Amino acid dipepetide frequency for Marburg marburgvirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.105AlaAla: 4.105 ± 1.226
0.411AlaCys: 0.411 ± 0.198
3.079AlaAsp: 3.079 ± 0.533
3.284AlaGlu: 3.284 ± 0.682
2.668AlaPhe: 2.668 ± 1.231
1.642AlaGly: 1.642 ± 0.501
1.232AlaHis: 1.232 ± 0.637
4.721AlaIle: 4.721 ± 1.052
2.668AlaLys: 2.668 ± 0.499
6.363AlaLeu: 6.363 ± 0.94
1.026AlaMet: 1.026 ± 0.276
2.258AlaAsn: 2.258 ± 0.566
2.258AlaPro: 2.258 ± 0.685
1.642AlaGln: 1.642 ± 0.576
3.489AlaArg: 3.489 ± 0.884
5.131AlaSer: 5.131 ± 1.153
2.053AlaThr: 2.053 ± 0.453
2.258AlaVal: 2.258 ± 0.343
1.026AlaTrp: 1.026 ± 0.523
2.463AlaTyr: 2.463 ± 0.892
0.0AlaXaa: 0.0 ± 0.0
Cys
1.437CysAla: 1.437 ± 0.481
1.026CysCys: 1.026 ± 0.324
0.821CysAsp: 0.821 ± 0.325
1.026CysGlu: 1.026 ± 0.455
1.232CysPhe: 1.232 ± 0.474
0.616CysGly: 0.616 ± 0.379
0.411CysHis: 0.411 ± 0.264
1.232CysIle: 1.232 ± 0.474
1.026CysLys: 1.026 ± 0.414
0.821CysLeu: 0.821 ± 0.318
0.0CysMet: 0.0 ± 0.0
0.616CysAsn: 0.616 ± 0.233
0.205CysPro: 0.205 ± 0.124
0.205CysGln: 0.205 ± 0.232
1.232CysArg: 1.232 ± 0.389
2.258CysSer: 2.258 ± 0.547
0.821CysThr: 0.821 ± 0.351
1.026CysVal: 1.026 ± 0.305
0.205CysTrp: 0.205 ± 0.124
0.616CysTyr: 0.616 ± 0.237
0.0CysXaa: 0.0 ± 0.0
Asp
4.516AspAla: 4.516 ± 1.003
1.232AspCys: 1.232 ± 0.389
3.079AspAsp: 3.079 ± 0.842
2.668AspGlu: 2.668 ± 0.91
2.874AspPhe: 2.874 ± 1.114
1.026AspGly: 1.026 ± 0.431
1.847AspHis: 1.847 ± 0.689
2.874AspIle: 2.874 ± 0.698
3.079AspLys: 3.079 ± 1.051
6.773AspLeu: 6.773 ± 0.796
1.026AspMet: 1.026 ± 0.664
2.258AspAsn: 2.258 ± 0.564
2.258AspPro: 2.258 ± 0.811
3.9AspGln: 3.9 ± 0.462
1.437AspArg: 1.437 ± 0.473
3.695AspSer: 3.695 ± 1.06
1.437AspThr: 1.437 ± 0.535
2.463AspVal: 2.463 ± 0.6
0.616AspTrp: 0.616 ± 0.234
1.232AspTyr: 1.232 ± 0.545
0.0AspXaa: 0.0 ± 0.0
Glu
2.668GluAla: 2.668 ± 0.313
0.821GluCys: 0.821 ± 0.495
4.721GluAsp: 4.721 ± 1.502
1.847GluGlu: 1.847 ± 0.565
1.847GluPhe: 1.847 ± 0.734
3.695GluGly: 3.695 ± 0.77
1.642GluHis: 1.642 ± 1.073
3.079GluIle: 3.079 ± 0.637
4.516GluLys: 4.516 ± 0.495
5.952GluLeu: 5.952 ± 1.188
0.411GluMet: 0.411 ± 0.198
3.079GluAsn: 3.079 ± 0.632
2.053GluPro: 2.053 ± 1.021
3.284GluGln: 3.284 ± 0.512
1.847GluArg: 1.847 ± 0.295
4.516GluSer: 4.516 ± 1.144
2.668GluThr: 2.668 ± 0.787
1.232GluVal: 1.232 ± 0.834
1.026GluTrp: 1.026 ± 0.557
1.847GluTyr: 1.847 ± 0.525
0.0GluXaa: 0.0 ± 0.0
Phe
0.821PheAla: 0.821 ± 0.383
0.821PheCys: 0.821 ± 0.337
2.874PheAsp: 2.874 ± 0.563
0.821PheGlu: 0.821 ± 0.379
1.642PhePhe: 1.642 ± 0.582
2.463PheGly: 2.463 ± 0.338
1.437PheHis: 1.437 ± 0.452
3.9PheIle: 3.9 ± 1.206
3.079PheLys: 3.079 ± 0.61
6.568PheLeu: 6.568 ± 1.314
0.205PheMet: 0.205 ± 0.124
1.642PheAsn: 1.642 ± 0.391
2.668PhePro: 2.668 ± 1.121
1.437PheGln: 1.437 ± 0.342
2.053PheArg: 2.053 ± 0.599
4.31PheSer: 4.31 ± 0.757
2.874PheThr: 2.874 ± 1.052
2.258PheVal: 2.258 ± 0.572
0.205PheTrp: 0.205 ± 0.124
0.821PheTyr: 0.821 ± 0.495
0.0PheXaa: 0.0 ± 0.0
Gly
2.053GlyAla: 2.053 ± 0.439
0.616GlyCys: 0.616 ± 0.237
1.847GlyAsp: 1.847 ± 0.923
3.284GlyGlu: 3.284 ± 0.342
2.258GlyPhe: 2.258 ± 0.489
2.463GlyGly: 2.463 ± 0.482
1.026GlyHis: 1.026 ± 0.4
4.721GlyIle: 4.721 ± 1.407
3.9GlyLys: 3.9 ± 0.514
4.926GlyLeu: 4.926 ± 0.839
1.026GlyMet: 1.026 ± 0.552
2.258GlyAsn: 2.258 ± 0.904
0.821GlyPro: 0.821 ± 0.469
3.489GlyGln: 3.489 ± 0.574
1.847GlyArg: 1.847 ± 0.513
3.695GlySer: 3.695 ± 0.702
3.9GlyThr: 3.9 ± 0.894
3.695GlyVal: 3.695 ± 1.243
0.821GlyTrp: 0.821 ± 0.578
1.437GlyTyr: 1.437 ± 0.473
0.0GlyXaa: 0.0 ± 0.0
His
1.437HisAla: 1.437 ± 0.62
0.205HisCys: 0.205 ± 0.124
1.026HisAsp: 1.026 ± 0.354
2.258HisGlu: 2.258 ± 0.589
1.232HisPhe: 1.232 ± 0.38
1.847HisGly: 1.847 ± 1.066
1.232HisHis: 1.232 ± 0.351
2.668HisIle: 2.668 ± 0.728
0.616HisLys: 0.616 ± 0.31
3.695HisLeu: 3.695 ± 0.522
0.616HisMet: 0.616 ± 0.424
1.437HisAsn: 1.437 ± 0.407
2.258HisPro: 2.258 ± 0.753
1.642HisGln: 1.642 ± 0.905
0.821HisArg: 0.821 ± 0.351
2.258HisSer: 2.258 ± 0.56
0.616HisThr: 0.616 ± 0.31
1.847HisVal: 1.847 ± 0.579
0.411HisTrp: 0.411 ± 0.191
1.642HisTyr: 1.642 ± 0.675
0.0HisXaa: 0.0 ± 0.0
Ile
3.9IleAla: 3.9 ± 0.948
1.232IleCys: 1.232 ± 0.368
3.695IleAsp: 3.695 ± 0.35
2.874IleGlu: 2.874 ± 0.809
3.284IlePhe: 3.284 ± 0.946
3.695IleGly: 3.695 ± 0.702
1.232IleHis: 1.232 ± 0.556
3.489IleIle: 3.489 ± 0.867
4.516IleLys: 4.516 ± 0.848
6.979IleLeu: 6.979 ± 0.704
1.026IleMet: 1.026 ± 0.69
4.105IleAsn: 4.105 ± 0.709
4.721IlePro: 4.721 ± 0.971
2.874IleGln: 2.874 ± 0.41
1.437IleArg: 1.437 ± 0.348
5.952IleSer: 5.952 ± 1.125
3.284IleThr: 3.284 ± 0.883
3.489IleVal: 3.489 ± 0.565
0.821IleTrp: 0.821 ± 0.202
1.232IleTyr: 1.232 ± 0.351
0.0IleXaa: 0.0 ± 0.0
Lys
2.053LysAla: 2.053 ± 0.63
0.411LysCys: 0.411 ± 0.193
2.668LysAsp: 2.668 ± 0.908
2.668LysGlu: 2.668 ± 0.662
1.232LysPhe: 1.232 ± 0.346
3.489LysGly: 3.489 ± 1.36
1.437LysHis: 1.437 ± 0.662
3.489LysIle: 3.489 ± 0.791
2.874LysLys: 2.874 ± 0.481
5.747LysLeu: 5.747 ± 1.353
1.232LysMet: 1.232 ± 0.641
3.695LysAsn: 3.695 ± 0.443
3.079LysPro: 3.079 ± 0.536
2.053LysGln: 2.053 ± 0.803
2.874LysArg: 2.874 ± 0.222
3.9LysSer: 3.9 ± 0.966
5.337LysThr: 5.337 ± 1.411
3.9LysVal: 3.9 ± 0.506
0.821LysTrp: 0.821 ± 0.297
2.463LysTyr: 2.463 ± 0.639
0.0LysXaa: 0.0 ± 0.0
Leu
7.184LeuAla: 7.184 ± 1.054
1.437LeuCys: 1.437 ± 0.678
5.952LeuAsp: 5.952 ± 0.881
6.158LeuGlu: 6.158 ± 0.848
4.926LeuPhe: 4.926 ± 1.222
6.568LeuGly: 6.568 ± 0.874
2.874LeuHis: 2.874 ± 0.692
6.363LeuIle: 6.363 ± 0.718
5.337LeuLys: 5.337 ± 1.895
10.673LeuLeu: 10.673 ± 0.816
2.258LeuMet: 2.258 ± 0.39
6.568LeuAsn: 6.568 ± 1.234
6.158LeuPro: 6.158 ± 1.584
4.105LeuGln: 4.105 ± 0.884
6.979LeuArg: 6.979 ± 0.733
11.084LeuSer: 11.084 ± 0.943
7.184LeuThr: 7.184 ± 1.019
3.695LeuVal: 3.695 ± 0.731
1.437LeuTrp: 1.437 ± 0.425
3.079LeuTyr: 3.079 ± 0.507
0.0LeuXaa: 0.0 ± 0.0
Met
1.232MetAla: 1.232 ± 0.734
0.205MetCys: 0.205 ± 0.239
0.821MetAsp: 0.821 ± 0.337
0.411MetGlu: 0.411 ± 0.383
1.026MetPhe: 1.026 ± 0.705
0.821MetGly: 0.821 ± 0.377
1.232MetHis: 1.232 ± 0.524
1.026MetIle: 1.026 ± 0.374
1.026MetLys: 1.026 ± 0.334
2.463MetLeu: 2.463 ± 0.709
0.411MetMet: 0.411 ± 0.264
1.026MetAsn: 1.026 ± 0.404
0.411MetPro: 0.411 ± 0.193
1.026MetGln: 1.026 ± 0.466
0.411MetArg: 0.411 ± 0.193
2.258MetSer: 2.258 ± 0.702
0.821MetThr: 0.821 ± 0.711
1.026MetVal: 1.026 ± 0.334
0.205MetTrp: 0.205 ± 0.232
0.411MetTyr: 0.411 ± 0.193
0.0MetXaa: 0.0 ± 0.0
Asn
2.668AsnAla: 2.668 ± 0.572
1.026AsnCys: 1.026 ± 0.619
2.668AsnAsp: 2.668 ± 0.59
2.258AsnGlu: 2.258 ± 0.745
2.874AsnPhe: 2.874 ± 1.165
1.642AsnGly: 1.642 ± 1.036
2.463AsnHis: 2.463 ± 0.735
3.284AsnIle: 3.284 ± 0.909
1.847AsnLys: 1.847 ± 0.404
8.415AsnLeu: 8.415 ± 1.335
1.437AsnMet: 1.437 ± 0.488
3.079AsnAsn: 3.079 ± 0.733
3.9AsnPro: 3.9 ± 0.676
3.489AsnGln: 3.489 ± 0.842
3.284AsnArg: 3.284 ± 0.736
3.695AsnSer: 3.695 ± 0.737
5.542AsnThr: 5.542 ± 1.957
2.053AsnVal: 2.053 ± 0.496
0.821AsnTrp: 0.821 ± 0.337
2.053AsnTyr: 2.053 ± 0.674
0.0AsnXaa: 0.0 ± 0.0
Pro
2.053ProAla: 2.053 ± 1.408
1.232ProCys: 1.232 ± 0.801
1.642ProAsp: 1.642 ± 0.281
2.874ProGlu: 2.874 ± 0.448
2.258ProPhe: 2.258 ± 0.513
2.258ProGly: 2.258 ± 0.329
1.232ProHis: 1.232 ± 0.468
2.668ProIle: 2.668 ± 0.765
2.258ProLys: 2.258 ± 0.47
5.747ProLeu: 5.747 ± 1.246
0.0ProMet: 0.0 ± 0.0
4.105ProAsn: 4.105 ± 1.726
7.594ProPro: 7.594 ± 2.683
2.874ProGln: 2.874 ± 0.962
1.642ProArg: 1.642 ± 0.828
6.363ProSer: 6.363 ± 0.859
4.31ProThr: 4.31 ± 1.937
3.079ProVal: 3.079 ± 0.846
0.0ProTrp: 0.0 ± 0.0
2.053ProTyr: 2.053 ± 0.766
0.0ProXaa: 0.0 ± 0.0
Gln
4.105GlnAla: 4.105 ± 1.004
0.821GlnCys: 0.821 ± 0.318
1.232GlnAsp: 1.232 ± 0.751
3.284GlnGlu: 3.284 ± 1.536
2.258GlnPhe: 2.258 ± 0.755
3.9GlnGly: 3.9 ± 1.499
2.463GlnHis: 2.463 ± 0.422
2.258GlnIle: 2.258 ± 0.351
3.284GlnLys: 3.284 ± 0.47
3.079GlnLeu: 3.079 ± 0.885
1.026GlnMet: 1.026 ± 0.393
3.695GlnAsn: 3.695 ± 0.578
1.437GlnPro: 1.437 ± 0.86
2.668GlnGln: 2.668 ± 0.767
2.053GlnArg: 2.053 ± 0.819
3.079GlnSer: 3.079 ± 0.471
3.284GlnThr: 3.284 ± 0.475
2.053GlnVal: 2.053 ± 0.719
0.0GlnTrp: 0.0 ± 0.0
1.847GlnTyr: 1.847 ± 0.475
0.0GlnXaa: 0.0 ± 0.0
Arg
2.668ArgAla: 2.668 ± 0.726
0.616ArgCys: 0.616 ± 0.371
1.232ArgAsp: 1.232 ± 0.213
3.489ArgGlu: 3.489 ± 0.528
1.232ArgPhe: 1.232 ± 0.49
1.642ArgGly: 1.642 ± 0.245
1.847ArgHis: 1.847 ± 0.571
3.284ArgIle: 3.284 ± 0.768
1.642ArgLys: 1.642 ± 0.389
4.926ArgLeu: 4.926 ± 1.575
0.821ArgMet: 0.821 ± 0.333
3.9ArgAsn: 3.9 ± 1.027
1.026ArgPro: 1.026 ± 0.701
2.463ArgGln: 2.463 ± 0.573
1.847ArgArg: 1.847 ± 0.434
3.9ArgSer: 3.9 ± 1.17
3.9ArgThr: 3.9 ± 0.556
3.9ArgVal: 3.9 ± 0.529
1.026ArgTrp: 1.026 ± 0.432
1.642ArgTyr: 1.642 ± 0.589
0.0ArgXaa: 0.0 ± 0.0
Ser
3.079SerAla: 3.079 ± 0.455
1.232SerCys: 1.232 ± 0.545
4.721SerAsp: 4.721 ± 1.288
4.926SerGlu: 4.926 ± 1.022
3.489SerPhe: 3.489 ± 1.393
4.926SerGly: 4.926 ± 1.285
1.642SerHis: 1.642 ± 0.582
5.747SerIle: 5.747 ± 0.798
4.721SerLys: 4.721 ± 1.575
9.442SerLeu: 9.442 ± 1.91
0.821SerMet: 0.821 ± 0.25
4.105SerAsn: 4.105 ± 0.614
5.747SerPro: 5.747 ± 0.961
4.516SerGln: 4.516 ± 1.489
4.105SerArg: 4.105 ± 1.354
9.031SerSer: 9.031 ± 0.598
7.184SerThr: 7.184 ± 1.544
3.695SerVal: 3.695 ± 0.542
1.026SerTrp: 1.026 ± 0.431
2.463SerTyr: 2.463 ± 0.628
0.0SerXaa: 0.0 ± 0.0
Thr
3.284ThrAla: 3.284 ± 0.989
1.847ThrCys: 1.847 ± 0.811
3.284ThrAsp: 3.284 ± 0.419
3.695ThrGlu: 3.695 ± 1.223
3.284ThrPhe: 3.284 ± 0.89
3.284ThrGly: 3.284 ± 1.208
1.437ThrHis: 1.437 ± 0.342
4.31ThrIle: 4.31 ± 1.06
3.489ThrLys: 3.489 ± 0.88
7.184ThrLeu: 7.184 ± 0.814
1.847ThrMet: 1.847 ± 0.611
5.131ThrAsn: 5.131 ± 2.308
3.9ThrPro: 3.9 ± 0.894
1.847ThrGln: 1.847 ± 0.706
5.131ThrArg: 5.131 ± 0.703
5.542ThrSer: 5.542 ± 1.469
5.131ThrThr: 5.131 ± 2.717
2.874ThrVal: 2.874 ± 1.014
0.205ThrTrp: 0.205 ± 0.124
1.026ThrTyr: 1.026 ± 0.664
0.0ThrXaa: 0.0 ± 0.0
Val
2.874ValAla: 2.874 ± 0.515
1.232ValCys: 1.232 ± 0.446
1.847ValAsp: 1.847 ± 0.584
2.874ValGlu: 2.874 ± 0.545
1.847ValPhe: 1.847 ± 0.542
1.642ValGly: 1.642 ± 0.674
2.053ValHis: 2.053 ± 0.299
2.668ValIle: 2.668 ± 0.774
3.695ValLys: 3.695 ± 1.037
5.131ValLeu: 5.131 ± 0.752
1.437ValMet: 1.437 ± 0.348
2.463ValAsn: 2.463 ± 0.728
3.079ValPro: 3.079 ± 1.218
2.463ValGln: 2.463 ± 0.392
2.258ValArg: 2.258 ± 0.296
3.079ValSer: 3.079 ± 1.127
4.105ValThr: 4.105 ± 1.251
2.258ValVal: 2.258 ± 1.084
0.411ValTrp: 0.411 ± 0.248
1.026ValTyr: 1.026 ± 0.357
0.0ValXaa: 0.0 ± 0.0
Trp
0.205TrpAla: 0.205 ± 0.221
0.0TrpCys: 0.0 ± 0.0
1.232TrpAsp: 1.232 ± 0.461
0.411TrpGlu: 0.411 ± 0.248
0.411TrpPhe: 0.411 ± 0.248
1.437TrpGly: 1.437 ± 0.823
0.205TrpHis: 0.205 ± 0.124
0.821TrpIle: 0.821 ± 0.297
0.616TrpLys: 0.616 ± 0.371
1.642TrpLeu: 1.642 ± 0.391
0.205TrpMet: 0.205 ± 0.124
0.0TrpAsn: 0.0 ± 0.0
0.411TrpPro: 0.411 ± 0.42
0.411TrpGln: 0.411 ± 0.43
0.616TrpArg: 0.616 ± 0.31
0.616TrpSer: 0.616 ± 0.237
1.437TrpThr: 1.437 ± 0.443
0.616TrpVal: 0.616 ± 0.234
0.205TrpTrp: 0.205 ± 0.221
0.821TrpTyr: 0.821 ± 0.495
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.437TyrAla: 1.437 ± 0.471
0.411TyrCys: 0.411 ± 0.248
1.847TyrAsp: 1.847 ± 0.284
1.642TyrGlu: 1.642 ± 0.662
1.026TyrPhe: 1.026 ± 0.288
1.026TyrGly: 1.026 ± 0.619
0.821TyrHis: 0.821 ± 0.351
1.232TyrIle: 1.232 ± 0.545
1.232TyrLys: 1.232 ± 0.469
3.695TyrLeu: 3.695 ± 0.828
1.232TyrMet: 1.232 ± 0.435
3.079TyrAsn: 3.079 ± 0.648
2.258TyrPro: 2.258 ± 0.473
1.437TyrGln: 1.437 ± 0.608
1.642TyrArg: 1.642 ± 0.457
2.258TyrSer: 2.258 ± 0.701
1.847TyrThr: 1.847 ± 0.861
1.026TyrVal: 1.026 ± 0.395
1.026TyrTrp: 1.026 ± 0.431
1.232TyrTyr: 1.232 ± 0.56
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (4873 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski