Amino acid dipepetide frequency for Marihabitans asiaticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.906AlaAla: 18.906 ± 0.212	0.847AlaCys: 0.847 ± 0.03	8.23AlaAsp: 8.23 ± 0.093	8.206AlaGlu: 8.206 ± 0.117	3.066AlaPhe: 3.066 ± 0.071	12.221AlaGly: 12.221 ± 0.149	2.554AlaHis: 2.554 ± 0.067	4.552AlaIle: 4.552 ± 0.076	2.954AlaLys: 2.954 ± 0.077	13.609AlaLeu: 13.609 ± 0.161	2.95AlaMet: 2.95 ± 0.065	1.693AlaAsn: 1.693 ± 0.048	6.056AlaPro: 6.056 ± 0.093	4.076AlaGln: 4.076 ± 0.069	9.952AlaArg: 9.952 ± 0.123	6.259AlaSer: 6.259 ± 0.085	7.16AlaThr: 7.16 ± 0.093	11.259AlaVal: 11.259 ± 0.15	1.842AlaTrp: 1.842 ± 0.048	2.13AlaTyr: 2.13 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.918CysAla: 0.918 ± 0.032	0.08CysCys: 0.08 ± 0.009	0.457CysAsp: 0.457 ± 0.025	0.394CysGlu: 0.394 ± 0.023	0.213CysPhe: 0.213 ± 0.015	0.843CysGly: 0.843 ± 0.032	0.173CysHis: 0.173 ± 0.014	0.206CysIle: 0.206 ± 0.018	0.097CysLys: 0.097 ± 0.011	0.645CysLeu: 0.645 ± 0.028	0.092CysMet: 0.092 ± 0.01	0.108CysAsn: 0.108 ± 0.011	0.446CysPro: 0.446 ± 0.026	0.179CysGln: 0.179 ± 0.014	0.51CysArg: 0.51 ± 0.027	0.415CysSer: 0.415 ± 0.021	0.446CysThr: 0.446 ± 0.024	0.566CysVal: 0.566 ± 0.023	0.085CysTrp: 0.085 ± 0.011	0.123CysTyr: 0.123 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.801AspAla: 7.801 ± 0.1	0.371AspCys: 0.371 ± 0.021	4.583AspAsp: 4.583 ± 0.095	5.142AspGlu: 5.142 ± 0.092	1.575AspPhe: 1.575 ± 0.05	6.532AspGly: 6.532 ± 0.098	1.589AspHis: 1.589 ± 0.045	2.215AspIle: 2.215 ± 0.047	1.169AspLys: 1.169 ± 0.048	7.503AspLeu: 7.503 ± 0.118	0.862AspMet: 0.862 ± 0.03	0.951AspAsn: 0.951 ± 0.04	4.829AspPro: 4.829 ± 0.078	1.9AspGln: 1.9 ± 0.047	4.715AspArg: 4.715 ± 0.084	2.693AspSer: 2.693 ± 0.063	2.828AspThr: 2.828 ± 0.059	5.73AspVal: 5.73 ± 0.086	0.921AspTrp: 0.921 ± 0.033	1.184AspTyr: 1.184 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.358GluAla: 7.358 ± 0.107	0.347GluCys: 0.347 ± 0.019	3.907GluAsp: 3.907 ± 0.071	4.097GluGlu: 4.097 ± 0.077	1.208GluPhe: 1.208 ± 0.044	5.495GluGly: 5.495 ± 0.095	1.972GluHis: 1.972 ± 0.047	2.691GluIle: 2.691 ± 0.053	1.253GluLys: 1.253 ± 0.049	6.808GluLeu: 6.808 ± 0.098	1.104GluMet: 1.104 ± 0.033	0.853GluAsn: 0.853 ± 0.036	3.227GluPro: 3.227 ± 0.068	2.911GluGln: 2.911 ± 0.069	5.999GluArg: 5.999 ± 0.097	3.203GluSer: 3.203 ± 0.063	3.011GluThr: 3.011 ± 0.057	6.241GluVal: 6.241 ± 0.085	0.739GluTrp: 0.739 ± 0.028	1.083GluTyr: 1.083 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.672PheAla: 3.672 ± 0.072	0.232PheCys: 0.232 ± 0.017	1.923PheAsp: 1.923 ± 0.049	1.556PheGlu: 1.556 ± 0.043	0.896PhePhe: 0.896 ± 0.039	2.829PheGly: 2.829 ± 0.065	0.495PheHis: 0.495 ± 0.023	0.78PheIle: 0.78 ± 0.034	0.369PheLys: 0.369 ± 0.023	2.177PheLeu: 2.177 ± 0.065	0.397PheMet: 0.397 ± 0.022	0.481PheAsn: 0.481 ± 0.027	1.078PhePro: 1.078 ± 0.035	0.531PheGln: 0.531 ± 0.027	1.382PheArg: 1.382 ± 0.039	1.312PheSer: 1.312 ± 0.042	1.678PheThr: 1.678 ± 0.052	2.597PheVal: 2.597 ± 0.059	0.358PheTrp: 0.358 ± 0.02	0.531PheTyr: 0.531 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.565GlyAla: 10.565 ± 0.15	0.781GlyCys: 0.781 ± 0.034	5.525GlyAsp: 5.525 ± 0.079	6.608GlyGlu: 6.608 ± 0.112	2.599GlyPhe: 2.599 ± 0.055	8.808GlyGly: 8.808 ± 0.125	2.212GlyHis: 2.212 ± 0.048	3.544GlyIle: 3.544 ± 0.077	2.161GlyLys: 2.161 ± 0.061	9.243GlyLeu: 9.243 ± 0.122	2.197GlyMet: 2.197 ± 0.05	1.443GlyAsn: 1.443 ± 0.046	4.33GlyPro: 4.33 ± 0.081	3.019GlyGln: 3.019 ± 0.07	7.362GlyArg: 7.362 ± 0.1	5.836GlySer: 5.836 ± 0.093	5.281GlyThr: 5.281 ± 0.076	8.509GlyVal: 8.509 ± 0.106	1.761GlyTrp: 1.761 ± 0.05	2.175GlyTyr: 2.175 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.581HisAla: 2.581 ± 0.06	0.175HisCys: 0.175 ± 0.011	1.632HisAsp: 1.632 ± 0.047	1.452HisGlu: 1.452 ± 0.038	0.533HisPhe: 0.533 ± 0.025	2.258HisGly: 2.258 ± 0.053	0.625HisHis: 0.625 ± 0.027	0.618HisIle: 0.618 ± 0.027	0.331HisLys: 0.331 ± 0.022	2.583HisLeu: 2.583 ± 0.057	0.287HisMet: 0.287 ± 0.019	0.338HisAsn: 0.338 ± 0.02	1.709HisPro: 1.709 ± 0.049	0.641HisGln: 0.641 ± 0.026	1.889HisArg: 1.889 ± 0.052	0.927HisSer: 0.927 ± 0.037	1.03HisThr: 1.03 ± 0.034	1.948HisVal: 1.948 ± 0.048	0.307HisTrp: 0.307 ± 0.018	0.404HisTyr: 0.404 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.193IleAla: 5.193 ± 0.074	0.316IleCys: 0.316 ± 0.02	2.79IleAsp: 2.79 ± 0.062	2.57IleGlu: 2.57 ± 0.059	0.972IlePhe: 0.972 ± 0.039	3.83IleGly: 3.83 ± 0.071	0.702IleHis: 0.702 ± 0.025	1.22IleIle: 1.22 ± 0.042	0.734IleLys: 0.734 ± 0.027	2.651IleLeu: 2.651 ± 0.059	0.518IleMet: 0.518 ± 0.026	0.739IleAsn: 0.739 ± 0.029	1.915IlePro: 1.915 ± 0.056	0.824IleGln: 0.824 ± 0.029	2.241IleArg: 2.241 ± 0.054	1.96IleSer: 1.96 ± 0.054	2.568IleThr: 2.568 ± 0.058	3.159IleVal: 3.159 ± 0.064	0.451IleTrp: 0.451 ± 0.025	0.645IleTyr: 0.645 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	2.438LysAla: 2.438 ± 0.074	0.078LysCys: 0.078 ± 0.009	1.289LysAsp: 1.289 ± 0.05	1.121LysGlu: 1.121 ± 0.044	0.394LysPhe: 0.394 ± 0.025	2.218LysGly: 2.218 ± 0.06	0.417LysHis: 0.417 ± 0.022	0.825LysIle: 0.825 ± 0.031	0.868LysLys: 0.868 ± 0.05	1.43LysLeu: 1.43 ± 0.046	0.358LysMet: 0.358 ± 0.022	0.424LysAsn: 0.424 ± 0.028	0.996LysPro: 0.996 ± 0.038	0.653LysGln: 0.653 ± 0.034	1.308LysArg: 1.308 ± 0.048	1.042LysSer: 1.042 ± 0.041	1.19LysThr: 1.19 ± 0.039	1.816LysVal: 1.816 ± 0.054	0.193LysTrp: 0.193 ± 0.015	0.399LysTyr: 0.399 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.757LeuAla: 14.757 ± 0.172	0.64LeuCys: 0.64 ± 0.027	7.134LeuAsp: 7.134 ± 0.105	5.572LeuGlu: 5.572 ± 0.085	2.189LeuPhe: 2.189 ± 0.059	9.83LeuGly: 9.83 ± 0.12	2.071LeuHis: 2.071 ± 0.05	3.161LeuIle: 3.161 ± 0.076	1.576LeuLys: 1.576 ± 0.049	10.472LeuLeu: 10.472 ± 0.15	1.616LeuMet: 1.616 ± 0.042	1.325LeuAsn: 1.325 ± 0.043	5.728LeuPro: 5.728 ± 0.076	2.319LeuGln: 2.319 ± 0.047	8.06LeuArg: 8.06 ± 0.113	5.268LeuSer: 5.268 ± 0.076	6.778LeuThr: 6.778 ± 0.093	10.109LeuVal: 10.109 ± 0.147	1.12LeuTrp: 1.12 ± 0.036	1.443LeuTyr: 1.443 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.45MetAla: 2.45 ± 0.056	0.148MetCys: 0.148 ± 0.012	0.945MetAsp: 0.945 ± 0.029	0.822MetGlu: 0.822 ± 0.032	0.444MetPhe: 0.444 ± 0.026	1.504MetGly: 1.504 ± 0.041	0.341MetHis: 0.341 ± 0.019	0.812MetIle: 0.812 ± 0.032	0.409MetLys: 0.409 ± 0.021	1.889MetLeu: 1.889 ± 0.047	0.313MetMet: 0.313 ± 0.02	0.365MetAsn: 0.365 ± 0.019	1.195MetPro: 1.195 ± 0.038	0.504MetGln: 0.504 ± 0.024	1.526MetArg: 1.526 ± 0.041	1.726MetSer: 1.726 ± 0.043	1.772MetThr: 1.772 ± 0.046	1.463MetVal: 1.463 ± 0.048	0.246MetTrp: 0.246 ± 0.015	0.306MetTyr: 0.306 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	1.89AsnAla: 1.89 ± 0.059	0.118AsnCys: 0.118 ± 0.011	0.92AsnAsp: 0.92 ± 0.041	0.788AsnGlu: 0.788 ± 0.029	0.458AsnPhe: 0.458 ± 0.025	1.264AsnGly: 1.264 ± 0.045	0.386AsnHis: 0.386 ± 0.023	0.63AsnIle: 0.63 ± 0.03	0.323AsnLys: 0.323 ± 0.019	1.633AsnLeu: 1.633 ± 0.045	0.222AsnMet: 0.222 ± 0.019	0.346AsnAsn: 0.346 ± 0.022	1.319AsnPro: 1.319 ± 0.042	0.448AsnGln: 0.448 ± 0.023	1.076AsnArg: 1.076 ± 0.039	0.686AsnSer: 0.686 ± 0.028	0.759AsnThr: 0.759 ± 0.029	1.33AsnVal: 1.33 ± 0.04	0.21AsnTrp: 0.21 ± 0.017	0.32AsnTyr: 0.32 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	6.83ProAla: 6.83 ± 0.12	0.29ProCys: 0.29 ± 0.019	4.174ProAsp: 4.174 ± 0.074	4.085ProGlu: 4.085 ± 0.068	1.695ProPhe: 1.695 ± 0.045	5.712ProGly: 5.712 ± 0.088	1.221ProHis: 1.221 ± 0.035	1.594ProIle: 1.594 ± 0.039	1.093ProLys: 1.093 ± 0.04	4.718ProLeu: 4.718 ± 0.078	1.084ProMet: 1.084 ± 0.035	0.745ProAsn: 0.745 ± 0.034	2.823ProPro: 2.823 ± 0.075	1.778ProGln: 1.778 ± 0.042	3.698ProArg: 3.698 ± 0.08	3.413ProSer: 3.413 ± 0.065	3.533ProThr: 3.533 ± 0.063	5.05ProVal: 5.05 ± 0.08	0.949ProTrp: 0.949 ± 0.034	1.042ProTyr: 1.042 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.065GlnAla: 4.065 ± 0.072	0.164GlnCys: 0.164 ± 0.015	1.605GlnAsp: 1.605 ± 0.046	1.605GlnGlu: 1.605 ± 0.046	0.56GlnPhe: 0.56 ± 0.025	2.314GlnGly: 2.314 ± 0.052	0.692GlnHis: 0.692 ± 0.029	1.347GlnIle: 1.347 ± 0.039	0.491GlnLys: 0.491 ± 0.027	3.094GlnLeu: 3.094 ± 0.057	0.679GlnMet: 0.679 ± 0.03	0.423GlnAsn: 0.423 ± 0.025	1.647GlnPro: 1.647 ± 0.044	1.145GlnGln: 1.145 ± 0.039	2.755GlnArg: 2.755 ± 0.063	1.407GlnSer: 1.407 ± 0.04	1.561GlnThr: 1.561 ± 0.044	3.165GlnVal: 3.165 ± 0.059	0.482GlnTrp: 0.482 ± 0.024	0.495GlnTyr: 0.495 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	9.245ArgAla: 9.245 ± 0.129	0.584ArgCys: 0.584 ± 0.028	4.651ArgAsp: 4.651 ± 0.07	5.158ArgGlu: 5.158 ± 0.082	1.999ArgPhe: 1.999 ± 0.046	5.866ArgGly: 5.866 ± 0.099	1.865ArgHis: 1.865 ± 0.051	2.807ArgIle: 2.807 ± 0.061	1.294ArgLys: 1.294 ± 0.042	7.959ArgLeu: 7.959 ± 0.114	1.879ArgMet: 1.879 ± 0.05	1.084ArgAsn: 1.084 ± 0.037	4.374ArgPro: 4.374 ± 0.074	2.289ArgGln: 2.289 ± 0.055	7.588ArgArg: 7.588 ± 0.111	4.709ArgSer: 4.709 ± 0.075	4.475ArgThr: 4.475 ± 0.073	6.507ArgVal: 6.507 ± 0.099	1.589ArgTrp: 1.589 ± 0.044	1.629ArgTyr: 1.629 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.847SerAla: 6.847 ± 0.089	0.413SerCys: 0.413 ± 0.021	3.072SerAsp: 3.072 ± 0.058	3.202SerGlu: 3.202 ± 0.072	1.537SerPhe: 1.537 ± 0.041	5.791SerGly: 5.791 ± 0.096	1.003SerHis: 1.003 ± 0.032	2.015SerIle: 2.015 ± 0.053	1.005SerLys: 1.005 ± 0.039	5.091SerLeu: 5.091 ± 0.071	1.331SerMet: 1.331 ± 0.04	0.817SerAsn: 0.817 ± 0.032	3.34SerPro: 3.34 ± 0.066	1.461SerGln: 1.461 ± 0.035	3.887SerArg: 3.887 ± 0.067	3.822SerSer: 3.822 ± 0.116	3.794SerThr: 3.794 ± 0.073	4.628SerVal: 4.628 ± 0.073	0.939SerTrp: 0.939 ± 0.031	1.139SerTyr: 1.139 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	7.148ThrAla: 7.148 ± 0.088	0.45ThrCys: 0.45 ± 0.023	3.758ThrAsp: 3.758 ± 0.065	3.374ThrGlu: 3.374 ± 0.064	1.772ThrPhe: 1.772 ± 0.047	5.862ThrGly: 5.862 ± 0.089	1.263ThrHis: 1.263 ± 0.036	2.311ThrIle: 2.311 ± 0.065	1.184ThrLys: 1.184 ± 0.047	5.585ThrLeu: 5.585 ± 0.087	1.132ThrMet: 1.132 ± 0.038	0.97ThrAsn: 0.97 ± 0.034	3.789ThrPro: 3.789 ± 0.072	1.564ThrGln: 1.564 ± 0.04	4.051ThrArg: 4.051 ± 0.068	3.711ThrSer: 3.711 ± 0.079	3.974ThrThr: 3.974 ± 0.076	5.506ThrVal: 5.506 ± 0.084	0.956ThrTrp: 0.956 ± 0.035	1.23ThrTyr: 1.23 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	12.036ValAla: 12.036 ± 0.142	0.678ValCys: 0.678 ± 0.028	6.326ValAsp: 6.326 ± 0.087	5.917ValGlu: 5.917 ± 0.091	2.088ValPhe: 2.088 ± 0.062	7.991ValGly: 7.991 ± 0.111	1.978ValHis: 1.978 ± 0.05	3.636ValIle: 3.636 ± 0.081	1.574ValLys: 1.574 ± 0.043	10.172ValLeu: 10.172 ± 0.142	1.653ValMet: 1.653 ± 0.048	1.41ValAsn: 1.41 ± 0.043	4.873ValPro: 4.873 ± 0.072	2.343ValGln: 2.343 ± 0.048	6.677ValArg: 6.677 ± 0.085	4.844ValSer: 4.844 ± 0.079	5.908ValThr: 5.908 ± 0.094	10.219ValVal: 10.219 ± 0.138	1.07ValTrp: 1.07 ± 0.034	1.355ValTyr: 1.355 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.679TrpAla: 1.679 ± 0.044	0.143TrpCys: 0.143 ± 0.012	0.77TrpAsp: 0.77 ± 0.026	0.707TrpGlu: 0.707 ± 0.028	0.496TrpPhe: 0.496 ± 0.021	1.068TrpGly: 1.068 ± 0.036	0.344TrpHis: 0.344 ± 0.02	0.535TrpIle: 0.535 ± 0.024	0.251TrpLys: 0.251 ± 0.017	1.754TrpLeu: 1.754 ± 0.044	0.28TrpMet: 0.28 ± 0.02	0.26TrpAsn: 0.26 ± 0.019	0.775TrpPro: 0.775 ± 0.032	0.573TrpGln: 0.573 ± 0.025	1.341TrpArg: 1.341 ± 0.041	0.989TrpSer: 0.989 ± 0.033	0.9TrpThr: 0.9 ± 0.028	1.358TrpVal: 1.358 ± 0.047	0.426TrpTrp: 0.426 ± 0.023	0.252TrpTyr: 0.252 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.144TyrAla: 2.144 ± 0.044	0.141TyrCys: 0.141 ± 0.012	1.407TyrAsp: 1.407 ± 0.045	1.132TyrGlu: 1.132 ± 0.039	0.581TyrPhe: 0.581 ± 0.029	1.721TyrGly: 1.721 ± 0.044	0.364TyrHis: 0.364 ± 0.018	0.498TyrIle: 0.498 ± 0.03	0.32TyrLys: 0.32 ± 0.02	2.149TyrLeu: 2.149 ± 0.051	0.225TyrMet: 0.225 ± 0.016	0.347TyrAsn: 0.347 ± 0.022	1.076TyrPro: 1.076 ± 0.033	0.537TyrGln: 0.537 ± 0.027	1.534TyrArg: 1.534 ± 0.043	0.913TyrSer: 0.913 ± 0.032	0.946TyrThr: 0.946 ± 0.039	1.59TyrVal: 1.59 ± 0.041	0.257TyrTrp: 0.257 ± 0.017	0.423TyrTyr: 0.423 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2675 proteins (889342 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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