Amino acid dipepetide frequency for Paragonimus westermani

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.844AlaAla: 5.844 ± 0.062	1.503AlaCys: 1.503 ± 0.022	3.764AlaAsp: 3.764 ± 0.032	3.961AlaGlu: 3.961 ± 0.038	2.618AlaPhe: 2.618 ± 0.024	3.597AlaGly: 3.597 ± 0.031	1.833AlaHis: 1.833 ± 0.018	3.311AlaIle: 3.311 ± 0.025	2.897AlaLys: 2.897 ± 0.027	6.346AlaLeu: 6.346 ± 0.043	1.411AlaMet: 1.411 ± 0.018	2.951AlaAsn: 2.951 ± 0.025	3.124AlaPro: 3.124 ± 0.031	2.695AlaGln: 2.695 ± 0.02	3.875AlaArg: 3.875 ± 0.029	6.214AlaSer: 6.214 ± 0.045	4.271AlaThr: 4.271 ± 0.029	5.025AlaVal: 5.025 ± 0.033	0.719AlaTrp: 0.719 ± 0.011	1.942AlaTyr: 1.942 ± 0.019	0.001AlaXaa: 0.001 ± 0.0
Cys	1.45CysAla: 1.45 ± 0.018	0.568CysCys: 0.568 ± 0.013	1.113CysAsp: 1.113 ± 0.016	1.087CysGlu: 1.087 ± 0.014	0.898CysPhe: 0.898 ± 0.013	1.349CysGly: 1.349 ± 0.02	0.603CysHis: 0.603 ± 0.011	1.033CysIle: 1.033 ± 0.014	0.852CysLys: 0.852 ± 0.016	2.475CysLeu: 2.475 ± 0.026	0.417CysMet: 0.417 ± 0.009	0.778CysAsn: 0.778 ± 0.013	1.245CysPro: 1.245 ± 0.018	0.846CysGln: 0.846 ± 0.012	1.336CysArg: 1.336 ± 0.019	2.069CysSer: 2.069 ± 0.024	1.288CysThr: 1.288 ± 0.015	1.539CysVal: 1.539 ± 0.02	0.268CysTrp: 0.268 ± 0.006	0.573CysTyr: 0.573 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	3.52AspAla: 3.52 ± 0.023	1.156AspCys: 1.156 ± 0.016	3.043AspAsp: 3.043 ± 0.04	3.576AspGlu: 3.576 ± 0.032	2.037AspPhe: 2.037 ± 0.019	3.092AspGly: 3.092 ± 0.033	1.37AspHis: 1.37 ± 0.015	2.404AspIle: 2.404 ± 0.023	2.101AspLys: 2.101 ± 0.024	5.352AspLeu: 5.352 ± 0.039	1.074AspMet: 1.074 ± 0.016	1.92AspAsn: 1.92 ± 0.019	2.828AspPro: 2.828 ± 0.024	2.123AspGln: 2.123 ± 0.023	3.392AspArg: 3.392 ± 0.027	4.759AspSer: 4.759 ± 0.033	2.868AspThr: 2.868 ± 0.026	3.585AspVal: 3.585 ± 0.03	0.767AspTrp: 0.767 ± 0.013	1.557AspTyr: 1.557 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	4.067GluAla: 4.067 ± 0.036	1.054GluCys: 1.054 ± 0.015	3.158GluAsp: 3.158 ± 0.029	3.969GluGlu: 3.969 ± 0.044	2.059GluPhe: 2.059 ± 0.02	2.212GluGly: 2.212 ± 0.025	1.593GluHis: 1.593 ± 0.016	2.531GluIle: 2.531 ± 0.024	2.877GluLys: 2.877 ± 0.032	6.284GluLeu: 6.284 ± 0.055	1.211GluMet: 1.211 ± 0.015	2.47GluAsn: 2.47 ± 0.022	2.606GluPro: 2.606 ± 0.024	2.737GluGln: 2.737 ± 0.03	3.71GluArg: 3.71 ± 0.038	4.327GluSer: 4.327 ± 0.032	3.292GluThr: 3.292 ± 0.027	3.398GluVal: 3.398 ± 0.031	0.591GluTrp: 0.591 ± 0.011	1.441GluTyr: 1.441 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	2.516PheAla: 2.516 ± 0.024	0.979PheCys: 0.979 ± 0.013	2.141PheAsp: 2.141 ± 0.02	1.986PheGlu: 1.986 ± 0.022	1.469PhePhe: 1.469 ± 0.018	2.451PheGly: 2.451 ± 0.027	1.114PheHis: 1.114 ± 0.015	1.926PheIle: 1.926 ± 0.02	1.482PheLys: 1.482 ± 0.018	3.765PheLeu: 3.765 ± 0.028	0.759PheMet: 0.759 ± 0.013	1.539PheAsn: 1.539 ± 0.019	1.951PhePro: 1.951 ± 0.021	1.552PheGln: 1.552 ± 0.015	2.392PheArg: 2.392 ± 0.022	3.398PheSer: 3.398 ± 0.029	2.479PheThr: 2.479 ± 0.023	2.78PheVal: 2.78 ± 0.021	0.464PheTrp: 0.464 ± 0.01	1.137PheTyr: 1.137 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	3.252GlyAla: 3.252 ± 0.032	1.2GlyCys: 1.2 ± 0.015	2.789GlyAsp: 2.789 ± 0.029	2.66GlyGlu: 2.66 ± 0.031	2.157GlyPhe: 2.157 ± 0.021	3.334GlyGly: 3.334 ± 0.041	1.567GlyHis: 1.567 ± 0.018	2.589GlyIle: 2.589 ± 0.03	2.406GlyLys: 2.406 ± 0.026	5.55GlyLeu: 5.55 ± 0.039	1.123GlyMet: 1.123 ± 0.014	2.068GlyAsn: 2.068 ± 0.021	2.842GlyPro: 2.842 ± 0.056	2.294GlyGln: 2.294 ± 0.023	3.429GlyArg: 3.429 ± 0.027	5.167GlySer: 5.167 ± 0.042	3.355GlyThr: 3.355 ± 0.029	3.5GlyVal: 3.5 ± 0.026	0.634GlyTrp: 0.634 ± 0.011	1.565GlyTyr: 1.565 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.707HisAla: 1.707 ± 0.018	0.703HisCys: 0.703 ± 0.012	1.102HisAsp: 1.102 ± 0.014	1.336HisGlu: 1.336 ± 0.016	1.174HisPhe: 1.174 ± 0.017	1.495HisGly: 1.495 ± 0.018	0.953HisHis: 0.953 ± 0.018	1.333HisIle: 1.333 ± 0.015	1.078HisLys: 1.078 ± 0.013	3.206HisLeu: 3.206 ± 0.025	0.587HisMet: 0.587 ± 0.01	1.047HisAsn: 1.047 ± 0.014	1.86HisPro: 1.86 ± 0.02	1.274HisGln: 1.274 ± 0.017	1.929HisArg: 1.929 ± 0.02	2.916HisSer: 2.916 ± 0.029	1.75HisThr: 1.75 ± 0.021	1.88HisVal: 1.88 ± 0.02	0.395HisTrp: 0.395 ± 0.008	0.781HisTyr: 0.781 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.119IleAla: 3.119 ± 0.023	1.138IleCys: 1.138 ± 0.016	2.499IleAsp: 2.499 ± 0.022	2.581IleGlu: 2.581 ± 0.024	1.844IlePhe: 1.844 ± 0.021	2.661IleGly: 2.661 ± 0.025	1.421IleHis: 1.421 ± 0.017	2.259IleIle: 2.259 ± 0.124	1.996IleLys: 1.996 ± 0.024	4.595IleLeu: 4.595 ± 0.033	0.924IleMet: 0.924 ± 0.014	1.966IleAsn: 1.966 ± 0.021	2.933IlePro: 2.933 ± 0.025	2.025IleGln: 2.025 ± 0.022	3.27IleArg: 3.27 ± 0.024	4.279IleSer: 4.279 ± 0.029	2.882IleThr: 2.882 ± 0.026	2.996IleVal: 2.996 ± 0.025	0.56IleTrp: 0.56 ± 0.01	1.398IleTyr: 1.398 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.784LysAla: 2.784 ± 0.025	0.925LysCys: 0.925 ± 0.015	2.022LysAsp: 2.022 ± 0.024	2.525LysGlu: 2.525 ± 0.026	1.496LysPhe: 1.496 ± 0.017	1.74LysGly: 1.74 ± 0.035	1.321LysHis: 1.321 ± 0.016	2.009LysIle: 2.009 ± 0.022	2.332LysLys: 2.332 ± 0.029	4.896LysLeu: 4.896 ± 0.037	0.988LysMet: 0.988 ± 0.015	1.662LysAsn: 1.662 ± 0.019	2.734LysPro: 2.734 ± 0.024	2.246LysGln: 2.246 ± 0.022	3.423LysArg: 3.423 ± 0.032	3.689LysSer: 3.689 ± 0.031	2.67LysThr: 2.67 ± 0.024	2.534LysVal: 2.534 ± 0.025	0.501LysTrp: 0.501 ± 0.011	1.182LysTyr: 1.182 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	7.105LeuAla: 7.105 ± 0.047	2.236LeuCys: 2.236 ± 0.023	5.463LeuAsp: 5.463 ± 0.036	5.644LeuGlu: 5.644 ± 0.051	4.166LeuPhe: 4.166 ± 0.03	4.983LeuGly: 4.983 ± 0.033	2.927LeuHis: 2.927 ± 0.026	5.048LeuIle: 5.048 ± 0.035	4.61LeuLys: 4.61 ± 0.034	10.846LeuLeu: 10.846 ± 0.071	1.968LeuMet: 1.968 ± 0.018	4.444LeuAsn: 4.444 ± 0.034	5.987LeuPro: 5.987 ± 0.042	4.448LeuGln: 4.448 ± 0.036	6.674LeuArg: 6.674 ± 0.04	9.372LeuSer: 9.372 ± 0.05	6.492LeuThr: 6.492 ± 0.037	6.376LeuVal: 6.376 ± 0.037	1.074LeuTrp: 1.074 ± 0.016	2.469LeuTyr: 2.469 ± 0.025	0.001LeuXaa: 0.001 ± 0.0
Met	1.408MetAla: 1.408 ± 0.016	0.445MetCys: 0.445 ± 0.009	1.277MetAsp: 1.277 ± 0.016	1.324MetGlu: 1.324 ± 0.02	0.818MetPhe: 0.818 ± 0.014	1.015MetGly: 1.015 ± 0.017	0.587MetHis: 0.587 ± 0.01	0.919MetIle: 0.919 ± 0.012	0.988MetLys: 0.988 ± 0.014	2.084MetLeu: 2.084 ± 0.022	0.446MetMet: 0.446 ± 0.01	0.979MetAsn: 0.979 ± 0.013	1.054MetPro: 1.054 ± 0.014	0.915MetGln: 0.915 ± 0.014	1.283MetArg: 1.283 ± 0.016	1.671MetSer: 1.671 ± 0.017	1.205MetThr: 1.205 ± 0.014	1.271MetVal: 1.271 ± 0.014	0.21MetTrp: 0.21 ± 0.007	0.499MetTyr: 0.499 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.893AsnAla: 2.893 ± 0.024	0.92AsnCys: 0.92 ± 0.014	1.96AsnAsp: 1.96 ± 0.021	2.359AsnGlu: 2.359 ± 0.023	1.568AsnPhe: 1.568 ± 0.019	2.609AsnGly: 2.609 ± 0.024	1.183AsnHis: 1.183 ± 0.015	1.896AsnIle: 1.896 ± 0.019	1.767AsnLys: 1.767 ± 0.018	4.266AsnLeu: 4.266 ± 0.031	0.883AsnMet: 0.883 ± 0.014	1.627AsnAsn: 1.627 ± 0.02	2.487AsnPro: 2.487 ± 0.025	1.884AsnGln: 1.884 ± 0.017	2.698AsnArg: 2.698 ± 0.023	3.899AsnSer: 3.899 ± 0.037	2.566AsnThr: 2.566 ± 0.021	2.791AsnVal: 2.791 ± 0.023	0.519AsnTrp: 0.519 ± 0.01	1.192AsnTyr: 1.192 ± 0.015	0.001AsnXaa: 0.001 ± 0.0
Pro	3.589ProAla: 3.589 ± 0.033	1.005ProCys: 1.005 ± 0.015	3.059ProAsp: 3.059 ± 0.024	3.077ProGlu: 3.077 ± 0.028	2.047ProPhe: 2.047 ± 0.021	3.213ProGly: 3.213 ± 0.063	1.524ProHis: 1.524 ± 0.019	2.792ProIle: 2.792 ± 0.024	2.409ProLys: 2.409 ± 0.023	5.042ProLeu: 5.042 ± 0.032	1.058ProMet: 1.058 ± 0.014	2.66ProAsn: 2.66 ± 0.029	4.187ProPro: 4.187 ± 0.047	2.084ProGln: 2.084 ± 0.019	2.957ProArg: 2.957 ± 0.028	5.906ProSer: 5.906 ± 0.048	4.247ProThr: 4.247 ± 0.038	4.376ProVal: 4.376 ± 0.033	0.567ProTrp: 0.567 ± 0.01	1.404ProTyr: 1.404 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	2.777GlnAla: 2.777 ± 0.025	0.894GlnCys: 0.894 ± 0.014	1.555GlnAsp: 1.555 ± 0.015	1.963GlnGlu: 1.963 ± 0.025	1.69GlnPhe: 1.69 ± 0.017	1.506GlnGly: 1.506 ± 0.022	1.319GlnHis: 1.319 ± 0.017	2.016GlnIle: 2.016 ± 0.02	1.927GlnLys: 1.927 ± 0.022	5.566GlnLeu: 5.566 ± 0.042	1.007GlnMet: 1.007 ± 0.014	1.706GlnAsn: 1.706 ± 0.018	2.876GlnPro: 2.876 ± 0.026	2.561GlnGln: 2.561 ± 0.048	2.814GlnArg: 2.814 ± 0.025	3.936GlnSer: 3.936 ± 0.034	2.946GlnThr: 2.946 ± 0.031	2.384GlnVal: 2.384 ± 0.02	0.504GlnTrp: 0.504 ± 0.009	1.022GlnTyr: 1.022 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	3.911ArgAla: 3.911 ± 0.03	1.382ArgCys: 1.382 ± 0.021	2.747ArgAsp: 2.747 ± 0.024	3.249ArgGlu: 3.249 ± 0.031	2.602ArgPhe: 2.602 ± 0.024	2.921ArgGly: 2.921 ± 0.032	1.873ArgHis: 1.873 ± 0.019	3.315ArgIle: 3.315 ± 0.025	3.108ArgLys: 3.108 ± 0.026	7.627ArgLeu: 7.627 ± 0.05	1.47ArgMet: 1.47 ± 0.014	2.531ArgAsn: 2.531 ± 0.021	3.429ArgPro: 3.429 ± 0.03	2.858ArgGln: 2.858 ± 0.025	5.197ArgArg: 5.197 ± 0.036	5.66ArgSer: 5.66 ± 0.04	3.846ArgThr: 3.846 ± 0.029	3.769ArgVal: 3.769 ± 0.033	0.822ArgTrp: 0.822 ± 0.014	1.734ArgTyr: 1.734 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.435SerAla: 6.435 ± 0.046	1.856SerCys: 1.856 ± 0.019	5.106SerAsp: 5.106 ± 0.034	4.922SerGlu: 4.922 ± 0.032	3.134SerPhe: 3.134 ± 0.025	5.652SerGly: 5.652 ± 0.043	2.469SerHis: 2.469 ± 0.028	3.959SerIle: 3.959 ± 0.029	3.841SerLys: 3.841 ± 0.034	8.516SerLeu: 8.516 ± 0.052	1.788SerMet: 1.788 ± 0.018	4.024SerAsn: 4.024 ± 0.033	5.589SerPro: 5.589 ± 0.05	3.697SerGln: 3.697 ± 0.03	5.335SerArg: 5.335 ± 0.036	10.622SerSer: 10.622 ± 0.092	6.744SerThr: 6.744 ± 0.05	6.644SerVal: 6.644 ± 0.04	0.952SerTrp: 0.952 ± 0.012	2.054SerTyr: 2.054 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	4.534ThrAla: 4.534 ± 0.032	1.306ThrCys: 1.306 ± 0.019	3.704ThrAsp: 3.704 ± 0.028	3.737ThrGlu: 3.737 ± 0.034	2.242ThrPhe: 2.242 ± 0.021	3.953ThrGly: 3.953 ± 0.03	1.693ThrHis: 1.693 ± 0.018	2.843ThrIle: 2.843 ± 0.025	2.686ThrLys: 2.686 ± 0.026	5.646ThrLeu: 5.646 ± 0.035	1.234ThrMet: 1.234 ± 0.015	2.932ThrAsn: 2.932 ± 0.029	3.687ThrPro: 3.687 ± 0.032	2.527ThrGln: 2.527 ± 0.025	3.453ThrArg: 3.453 ± 0.022	6.261ThrSer: 6.261 ± 0.046	4.655ThrThr: 4.655 ± 0.046	4.783ThrVal: 4.783 ± 0.034	0.626ThrTrp: 0.626 ± 0.012	1.615ThrTyr: 1.615 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	4.504ValAla: 4.504 ± 0.035	1.645ValCys: 1.645 ± 0.022	4.085ValAsp: 4.085 ± 0.03	3.654ValGlu: 3.654 ± 0.028	2.515ValPhe: 2.515 ± 0.027	3.637ValGly: 3.637 ± 0.03	2.034ValHis: 2.034 ± 0.018	3.206ValIle: 3.206 ± 0.029	2.737ValLys: 2.737 ± 0.027	6.109ValLeu: 6.109 ± 0.035	1.24ValMet: 1.24 ± 0.015	3.037ValAsn: 3.037 ± 0.023	3.753ValPro: 3.753 ± 0.031	2.663ValGln: 2.663 ± 0.026	4.162ValArg: 4.162 ± 0.03	5.914ValSer: 5.914 ± 0.035	4.275ValThr: 4.275 ± 0.033	4.37ValVal: 4.37 ± 0.041	0.751ValTrp: 0.751 ± 0.012	2.01ValTyr: 2.01 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	0.657TrpAla: 0.657 ± 0.011	0.26TrpCys: 0.26 ± 0.008	0.577TrpAsp: 0.577 ± 0.011	0.526TrpGlu: 0.526 ± 0.011	0.523TrpPhe: 0.523 ± 0.01	0.43TrpGly: 0.43 ± 0.009	0.324TrpHis: 0.324 ± 0.008	0.729TrpIle: 0.729 ± 0.013	0.552TrpLys: 0.552 ± 0.011	1.344TrpLeu: 1.344 ± 0.018	0.258TrpMet: 0.258 ± 0.007	0.578TrpAsn: 0.578 ± 0.011	0.609TrpPro: 0.609 ± 0.012	0.435TrpGln: 0.435 ± 0.009	0.785TrpArg: 0.785 ± 0.011	1.097TrpSer: 1.097 ± 0.016	0.74TrpThr: 0.74 ± 0.012	0.564TrpVal: 0.564 ± 0.011	0.17TrpTrp: 0.17 ± 0.006	0.31TrpTyr: 0.31 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.833TyrAla: 1.833 ± 0.018	0.612TyrCys: 0.612 ± 0.011	1.359TyrAsp: 1.359 ± 0.021	1.449TyrGlu: 1.449 ± 0.019	1.222TyrPhe: 1.222 ± 0.016	1.633TyrGly: 1.633 ± 0.025	0.798TyrHis: 0.798 ± 0.011	1.228TyrIle: 1.228 ± 0.017	1.034TyrLys: 1.034 ± 0.016	2.818TyrLeu: 2.818 ± 0.029	0.551TyrMet: 0.551 ± 0.01	1.046TyrAsn: 1.046 ± 0.015	1.421TyrPro: 1.421 ± 0.018	1.105TyrGln: 1.105 ± 0.014	1.938TyrArg: 1.938 ± 0.02	2.182TyrSer: 2.182 ± 0.021	1.547TyrThr: 1.547 ± 0.016	1.738TyrVal: 1.738 ± 0.019	0.373TyrTrp: 0.373 ± 0.008	0.869TyrTyr: 0.869 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12535 proteins (5687671 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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