Amino acid dipepetide frequency for Streptomyces aurantiacus JA 4570

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.327AlaAla: 22.327 ± 0.145	1.116AlaCys: 1.116 ± 0.022	8.867AlaAsp: 8.867 ± 0.067	8.854AlaGlu: 8.854 ± 0.082	3.499AlaPhe: 3.499 ± 0.044	13.325AlaGly: 13.325 ± 0.09	3.085AlaHis: 3.085 ± 0.044	3.282AlaIle: 3.282 ± 0.043	3.06AlaLys: 3.06 ± 0.053	14.528AlaLeu: 14.528 ± 0.101	2.481AlaMet: 2.481 ± 0.037	1.81AlaAsn: 1.81 ± 0.027	7.63AlaPro: 7.63 ± 0.073	3.717AlaGln: 3.717 ± 0.043	10.895AlaArg: 10.895 ± 0.083	5.701AlaSer: 5.701 ± 0.055	6.877AlaThr: 6.877 ± 0.059	12.326AlaVal: 12.326 ± 0.09	1.912AlaTrp: 1.912 ± 0.03	2.934AlaTyr: 2.934 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	1.165CysAla: 1.165 ± 0.025	0.099CysCys: 0.099 ± 0.006	0.47CysAsp: 0.47 ± 0.013	0.397CysGlu: 0.397 ± 0.015	0.225CysPhe: 0.225 ± 0.009	1.02CysGly: 1.02 ± 0.021	0.204CysHis: 0.204 ± 0.009	0.134CysIle: 0.134 ± 0.008	0.109CysLys: 0.109 ± 0.007	0.741CysLeu: 0.741 ± 0.018	0.137CysMet: 0.137 ± 0.007	0.125CysAsn: 0.125 ± 0.007	0.523CysPro: 0.523 ± 0.017	0.171CysGln: 0.171 ± 0.008	0.665CysArg: 0.665 ± 0.015	0.442CysSer: 0.442 ± 0.015	0.48CysThr: 0.48 ± 0.015	0.702CysVal: 0.702 ± 0.015	0.122CysTrp: 0.122 ± 0.008	0.15CysTyr: 0.15 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	8.118AspAla: 8.118 ± 0.07	0.43AspCys: 0.43 ± 0.015	3.861AspAsp: 3.861 ± 0.051	3.919AspGlu: 3.919 ± 0.047	1.643AspPhe: 1.643 ± 0.025	6.744AspGly: 6.744 ± 0.064	1.466AspHis: 1.466 ± 0.025	1.884AspIle: 1.884 ± 0.031	1.43AspLys: 1.43 ± 0.038	6.161AspLeu: 6.161 ± 0.057	0.876AspMet: 0.876 ± 0.019	0.929AspAsn: 0.929 ± 0.02	4.446AspPro: 4.446 ± 0.052	1.524AspGln: 1.524 ± 0.033	4.915AspArg: 4.915 ± 0.053	2.512AspSer: 2.512 ± 0.036	3.227AspThr: 3.227 ± 0.038	4.967AspVal: 4.967 ± 0.051	1.017AspTrp: 1.017 ± 0.022	1.078AspTyr: 1.078 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	7.249GluAla: 7.249 ± 0.077	0.371GluCys: 0.371 ± 0.013	2.783GluAsp: 2.783 ± 0.034	3.333GluGlu: 3.333 ± 0.043	1.493GluPhe: 1.493 ± 0.024	4.506GluGly: 4.506 ± 0.052	1.576GluHis: 1.576 ± 0.03	2.086GluIle: 2.086 ± 0.035	1.486GluLys: 1.486 ± 0.032	6.948GluLeu: 6.948 ± 0.064	0.842GluMet: 0.842 ± 0.02	0.963GluAsn: 0.963 ± 0.02	3.435GluPro: 3.435 ± 0.038	2.327GluGln: 2.327 ± 0.036	5.731GluArg: 5.731 ± 0.058	2.565GluSer: 2.565 ± 0.035	2.709GluThr: 2.709 ± 0.033	4.335GluVal: 4.335 ± 0.045	0.726GluTrp: 0.726 ± 0.018	1.107GluTyr: 1.107 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.72PheAla: 3.72 ± 0.041	0.26PheCys: 0.26 ± 0.01	1.97PheAsp: 1.97 ± 0.034	1.406PheGlu: 1.406 ± 0.026	0.863PhePhe: 0.863 ± 0.023	3.068PheGly: 3.068 ± 0.036	0.608PheHis: 0.608 ± 0.015	0.707PheIle: 0.707 ± 0.018	0.542PheLys: 0.542 ± 0.017	2.595PheLeu: 2.595 ± 0.043	0.412PheMet: 0.412 ± 0.014	0.565PheAsn: 0.565 ± 0.017	1.342PhePro: 1.342 ± 0.024	0.657PheGln: 0.657 ± 0.016	1.84PheArg: 1.84 ± 0.024	1.388PheSer: 1.388 ± 0.029	2.011PheThr: 2.011 ± 0.029	2.249PheVal: 2.249 ± 0.036	0.432PheTrp: 0.432 ± 0.014	0.536PheTyr: 0.536 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	12.039GlyAla: 12.039 ± 0.088	0.86GlyCys: 0.86 ± 0.021	5.514GlyAsp: 5.514 ± 0.06	5.467GlyGlu: 5.467 ± 0.05	2.87GlyPhe: 2.87 ± 0.032	9.579GlyGly: 9.579 ± 0.091	2.438GlyHis: 2.438 ± 0.035	3.296GlyIle: 3.296 ± 0.041	2.728GlyLys: 2.728 ± 0.043	9.494GlyLeu: 9.494 ± 0.075	1.996GlyMet: 1.996 ± 0.033	1.659GlyAsn: 1.659 ± 0.03	5.429GlyPro: 5.429 ± 0.057	2.74GlyGln: 2.74 ± 0.042	8.091GlyArg: 8.091 ± 0.066	5.31GlySer: 5.31 ± 0.062	6.247GlyThr: 6.247 ± 0.059	7.783GlyVal: 7.783 ± 0.065	1.627GlyTrp: 1.627 ± 0.03	2.18GlyTyr: 2.18 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.84HisAla: 2.84 ± 0.037	0.216HisCys: 0.216 ± 0.01	1.407HisAsp: 1.407 ± 0.026	1.256HisGlu: 1.256 ± 0.025	0.647HisPhe: 0.647 ± 0.015	2.504HisGly: 2.504 ± 0.037	0.724HisHis: 0.724 ± 0.019	0.696HisIle: 0.696 ± 0.016	0.385HisLys: 0.385 ± 0.013	2.46HisLeu: 2.46 ± 0.04	0.35HisMet: 0.35 ± 0.013	0.357HisAsn: 0.357 ± 0.014	1.858HisPro: 1.858 ± 0.03	0.713HisGln: 0.713 ± 0.018	2.169HisArg: 2.169 ± 0.031	0.981HisSer: 0.981 ± 0.018	1.383HisThr: 1.383 ± 0.023	1.768HisVal: 1.768 ± 0.027	0.375HisTrp: 0.375 ± 0.013	0.467HisTyr: 0.467 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.553IleAla: 4.553 ± 0.046	0.276IleCys: 0.276 ± 0.011	2.076IleAsp: 2.076 ± 0.029	1.864IleGlu: 1.864 ± 0.029	0.674IlePhe: 0.674 ± 0.019	3.415IleGly: 3.415 ± 0.045	0.568IleHis: 0.568 ± 0.016	0.783IleIle: 0.783 ± 0.019	0.759IleLys: 0.759 ± 0.02	2.263IleLeu: 2.263 ± 0.038	0.423IleMet: 0.423 ± 0.014	0.639IleAsn: 0.639 ± 0.015	1.645IlePro: 1.645 ± 0.026	0.668IleGln: 0.668 ± 0.017	2.061IleArg: 2.061 ± 0.03	1.559IleSer: 1.559 ± 0.027	2.036IleThr: 2.036 ± 0.033	2.519IleVal: 2.519 ± 0.038	0.367IleTrp: 0.367 ± 0.01	0.484IleTyr: 0.484 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	3.11LysAla: 3.11 ± 0.045	0.124LysCys: 0.124 ± 0.007	1.496LysAsp: 1.496 ± 0.038	1.317LysGlu: 1.317 ± 0.029	0.527LysPhe: 0.527 ± 0.017	2.015LysGly: 2.015 ± 0.039	0.469LysHis: 0.469 ± 0.014	0.875LysIle: 0.875 ± 0.021	1.106LysLys: 1.106 ± 0.036	2.125LysLeu: 2.125 ± 0.031	0.413LysMet: 0.413 ± 0.014	0.579LysAsn: 0.579 ± 0.018	1.506LysPro: 1.506 ± 0.03	0.733LysGln: 0.733 ± 0.022	1.503LysArg: 1.503 ± 0.026	1.297LysSer: 1.297 ± 0.027	1.349LysThr: 1.349 ± 0.026	1.981LysVal: 1.981 ± 0.036	0.308LysTrp: 0.308 ± 0.013	0.48LysTyr: 0.48 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.083LeuAla: 15.083 ± 0.084	0.874LeuCys: 0.874 ± 0.02	6.748LeuAsp: 6.748 ± 0.064	4.437LeuGlu: 4.437 ± 0.047	2.668LeuPhe: 2.668 ± 0.04	9.36LeuGly: 9.36 ± 0.079	2.243LeuHis: 2.243 ± 0.029	3.188LeuIle: 3.188 ± 0.047	2.179LeuLys: 2.179 ± 0.035	11.062LeuLeu: 11.062 ± 0.101	1.64LeuMet: 1.64 ± 0.026	1.672LeuAsn: 1.672 ± 0.027	6.54LeuPro: 6.54 ± 0.057	2.116LeuGln: 2.116 ± 0.033	8.788LeuArg: 8.788 ± 0.07	5.115LeuSer: 5.115 ± 0.051	6.771LeuThr: 6.771 ± 0.054	8.622LeuVal: 8.622 ± 0.076	1.271LeuTrp: 1.271 ± 0.02	1.835LeuTyr: 1.835 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.225MetAla: 2.225 ± 0.031	0.139MetCys: 0.139 ± 0.008	0.938MetAsp: 0.938 ± 0.017	0.771MetGlu: 0.771 ± 0.018	0.464MetPhe: 0.464 ± 0.016	1.38MetGly: 1.38 ± 0.027	0.344MetHis: 0.344 ± 0.011	0.638MetIle: 0.638 ± 0.019	0.447MetLys: 0.447 ± 0.013	1.726MetLeu: 1.726 ± 0.029	0.32MetMet: 0.32 ± 0.012	0.441MetAsn: 0.441 ± 0.012	1.11MetPro: 1.11 ± 0.02	0.412MetGln: 0.412 ± 0.012	1.404MetArg: 1.404 ± 0.025	1.196MetSer: 1.196 ± 0.024	1.489MetThr: 1.489 ± 0.027	1.296MetVal: 1.296 ± 0.023	0.224MetTrp: 0.224 ± 0.011	0.347MetTyr: 0.347 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.06AsnAla: 2.06 ± 0.028	0.168AsnCys: 0.168 ± 0.008	0.919AsnAsp: 0.919 ± 0.022	0.771AsnGlu: 0.771 ± 0.017	0.463AsnPhe: 0.463 ± 0.014	1.809AsnGly: 1.809 ± 0.031	0.382AsnHis: 0.382 ± 0.013	0.583AsnIle: 0.583 ± 0.016	0.454AsnLys: 0.454 ± 0.014	1.557AsnLeu: 1.557 ± 0.026	0.291AsnMet: 0.291 ± 0.011	0.398AsnAsn: 0.398 ± 0.014	1.326AsnPro: 1.326 ± 0.026	0.451AsnGln: 0.451 ± 0.014	1.175AsnArg: 1.175 ± 0.025	0.914AsnSer: 0.914 ± 0.023	1.037AsnThr: 1.037 ± 0.022	1.339AsnVal: 1.339 ± 0.024	0.278AsnTrp: 0.278 ± 0.012	0.392AsnTyr: 0.392 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.644ProAla: 8.644 ± 0.067	0.378ProCys: 0.378 ± 0.013	4.708ProAsp: 4.708 ± 0.055	4.305ProGlu: 4.305 ± 0.043	1.535ProPhe: 1.535 ± 0.028	7.062ProGly: 7.062 ± 0.07	1.489ProHis: 1.489 ± 0.03	1.228ProIle: 1.228 ± 0.024	1.359ProLys: 1.359 ± 0.029	5.507ProLeu: 5.507 ± 0.044	1.02ProMet: 1.02 ± 0.018	0.88ProAsn: 0.88 ± 0.018	3.705ProPro: 3.705 ± 0.056	1.742ProGln: 1.742 ± 0.031	4.331ProArg: 4.331 ± 0.044	3.087ProSer: 3.087 ± 0.041	3.129ProThr: 3.129 ± 0.045	5.276ProVal: 5.276 ± 0.049	0.905ProTrp: 0.905 ± 0.018	1.348ProTyr: 1.348 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.603GlnAla: 3.603 ± 0.048	0.181GlnCys: 0.181 ± 0.009	1.468GlnAsp: 1.468 ± 0.025	1.487GlnGlu: 1.487 ± 0.028	0.71GlnPhe: 0.71 ± 0.017	2.362GlnGly: 2.362 ± 0.038	0.713GlnHis: 0.713 ± 0.02	0.963GlnIle: 0.963 ± 0.021	0.616GlnLys: 0.616 ± 0.016	2.989GlnLeu: 2.989 ± 0.039	0.474GlnMet: 0.474 ± 0.012	0.462GlnAsn: 0.462 ± 0.015	1.709GlnPro: 1.709 ± 0.033	1.216GlnGln: 1.216 ± 0.03	2.471GlnArg: 2.471 ± 0.035	1.238GlnSer: 1.238 ± 0.022	1.205GlnThr: 1.205 ± 0.024	2.277GlnVal: 2.277 ± 0.039	0.457GlnTrp: 0.457 ± 0.014	0.575GlnTyr: 0.575 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	10.753ArgAla: 10.753 ± 0.081	0.659ArgCys: 0.659 ± 0.02	4.477ArgAsp: 4.477 ± 0.049	4.892ArgGlu: 4.892 ± 0.05	2.297ArgPhe: 2.297 ± 0.03	6.429ArgGly: 6.429 ± 0.065	2.318ArgHis: 2.318 ± 0.037	2.8ArgIle: 2.8 ± 0.032	1.707ArgLys: 1.707 ± 0.026	8.769ArgLeu: 8.769 ± 0.069	1.769ArgMet: 1.769 ± 0.026	1.253ArgAsn: 1.253 ± 0.026	5.105ArgPro: 5.105 ± 0.052	2.373ArgGln: 2.373 ± 0.038	8.015ArgArg: 8.015 ± 0.088	3.836ArgSer: 3.836 ± 0.049	5.346ArgThr: 5.346 ± 0.054	6.235ArgVal: 6.235 ± 0.057	1.367ArgTrp: 1.367 ± 0.026	1.729ArgTyr: 1.729 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.662SerAla: 6.662 ± 0.068	0.418SerCys: 0.418 ± 0.015	2.58SerAsp: 2.58 ± 0.035	2.302SerGlu: 2.302 ± 0.035	1.46SerPhe: 1.46 ± 0.026	5.988SerGly: 5.988 ± 0.056	0.98SerHis: 0.98 ± 0.021	1.272SerIle: 1.272 ± 0.023	1.084SerLys: 1.084 ± 0.026	4.683SerLeu: 4.683 ± 0.045	1.047SerMet: 1.047 ± 0.021	0.796SerAsn: 0.796 ± 0.02	3.108SerPro: 3.108 ± 0.045	1.119SerGln: 1.119 ± 0.023	3.586SerArg: 3.586 ± 0.036	2.711SerSer: 2.711 ± 0.042	2.87SerThr: 2.87 ± 0.036	4.102SerVal: 4.102 ± 0.044	0.86SerTrp: 0.86 ± 0.02	1.181SerTyr: 1.181 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	8.673ThrAla: 8.673 ± 0.075	0.419ThrCys: 0.419 ± 0.013	3.514ThrAsp: 3.514 ± 0.038	3.101ThrGlu: 3.101 ± 0.038	1.599ThrPhe: 1.599 ± 0.029	6.564ThrGly: 6.564 ± 0.058	1.239ThrHis: 1.239 ± 0.02	1.548ThrIle: 1.548 ± 0.025	1.285ThrLys: 1.285 ± 0.028	5.545ThrLeu: 5.545 ± 0.057	0.938ThrMet: 0.938 ± 0.022	0.943ThrAsn: 0.943 ± 0.021	4.112ThrPro: 4.112 ± 0.046	1.3ThrGln: 1.3 ± 0.025	3.925ThrArg: 3.925 ± 0.04	2.993ThrSer: 2.993 ± 0.038	3.558ThrThr: 3.558 ± 0.042	5.705ThrVal: 5.705 ± 0.051	0.865ThrTrp: 0.865 ± 0.022	1.418ThrTyr: 1.418 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	10.871ValAla: 10.871 ± 0.078	0.76ValCys: 0.76 ± 0.017	5.067ValAsp: 5.067 ± 0.05	4.617ValGlu: 4.617 ± 0.048	2.401ValPhe: 2.401 ± 0.037	6.903ValGly: 6.903 ± 0.067	1.96ValHis: 1.96 ± 0.03	2.698ValIle: 2.698 ± 0.036	1.771ValLys: 1.771 ± 0.035	9.317ValLeu: 9.317 ± 0.075	1.363ValMet: 1.363 ± 0.027	1.545ValAsn: 1.545 ± 0.028	5.273ValPro: 5.273 ± 0.053	2.035ValGln: 2.035 ± 0.033	7.412ValArg: 7.412 ± 0.06	4.182ValSer: 4.182 ± 0.041	5.44ValThr: 5.44 ± 0.053	8.018ValVal: 8.018 ± 0.073	1.14ValTrp: 1.14 ± 0.024	1.473ValTyr: 1.473 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.657TrpAla: 1.657 ± 0.029	0.16TrpCys: 0.16 ± 0.008	0.825TrpAsp: 0.825 ± 0.021	0.706TrpGlu: 0.706 ± 0.017	0.485TrpPhe: 0.485 ± 0.015	1.052TrpGly: 1.052 ± 0.023	0.362TrpHis: 0.362 ± 0.014	0.519TrpIle: 0.519 ± 0.015	0.383TrpLys: 0.383 ± 0.012	1.771TrpLeu: 1.771 ± 0.028	0.279TrpMet: 0.279 ± 0.01	0.395TrpAsn: 0.395 ± 0.013	0.824TrpPro: 0.824 ± 0.018	0.617TrpGln: 0.617 ± 0.018	1.37TrpArg: 1.37 ± 0.025	0.918TrpSer: 0.918 ± 0.025	0.957TrpThr: 0.957 ± 0.019	0.975TrpVal: 0.975 ± 0.024	0.34TrpTrp: 0.34 ± 0.012	0.344TrpTyr: 0.344 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.875TyrAla: 2.875 ± 0.036	0.169TyrCys: 0.169 ± 0.007	1.456TyrAsp: 1.456 ± 0.03	1.37TyrGlu: 1.37 ± 0.025	0.648TyrPhe: 0.648 ± 0.016	2.264TyrGly: 2.264 ± 0.037	0.386TyrHis: 0.386 ± 0.012	0.451TyrIle: 0.451 ± 0.015	0.421TyrLys: 0.421 ± 0.017	1.972TyrLeu: 1.972 ± 0.027	0.238TyrMet: 0.238 ± 0.01	0.355TyrAsn: 0.355 ± 0.012	1.012TyrPro: 1.012 ± 0.021	0.547TyrGln: 0.547 ± 0.016	1.78TyrArg: 1.78 ± 0.028	0.865TyrSer: 0.865 ± 0.021	1.125TyrThr: 1.125 ± 0.022	1.771TyrVal: 1.771 ± 0.026	0.348TyrTrp: 0.348 ± 0.013	0.433TyrTyr: 0.433 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7750 proteins (2462931 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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