Amino acid dipepetide frequency for Streptococcus phage Javan340

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.805AlaAla: 3.805 ± 1.316
0.577AlaCys: 0.577 ± 0.242
3.69AlaAsp: 3.69 ± 0.573
5.535AlaGlu: 5.535 ± 0.648
2.883AlaPhe: 2.883 ± 0.605
3.575AlaGly: 3.575 ± 0.501
0.461AlaHis: 0.461 ± 0.219
5.996AlaIle: 5.996 ± 1.12
4.497AlaLys: 4.497 ± 0.706
6.688AlaLeu: 6.688 ± 1.139
1.73AlaMet: 1.73 ± 0.378
3.459AlaAsn: 3.459 ± 0.997
1.384AlaPro: 1.384 ± 0.391
2.998AlaGln: 2.998 ± 0.647
1.96AlaArg: 1.96 ± 0.463
3.113AlaSer: 3.113 ± 0.727
4.151AlaThr: 4.151 ± 0.551
4.382AlaVal: 4.382 ± 0.932
0.577AlaTrp: 0.577 ± 0.219
3.229AlaTyr: 3.229 ± 0.553
0.0AlaXaa: 0.0 ± 0.0
Cys
0.461CysAla: 0.461 ± 0.305
0.0CysCys: 0.0 ± 0.0
0.231CysAsp: 0.231 ± 0.14
0.692CysGlu: 0.692 ± 0.348
0.231CysPhe: 0.231 ± 0.227
0.115CysGly: 0.115 ± 0.111
0.115CysHis: 0.115 ± 0.114
0.231CysIle: 0.231 ± 0.221
0.692CysLys: 0.692 ± 0.434
0.461CysLeu: 0.461 ± 0.208
0.231CysMet: 0.231 ± 0.153
0.461CysAsn: 0.461 ± 0.302
0.231CysPro: 0.231 ± 0.158
0.461CysGln: 0.461 ± 0.243
0.231CysArg: 0.231 ± 0.152
0.461CysSer: 0.461 ± 0.267
0.231CysThr: 0.231 ± 0.188
0.346CysVal: 0.346 ± 0.189
0.115CysTrp: 0.115 ± 0.091
0.577CysTyr: 0.577 ± 0.309
0.0CysXaa: 0.0 ± 0.0
Asp
3.229AspAla: 3.229 ± 0.623
0.577AspCys: 0.577 ± 0.288
4.267AspAsp: 4.267 ± 0.757
5.074AspGlu: 5.074 ± 0.962
3.113AspPhe: 3.113 ± 0.589
3.805AspGly: 3.805 ± 0.807
0.577AspHis: 0.577 ± 0.258
5.766AspIle: 5.766 ± 1.172
4.613AspLys: 4.613 ± 0.704
5.074AspLeu: 5.074 ± 0.868
2.076AspMet: 2.076 ± 0.524
2.883AspAsn: 2.883 ± 0.66
1.845AspPro: 1.845 ± 0.393
1.384AspGln: 1.384 ± 0.366
2.422AspArg: 2.422 ± 0.578
2.768AspSer: 2.768 ± 0.589
2.768AspThr: 2.768 ± 0.583
4.728AspVal: 4.728 ± 0.488
0.807AspTrp: 0.807 ± 0.283
2.191AspTyr: 2.191 ± 0.601
0.0AspXaa: 0.0 ± 0.0
Glu
6.227GluAla: 6.227 ± 1.112
0.461GluCys: 0.461 ± 0.218
4.728GluAsp: 4.728 ± 0.832
9.686GluGlu: 9.686 ± 1.457
3.69GluPhe: 3.69 ± 0.724
4.497GluGly: 4.497 ± 0.599
0.807GluHis: 0.807 ± 0.3
5.766GluIle: 5.766 ± 0.872
5.996GluLys: 5.996 ± 0.973
10.378GluLeu: 10.378 ± 1.46
2.768GluMet: 2.768 ± 0.538
4.728GluAsn: 4.728 ± 0.551
1.614GluPro: 1.614 ± 0.651
3.344GluGln: 3.344 ± 0.466
4.728GluArg: 4.728 ± 0.9
4.382GluSer: 4.382 ± 0.728
4.613GluThr: 4.613 ± 0.693
5.189GluVal: 5.189 ± 0.708
1.038GluTrp: 1.038 ± 0.318
2.652GluTyr: 2.652 ± 0.632
0.0GluXaa: 0.0 ± 0.0
Phe
2.191PheAla: 2.191 ± 0.496
0.0PheCys: 0.0 ± 0.0
3.344PheAsp: 3.344 ± 0.595
4.497PheGlu: 4.497 ± 0.941
2.537PhePhe: 2.537 ± 0.616
4.036PheGly: 4.036 ± 0.963
0.461PheHis: 0.461 ± 0.254
3.69PheIle: 3.69 ± 0.806
3.69PheLys: 3.69 ± 0.53
3.229PheLeu: 3.229 ± 0.75
0.692PheMet: 0.692 ± 0.284
2.306PheAsn: 2.306 ± 0.395
1.153PhePro: 1.153 ± 0.376
2.076PheGln: 2.076 ± 0.469
1.96PheArg: 1.96 ± 0.41
2.537PheSer: 2.537 ± 0.528
1.96PheThr: 1.96 ± 0.565
2.768PheVal: 2.768 ± 0.518
0.461PheTrp: 0.461 ± 0.204
1.384PheTyr: 1.384 ± 0.429
0.0PheXaa: 0.0 ± 0.0
Gly
4.036GlyAla: 4.036 ± 1.053
0.346GlyCys: 0.346 ± 0.224
4.728GlyAsp: 4.728 ± 0.867
4.267GlyGlu: 4.267 ± 0.664
3.113GlyPhe: 3.113 ± 0.607
3.921GlyGly: 3.921 ± 0.596
1.153GlyHis: 1.153 ± 0.404
4.728GlyIle: 4.728 ± 1.213
4.151GlyLys: 4.151 ± 0.532
5.189GlyLeu: 5.189 ± 1.044
2.191GlyMet: 2.191 ± 0.521
3.921GlyAsn: 3.921 ± 0.816
1.038GlyPro: 1.038 ± 0.365
2.191GlyGln: 2.191 ± 0.561
2.652GlyArg: 2.652 ± 0.639
3.575GlySer: 3.575 ± 0.689
3.69GlyThr: 3.69 ± 0.557
3.69GlyVal: 3.69 ± 0.538
0.692GlyTrp: 0.692 ± 0.329
2.998GlyTyr: 2.998 ± 0.715
0.0GlyXaa: 0.0 ± 0.0
His
0.346HisAla: 0.346 ± 0.16
0.346HisCys: 0.346 ± 0.196
1.038HisAsp: 1.038 ± 0.394
0.807HisGlu: 0.807 ± 0.338
1.268HisPhe: 1.268 ± 0.275
1.038HisGly: 1.038 ± 0.314
0.577HisHis: 0.577 ± 0.259
1.845HisIle: 1.845 ± 0.438
0.577HisLys: 0.577 ± 0.239
1.038HisLeu: 1.038 ± 0.343
0.231HisMet: 0.231 ± 0.135
0.923HisAsn: 0.923 ± 0.365
0.577HisPro: 0.577 ± 0.241
1.153HisGln: 1.153 ± 0.413
0.461HisArg: 0.461 ± 0.259
0.807HisSer: 0.807 ± 0.307
1.038HisThr: 1.038 ± 0.374
0.692HisVal: 0.692 ± 0.252
0.231HisTrp: 0.231 ± 0.183
0.346HisTyr: 0.346 ± 0.245
0.0HisXaa: 0.0 ± 0.0
Ile
5.65IleAla: 5.65 ± 0.989
0.346IleCys: 0.346 ± 0.255
5.304IleAsp: 5.304 ± 0.785
4.151IleGlu: 4.151 ± 0.73
3.344IlePhe: 3.344 ± 0.544
4.151IleGly: 4.151 ± 0.738
1.268IleHis: 1.268 ± 0.361
4.267IleIle: 4.267 ± 0.692
6.804IleLys: 6.804 ± 1.159
5.766IleLeu: 5.766 ± 0.861
1.268IleMet: 1.268 ± 0.297
3.921IleAsn: 3.921 ± 0.842
2.306IlePro: 2.306 ± 0.471
2.652IleGln: 2.652 ± 0.468
3.229IleArg: 3.229 ± 0.611
6.227IleSer: 6.227 ± 0.879
5.074IleThr: 5.074 ± 0.925
2.883IleVal: 2.883 ± 0.57
0.807IleTrp: 0.807 ± 0.412
1.96IleTyr: 1.96 ± 0.555
0.0IleXaa: 0.0 ± 0.0
Lys
5.535LysAla: 5.535 ± 1.077
0.231LysCys: 0.231 ± 0.168
4.613LysAsp: 4.613 ± 1.062
8.072LysGlu: 8.072 ± 1.104
2.998LysPhe: 2.998 ± 0.547
3.921LysGly: 3.921 ± 0.698
1.153LysHis: 1.153 ± 0.32
5.189LysIle: 5.189 ± 0.943
7.726LysLys: 7.726 ± 1.181
5.996LysLeu: 5.996 ± 0.897
2.306LysMet: 2.306 ± 0.507
3.805LysAsn: 3.805 ± 0.7
2.768LysPro: 2.768 ± 0.596
3.805LysGln: 3.805 ± 0.749
4.958LysArg: 4.958 ± 1.219
4.613LysSer: 4.613 ± 0.603
5.304LysThr: 5.304 ± 0.76
4.728LysVal: 4.728 ± 0.704
1.038LysTrp: 1.038 ± 0.314
3.344LysTyr: 3.344 ± 0.809
0.0LysXaa: 0.0 ± 0.0
Leu
6.112LeuAla: 6.112 ± 0.948
0.577LeuCys: 0.577 ± 0.349
6.112LeuAsp: 6.112 ± 0.871
9.225LeuGlu: 9.225 ± 1.61
3.69LeuPhe: 3.69 ± 0.665
5.535LeuGly: 5.535 ± 0.784
1.384LeuHis: 1.384 ± 0.364
4.267LeuIle: 4.267 ± 0.782
9.917LeuLys: 9.917 ± 0.948
6.688LeuLeu: 6.688 ± 1.183
2.306LeuMet: 2.306 ± 0.497
3.459LeuAsn: 3.459 ± 0.522
1.845LeuPro: 1.845 ± 0.656
2.422LeuGln: 2.422 ± 0.65
4.497LeuArg: 4.497 ± 1.14
6.458LeuSer: 6.458 ± 1.116
5.65LeuThr: 5.65 ± 0.735
4.267LeuVal: 4.267 ± 0.668
1.038LeuTrp: 1.038 ± 0.414
1.96LeuTyr: 1.96 ± 0.496
0.0LeuXaa: 0.0 ± 0.0
Met
1.153MetAla: 1.153 ± 0.418
0.0MetCys: 0.0 ± 0.0
1.153MetAsp: 1.153 ± 0.315
2.422MetGlu: 2.422 ± 0.528
1.268MetPhe: 1.268 ± 0.478
1.384MetGly: 1.384 ± 0.371
0.461MetHis: 0.461 ± 0.208
1.96MetIle: 1.96 ± 0.59
2.191MetLys: 2.191 ± 0.533
2.076MetLeu: 2.076 ± 0.416
0.577MetMet: 0.577 ± 0.318
1.499MetAsn: 1.499 ± 0.39
0.346MetPro: 0.346 ± 0.235
0.692MetGln: 0.692 ± 0.267
1.384MetArg: 1.384 ± 0.493
1.845MetSer: 1.845 ± 0.476
1.614MetThr: 1.614 ± 0.427
1.384MetVal: 1.384 ± 0.379
0.346MetTrp: 0.346 ± 0.201
0.577MetTyr: 0.577 ± 0.259
0.0MetXaa: 0.0 ± 0.0
Asn
3.459AsnAla: 3.459 ± 0.857
0.577AsnCys: 0.577 ± 0.303
2.652AsnAsp: 2.652 ± 0.573
4.382AsnGlu: 4.382 ± 0.592
2.191AsnPhe: 2.191 ± 0.419
5.65AsnGly: 5.65 ± 0.969
0.807AsnHis: 0.807 ± 0.289
3.113AsnIle: 3.113 ± 0.602
3.805AsnLys: 3.805 ± 0.693
3.344AsnLeu: 3.344 ± 0.624
1.499AsnMet: 1.499 ± 0.542
2.768AsnAsn: 2.768 ± 0.528
2.998AsnPro: 2.998 ± 0.583
3.459AsnGln: 3.459 ± 0.745
2.422AsnArg: 2.422 ± 0.607
3.229AsnSer: 3.229 ± 0.81
2.883AsnThr: 2.883 ± 0.512
3.113AsnVal: 3.113 ± 0.764
0.692AsnTrp: 0.692 ± 0.284
1.038AsnTyr: 1.038 ± 0.397
0.0AsnXaa: 0.0 ± 0.0
Pro
1.845ProAla: 1.845 ± 0.459
0.346ProCys: 0.346 ± 0.228
1.268ProAsp: 1.268 ± 0.589
1.96ProGlu: 1.96 ± 0.539
1.153ProPhe: 1.153 ± 0.318
0.923ProGly: 0.923 ± 0.306
0.807ProHis: 0.807 ± 0.271
2.768ProIle: 2.768 ± 0.519
1.384ProLys: 1.384 ± 0.508
3.113ProLeu: 3.113 ± 0.421
0.231ProMet: 0.231 ± 0.179
0.807ProAsn: 0.807 ± 0.276
0.115ProPro: 0.115 ± 0.114
1.499ProGln: 1.499 ± 0.454
0.807ProArg: 0.807 ± 0.289
1.845ProSer: 1.845 ± 0.362
2.537ProThr: 2.537 ± 0.697
2.076ProVal: 2.076 ± 0.367
0.461ProTrp: 0.461 ± 0.18
0.807ProTyr: 0.807 ± 0.312
0.0ProXaa: 0.0 ± 0.0
Gln
3.575GlnAla: 3.575 ± 0.78
0.115GlnCys: 0.115 ± 0.121
1.384GlnAsp: 1.384 ± 0.365
3.805GlnGlu: 3.805 ± 0.585
1.153GlnPhe: 1.153 ± 0.338
2.422GlnGly: 2.422 ± 0.657
0.807GlnHis: 0.807 ± 0.325
1.614GlnIle: 1.614 ± 0.643
3.921GlnLys: 3.921 ± 0.519
4.613GlnLeu: 4.613 ± 0.739
0.807GlnMet: 0.807 ± 0.272
2.537GlnAsn: 2.537 ± 0.495
1.038GlnPro: 1.038 ± 0.27
1.614GlnGln: 1.614 ± 0.519
1.499GlnArg: 1.499 ± 0.43
2.998GlnSer: 2.998 ± 0.477
3.229GlnThr: 3.229 ± 0.587
2.191GlnVal: 2.191 ± 0.449
0.231GlnTrp: 0.231 ± 0.17
1.038GlnTyr: 1.038 ± 0.314
0.0GlnXaa: 0.0 ± 0.0
Arg
3.229ArgAla: 3.229 ± 0.791
0.231ArgCys: 0.231 ± 0.173
2.883ArgAsp: 2.883 ± 0.604
4.151ArgGlu: 4.151 ± 0.935
2.076ArgPhe: 2.076 ± 0.608
2.191ArgGly: 2.191 ± 0.419
0.692ArgHis: 0.692 ± 0.389
2.768ArgIle: 2.768 ± 0.662
4.728ArgLys: 4.728 ± 0.894
3.921ArgLeu: 3.921 ± 0.745
1.038ArgMet: 1.038 ± 0.443
3.229ArgAsn: 3.229 ± 0.592
1.384ArgPro: 1.384 ± 0.473
1.614ArgGln: 1.614 ± 0.363
2.422ArgArg: 2.422 ± 0.693
2.306ArgSer: 2.306 ± 0.534
1.96ArgThr: 1.96 ± 0.461
1.96ArgVal: 1.96 ± 0.487
1.038ArgTrp: 1.038 ± 0.335
2.191ArgTyr: 2.191 ± 0.491
0.0ArgXaa: 0.0 ± 0.0
Ser
3.805SerAla: 3.805 ± 0.85
0.346SerCys: 0.346 ± 0.178
2.998SerAsp: 2.998 ± 0.632
4.958SerGlu: 4.958 ± 0.962
2.768SerPhe: 2.768 ± 0.494
4.151SerGly: 4.151 ± 0.724
0.577SerHis: 0.577 ± 0.246
4.382SerIle: 4.382 ± 0.864
4.036SerLys: 4.036 ± 0.569
5.074SerLeu: 5.074 ± 0.772
0.807SerMet: 0.807 ± 0.377
4.151SerAsn: 4.151 ± 0.664
1.73SerPro: 1.73 ± 0.465
1.96SerGln: 1.96 ± 0.469
2.422SerArg: 2.422 ± 0.616
3.69SerSer: 3.69 ± 1.023
4.151SerThr: 4.151 ± 0.7
4.151SerVal: 4.151 ± 0.716
0.577SerTrp: 0.577 ± 0.236
2.652SerTyr: 2.652 ± 0.677
0.0SerXaa: 0.0 ± 0.0
Thr
3.921ThrAla: 3.921 ± 0.752
0.231ThrCys: 0.231 ± 0.153
3.229ThrAsp: 3.229 ± 0.866
4.036ThrGlu: 4.036 ± 0.771
3.69ThrPhe: 3.69 ± 0.671
4.267ThrGly: 4.267 ± 0.619
1.499ThrHis: 1.499 ± 0.421
5.304ThrIle: 5.304 ± 0.859
4.958ThrLys: 4.958 ± 0.695
5.189ThrLeu: 5.189 ± 0.699
1.153ThrMet: 1.153 ± 0.424
3.229ThrAsn: 3.229 ± 0.511
0.807ThrPro: 0.807 ± 0.234
2.422ThrGln: 2.422 ± 0.523
3.229ThrArg: 3.229 ± 0.542
2.768ThrSer: 2.768 ± 0.623
3.229ThrThr: 3.229 ± 0.626
4.728ThrVal: 4.728 ± 0.96
0.692ThrTrp: 0.692 ± 0.239
1.614ThrTyr: 1.614 ± 0.532
0.0ThrXaa: 0.0 ± 0.0
Val
3.575ValAla: 3.575 ± 0.619
0.461ValCys: 0.461 ± 0.258
4.497ValAsp: 4.497 ± 0.58
5.535ValGlu: 5.535 ± 0.848
1.614ValPhe: 1.614 ± 0.458
4.151ValGly: 4.151 ± 0.806
0.923ValHis: 0.923 ± 0.337
4.843ValIle: 4.843 ± 0.716
5.766ValLys: 5.766 ± 0.946
4.613ValLeu: 4.613 ± 0.661
1.384ValMet: 1.384 ± 0.265
2.883ValAsn: 2.883 ± 0.432
1.845ValPro: 1.845 ± 0.557
1.384ValGln: 1.384 ± 0.484
2.076ValArg: 2.076 ± 0.794
3.69ValSer: 3.69 ± 0.682
4.036ValThr: 4.036 ± 0.758
4.151ValVal: 4.151 ± 0.977
0.807ValTrp: 0.807 ± 0.396
1.384ValTyr: 1.384 ± 0.439
0.0ValXaa: 0.0 ± 0.0
Trp
0.692TrpAla: 0.692 ± 0.388
0.231TrpCys: 0.231 ± 0.145
0.346TrpAsp: 0.346 ± 0.176
1.153TrpGlu: 1.153 ± 0.384
0.577TrpPhe: 0.577 ± 0.246
0.692TrpGly: 0.692 ± 0.24
0.346TrpHis: 0.346 ± 0.171
0.807TrpIle: 0.807 ± 0.318
0.692TrpLys: 0.692 ± 0.282
1.153TrpLeu: 1.153 ± 0.365
0.461TrpMet: 0.461 ± 0.286
1.499TrpAsn: 1.499 ± 0.68
0.231TrpPro: 0.231 ± 0.162
0.807TrpGln: 0.807 ± 0.347
0.807TrpArg: 0.807 ± 0.293
0.461TrpSer: 0.461 ± 0.2
0.231TrpThr: 0.231 ± 0.139
0.577TrpVal: 0.577 ± 0.246
0.346TrpTrp: 0.346 ± 0.159
0.692TrpTyr: 0.692 ± 0.221
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.96TyrAla: 1.96 ± 0.399
0.577TyrCys: 0.577 ± 0.259
1.499TyrAsp: 1.499 ± 0.371
2.883TyrGlu: 2.883 ± 0.549
1.614TyrPhe: 1.614 ± 0.491
1.845TyrGly: 1.845 ± 0.364
0.461TyrHis: 0.461 ± 0.2
2.076TyrIle: 2.076 ± 0.572
1.96TyrLys: 1.96 ± 0.481
3.805TyrLeu: 3.805 ± 0.769
0.461TyrMet: 0.461 ± 0.244
1.614TyrAsn: 1.614 ± 0.422
1.499TyrPro: 1.499 ± 0.472
2.652TyrGln: 2.652 ± 0.752
1.845TyrArg: 1.845 ± 0.527
1.614TyrSer: 1.614 ± 0.5
1.845TyrThr: 1.845 ± 0.629
1.614TyrVal: 1.614 ± 0.387
0.807TyrTrp: 0.807 ± 0.305
1.614TyrTyr: 1.614 ± 0.461
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 43 proteins (8673 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski