Amino acid dipepetide frequency for Eoetvoesia caeni

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.145AlaAla: 15.145 ± 0.159	1.231AlaCys: 1.231 ± 0.033	5.991AlaAsp: 5.991 ± 0.076	5.856AlaGlu: 5.856 ± 0.072	3.788AlaPhe: 3.788 ± 0.059	9.751AlaGly: 9.751 ± 0.114	2.457AlaHis: 2.457 ± 0.041	5.684AlaIle: 5.684 ± 0.083	3.998AlaLys: 3.998 ± 0.067	13.06AlaLeu: 13.06 ± 0.122	3.346AlaMet: 3.346 ± 0.048	3.077AlaAsn: 3.077 ± 0.053	5.174AlaPro: 5.174 ± 0.074	5.616AlaGln: 5.616 ± 0.075	7.341AlaArg: 7.341 ± 0.095	6.576AlaSer: 6.576 ± 0.092	5.575AlaThr: 5.575 ± 0.078	8.159AlaVal: 8.159 ± 0.08	1.701AlaTrp: 1.701 ± 0.036	2.725AlaTyr: 2.725 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.05CysAla: 1.05 ± 0.029	0.156CysCys: 0.156 ± 0.011	0.508CysAsp: 0.508 ± 0.022	0.481CysGlu: 0.481 ± 0.019	0.323CysPhe: 0.323 ± 0.014	0.965CysGly: 0.965 ± 0.029	0.272CysHis: 0.272 ± 0.014	0.477CysIle: 0.477 ± 0.017	0.268CysLys: 0.268 ± 0.013	0.905CysLeu: 0.905 ± 0.026	0.217CysMet: 0.217 ± 0.012	0.25CysAsn: 0.25 ± 0.014	0.541CysPro: 0.541 ± 0.022	0.3CysGln: 0.3 ± 0.013	0.56CysArg: 0.56 ± 0.019	0.551CysSer: 0.551 ± 0.021	0.51CysThr: 0.51 ± 0.017	0.733CysVal: 0.733 ± 0.026	0.115CysTrp: 0.115 ± 0.009	0.251CysTyr: 0.251 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.162AspAla: 6.162 ± 0.075	0.474AspCys: 0.474 ± 0.019	2.888AspAsp: 2.888 ± 0.056	3.302AspGlu: 3.302 ± 0.046	1.969AspPhe: 1.969 ± 0.037	4.253AspGly: 4.253 ± 0.073	1.161AspHis: 1.161 ± 0.032	2.887AspIle: 2.887 ± 0.045	1.952AspLys: 1.952 ± 0.041	5.33AspLeu: 5.33 ± 0.068	1.293AspMet: 1.293 ± 0.029	1.427AspAsn: 1.427 ± 0.035	2.93AspPro: 2.93 ± 0.046	1.844AspGln: 1.844 ± 0.035	3.176AspArg: 3.176 ± 0.047	2.81AspSer: 2.81 ± 0.048	2.76AspThr: 2.76 ± 0.063	3.748AspVal: 3.748 ± 0.067	0.958AspTrp: 0.958 ± 0.026	1.577AspTyr: 1.577 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.928GluAla: 5.928 ± 0.073	0.431GluCys: 0.431 ± 0.017	2.349GluAsp: 2.349 ± 0.041	2.467GluGlu: 2.467 ± 0.05	1.884GluPhe: 1.884 ± 0.043	3.681GluGly: 3.681 ± 0.054	1.552GluHis: 1.552 ± 0.039	3.008GluIle: 3.008 ± 0.053	2.163GluLys: 2.163 ± 0.048	5.786GluLeu: 5.786 ± 0.061	1.301GluMet: 1.301 ± 0.027	1.668GluAsn: 1.668 ± 0.035	2.582GluPro: 2.582 ± 0.042	2.986GluGln: 2.986 ± 0.052	4.271GluArg: 4.271 ± 0.054	2.873GluSer: 2.873 ± 0.044	2.746GluThr: 2.746 ± 0.043	3.695GluVal: 3.695 ± 0.05	0.715GluTrp: 0.715 ± 0.022	1.258GluTyr: 1.258 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.787PheAla: 3.787 ± 0.057	0.389PheCys: 0.389 ± 0.018	2.39PheAsp: 2.39 ± 0.044	2.062PheGlu: 2.062 ± 0.044	1.414PhePhe: 1.414 ± 0.035	3.222PheGly: 3.222 ± 0.05	0.757PheHis: 0.757 ± 0.024	1.813PheIle: 1.813 ± 0.042	1.306PheLys: 1.306 ± 0.037	3.33PheLeu: 3.33 ± 0.054	0.891PheMet: 0.891 ± 0.025	1.273PheAsn: 1.273 ± 0.032	1.526PhePro: 1.526 ± 0.034	1.162PheGln: 1.162 ± 0.031	1.855PheArg: 1.855 ± 0.036	2.437PheSer: 2.437 ± 0.045	1.91PheThr: 1.91 ± 0.039	2.637PheVal: 2.637 ± 0.05	0.536PheTrp: 0.536 ± 0.021	0.977PheTyr: 0.977 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	7.949GlyAla: 7.949 ± 0.088	0.828GlyCys: 0.828 ± 0.028	3.835GlyAsp: 3.835 ± 0.069	4.047GlyGlu: 4.047 ± 0.055	3.198GlyPhe: 3.198 ± 0.054	6.286GlyGly: 6.286 ± 0.084	1.912GlyHis: 1.912 ± 0.04	4.443GlyIle: 4.443 ± 0.068	3.669GlyLys: 3.669 ± 0.056	8.747GlyLeu: 8.747 ± 0.093	2.412GlyMet: 2.412 ± 0.05	2.384GlyAsn: 2.384 ± 0.06	3.041GlyPro: 3.041 ± 0.048	3.586GlyGln: 3.586 ± 0.057	5.052GlyArg: 5.052 ± 0.062	4.628GlySer: 4.628 ± 0.068	4.318GlyThr: 4.318 ± 0.07	6.046GlyVal: 6.046 ± 0.068	1.334GlyTrp: 1.334 ± 0.026	2.409GlyTyr: 2.409 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.617HisAla: 2.617 ± 0.046	0.269HisCys: 0.269 ± 0.014	1.285HisAsp: 1.285 ± 0.034	1.304HisGlu: 1.304 ± 0.033	0.868HisPhe: 0.868 ± 0.024	2.05HisGly: 2.05 ± 0.041	0.614HisHis: 0.614 ± 0.022	1.223HisIle: 1.223 ± 0.028	0.646HisLys: 0.646 ± 0.022	2.196HisLeu: 2.196 ± 0.044	0.546HisMet: 0.546 ± 0.021	0.664HisAsn: 0.664 ± 0.024	1.396HisPro: 1.396 ± 0.03	0.772HisGln: 0.772 ± 0.021	1.357HisArg: 1.357 ± 0.037	1.224HisSer: 1.224 ± 0.026	1.16HisThr: 1.16 ± 0.032	1.572HisVal: 1.572 ± 0.033	0.413HisTrp: 0.413 ± 0.016	0.723HisTyr: 0.723 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.387IleAla: 6.387 ± 0.069	0.479IleCys: 0.479 ± 0.02	3.39IleAsp: 3.39 ± 0.048	3.468IleGlu: 3.468 ± 0.056	1.578IlePhe: 1.578 ± 0.041	4.437IleGly: 4.437 ± 0.076	0.979IleHis: 0.979 ± 0.027	2.446IleIle: 2.446 ± 0.049	1.928IleLys: 1.928 ± 0.037	4.278IleLeu: 4.278 ± 0.057	1.062IleMet: 1.062 ± 0.031	1.712IleAsn: 1.712 ± 0.038	2.437IlePro: 2.437 ± 0.04	1.719IleGln: 1.719 ± 0.033	2.934IleArg: 2.934 ± 0.043	3.047IleSer: 3.047 ± 0.048	2.942IleThr: 2.942 ± 0.056	4.076IleVal: 4.076 ± 0.063	0.638IleTrp: 0.638 ± 0.022	1.22IleTyr: 1.22 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.102LysAla: 4.102 ± 0.072	0.187LysCys: 0.187 ± 0.012	1.804LysAsp: 1.804 ± 0.043	1.848LysGlu: 1.848 ± 0.04	1.014LysPhe: 1.014 ± 0.026	2.613LysGly: 2.613 ± 0.048	0.829LysHis: 0.829 ± 0.026	1.771LysIle: 1.771 ± 0.041	1.584LysLys: 1.584 ± 0.044	3.768LysLeu: 3.768 ± 0.052	0.902LysMet: 0.902 ± 0.027	1.192LysAsn: 1.192 ± 0.03	2.137LysPro: 2.137 ± 0.039	1.59LysGln: 1.59 ± 0.034	2.367LysArg: 2.367 ± 0.041	2.045LysSer: 2.045 ± 0.038	2.203LysThr: 2.203 ± 0.04	2.698LysVal: 2.698 ± 0.046	0.429LysTrp: 0.429 ± 0.017	0.761LysTyr: 0.761 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.684LeuAla: 13.684 ± 0.129	1.036LeuCys: 1.036 ± 0.028	5.88LeuAsp: 5.88 ± 0.059	5.452LeuGlu: 5.452 ± 0.066	3.704LeuPhe: 3.704 ± 0.057	8.495LeuGly: 8.495 ± 0.093	2.267LeuHis: 2.267 ± 0.047	5.242LeuIle: 5.242 ± 0.082	3.839LeuLys: 3.839 ± 0.056	10.94LeuLeu: 10.94 ± 0.14	2.483LeuMet: 2.483 ± 0.038	3.245LeuAsn: 3.245 ± 0.053	5.746LeuPro: 5.746 ± 0.075	3.871LeuGln: 3.871 ± 0.059	7.173LeuArg: 7.173 ± 0.075	6.712LeuSer: 6.712 ± 0.069	5.343LeuThr: 5.343 ± 0.067	7.326LeuVal: 7.326 ± 0.074	1.235LeuTrp: 1.235 ± 0.037	2.396LeuTyr: 2.396 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.072MetAla: 3.072 ± 0.052	0.17MetCys: 0.17 ± 0.012	1.08MetAsp: 1.08 ± 0.031	1.063MetGlu: 1.063 ± 0.028	0.777MetPhe: 0.777 ± 0.025	1.91MetGly: 1.91 ± 0.04	0.627MetHis: 0.627 ± 0.023	1.087MetIle: 1.087 ± 0.029	1.023MetLys: 1.023 ± 0.03	2.835MetLeu: 2.835 ± 0.059	0.613MetMet: 0.613 ± 0.024	0.953MetAsn: 0.953 ± 0.026	1.52MetPro: 1.52 ± 0.034	1.22MetGln: 1.22 ± 0.031	1.688MetArg: 1.688 ± 0.033	1.801MetSer: 1.801 ± 0.031	1.55MetThr: 1.55 ± 0.033	1.691MetVal: 1.691 ± 0.038	0.224MetTrp: 0.224 ± 0.012	0.427MetTyr: 0.427 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.366AsnAla: 3.366 ± 0.051	0.29AsnCys: 0.29 ± 0.016	1.581AsnAsp: 1.581 ± 0.04	1.593AsnGlu: 1.593 ± 0.037	1.045AsnPhe: 1.045 ± 0.032	2.575AsnGly: 2.575 ± 0.047	0.617AsnHis: 0.617 ± 0.018	1.617AsnIle: 1.617 ± 0.036	1.031AsnLys: 1.031 ± 0.026	3.027AsnLeu: 3.027 ± 0.047	0.741AsnMet: 0.741 ± 0.023	1.01AsnAsn: 1.01 ± 0.027	1.924AsnPro: 1.924 ± 0.042	1.073AsnGln: 1.073 ± 0.028	1.788AsnArg: 1.788 ± 0.036	1.574AsnSer: 1.574 ± 0.035	1.713AsnThr: 1.713 ± 0.042	2.174AsnVal: 2.174 ± 0.041	0.465AsnTrp: 0.465 ± 0.018	0.796AsnTyr: 0.796 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.122ProAla: 6.122 ± 0.077	0.382ProCys: 0.382 ± 0.015	3.233ProAsp: 3.233 ± 0.054	3.536ProGlu: 3.536 ± 0.049	1.829ProPhe: 1.829 ± 0.036	4.154ProGly: 4.154 ± 0.051	1.069ProHis: 1.069 ± 0.028	2.311ProIle: 2.311 ± 0.046	1.677ProLys: 1.677 ± 0.036	4.888ProLeu: 4.888 ± 0.063	1.302ProMet: 1.302 ± 0.031	1.493ProAsn: 1.493 ± 0.033	2.355ProPro: 2.355 ± 0.056	2.084ProGln: 2.084 ± 0.038	2.585ProArg: 2.585 ± 0.049	2.944ProSer: 2.944 ± 0.044	2.414ProThr: 2.414 ± 0.043	4.033ProVal: 4.033 ± 0.054	0.761ProTrp: 0.761 ± 0.022	1.309ProTyr: 1.309 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	6.074GlnAla: 6.074 ± 0.076	0.34GlnCys: 0.34 ± 0.017	1.872GlnAsp: 1.872 ± 0.039	2.099GlnGlu: 2.099 ± 0.04	1.397GlnPhe: 1.397 ± 0.026	3.222GlnGly: 3.222 ± 0.051	1.012GlnHis: 1.012 ± 0.028	2.095GlnIle: 2.095 ± 0.041	1.32GlnLys: 1.32 ± 0.032	4.171GlnLeu: 4.171 ± 0.058	0.983GlnMet: 0.983 ± 0.024	1.14GlnAsn: 1.14 ± 0.027	2.228GlnPro: 2.228 ± 0.046	2.035GlnGln: 2.035 ± 0.043	3.167GlnArg: 3.167 ± 0.05	2.311GlnSer: 2.311 ± 0.044	2.158GlnThr: 2.158 ± 0.044	2.938GlnVal: 2.938 ± 0.052	0.698GlnTrp: 0.698 ± 0.021	1.007GlnTyr: 1.007 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	6.413ArgAla: 6.413 ± 0.07	0.608ArgCys: 0.608 ± 0.022	3.274ArgAsp: 3.274 ± 0.044	3.65ArgGlu: 3.65 ± 0.056	2.449ArgPhe: 2.449 ± 0.043	4.157ArgGly: 4.157 ± 0.055	1.772ArgHis: 1.772 ± 0.036	3.725ArgIle: 3.725 ± 0.051	2.341ArgLys: 2.341 ± 0.04	7.365ArgLeu: 7.365 ± 0.089	1.739ArgMet: 1.739 ± 0.036	2.116ArgAsn: 2.116 ± 0.036	3.02ArgPro: 3.02 ± 0.046	3.121ArgGln: 3.121 ± 0.052	4.752ArgArg: 4.752 ± 0.073	3.548ArgSer: 3.548 ± 0.054	3.037ArgThr: 3.037 ± 0.045	4.337ArgVal: 4.337 ± 0.056	1.001ArgTrp: 1.001 ± 0.029	2.13ArgTyr: 2.13 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.293SerAla: 6.293 ± 0.077	0.553SerCys: 0.553 ± 0.021	2.982SerAsp: 2.982 ± 0.056	2.743SerGlu: 2.743 ± 0.041	2.211SerPhe: 2.211 ± 0.038	5.315SerGly: 5.315 ± 0.077	1.282SerHis: 1.282 ± 0.03	3.113SerIle: 3.113 ± 0.056	1.857SerLys: 1.857 ± 0.039	6.235SerLeu: 6.235 ± 0.071	1.611SerMet: 1.611 ± 0.036	1.752SerAsn: 1.752 ± 0.037	2.904SerPro: 2.904 ± 0.048	2.395SerGln: 2.395 ± 0.048	3.632SerArg: 3.632 ± 0.056	3.686SerSer: 3.686 ± 0.057	3.157SerThr: 3.157 ± 0.05	4.384SerVal: 4.384 ± 0.094	0.847SerTrp: 0.847 ± 0.024	1.467SerTyr: 1.467 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	5.583ThrAla: 5.583 ± 0.074	0.415ThrCys: 0.415 ± 0.017	2.578ThrAsp: 2.578 ± 0.049	2.636ThrGlu: 2.636 ± 0.046	1.745ThrPhe: 1.745 ± 0.04	4.536ThrGly: 4.536 ± 0.072	1.213ThrHis: 1.213 ± 0.033	2.655ThrIle: 2.655 ± 0.056	1.398ThrLys: 1.398 ± 0.037	6.359ThrLeu: 6.359 ± 0.069	1.168ThrMet: 1.168 ± 0.034	1.242ThrAsn: 1.242 ± 0.031	3.358ThrPro: 3.358 ± 0.046	2.141ThrGln: 2.141 ± 0.041	3.154ThrArg: 3.154 ± 0.05	2.861ThrSer: 2.861 ± 0.048	2.819ThrThr: 2.819 ± 0.07	4.287ThrVal: 4.287 ± 0.104	0.732ThrTrp: 0.732 ± 0.029	1.209ThrTyr: 1.209 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	8.438ValAla: 8.438 ± 0.096	0.745ValCys: 0.745 ± 0.023	3.925ValAsp: 3.925 ± 0.071	3.802ValGlu: 3.802 ± 0.055	2.878ValPhe: 2.878 ± 0.054	5.38ValGly: 5.38 ± 0.068	1.554ValHis: 1.554 ± 0.029	3.682ValIle: 3.682 ± 0.051	2.516ValLys: 2.516 ± 0.047	8.231ValLeu: 8.231 ± 0.091	1.786ValMet: 1.786 ± 0.039	2.229ValAsn: 2.229 ± 0.04	3.696ValPro: 3.696 ± 0.057	2.991ValGln: 2.991 ± 0.047	4.684ValArg: 4.684 ± 0.062	4.415ValSer: 4.415 ± 0.067	3.709ValThr: 3.709 ± 0.087	5.925ValVal: 5.925 ± 0.077	0.955ValTrp: 0.955 ± 0.026	1.743ValTyr: 1.743 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.336TrpAla: 1.336 ± 0.034	0.158TrpCys: 0.158 ± 0.011	0.594TrpAsp: 0.594 ± 0.022	0.604TrpGlu: 0.604 ± 0.022	0.542TrpPhe: 0.542 ± 0.02	0.922TrpGly: 0.922 ± 0.03	0.433TrpHis: 0.433 ± 0.02	0.709TrpIle: 0.709 ± 0.027	0.487TrpLys: 0.487 ± 0.017	2.056TrpLeu: 2.056 ± 0.042	0.394TrpMet: 0.394 ± 0.018	0.465TrpAsn: 0.465 ± 0.02	0.693TrpPro: 0.693 ± 0.022	0.754TrpGln: 0.754 ± 0.023	1.166TrpArg: 1.166 ± 0.034	0.851TrpSer: 0.851 ± 0.029	0.683TrpThr: 0.683 ± 0.023	0.979TrpVal: 0.979 ± 0.022	0.242TrpTrp: 0.242 ± 0.016	0.342TrpTyr: 0.342 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.743TyrAla: 2.743 ± 0.048	0.292TyrCys: 0.292 ± 0.015	1.462TyrAsp: 1.462 ± 0.032	1.333TyrGlu: 1.333 ± 0.03	1.064TyrPhe: 1.064 ± 0.03	2.197TyrGly: 2.197 ± 0.039	0.518TyrHis: 0.518 ± 0.019	1.169TyrIle: 1.169 ± 0.034	0.838TyrLys: 0.838 ± 0.026	2.561TyrLeu: 2.561 ± 0.044	0.541TyrMet: 0.541 ± 0.018	0.71TyrAsn: 0.71 ± 0.022	1.273TyrPro: 1.273 ± 0.029	1.008TyrGln: 1.008 ± 0.026	1.851TyrArg: 1.851 ± 0.04	1.525TyrSer: 1.525 ± 0.032	1.384TyrThr: 1.384 ± 0.03	1.846TyrVal: 1.846 ± 0.036	0.411TyrTrp: 0.411 ± 0.016	0.738TyrTyr: 0.738 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4508 proteins (1422334 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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