Amino acid dipepetide frequency for Bombus vosnesenskii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.32AlaAla: 5.32 ± 0.04	1.068AlaCys: 1.068 ± 0.016	2.949AlaAsp: 2.949 ± 0.019	4.206AlaGlu: 4.206 ± 0.034	1.947AlaPhe: 1.947 ± 0.013	3.42AlaGly: 3.42 ± 0.026	1.302AlaHis: 1.302 ± 0.011	3.376AlaIle: 3.376 ± 0.017	3.595AlaLys: 3.595 ± 0.033	5.614AlaLeu: 5.614 ± 0.034	1.445AlaMet: 1.445 ± 0.012	2.713AlaAsn: 2.713 ± 0.015	2.864AlaPro: 2.864 ± 0.023	2.576AlaGln: 2.576 ± 0.021	3.34AlaArg: 3.34 ± 0.02	5.073AlaSer: 5.073 ± 0.025	4.126AlaThr: 4.126 ± 0.022	3.902AlaVal: 3.902 ± 0.023	0.599AlaTrp: 0.599 ± 0.008	1.489AlaTyr: 1.489 ± 0.011	0.001AlaXaa: 0.001 ± 0.0
Cys	0.988CysAla: 0.988 ± 0.012	0.463CysCys: 0.463 ± 0.008	1.075CysAsp: 1.075 ± 0.012	1.097CysGlu: 1.097 ± 0.017	0.662CysPhe: 0.662 ± 0.01	1.221CysGly: 1.221 ± 0.023	0.483CysHis: 0.483 ± 0.007	1.091CysIle: 1.091 ± 0.014	1.148CysLys: 1.148 ± 0.02	1.68CysLeu: 1.68 ± 0.018	0.377CysMet: 0.377 ± 0.005	0.962CysAsn: 0.962 ± 0.013	0.969CysPro: 0.969 ± 0.02	0.758CysGln: 0.758 ± 0.012	1.053CysArg: 1.053 ± 0.019	1.555CysSer: 1.555 ± 0.021	1.079CysThr: 1.079 ± 0.016	1.151CysVal: 1.151 ± 0.019	0.207CysTrp: 0.207 ± 0.004	0.538CysTyr: 0.538 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	3.012AspAla: 3.012 ± 0.019	0.939AspCys: 0.939 ± 0.014	3.491AspAsp: 3.491 ± 0.025	4.208AspGlu: 4.208 ± 0.024	1.935AspPhe: 1.935 ± 0.015	3.006AspGly: 3.006 ± 0.022	1.136AspHis: 1.136 ± 0.009	3.496AspIle: 3.496 ± 0.02	3.363AspLys: 3.363 ± 0.027	4.721AspLeu: 4.721 ± 0.024	1.184AspMet: 1.184 ± 0.01	2.658AspAsn: 2.658 ± 0.02	2.444AspPro: 2.444 ± 0.021	1.841AspGln: 1.841 ± 0.013	2.785AspArg: 2.785 ± 0.025	4.501AspSer: 4.501 ± 0.025	3.202AspThr: 3.202 ± 0.018	3.463AspVal: 3.463 ± 0.019	0.621AspTrp: 0.621 ± 0.008	1.717AspTyr: 1.717 ± 0.013	0.001AspXaa: 0.001 ± 0.0
Glu	4.335GluAla: 4.335 ± 0.035	1.171GluCys: 1.171 ± 0.023	4.403GluAsp: 4.403 ± 0.025	7.228GluGlu: 7.228 ± 0.079	2.085GluPhe: 2.085 ± 0.012	3.207GluGly: 3.207 ± 0.025	1.545GluHis: 1.545 ± 0.011	4.105GluIle: 4.105 ± 0.025	5.568GluLys: 5.568 ± 0.057	6.088GluLeu: 6.088 ± 0.04	1.597GluMet: 1.597 ± 0.011	4.031GluAsn: 4.031 ± 0.024	2.67GluPro: 2.67 ± 0.025	3.127GluGln: 3.127 ± 0.032	4.246GluArg: 4.246 ± 0.034	5.078GluSer: 5.078 ± 0.032	4.127GluThr: 4.127 ± 0.035	3.884GluVal: 3.884 ± 0.031	0.644GluTrp: 0.644 ± 0.007	1.974GluTyr: 1.974 ± 0.014	0.001GluXaa: 0.001 ± 0.0
Phe	1.893PheAla: 1.893 ± 0.015	0.7PheCys: 0.7 ± 0.009	1.866PheAsp: 1.866 ± 0.013	2.017PheGlu: 2.017 ± 0.015	1.284PhePhe: 1.284 ± 0.015	2.017PheGly: 2.017 ± 0.016	0.901PheHis: 0.901 ± 0.009	1.938PheIle: 1.938 ± 0.019	1.839PheLys: 1.839 ± 0.013	3.227PheLeu: 3.227 ± 0.022	0.722PheMet: 0.722 ± 0.008	1.601PheAsn: 1.601 ± 0.013	1.511PhePro: 1.511 ± 0.013	1.335PheGln: 1.335 ± 0.012	1.709PheArg: 1.709 ± 0.015	2.693PheSer: 2.693 ± 0.017	1.966PheThr: 1.966 ± 0.019	2.149PheVal: 2.149 ± 0.018	0.383PheTrp: 0.383 ± 0.006	1.128PheTyr: 1.128 ± 0.012	0.001PheXaa: 0.001 ± 0.0
Gly	3.151GlyAla: 3.151 ± 0.026	0.958GlyCys: 0.958 ± 0.017	2.874GlyAsp: 2.874 ± 0.017	3.317GlyGlu: 3.317 ± 0.021	1.95GlyPhe: 1.95 ± 0.015	4.532GlyGly: 4.532 ± 0.052	1.378GlyHis: 1.378 ± 0.012	3.025GlyIle: 3.025 ± 0.021	3.342GlyLys: 3.342 ± 0.019	4.279GlyLeu: 4.279 ± 0.029	1.172GlyMet: 1.172 ± 0.012	2.799GlyAsn: 2.799 ± 0.019	2.551GlyPro: 2.551 ± 0.032	2.221GlyGln: 2.221 ± 0.018	3.044GlyArg: 3.044 ± 0.019	5.122GlySer: 5.122 ± 0.032	3.377GlyThr: 3.377 ± 0.029	3.189GlyVal: 3.189 ± 0.021	0.625GlyTrp: 0.625 ± 0.009	1.833GlyTyr: 1.833 ± 0.021	0.001GlyXaa: 0.001 ± 0.0
His	1.384HisAla: 1.384 ± 0.011	0.557HisCys: 0.557 ± 0.007	1.078HisAsp: 1.078 ± 0.009	1.415HisGlu: 1.415 ± 0.01	0.856HisPhe: 0.856 ± 0.008	1.37HisGly: 1.37 ± 0.014	1.194HisHis: 1.194 ± 0.021	1.354HisIle: 1.354 ± 0.013	1.348HisLys: 1.348 ± 0.011	2.287HisLeu: 2.287 ± 0.015	0.592HisMet: 0.592 ± 0.007	1.19HisAsn: 1.19 ± 0.011	1.409HisPro: 1.409 ± 0.015	1.287HisGln: 1.287 ± 0.013	1.575HisArg: 1.575 ± 0.013	2.07HisSer: 2.07 ± 0.014	1.428HisThr: 1.428 ± 0.011	1.44HisVal: 1.44 ± 0.012	0.288HisTrp: 0.288 ± 0.005	0.809HisTyr: 0.809 ± 0.008	0.001HisXaa: 0.001 ± 0.0
Ile	3.423IleAla: 3.423 ± 0.018	1.171IleCys: 1.171 ± 0.012	3.124IleAsp: 3.124 ± 0.018	3.981IleGlu: 3.981 ± 0.03	2.071IlePhe: 2.071 ± 0.02	2.826IleGly: 2.826 ± 0.019	1.357IleHis: 1.357 ± 0.012	3.204IleIle: 3.204 ± 0.025	3.593IleLys: 3.593 ± 0.023	5.171IleLeu: 5.171 ± 0.035	1.19IleMet: 1.19 ± 0.01	2.812IleAsn: 2.812 ± 0.021	2.925IlePro: 2.925 ± 0.016	2.463IleGln: 2.463 ± 0.018	2.836IleArg: 2.836 ± 0.014	4.609IleSer: 4.609 ± 0.022	3.37IleThr: 3.37 ± 0.022	3.532IleVal: 3.532 ± 0.02	0.535IleTrp: 0.535 ± 0.007	1.667IleTyr: 1.667 ± 0.013	0.001IleXaa: 0.001 ± 0.0
Lys	3.422LysAla: 3.422 ± 0.027	1.224LysCys: 1.224 ± 0.02	3.643LysAsp: 3.643 ± 0.029	5.282LysGlu: 5.282 ± 0.041	1.947LysPhe: 1.947 ± 0.014	2.741LysGly: 2.741 ± 0.023	1.523LysHis: 1.523 ± 0.011	3.724LysIle: 3.724 ± 0.026	5.306LysLys: 5.306 ± 0.047	5.737LysLeu: 5.737 ± 0.032	1.447LysMet: 1.447 ± 0.012	3.214LysAsn: 3.214 ± 0.023	2.972LysPro: 2.972 ± 0.04	2.929LysGln: 2.929 ± 0.022	3.901LysArg: 3.901 ± 0.025	4.875LysSer: 4.875 ± 0.034	3.528LysThr: 3.528 ± 0.022	3.601LysVal: 3.601 ± 0.025	0.65LysTrp: 0.65 ± 0.008	2.01LysTyr: 2.01 ± 0.015	0.001LysXaa: 0.001 ± 0.0
Leu	5.67LeuAla: 5.67 ± 0.03	1.681LeuCys: 1.681 ± 0.014	4.715LeuAsp: 4.715 ± 0.024	6.57LeuGlu: 6.57 ± 0.049	2.838LeuPhe: 2.838 ± 0.025	4.261LeuGly: 4.261 ± 0.024	2.42LeuHis: 2.42 ± 0.017	4.374LeuIle: 4.374 ± 0.028	5.874LeuLys: 5.874 ± 0.033	8.442LeuLeu: 8.442 ± 0.046	1.905LeuMet: 1.905 ± 0.015	4.317LeuAsn: 4.317 ± 0.023	4.679LeuPro: 4.679 ± 0.023	4.834LeuGln: 4.834 ± 0.035	5.355LeuArg: 5.355 ± 0.026	7.186LeuSer: 7.186 ± 0.025	5.042LeuThr: 5.042 ± 0.023	4.848LeuVal: 4.848 ± 0.026	0.88LeuTrp: 0.88 ± 0.01	2.525LeuTyr: 2.525 ± 0.019	0.001LeuXaa: 0.001 ± 0.0
Met	1.495MetAla: 1.495 ± 0.012	0.389MetCys: 0.389 ± 0.006	1.33MetAsp: 1.33 ± 0.01	1.748MetGlu: 1.748 ± 0.015	0.774MetPhe: 0.774 ± 0.009	1.104MetGly: 1.104 ± 0.012	0.508MetHis: 0.508 ± 0.006	1.13MetIle: 1.13 ± 0.01	1.479MetLys: 1.479 ± 0.011	2.007MetLeu: 2.007 ± 0.014	0.599MetMet: 0.599 ± 0.007	1.083MetAsn: 1.083 ± 0.011	1.055MetPro: 1.055 ± 0.011	1.106MetGln: 1.106 ± 0.012	1.104MetArg: 1.104 ± 0.009	1.842MetSer: 1.842 ± 0.012	1.244MetThr: 1.244 ± 0.01	1.229MetVal: 1.229 ± 0.01	0.237MetTrp: 0.237 ± 0.005	0.673MetTyr: 0.673 ± 0.007	0.0MetXaa: 0.0 ± 0.0
Asn	2.958AsnAla: 2.958 ± 0.018	0.888AsnCys: 0.888 ± 0.01	2.714AsnAsp: 2.714 ± 0.018	3.5AsnGlu: 3.5 ± 0.025	1.704AsnPhe: 1.704 ± 0.014	2.946AsnGly: 2.946 ± 0.022	1.199AsnHis: 1.199 ± 0.012	3.416AsnIle: 3.416 ± 0.024	3.187AsnLys: 3.187 ± 0.021	4.483AsnLeu: 4.483 ± 0.022	1.172AsnMet: 1.172 ± 0.01	3.328AsnAsn: 3.328 ± 0.028	2.186AsnPro: 2.186 ± 0.02	2.167AsnGln: 2.167 ± 0.018	2.413AsnArg: 2.413 ± 0.015	4.283AsnSer: 4.283 ± 0.026	3.079AsnThr: 3.079 ± 0.018	3.448AsnVal: 3.448 ± 0.019	0.492AsnTrp: 0.492 ± 0.007	1.552AsnTyr: 1.552 ± 0.013	0.001AsnXaa: 0.001 ± 0.0
Pro	3.211ProAla: 3.211 ± 0.022	0.78ProCys: 0.78 ± 0.028	2.512ProAsp: 2.512 ± 0.017	3.416ProGlu: 3.416 ± 0.031	1.509ProPhe: 1.509 ± 0.014	3.173ProGly: 3.173 ± 0.053	1.282ProHis: 1.282 ± 0.014	2.642ProIle: 2.642 ± 0.016	2.675ProLys: 2.675 ± 0.024	4.149ProLeu: 4.149 ± 0.024	1.051ProMet: 1.051 ± 0.01	2.346ProAsn: 2.346 ± 0.021	4.987ProPro: 4.987 ± 0.06	2.391ProGln: 2.391 ± 0.022	2.781ProArg: 2.781 ± 0.022	4.743ProSer: 4.743 ± 0.031	3.475ProThr: 3.475 ± 0.026	3.238ProVal: 3.238 ± 0.021	0.482ProTrp: 0.482 ± 0.006	1.485ProTyr: 1.485 ± 0.013	0.001ProXaa: 0.001 ± 0.0
Gln	2.778GlnAla: 2.778 ± 0.021	0.784GlnCys: 0.784 ± 0.014	2.053GlnAsp: 2.053 ± 0.014	3.337GlnGlu: 3.337 ± 0.027	1.309GlnPhe: 1.309 ± 0.012	2.056GlnGly: 2.056 ± 0.015	1.455GlnHis: 1.455 ± 0.014	2.379GlnIle: 2.379 ± 0.017	2.776GlnLys: 2.776 ± 0.023	4.22GlnLeu: 4.22 ± 0.027	1.012GlnMet: 1.012 ± 0.013	2.496GlnAsn: 2.496 ± 0.02	2.378GlnPro: 2.378 ± 0.022	4.62GlnGln: 4.62 ± 0.064	2.818GlnArg: 2.818 ± 0.021	3.507GlnSer: 3.507 ± 0.028	2.642GlnThr: 2.642 ± 0.021	2.46GlnVal: 2.46 ± 0.017	0.464GlnTrp: 0.464 ± 0.006	1.34GlnTyr: 1.34 ± 0.011	0.001GlnXaa: 0.001 ± 0.0
Arg	3.143ArgAla: 3.143 ± 0.021	1.085ArgCys: 1.085 ± 0.013	3.019ArgAsp: 3.019 ± 0.023	3.941ArgGlu: 3.941 ± 0.029	1.804ArgPhe: 1.804 ± 0.011	2.98ArgGly: 2.98 ± 0.021	1.534ArgHis: 1.534 ± 0.013	2.967ArgIle: 2.967 ± 0.014	3.976ArgLys: 3.976 ± 0.022	4.951ArgLeu: 4.951 ± 0.031	1.172ArgMet: 1.172 ± 0.011	2.858ArgAsn: 2.858 ± 0.017	2.703ArgPro: 2.703 ± 0.027	2.56ArgGln: 2.56 ± 0.014	4.422ArgArg: 4.422 ± 0.039	4.658ArgSer: 4.658 ± 0.035	3.021ArgThr: 3.021 ± 0.015	3.023ArgVal: 3.023 ± 0.02	0.621ArgTrp: 0.621 ± 0.01	1.736ArgTyr: 1.736 ± 0.012	0.001ArgXaa: 0.001 ± 0.0
Ser	4.718SerAla: 4.718 ± 0.022	1.434SerCys: 1.434 ± 0.023	4.393SerAsp: 4.393 ± 0.022	5.158SerGlu: 5.158 ± 0.026	2.56SerPhe: 2.56 ± 0.016	4.992SerGly: 4.992 ± 0.035	1.922SerHis: 1.922 ± 0.014	4.41SerIle: 4.41 ± 0.022	4.861SerLys: 4.861 ± 0.029	7.163SerLeu: 7.163 ± 0.027	1.84SerMet: 1.84 ± 0.013	4.516SerAsn: 4.516 ± 0.03	5.225SerPro: 5.225 ± 0.04	3.741SerGln: 3.741 ± 0.024	4.631SerArg: 4.631 ± 0.035	9.6SerSer: 9.6 ± 0.07	5.944SerThr: 5.944 ± 0.038	4.959SerVal: 4.959 ± 0.023	0.867SerTrp: 0.867 ± 0.01	2.199SerTyr: 2.199 ± 0.015	0.001SerXaa: 0.001 ± 0.0
Thr	3.873ThrAla: 3.873 ± 0.02	1.178ThrCys: 1.178 ± 0.017	3.066ThrAsp: 3.066 ± 0.017	4.133ThrGlu: 4.133 ± 0.037	2.027ThrPhe: 2.027 ± 0.014	3.491ThrGly: 3.491 ± 0.023	1.274ThrHis: 1.274 ± 0.009	3.541ThrIle: 3.541 ± 0.021	3.579ThrLys: 3.579 ± 0.025	5.279ThrLeu: 5.279 ± 0.026	1.371ThrMet: 1.371 ± 0.011	3.148ThrAsn: 3.148 ± 0.021	3.796ThrPro: 3.796 ± 0.036	2.438ThrGln: 2.438 ± 0.019	2.84ThrArg: 2.84 ± 0.018	5.747ThrSer: 5.747 ± 0.036	4.946ThrThr: 4.946 ± 0.054	3.941ThrVal: 3.941 ± 0.027	0.634ThrTrp: 0.634 ± 0.008	1.647ThrTyr: 1.647 ± 0.014	0.001ThrXaa: 0.001 ± 0.0
Val	4.018ValAla: 4.018 ± 0.023	1.201ValCys: 1.201 ± 0.015	3.239ValAsp: 3.239 ± 0.019	4.039ValGlu: 4.039 ± 0.041	1.97ValPhe: 1.97 ± 0.017	3.106ValGly: 3.106 ± 0.021	1.445ValHis: 1.445 ± 0.01	3.349ValIle: 3.349 ± 0.019	3.66ValLys: 3.66 ± 0.021	5.235ValLeu: 5.235 ± 0.031	1.308ValMet: 1.308 ± 0.01	2.91ValAsn: 2.91 ± 0.017	3.248ValPro: 3.248 ± 0.02	2.759ValGln: 2.759 ± 0.021	2.995ValArg: 2.995 ± 0.018	4.898ValSer: 4.898 ± 0.023	4.058ValThr: 4.058 ± 0.035	3.822ValVal: 3.822 ± 0.024	0.612ValTrp: 0.612 ± 0.008	1.69ValTyr: 1.69 ± 0.014	0.001ValXaa: 0.001 ± 0.0
Trp	0.536TrpAla: 0.536 ± 0.008	0.22TrpCys: 0.22 ± 0.004	0.544TrpAsp: 0.544 ± 0.007	0.648TrpGlu: 0.648 ± 0.007	0.4TrpPhe: 0.4 ± 0.006	0.488TrpGly: 0.488 ± 0.008	0.245TrpHis: 0.245 ± 0.005	0.648TrpIle: 0.648 ± 0.008	0.715TrpLys: 0.715 ± 0.009	1.069TrpLeu: 1.069 ± 0.013	0.274TrpMet: 0.274 ± 0.005	0.608TrpAsn: 0.608 ± 0.008	0.409TrpPro: 0.409 ± 0.006	0.47TrpGln: 0.47 ± 0.007	0.66TrpArg: 0.66 ± 0.007	0.819TrpSer: 0.819 ± 0.009	0.588TrpThr: 0.588 ± 0.007	0.517TrpVal: 0.517 ± 0.006	0.169TrpTrp: 0.169 ± 0.004	0.341TrpTyr: 0.341 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.598TyrAla: 1.598 ± 0.011	0.668TyrCys: 0.668 ± 0.008	1.638TyrAsp: 1.638 ± 0.013	1.872TyrGlu: 1.872 ± 0.011	1.247TyrPhe: 1.247 ± 0.014	1.801TyrGly: 1.801 ± 0.019	0.829TyrHis: 0.829 ± 0.008	1.689TyrIle: 1.689 ± 0.015	1.793TyrLys: 1.793 ± 0.014	2.612TyrLeu: 2.612 ± 0.019	0.704TyrMet: 0.704 ± 0.007	1.524TyrAsn: 1.524 ± 0.013	1.344TyrPro: 1.344 ± 0.017	1.262TyrGln: 1.262 ± 0.01	1.666TyrArg: 1.666 ± 0.012	2.273TyrSer: 2.273 ± 0.017	1.707TyrThr: 1.707 ± 0.017	1.767TyrVal: 1.767 ± 0.013	0.359TyrTrp: 0.359 ± 0.006	1.142TyrTyr: 1.142 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.002XaaLys: 0.002 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 19375 proteins (14450676 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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