Amino acid dipepetide frequency for Seonamhaeicola aphaedonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.692AlaAla: 3.692 ± 0.082	0.621AlaCys: 0.621 ± 0.026	3.009AlaAsp: 3.009 ± 0.067	3.701AlaGlu: 3.701 ± 0.073	3.309AlaPhe: 3.309 ± 0.062	3.708AlaGly: 3.708 ± 0.077	1.152AlaHis: 1.152 ± 0.037	5.356AlaIle: 5.356 ± 0.074	4.474AlaLys: 4.474 ± 0.079	6.12AlaLeu: 6.12 ± 0.084	1.442AlaMet: 1.442 ± 0.042	3.385AlaAsn: 3.385 ± 0.067	1.815AlaPro: 1.815 ± 0.048	2.16AlaGln: 2.16 ± 0.044	1.959AlaArg: 1.959 ± 0.05	4.203AlaSer: 4.203 ± 0.073	3.301AlaThr: 3.301 ± 0.062	3.693AlaVal: 3.693 ± 0.067	0.688AlaTrp: 0.688 ± 0.026	2.507AlaTyr: 2.507 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.434CysAla: 0.434 ± 0.021	0.097CysCys: 0.097 ± 0.01	0.477CysAsp: 0.477 ± 0.04	0.489CysGlu: 0.489 ± 0.021	0.457CysPhe: 0.457 ± 0.021	0.618CysGly: 0.618 ± 0.027	0.227CysHis: 0.227 ± 0.018	0.595CysIle: 0.595 ± 0.025	0.558CysLys: 0.558 ± 0.028	0.703CysLeu: 0.703 ± 0.027	0.165CysMet: 0.165 ± 0.013	0.445CysAsn: 0.445 ± 0.022	0.345CysPro: 0.345 ± 0.02	0.233CysGln: 0.233 ± 0.015	0.195CysArg: 0.195 ± 0.015	0.548CysSer: 0.548 ± 0.024	0.442CysThr: 0.442 ± 0.025	0.471CysVal: 0.471 ± 0.023	0.084CysTrp: 0.084 ± 0.009	0.345CysTyr: 0.345 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.533AspAla: 3.533 ± 0.057	0.447AspCys: 0.447 ± 0.033	3.196AspAsp: 3.196 ± 0.068	3.776AspGlu: 3.776 ± 0.06	3.665AspPhe: 3.665 ± 0.058	3.712AspGly: 3.712 ± 0.108	0.847AspHis: 0.847 ± 0.029	5.021AspIle: 5.021 ± 0.07	4.204AspLys: 4.204 ± 0.072	5.09AspLeu: 5.09 ± 0.076	1.18AspMet: 1.18 ± 0.036	3.499AspAsn: 3.499 ± 0.081	1.562AspPro: 1.562 ± 0.047	1.306AspGln: 1.306 ± 0.034	1.822AspArg: 1.822 ± 0.046	3.358AspSer: 3.358 ± 0.063	2.913AspThr: 2.913 ± 0.063	3.757AspVal: 3.757 ± 0.065	0.8AspTrp: 0.8 ± 0.031	3.007AspTyr: 3.007 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	4.569GluAla: 4.569 ± 0.074	0.342GluCys: 0.342 ± 0.019	3.809GluAsp: 3.809 ± 0.06	4.576GluGlu: 4.576 ± 0.083	3.063GluPhe: 3.063 ± 0.056	3.691GluGly: 3.691 ± 0.064	1.242GluHis: 1.242 ± 0.037	5.234GluIle: 5.234 ± 0.077	5.4GluLys: 5.4 ± 0.104	6.053GluLeu: 6.053 ± 0.081	1.456GluMet: 1.456 ± 0.039	4.556GluAsn: 4.556 ± 0.063	1.662GluPro: 1.662 ± 0.038	2.205GluGln: 2.205 ± 0.044	2.473GluArg: 2.473 ± 0.056	3.589GluSer: 3.589 ± 0.058	3.985GluThr: 3.985 ± 0.063	4.402GluVal: 4.402 ± 0.068	0.624GluTrp: 0.624 ± 0.025	2.42GluTyr: 2.42 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	2.75PheAla: 2.75 ± 0.055	0.462PheCys: 0.462 ± 0.02	3.33PheAsp: 3.33 ± 0.062	3.501PheGlu: 3.501 ± 0.057	2.731PhePhe: 2.731 ± 0.06	3.63PheGly: 3.63 ± 0.065	0.86PheHis: 0.86 ± 0.026	4.042PheIle: 4.042 ± 0.066	4.362PheLys: 4.362 ± 0.084	4.703PheLeu: 4.703 ± 0.088	1.083PheMet: 1.083 ± 0.032	3.726PheAsn: 3.726 ± 0.067	1.719PhePro: 1.719 ± 0.039	1.479PheGln: 1.479 ± 0.041	1.624PheArg: 1.624 ± 0.043	4.0PheSer: 4.0 ± 0.073	2.996PheThr: 2.996 ± 0.063	3.033PheVal: 3.033 ± 0.055	0.598PheTrp: 0.598 ± 0.025	2.204PheTyr: 2.204 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.068GlyAla: 4.068 ± 0.082	0.606GlyCys: 0.606 ± 0.03	3.561GlyAsp: 3.561 ± 0.069	3.553GlyGlu: 3.553 ± 0.063	3.703GlyPhe: 3.703 ± 0.062	4.421GlyGly: 4.421 ± 0.093	1.147GlyHis: 1.147 ± 0.036	5.329GlyIle: 5.329 ± 0.09	4.918GlyLys: 4.918 ± 0.07	5.887GlyLeu: 5.887 ± 0.082	1.561GlyMet: 1.561 ± 0.039	3.764GlyAsn: 3.764 ± 0.079	1.382GlyPro: 1.382 ± 0.038	1.83GlyGln: 1.83 ± 0.043	2.103GlyArg: 2.103 ± 0.048	3.776GlySer: 3.776 ± 0.07	3.797GlyThr: 3.797 ± 0.088	4.388GlyVal: 4.388 ± 0.062	0.864GlyTrp: 0.864 ± 0.038	2.904GlyTyr: 2.904 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	0.984HisAla: 0.984 ± 0.031	0.198HisCys: 0.198 ± 0.015	0.938HisAsp: 0.938 ± 0.031	1.011HisGlu: 1.011 ± 0.037	1.211HisPhe: 1.211 ± 0.035	1.174HisGly: 1.174 ± 0.038	0.503HisHis: 0.503 ± 0.024	1.589HisIle: 1.589 ± 0.042	1.314HisLys: 1.314 ± 0.037	1.774HisLeu: 1.774 ± 0.045	0.352HisMet: 0.352 ± 0.019	1.104HisAsn: 1.104 ± 0.038	0.837HisPro: 0.837 ± 0.031	0.708HisGln: 0.708 ± 0.028	0.656HisArg: 0.656 ± 0.023	1.097HisSer: 1.097 ± 0.032	0.922HisThr: 0.922 ± 0.031	1.018HisVal: 1.018 ± 0.033	0.267HisTrp: 0.267 ± 0.017	0.926HisTyr: 0.926 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.214IleAla: 5.214 ± 0.082	0.647IleCys: 0.647 ± 0.025	5.156IleAsp: 5.156 ± 0.074	5.896IleGlu: 5.896 ± 0.078	3.544IlePhe: 3.544 ± 0.067	5.127IleGly: 5.127 ± 0.076	1.411IleHis: 1.411 ± 0.035	6.243IleIle: 6.243 ± 0.101	6.301IleLys: 6.301 ± 0.088	6.983IleLeu: 6.983 ± 0.102	1.516IleMet: 1.516 ± 0.037	5.194IleAsn: 5.194 ± 0.08	3.289IlePro: 3.289 ± 0.049	2.494IleGln: 2.494 ± 0.053	2.519IleArg: 2.519 ± 0.043	5.654IleSer: 5.654 ± 0.075	4.739IleThr: 4.739 ± 0.079	4.722IleVal: 4.722 ± 0.076	0.754IleTrp: 0.754 ± 0.031	2.935IleTyr: 2.935 ± 0.06	0.0IleXaa: 0.0 ± 0.0
Lys	5.199LysAla: 5.199 ± 0.097	0.364LysCys: 0.364 ± 0.018	4.726LysAsp: 4.726 ± 0.082	6.014LysGlu: 6.014 ± 0.092	3.06LysPhe: 3.06 ± 0.059	4.74LysGly: 4.74 ± 0.074	1.622LysHis: 1.622 ± 0.045	6.085LysIle: 6.085 ± 0.095	6.817LysLys: 6.817 ± 0.107	6.881LysLeu: 6.881 ± 0.09	1.953LysMet: 1.953 ± 0.054	5.182LysAsn: 5.182 ± 0.073	2.768LysPro: 2.768 ± 0.061	3.016LysGln: 3.016 ± 0.053	3.16LysArg: 3.16 ± 0.069	4.797LysSer: 4.797 ± 0.077	4.841LysThr: 4.841 ± 0.073	4.745LysVal: 4.745 ± 0.072	0.809LysTrp: 0.809 ± 0.029	3.101LysTyr: 3.101 ± 0.06	0.0LysXaa: 0.0 ± 0.0
Leu	5.414LeuAla: 5.414 ± 0.076	0.728LeuCys: 0.728 ± 0.028	4.994LeuAsp: 4.994 ± 0.081	6.178LeuGlu: 6.178 ± 0.087	4.826LeuPhe: 4.826 ± 0.096	5.824LeuGly: 5.824 ± 0.092	1.524LeuHis: 1.524 ± 0.04	6.889LeuIle: 6.889 ± 0.123	8.305LeuLys: 8.305 ± 0.116	8.307LeuLeu: 8.307 ± 0.114	1.981LeuMet: 1.981 ± 0.045	6.155LeuAsn: 6.155 ± 0.087	3.466LeuPro: 3.466 ± 0.057	2.946LeuGln: 2.946 ± 0.052	3.113LeuArg: 3.113 ± 0.05	6.621LeuSer: 6.621 ± 0.099	4.891LeuThr: 4.891 ± 0.076	5.556LeuVal: 5.556 ± 0.078	0.893LeuTrp: 0.893 ± 0.036	3.225LeuTyr: 3.225 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	1.618MetAla: 1.618 ± 0.043	0.143MetCys: 0.143 ± 0.013	1.08MetAsp: 1.08 ± 0.032	1.248MetGlu: 1.248 ± 0.04	0.942MetPhe: 0.942 ± 0.033	1.374MetGly: 1.374 ± 0.039	0.404MetHis: 0.404 ± 0.021	1.486MetIle: 1.486 ± 0.044	2.001MetLys: 2.001 ± 0.05	2.002MetLeu: 2.002 ± 0.051	0.542MetMet: 0.542 ± 0.026	1.293MetAsn: 1.293 ± 0.034	0.909MetPro: 0.909 ± 0.028	0.776MetGln: 0.776 ± 0.025	0.836MetArg: 0.836 ± 0.026	1.426MetSer: 1.426 ± 0.039	1.175MetThr: 1.175 ± 0.036	1.401MetVal: 1.401 ± 0.038	0.162MetTrp: 0.162 ± 0.012	0.711MetTyr: 0.711 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.705AsnAla: 3.705 ± 0.068	0.496AsnCys: 0.496 ± 0.026	3.579AsnAsp: 3.579 ± 0.074	3.948AsnGlu: 3.948 ± 0.055	3.234AsnPhe: 3.234 ± 0.062	4.075AsnGly: 4.075 ± 0.086	1.257AsnHis: 1.257 ± 0.039	5.346AsnIle: 5.346 ± 0.084	4.818AsnLys: 4.818 ± 0.082	5.679AsnLeu: 5.679 ± 0.087	1.334AsnMet: 1.334 ± 0.034	4.369AsnAsn: 4.369 ± 0.102	2.857AsnPro: 2.857 ± 0.066	2.234AsnGln: 2.234 ± 0.046	2.35AsnArg: 2.35 ± 0.053	3.877AsnSer: 3.877 ± 0.076	3.875AsnThr: 3.875 ± 0.083	3.633AsnVal: 3.633 ± 0.067	0.858AsnTrp: 0.858 ± 0.027	2.959AsnTyr: 2.959 ± 0.056	0.0AsnXaa: 0.0 ± 0.0
Pro	1.688ProAla: 1.688 ± 0.044	0.219ProCys: 0.219 ± 0.015	2.161ProAsp: 2.161 ± 0.052	2.904ProGlu: 2.904 ± 0.062	1.989ProPhe: 1.989 ± 0.047	1.866ProGly: 1.866 ± 0.05	0.667ProHis: 0.667 ± 0.026	2.711ProIle: 2.711 ± 0.049	2.764ProLys: 2.764 ± 0.06	2.938ProLeu: 2.938 ± 0.05	0.727ProMet: 0.727 ± 0.027	2.451ProAsn: 2.451 ± 0.056	0.841ProPro: 0.841 ± 0.031	1.112ProGln: 1.112 ± 0.032	0.998ProArg: 0.998 ± 0.031	2.154ProSer: 2.154 ± 0.051	1.893ProThr: 1.893 ± 0.048	2.207ProVal: 2.207 ± 0.046	0.406ProTrp: 0.406 ± 0.02	1.486ProTyr: 1.486 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	1.846GlnAla: 1.846 ± 0.041	0.215GlnCys: 0.215 ± 0.015	1.695GlnAsp: 1.695 ± 0.044	2.148GlnGlu: 2.148 ± 0.045	1.662GlnPhe: 1.662 ± 0.035	1.855GlnGly: 1.855 ± 0.045	0.604GlnHis: 0.604 ± 0.023	2.53GlnIle: 2.53 ± 0.046	2.569GlnLys: 2.569 ± 0.059	3.336GlnLeu: 3.336 ± 0.054	0.719GlnMet: 0.719 ± 0.029	2.152GlnAsn: 2.152 ± 0.046	1.113GlnPro: 1.113 ± 0.037	1.229GlnGln: 1.229 ± 0.034	1.181GlnArg: 1.181 ± 0.035	1.934GlnSer: 1.934 ± 0.048	1.781GlnThr: 1.781 ± 0.045	1.968GlnVal: 1.968 ± 0.041	0.38GlnTrp: 0.38 ± 0.021	1.377GlnTyr: 1.377 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.04ArgAla: 2.04 ± 0.046	0.213ArgCys: 0.213 ± 0.014	1.845ArgAsp: 1.845 ± 0.045	2.128ArgGlu: 2.128 ± 0.052	1.879ArgPhe: 1.879 ± 0.047	2.05ArgGly: 2.05 ± 0.045	0.691ArgHis: 0.691 ± 0.028	2.851ArgIle: 2.851 ± 0.051	2.711ArgLys: 2.711 ± 0.062	3.38ArgLeu: 3.38 ± 0.056	0.823ArgMet: 0.823 ± 0.031	2.103ArgAsn: 2.103 ± 0.049	1.143ArgPro: 1.143 ± 0.035	1.085ArgGln: 1.085 ± 0.037	1.328ArgArg: 1.328 ± 0.04	1.888ArgSer: 1.888 ± 0.046	1.804ArgThr: 1.804 ± 0.049	2.126ArgVal: 2.126 ± 0.046	0.426ArgTrp: 0.426 ± 0.019	1.551ArgTyr: 1.551 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	3.459SerAla: 3.459 ± 0.064	0.656SerCys: 0.656 ± 0.028	3.431SerAsp: 3.431 ± 0.057	4.104SerGlu: 4.104 ± 0.067	3.751SerPhe: 3.751 ± 0.057	4.634SerGly: 4.634 ± 0.09	1.165SerHis: 1.165 ± 0.033	5.361SerIle: 5.361 ± 0.081	5.371SerLys: 5.371 ± 0.085	5.851SerLeu: 5.851 ± 0.092	1.282SerMet: 1.282 ± 0.034	4.184SerAsn: 4.184 ± 0.076	2.04SerPro: 2.04 ± 0.046	2.03SerGln: 2.03 ± 0.048	2.124SerArg: 2.124 ± 0.047	4.213SerSer: 4.213 ± 0.081	3.383SerThr: 3.383 ± 0.076	4.007SerVal: 4.007 ± 0.066	0.754SerTrp: 0.754 ± 0.03	2.793SerTyr: 2.793 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	3.244ThrAla: 3.244 ± 0.066	0.417ThrCys: 0.417 ± 0.025	3.174ThrAsp: 3.174 ± 0.064	3.221ThrGlu: 3.221 ± 0.056	3.175ThrPhe: 3.175 ± 0.062	3.835ThrGly: 3.835 ± 0.078	1.053ThrHis: 1.053 ± 0.032	5.033ThrIle: 5.033 ± 0.085	4.106ThrLys: 4.106 ± 0.062	5.195ThrLeu: 5.195 ± 0.077	1.019ThrMet: 1.019 ± 0.032	3.436ThrAsn: 3.436 ± 0.074	2.48ThrPro: 2.48 ± 0.055	1.757ThrGln: 1.757 ± 0.045	1.579ThrArg: 1.579 ± 0.04	3.692ThrSer: 3.692 ± 0.066	3.334ThrThr: 3.334 ± 0.083	3.671ThrVal: 3.671 ± 0.075	0.623ThrTrp: 0.623 ± 0.03	2.431ThrTyr: 2.431 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	3.833ValAla: 3.833 ± 0.061	0.572ValCys: 0.572 ± 0.023	3.556ValAsp: 3.556 ± 0.059	3.872ValGlu: 3.872 ± 0.065	3.522ValPhe: 3.522 ± 0.057	3.807ValGly: 3.807 ± 0.061	1.03ValHis: 1.03 ± 0.036	4.905ValIle: 4.905 ± 0.074	4.663ValLys: 4.663 ± 0.072	6.147ValLeu: 6.147 ± 0.094	1.283ValMet: 1.283 ± 0.041	3.738ValAsn: 3.738 ± 0.062	2.167ValPro: 2.167 ± 0.045	1.682ValGln: 1.682 ± 0.042	1.956ValArg: 1.956 ± 0.042	4.461ValSer: 4.461 ± 0.075	3.444ValThr: 3.444 ± 0.068	4.242ValVal: 4.242 ± 0.074	0.628ValTrp: 0.628 ± 0.026	2.489ValTyr: 2.489 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.606TrpAla: 0.606 ± 0.027	0.125TrpCys: 0.125 ± 0.01	0.677TrpAsp: 0.677 ± 0.025	0.7TrpGlu: 0.7 ± 0.027	0.617TrpPhe: 0.617 ± 0.026	0.757TrpGly: 0.757 ± 0.034	0.268TrpHis: 0.268 ± 0.016	0.747TrpIle: 0.747 ± 0.03	0.849TrpLys: 0.849 ± 0.032	1.015TrpLeu: 1.015 ± 0.037	0.316TrpMet: 0.316 ± 0.019	0.815TrpAsn: 0.815 ± 0.036	0.252TrpPro: 0.252 ± 0.016	0.427TrpGln: 0.427 ± 0.023	0.449TrpArg: 0.449 ± 0.023	0.68TrpSer: 0.68 ± 0.027	0.623TrpThr: 0.623 ± 0.03	0.715TrpVal: 0.715 ± 0.027	0.181TrpTrp: 0.181 ± 0.014	0.495TrpTyr: 0.495 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.4TyrAla: 2.4 ± 0.057	0.359TyrCys: 0.359 ± 0.018	2.302TyrAsp: 2.302 ± 0.055	2.381TyrGlu: 2.381 ± 0.057	2.489TyrPhe: 2.489 ± 0.05	2.664TyrGly: 2.664 ± 0.059	0.912TyrHis: 0.912 ± 0.032	2.984TyrIle: 2.984 ± 0.052	3.375TyrLys: 3.375 ± 0.058	3.796TyrLeu: 3.796 ± 0.068	0.792TyrMet: 0.792 ± 0.03	2.929TyrAsn: 2.929 ± 0.064	1.535TyrPro: 1.535 ± 0.039	1.588TyrGln: 1.588 ± 0.046	1.64TyrArg: 1.64 ± 0.043	2.627TyrSer: 2.627 ± 0.055	2.336TyrThr: 2.336 ± 0.052	2.239TyrVal: 2.239 ± 0.048	0.518TyrTrp: 0.518 ± 0.022	1.905TyrTyr: 1.905 ± 0.057	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2965 proteins (1052557 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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