 0.011
2.098AsnAsp: 2.098 ± 0.031
2.73AsnGlu: 2.73 ± 0.037
1.591AsnPhe: 1.591 ± 0.025
3.406AsnGly: 3.406 ± 0.058
0.955AsnHis: 0.955 ± 0.018
2.63AsnIle: 2.63 ± 0.038
2.522AsnLys: 2.522 ± 0.038
3.798AsnLeu: 3.798 ± 0.041
1.109AsnMet: 1.109 ± 0.024
1.936AsnAsn: 1.936 ± 0.034
2.149AsnPro: 2.149 ± 0.031
1.857AsnGln: 1.857 ± 0.029
2.015AsnArg: 2.015 ± 0.03
2.56AsnSer: 2.56 ± 0.041
2.299AsnThr: 2.299 ± 0.037
2.873AsnVal: 2.873 ± 0.035
0.655AsnTrp: 0.655 ± 0.018
1.651AsnTyr: 1.651 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
3.17ProAla: 3.17 ± 0.047
0.213ProCys: 0.213 ± 0.011
2.34ProAsp: 2.34 ± 0.033
2.727ProGlu: 2.727 ± 0.036
1.894ProPhe: 1.894 ± 0.027
2.473ProGly: 2.473 ± 0.036
0.898ProHis: 0.898 ± 0.017
2.784ProIle: 2.784 ± 0.028
1.914ProLys: 1.914 ± 0.028
3.94ProLeu: 3.94 ± 0.044
0.962ProMet: 0.962 ± 0.02
1.695ProAsn: 1.695 ± 0.03
1.122ProPro: 1.122 ± 0.022
1.431ProGln: 1.431 ± 0.025
1.245ProArg: 1.245 ± 0.025
2.697ProSer: 2.697 ± 0.033
2.247ProThr: 2.247 ± 0.033
2.91ProVal: 2.91 ± 0.031
0.49ProTrp: 0.49 ± 0.014
1.566ProTyr: 1.566 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
3.602GlnAla: 3.602 ± 0.041
0.201GlnCys: 0.201 ± 0.01
1.903GlnAsp: 1.903 ± 0.029
2.642GlnGlu: 2.642 ± 0.04
1.698GlnPhe: 1.698 ± 0.025
2.695GlnGly: 2.695 ± 0.035
0.872GlnHis: 0.872 ± 0.019
2.921GlnIle: 2.921 ± 0.035
2.27GlnLys: 2.27 ± 0.029
4.639GlnLeu: 4.639 ± 0.051
1.267GlnMet: 1.267 ± 0.021
1.545GlnAsn: 1.545 ± 0.025
1.518GlnPro: 1.518 ± 0.024
2.051GlnGln: 2.051 ± 0.041
1.769GlnArg: 1.769 ± 0.028
2.536GlnSer: 2.536 ± 0.033
2.342GlnThr: 2.342 ± 0.031
2.821GlnVal: 2.821 ± 0.037
0.574GlnTrp: 0.574 ± 0.015
1.35GlnTyr: 1.35 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
2.942ArgAla: 2.942 ± 0.042
0.318ArgCys: 0.318 ± 0.012
2.121ArgAsp: 2.121 ± 0.031
3.068ArgGlu: 3.068 ± 0.045
2.044ArgPhe: 2.044 ± 0.032
2.557ArgGly: 2.557 ± 0.033
0.89ArgHis: 0.89 ± 0.022
3.514ArgIle: 3.514 ± 0.04
2.894ArgLys: 2.894 ± 0.035
4.585ArgLeu: 4.585 ± 0.047
1.488ArgMet: 1.488 ± 0.026
1.982ArgAsn: 1.982 ± 0.028
1.377ArgPro: 1.377 ± 0.028
1.793ArgGln: 1.793 ± 0.027
2.052ArgArg: 2.052 ± 0.032
2.804ArgSer: 2.804 ± 0.037
2.434ArgThr: 2.434 ± 0.027
2.857ArgVal: 2.857 ± 0.035
0.623ArgTrp: 0.623 ± 0.016
1.704ArgTyr: 1.704 ± 0.024
0.0ArgXaa: 0.0 ± 0.0
Ser
4.946SerAla: 4.946 ± 0.054
0.436SerCys: 0.436 ± 0.015
3.286SerAsp: 3.286 ± 0.037
3.793SerGlu: 3.793 ± 0.041
3.218SerPhe: 3.218 ± 0.034
5.38SerGly: 5.38 ± 0.063
1.277SerHis: 1.277 ± 0.023
4.763SerIle: 4.763 ± 0.05
3.646SerLys: 3.646 ± 0.045
6.923SerLeu: 6.923 ± 0.055
1.864SerMet: 1.864 ± 0.025
2.759SerAsn: 2.759 ± 0.038
2.534SerPro: 2.534 ± 0.034
2.377SerGln: 2.377 ± 0.036
2.745SerArg: 2.745 ± 0.036
5.072SerSer: 5.072 ± 0.067
3.749SerThr: 3.749 ± 0.05
4.602SerVal: 4.602 ± 0.045
0.898SerTrp: 0.898 ± 0.021
2.543SerTyr: 2.543 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
4.79ThrAla: 4.79 ± 0.057
0.358ThrCys: 0.358 ± 0.013
2.926ThrAsp: 2.926 ± 0.04
3.086ThrGlu: 3.086 ± 0.037
2.598ThrPhe: 2.598 ± 0.031
4.54ThrGly: 4.54 ± 0.098
1.074ThrHis: 1.074 ± 0.022
4.272ThrIle: 4.272 ± 0.044
2.9ThrLys: 2.9 ± 0.037
5.749ThrLeu: 5.749 ± 0.052
1.444ThrMet: 1.444 ± 0.024
2.473ThrAsn: 2.473 ± 0.038
2.602ThrPro: 2.602 ± 0.04
1.846ThrGln: 1.846 ± 0.026
2.122ThrArg: 2.122 ± 0.031
3.885ThrSer: 3.885 ± 0.047
3.396ThrThr: 3.396 ± 0.05
4.437ThrVal: 4.437 ± 0.066
0.74ThrTrp: 0.74 ± 0.02
2.247ThrTyr: 2.247 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
5.178ValAla: 5.178 ± 0.053
0.593ValCys: 0.593 ± 0.015
3.682ValAsp: 3.682 ± 0.037
3.987ValGlu: 3.987 ± 0.05
2.894ValPhe: 2.894 ± 0.035
4.598ValGly: 4.598 ± 0.045
1.44ValHis: 1.44 ± 0.023
5.017ValIle: 5.017 ± 0.05
4.126ValLys: 4.126 ± 0.046
6.753ValLeu: 6.753 ± 0.063
1.9ValMet: 1.9 ± 0.026
3.026ValAsn: 3.026 ± 0.042
2.809ValPro: 2.809 ± 0.037
2.699ValGln: 2.699 ± 0.036
3.039ValArg: 3.039 ± 0.036
5.001ValSer: 5.001 ± 0.053
4.546ValThr: 4.546 ± 0.074
4.96ValVal: 4.96 ± 0.056
0.867ValTrp: 0.867 ± 0.019
2.438ValTyr: 2.438 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
0.872TrpAla: 0.872 ± 0.022
0.102TrpCys: 0.102 ± 0.008
0.701TrpAsp: 0.701 ± 0.017
0.736TrpGlu: 0.736 ± 0.019
0.575TrpPhe: 0.575 ± 0.016
0.882TrpGly: 0.882 ± 0.022
0.309TrpHis: 0.309 ± 0.012
0.93TrpIle: 0.93 ± 0.019
0.794TrpLys: 0.794 ± 0.017
1.439TrpLeu: 1.439 ± 0.025
0.442TrpMet: 0.442 ± 0.012
0.754TrpAsn: 0.754 ± 0.019
0.365TrpPro: 0.365 ± 0.01
0.574TrpGln: 0.574 ± 0.015
0.573TrpArg: 0.573 ± 0.015
0.875TrpSer: 0.875 ± 0.021
0.745TrpThr: 0.745 ± 0.02
0.886TrpVal: 0.886 ± 0.021
0.183TrpTrp: 0.183 ± 0.008
0.456TrpTyr: 0.456 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.692TyrAla: 2.692 ± 0.036
0.288TyrCys: 0.288 ± 0.011
1.781TyrAsp: 1.781 ± 0.033
2.234TyrGlu: 2.234 ± 0.032
1.705TyrPhe: 1.705 ± 0.026
2.594TyrGly: 2.594 ± 0.036
0.774TyrHis: 0.774 ± 0.018
2.174TyrIle: 2.174 ± 0.03
1.884TyrLys: 1.884 ± 0.033
3.626TyrLeu: 3.626 ± 0.041
0.97TyrMet: 0.97 ± 0.023
1.566TyrAsn: 1.566 ± 0.032
1.527TyrPro: 1.527 ± 0.028
1.4TyrGln: 1.4 ± 0.026
1.863TyrArg: 1.863 ± 0.028
2.297TyrSer: 2.297 ± 0.03
2.084TyrThr: 2.084 ± 0.032
2.538TyrVal: 2.538 ± 0.034
0.496TyrTrp: 0.496 ± 0.017
1.439TyrTyr: 1.439 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.001XaaSer: 0.001 ± 0.001
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7849 proteins (2589470 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski