Amino acid dipepetide frequency for Pseudoxanthomonas suwonensis (strain 11-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.656AlaAla: 19.656 ± 0.256	1.206AlaCys: 1.206 ± 0.036	7.018AlaAsp: 7.018 ± 0.087	7.504AlaGlu: 7.504 ± 0.083	3.955AlaPhe: 3.955 ± 0.061	12.715AlaGly: 12.715 ± 0.131	2.421AlaHis: 2.421 ± 0.054	5.05AlaIle: 5.05 ± 0.089	2.774AlaLys: 2.774 ± 0.075	15.49AlaLeu: 15.49 ± 0.164	3.464AlaMet: 3.464 ± 0.058	2.729AlaAsn: 2.729 ± 0.063	6.982AlaPro: 6.982 ± 0.107	4.947AlaGln: 4.947 ± 0.079	11.039AlaArg: 11.039 ± 0.123	6.733AlaSer: 6.733 ± 0.087	6.309AlaThr: 6.309 ± 0.089	9.096AlaVal: 9.096 ± 0.101	2.384AlaTrp: 2.384 ± 0.059	2.475AlaTyr: 2.475 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.017CysAla: 1.017 ± 0.036	0.098CysCys: 0.098 ± 0.01	0.431CysAsp: 0.431 ± 0.025	0.437CysGlu: 0.437 ± 0.021	0.257CysPhe: 0.257 ± 0.018	0.877CysGly: 0.877 ± 0.03	0.237CysHis: 0.237 ± 0.016	0.327CysIle: 0.327 ± 0.017	0.161CysLys: 0.161 ± 0.014	0.76CysLeu: 0.76 ± 0.029	0.147CysMet: 0.147 ± 0.013	0.188CysAsn: 0.188 ± 0.013	0.406CysPro: 0.406 ± 0.022	0.238CysGln: 0.238 ± 0.016	0.604CysArg: 0.604 ± 0.025	0.424CysSer: 0.424 ± 0.021	0.42CysThr: 0.42 ± 0.02	0.63CysVal: 0.63 ± 0.026	0.118CysTrp: 0.118 ± 0.011	0.178CysTyr: 0.178 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.971AspAla: 7.971 ± 0.104	0.421AspCys: 0.421 ± 0.021	3.013AspAsp: 3.013 ± 0.06	3.464AspGlu: 3.464 ± 0.067	1.92AspPhe: 1.92 ± 0.047	6.057AspGly: 6.057 ± 0.09	1.14AspHis: 1.14 ± 0.029	2.145AspIle: 2.145 ± 0.05	1.16AspLys: 1.16 ± 0.043	5.691AspLeu: 5.691 ± 0.069	1.11AspMet: 1.11 ± 0.032	1.228AspAsn: 1.228 ± 0.037	3.999AspPro: 3.999 ± 0.068	1.766AspGln: 1.766 ± 0.043	4.161AspArg: 4.161 ± 0.064	2.394AspSer: 2.394 ± 0.051	2.59AspThr: 2.59 ± 0.058	3.927AspVal: 3.927 ± 0.07	1.101AspTrp: 1.101 ± 0.034	1.566AspTyr: 1.566 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	8.233GluAla: 8.233 ± 0.103	0.343GluCys: 0.343 ± 0.019	2.911GluAsp: 2.911 ± 0.055	3.065GluGlu: 3.065 ± 0.064	1.782GluPhe: 1.782 ± 0.045	4.742GluGly: 4.742 ± 0.067	1.375GluHis: 1.375 ± 0.038	2.331GluIle: 2.331 ± 0.058	1.507GluLys: 1.507 ± 0.045	6.679GluLeu: 6.679 ± 0.082	1.109GluMet: 1.109 ± 0.036	1.119GluAsn: 1.119 ± 0.036	3.076GluPro: 3.076 ± 0.072	2.769GluGln: 2.769 ± 0.056	5.53GluArg: 5.53 ± 0.079	2.441GluSer: 2.441 ± 0.05	2.393GluThr: 2.393 ± 0.052	4.578GluVal: 4.578 ± 0.066	0.836GluTrp: 0.836 ± 0.028	1.22GluTyr: 1.22 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.127PheAla: 4.127 ± 0.077	0.313PheCys: 0.313 ± 0.018	2.428PheAsp: 2.428 ± 0.047	2.019PheGlu: 2.019 ± 0.046	1.161PhePhe: 1.161 ± 0.044	3.338PheGly: 3.338 ± 0.065	0.746PheHis: 0.746 ± 0.03	1.138PheIle: 1.138 ± 0.038	0.694PheLys: 0.694 ± 0.029	3.081PheLeu: 3.081 ± 0.056	0.617PheMet: 0.617 ± 0.024	0.971PheAsn: 0.971 ± 0.037	1.453PhePro: 1.453 ± 0.04	0.98PheGln: 0.98 ± 0.027	2.216PheArg: 2.216 ± 0.048	1.754PheSer: 1.754 ± 0.048	1.496PheThr: 1.496 ± 0.041	2.496PheVal: 2.496 ± 0.046	0.505PheTrp: 0.505 ± 0.023	0.781PheTyr: 0.781 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.463GlyAla: 9.463 ± 0.119	0.829GlyCys: 0.829 ± 0.031	4.905GlyAsp: 4.905 ± 0.075	5.441GlyGlu: 5.441 ± 0.086	3.443GlyPhe: 3.443 ± 0.065	7.83GlyGly: 7.83 ± 0.104	2.184GlyHis: 2.184 ± 0.049	3.869GlyIle: 3.869 ± 0.067	2.797GlyLys: 2.797 ± 0.069	9.679GlyLeu: 9.679 ± 0.118	2.46GlyMet: 2.46 ± 0.051	2.383GlyAsn: 2.383 ± 0.056	3.601GlyPro: 3.601 ± 0.061	3.588GlyGln: 3.588 ± 0.063	7.172GlyArg: 7.172 ± 0.091	4.77GlySer: 4.77 ± 0.073	4.48GlyThr: 4.48 ± 0.072	6.618GlyVal: 6.618 ± 0.086	1.832GlyTrp: 1.832 ± 0.045	2.371GlyTyr: 2.371 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	3.052HisAla: 3.052 ± 0.06	0.237HisCys: 0.237 ± 0.014	1.244HisAsp: 1.244 ± 0.04	1.178HisGlu: 1.178 ± 0.033	0.755HisPhe: 0.755 ± 0.025	2.486HisGly: 2.486 ± 0.06	0.612HisHis: 0.612 ± 0.028	0.643HisIle: 0.643 ± 0.027	0.42HisLys: 0.42 ± 0.022	2.121HisLeu: 2.121 ± 0.058	0.418HisMet: 0.418 ± 0.02	0.438HisAsn: 0.438 ± 0.022	1.54HisPro: 1.54 ± 0.046	0.633HisGln: 0.633 ± 0.022	1.643HisArg: 1.643 ± 0.039	0.881HisSer: 0.881 ± 0.032	0.842HisThr: 0.842 ± 0.029	1.661HisVal: 1.661 ± 0.044	0.419HisTrp: 0.419 ± 0.023	0.627HisTyr: 0.627 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.618IleAla: 5.618 ± 0.081	0.276IleCys: 0.276 ± 0.018	2.927IleAsp: 2.927 ± 0.055	2.773IleGlu: 2.773 ± 0.057	0.892IlePhe: 0.892 ± 0.034	4.003IleGly: 4.003 ± 0.068	0.773IleHis: 0.773 ± 0.026	1.17IleIle: 1.17 ± 0.042	0.909IleLys: 0.909 ± 0.033	2.917IleLeu: 2.917 ± 0.061	0.46IleMet: 0.46 ± 0.022	1.084IleAsn: 1.084 ± 0.04	1.99IlePro: 1.99 ± 0.041	1.025IleGln: 1.025 ± 0.031	2.676IleArg: 2.676 ± 0.049	1.834IleSer: 1.834 ± 0.054	1.783IleThr: 1.783 ± 0.04	2.864IleVal: 2.864 ± 0.052	0.393IleTrp: 0.393 ± 0.023	0.72IleTyr: 0.72 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.052LysAla: 3.052 ± 0.071	0.126LysCys: 0.126 ± 0.014	1.243LysAsp: 1.243 ± 0.05	1.053LysGlu: 1.053 ± 0.038	0.647LysPhe: 0.647 ± 0.027	1.832LysGly: 1.832 ± 0.05	0.48LysHis: 0.48 ± 0.023	0.967LysIle: 0.967 ± 0.035	0.919LysLys: 0.919 ± 0.051	2.599LysLeu: 2.599 ± 0.061	0.5LysMet: 0.5 ± 0.023	0.512LysAsn: 0.512 ± 0.021	1.621LysPro: 1.621 ± 0.04	0.877LysGln: 0.877 ± 0.029	1.839LysArg: 1.839 ± 0.051	1.068LysSer: 1.068 ± 0.035	1.221LysThr: 1.221 ± 0.043	2.199LysVal: 2.199 ± 0.06	0.254LysTrp: 0.254 ± 0.016	0.541LysTyr: 0.541 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	16.494LeuAla: 16.494 ± 0.172	0.934LeuCys: 0.934 ± 0.028	6.883LeuAsp: 6.883 ± 0.095	6.651LeuGlu: 6.651 ± 0.091	3.32LeuPhe: 3.32 ± 0.065	9.089LeuGly: 9.089 ± 0.116	2.485LeuHis: 2.485 ± 0.056	2.807LeuIle: 2.807 ± 0.061	2.52LeuLys: 2.52 ± 0.054	12.516LeuLeu: 12.516 ± 0.169	1.983LeuMet: 1.983 ± 0.049	2.0LeuAsn: 2.0 ± 0.046	7.061LeuPro: 7.061 ± 0.105	4.188LeuGln: 4.188 ± 0.073	9.397LeuArg: 9.397 ± 0.116	5.311LeuSer: 5.311 ± 0.073	3.906LeuThr: 3.906 ± 0.06	9.044LeuVal: 9.044 ± 0.106	1.428LeuTrp: 1.428 ± 0.041	2.207LeuTyr: 2.207 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.802MetAla: 2.802 ± 0.053	0.149MetCys: 0.149 ± 0.013	1.186MetAsp: 1.186 ± 0.034	1.023MetGlu: 1.023 ± 0.033	0.611MetPhe: 0.611 ± 0.025	1.582MetGly: 1.582 ± 0.049	0.49MetHis: 0.49 ± 0.023	0.757MetIle: 0.757 ± 0.031	0.678MetLys: 0.678 ± 0.026	2.357MetLeu: 2.357 ± 0.045	0.406MetMet: 0.406 ± 0.023	0.585MetAsn: 0.585 ± 0.027	1.451MetPro: 1.451 ± 0.038	0.878MetGln: 0.878 ± 0.03	1.765MetArg: 1.765 ± 0.044	1.464MetSer: 1.464 ± 0.045	1.194MetThr: 1.194 ± 0.032	1.477MetVal: 1.477 ± 0.042	0.222MetTrp: 0.222 ± 0.016	0.357MetTyr: 0.357 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.929AsnAla: 2.929 ± 0.059	0.194AsnCys: 0.194 ± 0.014	1.229AsnAsp: 1.229 ± 0.04	1.07AsnGlu: 1.07 ± 0.034	0.764AsnPhe: 0.764 ± 0.032	2.04AsnGly: 2.04 ± 0.049	0.478AsnHis: 0.478 ± 0.023	0.956AsnIle: 0.956 ± 0.036	0.472AsnLys: 0.472 ± 0.025	2.367AsnLeu: 2.367 ± 0.049	0.392AsnMet: 0.392 ± 0.022	0.599AsnAsn: 0.599 ± 0.031	1.738AsnPro: 1.738 ± 0.046	0.742AsnGln: 0.742 ± 0.028	1.72AsnArg: 1.72 ± 0.042	0.997AsnSer: 0.997 ± 0.034	1.149AsnThr: 1.149 ± 0.035	1.641AsnVal: 1.641 ± 0.044	0.369AsnTrp: 0.369 ± 0.024	0.596AsnTyr: 0.596 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	8.559ProAla: 8.559 ± 0.147	0.345ProCys: 0.345 ± 0.023	3.621ProAsp: 3.621 ± 0.062	3.91ProGlu: 3.91 ± 0.056	1.643ProPhe: 1.643 ± 0.043	5.83ProGly: 5.83 ± 0.087	1.098ProHis: 1.098 ± 0.033	1.557ProIle: 1.557 ± 0.044	1.194ProLys: 1.194 ± 0.046	5.923ProLeu: 5.923 ± 0.086	1.229ProMet: 1.229 ± 0.034	1.094ProAsn: 1.094 ± 0.04	3.329ProPro: 3.329 ± 0.071	2.188ProGln: 2.188 ± 0.053	4.137ProArg: 4.137 ± 0.063	2.573ProSer: 2.573 ± 0.053	2.179ProThr: 2.179 ± 0.051	4.89ProVal: 4.89 ± 0.079	0.968ProTrp: 0.968 ± 0.034	1.162ProTyr: 1.162 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	5.975GlnAla: 5.975 ± 0.11	0.221GlnCys: 0.221 ± 0.016	1.6GlnAsp: 1.6 ± 0.037	1.663GlnGlu: 1.663 ± 0.042	1.074GlnPhe: 1.074 ± 0.036	2.838GlnGly: 2.838 ± 0.054	0.754GlnHis: 0.754 ± 0.03	1.186GlnIle: 1.186 ± 0.036	0.816GlnLys: 0.816 ± 0.029	4.251GlnLeu: 4.251 ± 0.077	0.769GlnMet: 0.769 ± 0.03	0.67GlnAsn: 0.67 ± 0.029	2.406GlnPro: 2.406 ± 0.053	1.768GlnGln: 1.768 ± 0.05	3.517GlnArg: 3.517 ± 0.066	1.457GlnSer: 1.457 ± 0.04	1.26GlnThr: 1.26 ± 0.04	3.475GlnVal: 3.475 ± 0.062	0.623GlnTrp: 0.623 ± 0.025	0.752GlnTyr: 0.752 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	9.26ArgAla: 9.26 ± 0.112	0.577ArgCys: 0.577 ± 0.026	4.64ArgAsp: 4.64 ± 0.063	5.464ArgGlu: 5.464 ± 0.084	2.986ArgPhe: 2.986 ± 0.054	6.101ArgGly: 6.101 ± 0.085	2.062ArgHis: 2.062 ± 0.043	4.008ArgIle: 4.008 ± 0.055	2.054ArgLys: 2.054 ± 0.056	9.178ArgLeu: 9.178 ± 0.13	2.125ArgMet: 2.125 ± 0.044	1.992ArgAsn: 1.992 ± 0.037	4.216ArgPro: 4.216 ± 0.077	3.435ArgGln: 3.435 ± 0.067	6.976ArgArg: 6.976 ± 0.102	3.757ArgSer: 3.757 ± 0.061	3.451ArgThr: 3.451 ± 0.06	5.617ArgVal: 5.617 ± 0.077	1.419ArgTrp: 1.419 ± 0.038	2.231ArgTyr: 2.231 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	5.713SerAla: 5.713 ± 0.085	0.372SerCys: 0.372 ± 0.019	2.514SerAsp: 2.514 ± 0.059	2.413SerGlu: 2.413 ± 0.055	1.743SerPhe: 1.743 ± 0.042	5.003SerGly: 5.003 ± 0.079	1.068SerHis: 1.068 ± 0.032	1.966SerIle: 1.966 ± 0.044	1.085SerLys: 1.085 ± 0.037	5.433SerLeu: 5.433 ± 0.074	1.04SerMet: 1.04 ± 0.031	1.158SerAsn: 1.158 ± 0.04	2.944SerPro: 2.944 ± 0.06	1.62SerGln: 1.62 ± 0.043	3.92SerArg: 3.92 ± 0.059	2.524SerSer: 2.524 ± 0.047	2.466SerThr: 2.466 ± 0.053	3.391SerVal: 3.391 ± 0.056	0.806SerTrp: 0.806 ± 0.029	1.185SerTyr: 1.185 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.566ThrAla: 5.566 ± 0.082	0.377ThrCys: 0.377 ± 0.02	2.218ThrAsp: 2.218 ± 0.049	1.987ThrGlu: 1.987 ± 0.051	1.302ThrPhe: 1.302 ± 0.039	4.73ThrGly: 4.73 ± 0.065	0.923ThrHis: 0.923 ± 0.028	1.858ThrIle: 1.858 ± 0.043	0.802ThrLys: 0.802 ± 0.037	5.443ThrLeu: 5.443 ± 0.072	0.775ThrMet: 0.775 ± 0.029	0.886ThrAsn: 0.886 ± 0.034	3.23ThrPro: 3.23 ± 0.062	1.22ThrGln: 1.22 ± 0.033	3.535ThrArg: 3.535 ± 0.046	2.21ThrSer: 2.21 ± 0.049	2.419ThrThr: 2.419 ± 0.049	3.798ThrVal: 3.798 ± 0.071	0.733ThrTrp: 0.733 ± 0.026	0.923ThrTyr: 0.923 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	10.28ValAla: 10.28 ± 0.115	0.599ValCys: 0.599 ± 0.027	4.657ValAsp: 4.657 ± 0.073	4.976ValGlu: 4.976 ± 0.063	2.606ValPhe: 2.606 ± 0.055	5.596ValGly: 5.596 ± 0.081	1.673ValHis: 1.673 ± 0.042	2.915ValIle: 2.915 ± 0.056	1.638ValLys: 1.638 ± 0.047	8.994ValLeu: 8.994 ± 0.123	1.559ValMet: 1.559 ± 0.046	1.762ValAsn: 1.762 ± 0.048	4.407ValPro: 4.407 ± 0.072	2.694ValGln: 2.694 ± 0.048	5.995ValArg: 5.995 ± 0.086	3.76ValSer: 3.76 ± 0.058	3.463ValThr: 3.463 ± 0.064	6.78ValVal: 6.78 ± 0.095	0.859ValTrp: 0.859 ± 0.028	1.578ValTyr: 1.578 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.35TrpAla: 1.35 ± 0.045	0.158TrpCys: 0.158 ± 0.011	0.773TrpAsp: 0.773 ± 0.033	0.746TrpGlu: 0.746 ± 0.029	0.622TrpPhe: 0.622 ± 0.029	0.988TrpGly: 0.988 ± 0.032	0.408TrpHis: 0.408 ± 0.021	0.724TrpIle: 0.724 ± 0.035	0.472TrpLys: 0.472 ± 0.024	2.384TrpLeu: 2.384 ± 0.055	0.465TrpMet: 0.465 ± 0.024	0.497TrpAsn: 0.497 ± 0.025	0.841TrpPro: 0.841 ± 0.031	0.724TrpGln: 0.724 ± 0.026	1.5TrpArg: 1.5 ± 0.046	0.883TrpSer: 0.883 ± 0.028	0.767TrpThr: 0.767 ± 0.029	0.976TrpVal: 0.976 ± 0.034	0.333TrpTrp: 0.333 ± 0.02	0.391TrpTyr: 0.391 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.829TyrAla: 2.829 ± 0.057	0.18TyrCys: 0.18 ± 0.013	1.384TyrAsp: 1.384 ± 0.036	1.202TyrGlu: 1.202 ± 0.039	0.831TyrPhe: 0.831 ± 0.029	2.037TyrGly: 2.037 ± 0.05	0.444TyrHis: 0.444 ± 0.022	0.717TyrIle: 0.717 ± 0.028	0.476TyrLys: 0.476 ± 0.025	2.357TyrLeu: 2.357 ± 0.055	0.402TyrMet: 0.402 ± 0.019	0.55TyrAsn: 0.55 ± 0.024	1.139TyrPro: 1.139 ± 0.037	0.796TyrGln: 0.796 ± 0.03	2.204TyrArg: 2.204 ± 0.052	1.131TyrSer: 1.131 ± 0.04	1.15TyrThr: 1.15 ± 0.037	1.634TyrVal: 1.634 ± 0.044	0.401TyrTrp: 0.401 ± 0.019	0.614TyrTyr: 0.614 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3068 proteins (1012518 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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