Amino acid dipepetide frequency for Phyllostomus discolor (pale spear-nosed bat)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.436AlaAla: 7.436 ± 0.033	1.368AlaCys: 1.368 ± 0.01	3.098AlaAsp: 3.098 ± 0.013	5.125AlaGlu: 5.125 ± 0.026	2.453AlaPhe: 2.453 ± 0.013	4.955AlaGly: 4.955 ± 0.024	1.587AlaHis: 1.587 ± 0.009	2.616AlaIle: 2.616 ± 0.012	3.507AlaLys: 3.507 ± 0.026	7.245AlaLeu: 7.245 ± 0.028	1.469AlaMet: 1.469 ± 0.008	1.987AlaAsn: 1.987 ± 0.011	4.696AlaPro: 4.696 ± 0.028	3.508AlaGln: 3.508 ± 0.02	3.875AlaArg: 3.875 ± 0.017	6.077AlaSer: 6.077 ± 0.023	3.614AlaThr: 3.614 ± 0.013	4.722AlaVal: 4.722 ± 0.015	0.759AlaTrp: 0.759 ± 0.007	1.469AlaTyr: 1.469 ± 0.01	0.005AlaXaa: 0.005 ± 0.0
Cys	1.229CysAla: 1.229 ± 0.009	0.589CysCys: 0.589 ± 0.01	0.991CysAsp: 0.991 ± 0.009	1.248CysGlu: 1.248 ± 0.012	0.786CysPhe: 0.786 ± 0.005	1.668CysGly: 1.668 ± 0.017	0.635CysHis: 0.635 ± 0.007	0.854CysIle: 0.854 ± 0.007	1.043CysLys: 1.043 ± 0.009	2.032CysLeu: 2.032 ± 0.011	0.369CysMet: 0.369 ± 0.004	0.73CysAsn: 0.73 ± 0.007	1.333CysPro: 1.333 ± 0.012	1.052CysGln: 1.052 ± 0.009	1.273CysArg: 1.273 ± 0.01	1.945CysSer: 1.945 ± 0.013	1.027CysThr: 1.027 ± 0.009	1.257CysVal: 1.257 ± 0.01	0.256CysTrp: 0.256 ± 0.003	0.526CysTyr: 0.526 ± 0.005	0.003CysXaa: 0.003 ± 0.0
Asp	2.978AspAla: 2.978 ± 0.013	1.016AspCys: 1.016 ± 0.009	2.705AspAsp: 2.705 ± 0.016	3.411AspGlu: 3.411 ± 0.016	2.046AspPhe: 2.046 ± 0.01	3.347AspGly: 3.347 ± 0.019	1.145AspHis: 1.145 ± 0.007	2.529AspIle: 2.529 ± 0.021	2.544AspLys: 2.544 ± 0.014	5.098AspLeu: 5.098 ± 0.019	1.117AspMet: 1.117 ± 0.008	1.625AspAsn: 1.625 ± 0.01	3.002AspPro: 3.002 ± 0.015	1.895AspGln: 1.895 ± 0.011	2.546AspArg: 2.546 ± 0.013	4.362AspSer: 4.362 ± 0.018	2.526AspThr: 2.526 ± 0.013	3.149AspVal: 3.149 ± 0.034	0.599AspTrp: 0.599 ± 0.006	1.47AspTyr: 1.47 ± 0.011	0.004AspXaa: 0.004 ± 0.0
Glu	5.542GluAla: 5.542 ± 0.022	1.395GluCys: 1.395 ± 0.017	4.544GluAsp: 4.544 ± 0.019	8.249GluGlu: 8.249 ± 0.043	1.946GluPhe: 1.946 ± 0.011	4.417GluGly: 4.417 ± 0.025	1.542GluHis: 1.542 ± 0.009	3.056GluIle: 3.056 ± 0.016	5.483GluLys: 5.483 ± 0.029	6.579GluLeu: 6.579 ± 0.031	1.674GluMet: 1.674 ± 0.01	3.056GluAsn: 3.056 ± 0.016	3.483GluPro: 3.483 ± 0.018	3.356GluGln: 3.356 ± 0.019	4.269GluArg: 4.269 ± 0.023	4.619GluSer: 4.619 ± 0.018	3.448GluThr: 3.448 ± 0.017	4.227GluVal: 4.227 ± 0.018	0.667GluTrp: 0.667 ± 0.005	1.519GluTyr: 1.519 ± 0.011	0.006GluXaa: 0.006 ± 0.001
Phe	1.857PheAla: 1.857 ± 0.009	0.862PheCys: 0.862 ± 0.006	1.59PheAsp: 1.59 ± 0.009	1.933PheGlu: 1.933 ± 0.009	1.434PhePhe: 1.434 ± 0.01	2.073PheGly: 2.073 ± 0.013	0.977PheHis: 0.977 ± 0.007	1.639PheIle: 1.639 ± 0.012	1.68PheLys: 1.68 ± 0.013	3.737PheLeu: 3.737 ± 0.018	0.713PheMet: 0.713 ± 0.005	1.225PheAsn: 1.225 ± 0.008	1.943PhePro: 1.943 ± 0.011	1.724PheGln: 1.724 ± 0.009	1.874PheArg: 1.874 ± 0.01	3.246PheSer: 3.246 ± 0.013	1.899PheThr: 1.899 ± 0.01	1.968PheVal: 1.968 ± 0.012	0.437PheTrp: 0.437 ± 0.005	1.065PheTyr: 1.065 ± 0.007	0.004PheXaa: 0.004 ± 0.0
Gly	4.83GlyAla: 4.83 ± 0.027	1.238GlyCys: 1.238 ± 0.011	3.216GlyAsp: 3.216 ± 0.016	4.242GlyGlu: 4.242 ± 0.025	2.273GlyPhe: 2.273 ± 0.013	5.224GlyGly: 5.224 ± 0.034	1.726GlyHis: 1.726 ± 0.01	2.523GlyIle: 2.523 ± 0.011	3.718GlyLys: 3.718 ± 0.018	5.789GlyLeu: 5.789 ± 0.023	1.233GlyMet: 1.233 ± 0.01	2.261GlyAsn: 2.261 ± 0.012	4.775GlyPro: 4.775 ± 0.055	2.854GlyGln: 2.854 ± 0.015	3.927GlyArg: 3.927 ± 0.018	6.113GlySer: 6.113 ± 0.028	3.625GlyThr: 3.625 ± 0.017	3.534GlyVal: 3.534 ± 0.02	0.756GlyTrp: 0.756 ± 0.007	1.644GlyTyr: 1.644 ± 0.009	0.008GlyXaa: 0.008 ± 0.001
His	1.357HisAla: 1.357 ± 0.009	0.698HisCys: 0.698 ± 0.006	0.889HisAsp: 0.889 ± 0.006	1.304HisGlu: 1.304 ± 0.008	1.034HisPhe: 1.034 ± 0.007	1.562HisGly: 1.562 ± 0.012	0.93HisHis: 0.93 ± 0.01	1.192HisIle: 1.192 ± 0.008	1.264HisLys: 1.264 ± 0.007	2.901HisLeu: 2.901 ± 0.012	0.553HisMet: 0.553 ± 0.005	0.812HisAsn: 0.812 ± 0.006	1.715HisPro: 1.715 ± 0.011	1.418HisGln: 1.418 ± 0.011	1.653HisArg: 1.653 ± 0.009	2.331HisSer: 2.331 ± 0.011	1.566HisThr: 1.566 ± 0.012	1.51HisVal: 1.51 ± 0.009	0.325HisTrp: 0.325 ± 0.004	0.793HisTyr: 0.793 ± 0.006	0.003HisXaa: 0.003 ± 0.0
Ile	2.423IleAla: 2.423 ± 0.013	0.963IleCys: 0.963 ± 0.008	1.937IleAsp: 1.937 ± 0.013	2.502IleGlu: 2.502 ± 0.013	1.665IlePhe: 1.665 ± 0.011	2.069IleGly: 2.069 ± 0.011	1.244IleHis: 1.244 ± 0.009	2.163IleIle: 2.163 ± 0.013	2.468IleLys: 2.468 ± 0.016	4.156IleLeu: 4.156 ± 0.018	0.922IleMet: 0.922 ± 0.006	1.692IleAsn: 1.692 ± 0.01	2.533IlePro: 2.533 ± 0.013	2.218IleGln: 2.218 ± 0.012	2.231IleArg: 2.231 ± 0.011	3.537IleSer: 3.537 ± 0.017	2.42IleThr: 2.42 ± 0.014	2.31IleVal: 2.31 ± 0.013	0.448IleTrp: 0.448 ± 0.005	1.225IleTyr: 1.225 ± 0.008	0.004IleXaa: 0.004 ± 0.0
Lys	4.117LysAla: 4.117 ± 0.021	1.079LysCys: 1.079 ± 0.009	3.17LysAsp: 3.17 ± 0.018	5.164LysGlu: 5.164 ± 0.027	1.659LysPhe: 1.659 ± 0.014	3.324LysGly: 3.324 ± 0.036	1.397LysHis: 1.397 ± 0.009	2.593LysIle: 2.593 ± 0.014	4.704LysLys: 4.704 ± 0.03	5.078LysLeu: 5.078 ± 0.024	1.444LysMet: 1.444 ± 0.019	2.29LysAsn: 2.29 ± 0.013	3.128LysPro: 3.128 ± 0.02	2.665LysGln: 2.665 ± 0.016	3.251LysArg: 3.251 ± 0.013	3.97LysSer: 3.97 ± 0.017	3.088LysThr: 3.088 ± 0.016	3.463LysVal: 3.463 ± 0.022	0.581LysTrp: 0.581 ± 0.006	1.504LysTyr: 1.504 ± 0.016	0.007LysXaa: 0.007 ± 0.001
Leu	6.764LeuAla: 6.764 ± 0.024	2.045LeuCys: 2.045 ± 0.011	4.753LeuAsp: 4.753 ± 0.015	7.409LeuGlu: 7.409 ± 0.034	3.105LeuPhe: 3.105 ± 0.017	5.782LeuGly: 5.782 ± 0.021	2.749LeuHis: 2.749 ± 0.013	3.535LeuIle: 3.535 ± 0.016	5.757LeuLys: 5.757 ± 0.03	10.527LeuLeu: 10.527 ± 0.041	1.876LeuMet: 1.876 ± 0.01	3.4LeuAsn: 3.4 ± 0.015	6.223LeuPro: 6.223 ± 0.024	5.966LeuGln: 5.966 ± 0.031	6.054LeuArg: 6.054 ± 0.025	8.016LeuSer: 8.016 ± 0.024	4.915LeuThr: 4.915 ± 0.017	5.275LeuVal: 5.275 ± 0.021	1.049LeuTrp: 1.049 ± 0.008	2.364LeuTyr: 2.364 ± 0.013	0.01LeuXaa: 0.01 ± 0.001
Met	1.832MetAla: 1.832 ± 0.009	0.366MetCys: 0.366 ± 0.004	1.217MetAsp: 1.217 ± 0.008	1.853MetGlu: 1.853 ± 0.011	0.668MetPhe: 0.668 ± 0.005	1.214MetGly: 1.214 ± 0.008	0.468MetHis: 0.468 ± 0.005	0.756MetIle: 0.756 ± 0.005	1.409MetLys: 1.409 ± 0.009	1.923MetLeu: 1.923 ± 0.01	0.543MetMet: 0.543 ± 0.006	0.862MetAsn: 0.862 ± 0.007	1.163MetPro: 1.163 ± 0.022	0.952MetGln: 0.952 ± 0.008	1.008MetArg: 1.008 ± 0.008	1.536MetSer: 1.536 ± 0.009	1.068MetThr: 1.068 ± 0.007	1.314MetVal: 1.314 ± 0.008	0.216MetTrp: 0.216 ± 0.003	0.543MetTyr: 0.543 ± 0.006	0.002MetXaa: 0.002 ± 0.0
Asn	2.033AsnAla: 2.033 ± 0.011	0.765AsnCys: 0.765 ± 0.007	1.47AsnAsp: 1.47 ± 0.01	2.151AsnGlu: 2.151 ± 0.012	1.351AsnPhe: 1.351 ± 0.008	2.41AsnGly: 2.41 ± 0.015	0.931AsnHis: 0.931 ± 0.007	1.942AsnIle: 1.942 ± 0.012	2.123AsnLys: 2.123 ± 0.012	3.595AsnLeu: 3.595 ± 0.017	0.858AsnMet: 0.858 ± 0.006	1.453AsnAsn: 1.453 ± 0.01	2.059AsnPro: 2.059 ± 0.011	1.683AsnGln: 1.683 ± 0.013	1.766AsnArg: 1.766 ± 0.009	3.104AsnSer: 3.104 ± 0.016	1.901AsnThr: 1.901 ± 0.01	2.097AsnVal: 2.097 ± 0.01	0.418AsnTrp: 0.418 ± 0.004	1.051AsnTyr: 1.051 ± 0.01	0.004AsnXaa: 0.004 ± 0.0
Pro	5.539ProAla: 5.539 ± 0.027	1.145ProCys: 1.145 ± 0.011	2.966ProAsp: 2.966 ± 0.027	4.766ProGlu: 4.766 ± 0.025	1.857ProPhe: 1.857 ± 0.01	5.782ProGly: 5.782 ± 0.051	1.494ProHis: 1.494 ± 0.01	1.804ProIle: 1.804 ± 0.012	2.94ProLys: 2.94 ± 0.043	5.414ProLeu: 5.414 ± 0.021	1.071ProMet: 1.071 ± 0.008	1.803ProAsn: 1.803 ± 0.011	6.955ProPro: 6.955 ± 0.052	3.058ProGln: 3.058 ± 0.018	3.573ProArg: 3.573 ± 0.018	6.197ProSer: 6.197 ± 0.028	3.244ProThr: 3.244 ± 0.017	3.992ProVal: 3.992 ± 0.018	0.663ProTrp: 0.663 ± 0.007	1.49ProTyr: 1.49 ± 0.013	0.01ProXaa: 0.01 ± 0.001
Gln	3.713GlnAla: 3.713 ± 0.022	0.913GlnCys: 0.913 ± 0.008	2.392GlnAsp: 2.392 ± 0.01	4.093GlnGlu: 4.093 ± 0.023	1.322GlnPhe: 1.322 ± 0.008	3.015GlnGly: 3.015 ± 0.019	1.346GlnHis: 1.346 ± 0.008	1.92GlnIle: 1.92 ± 0.01	3.008GlnLys: 3.008 ± 0.018	4.897GlnLeu: 4.897 ± 0.025	1.121GlnMet: 1.121 ± 0.008	1.858GlnAsn: 1.858 ± 0.011	3.027GlnPro: 3.027 ± 0.021	3.364GlnGln: 3.364 ± 0.03	3.125GlnArg: 3.125 ± 0.018	3.336GlnSer: 3.336 ± 0.016	2.373GlnThr: 2.373 ± 0.011	2.884GlnVal: 2.884 ± 0.014	0.53GlnTrp: 0.53 ± 0.005	1.13GlnTyr: 1.13 ± 0.008	0.004GlnXaa: 0.004 ± 0.0
Arg	4.047ArgAla: 4.047 ± 0.018	1.173ArgCys: 1.173 ± 0.012	2.854ArgAsp: 2.854 ± 0.014	4.246ArgGlu: 4.246 ± 0.02	1.753ArgPhe: 1.753 ± 0.011	3.741ArgGly: 3.741 ± 0.018	1.561ArgHis: 1.561 ± 0.009	2.285ArgIle: 2.285 ± 0.011	3.673ArgLys: 3.673 ± 0.014	5.514ArgLeu: 5.514 ± 0.024	1.173ArgMet: 1.173 ± 0.008	2.07ArgAsn: 2.07 ± 0.009	3.482ArgPro: 3.482 ± 0.016	2.765ArgGln: 2.765 ± 0.016	4.623ArgArg: 4.623 ± 0.025	4.61ArgSer: 4.61 ± 0.028	2.929ArgThr: 2.929 ± 0.013	3.206ArgVal: 3.206 ± 0.016	0.668ArgTrp: 0.668 ± 0.006	1.372ArgTyr: 1.372 ± 0.009	0.006ArgXaa: 0.006 ± 0.0
Ser	5.697SerAla: 5.697 ± 0.02	1.741SerCys: 1.741 ± 0.012	4.092SerAsp: 4.092 ± 0.025	5.445SerGlu: 5.445 ± 0.021	2.887SerPhe: 2.887 ± 0.013	5.832SerGly: 5.832 ± 0.025	2.159SerHis: 2.159 ± 0.012	3.045SerIle: 3.045 ± 0.013	4.132SerLys: 4.132 ± 0.017	8.284SerLeu: 8.284 ± 0.025	1.606SerMet: 1.606 ± 0.011	2.635SerAsn: 2.635 ± 0.013	6.7SerPro: 6.7 ± 0.037	4.056SerGln: 4.056 ± 0.016	4.812SerArg: 4.812 ± 0.029	9.955SerSer: 9.955 ± 0.048	4.622SerThr: 4.622 ± 0.022	4.941SerVal: 4.941 ± 0.018	1.023SerTrp: 1.023 ± 0.008	2.008SerTyr: 2.008 ± 0.011	0.008SerXaa: 0.008 ± 0.001
Thr	3.802ThrAla: 3.802 ± 0.016	1.259ThrCys: 1.259 ± 0.011	2.415ThrAsp: 2.415 ± 0.012	3.631ThrGlu: 3.631 ± 0.017	1.953ThrPhe: 1.953 ± 0.01	3.564ThrGly: 3.564 ± 0.02	1.27ThrHis: 1.27 ± 0.009	2.229ThrIle: 2.229 ± 0.013	2.615ThrLys: 2.615 ± 0.013	5.176ThrLeu: 5.176 ± 0.017	1.068ThrMet: 1.068 ± 0.006	1.673ThrAsn: 1.673 ± 0.009	3.939ThrPro: 3.939 ± 0.023	2.33ThrGln: 2.33 ± 0.013	2.518ThrArg: 2.518 ± 0.011	4.798ThrSer: 4.798 ± 0.021	3.015ThrThr: 3.015 ± 0.019	3.769ThrVal: 3.769 ± 0.018	0.656ThrTrp: 0.656 ± 0.007	1.344ThrTyr: 1.344 ± 0.008	0.006ThrXaa: 0.006 ± 0.001
Val	4.291ValAla: 4.291 ± 0.015	1.373ValCys: 1.373 ± 0.01	2.972ValAsp: 2.972 ± 0.026	3.843ValGlu: 3.843 ± 0.016	2.203ValPhe: 2.203 ± 0.012	3.298ValGly: 3.298 ± 0.015	1.62ValHis: 1.62 ± 0.011	2.695ValIle: 2.695 ± 0.012	3.376ValLys: 3.376 ± 0.018	6.043ValLeu: 6.043 ± 0.02	1.244ValMet: 1.244 ± 0.007	2.216ValAsn: 2.216 ± 0.012	3.868ValPro: 3.868 ± 0.018	2.784ValGln: 2.784 ± 0.013	3.068ValArg: 3.068 ± 0.013	4.935ValSer: 4.935 ± 0.019	3.72ValThr: 3.72 ± 0.02	3.885ValVal: 3.885 ± 0.017	0.675ValTrp: 0.675 ± 0.006	1.512ValTyr: 1.512 ± 0.009	0.004ValXaa: 0.004 ± 0.0
Trp	0.763TrpAla: 0.763 ± 0.006	0.229TrpCys: 0.229 ± 0.003	0.627TrpAsp: 0.627 ± 0.006	0.776TrpGlu: 0.776 ± 0.006	0.39TrpPhe: 0.39 ± 0.004	0.677TrpGly: 0.677 ± 0.007	0.307TrpHis: 0.307 ± 0.005	0.48TrpIle: 0.48 ± 0.005	0.73TrpLys: 0.73 ± 0.006	1.139TrpLeu: 1.139 ± 0.008	0.3TrpMet: 0.3 ± 0.004	0.497TrpAsn: 0.497 ± 0.005	0.509TrpPro: 0.509 ± 0.005	0.52TrpGln: 0.52 ± 0.005	0.714TrpArg: 0.714 ± 0.006	0.821TrpSer: 0.821 ± 0.008	0.626TrpThr: 0.626 ± 0.005	0.648TrpVal: 0.648 ± 0.005	0.172TrpTrp: 0.172 ± 0.003	0.305TrpTyr: 0.305 ± 0.004	0.002TrpXaa: 0.002 ± 0.0
Tyr	1.316TyrAla: 1.316 ± 0.008	0.624TyrCys: 0.624 ± 0.005	1.212TyrAsp: 1.212 ± 0.009	1.681TyrGlu: 1.681 ± 0.014	1.089TyrPhe: 1.089 ± 0.008	1.545TyrGly: 1.545 ± 0.01	0.717TyrHis: 0.717 ± 0.005	1.274TyrIle: 1.274 ± 0.009	1.494TyrLys: 1.494 ± 0.028	2.439TyrLeu: 2.439 ± 0.011	0.558TyrMet: 0.558 ± 0.005	1.016TyrAsn: 1.016 ± 0.007	1.222TyrPro: 1.222 ± 0.009	1.2TyrGln: 1.2 ± 0.008	1.582TyrArg: 1.582 ± 0.012	2.163TyrSer: 2.163 ± 0.012	1.398TyrThr: 1.398 ± 0.01	1.471TyrVal: 1.471 ± 0.009	0.332TyrTrp: 0.332 ± 0.004	0.852TyrTyr: 0.852 ± 0.007	0.003TyrXaa: 0.003 ± 0.0
Xaa	0.006XaaAla: 0.006 ± 0.001	0.002XaaCys: 0.002 ± 0.0	0.005XaaAsp: 0.005 ± 0.0	0.006XaaGlu: 0.006 ± 0.0	0.005XaaPhe: 0.005 ± 0.001	0.01XaaGly: 0.01 ± 0.001	0.003XaaHis: 0.003 ± 0.0	0.004XaaIle: 0.004 ± 0.0	0.009XaaLys: 0.009 ± 0.001	0.011XaaLeu: 0.011 ± 0.001	0.002XaaMet: 0.002 ± 0.0	0.005XaaAsn: 0.005 ± 0.0	0.007XaaPro: 0.007 ± 0.001	0.004XaaGln: 0.004 ± 0.0	0.006XaaArg: 0.006 ± 0.0	0.006XaaSer: 0.006 ± 0.001	0.004XaaThr: 0.004 ± 0.0	0.006XaaVal: 0.006 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.002XaaTyr: 0.002 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 38810 proteins (27107871 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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