Amino acid dipepetide frequency for Mycobacterium phage Changeling

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.877AlaAla: 11.877 ± 1.25
0.557AlaCys: 0.557 ± 0.203
5.444AlaAsp: 5.444 ± 0.502
7.423AlaGlu: 7.423 ± 0.722
3.835AlaPhe: 3.835 ± 0.474
8.536AlaGly: 8.536 ± 0.838
1.546AlaHis: 1.546 ± 0.266
4.145AlaIle: 4.145 ± 0.527
5.196AlaLys: 5.196 ± 0.575
9.588AlaLeu: 9.588 ± 0.908
3.217AlaMet: 3.217 ± 0.438
2.907AlaAsn: 2.907 ± 0.579
4.516AlaPro: 4.516 ± 0.574
3.711AlaGln: 3.711 ± 0.623
6.495AlaArg: 6.495 ± 0.847
5.072AlaSer: 5.072 ± 0.608
5.072AlaThr: 5.072 ± 0.658
7.237AlaVal: 7.237 ± 0.692
1.423AlaTrp: 1.423 ± 0.272
3.031AlaTyr: 3.031 ± 0.494
0.0AlaXaa: 0.0 ± 0.0
Cys
0.68CysAla: 0.68 ± 0.197
0.062CysCys: 0.062 ± 0.055
0.433CysAsp: 0.433 ± 0.17
0.68CysGlu: 0.68 ± 0.216
0.371CysPhe: 0.371 ± 0.172
0.804CysGly: 0.804 ± 0.244
0.186CysHis: 0.186 ± 0.14
0.371CysIle: 0.371 ± 0.149
0.371CysLys: 0.371 ± 0.132
0.68CysLeu: 0.68 ± 0.19
0.186CysMet: 0.186 ± 0.118
0.371CysAsn: 0.371 ± 0.133
0.371CysPro: 0.371 ± 0.159
0.186CysGln: 0.186 ± 0.124
0.433CysArg: 0.433 ± 0.19
0.247CysSer: 0.247 ± 0.118
0.742CysThr: 0.742 ± 0.243
0.619CysVal: 0.619 ± 0.19
0.309CysTrp: 0.309 ± 0.146
0.371CysTyr: 0.371 ± 0.147
0.0CysXaa: 0.0 ± 0.0
Asp
6.248AspAla: 6.248 ± 0.692
0.68AspCys: 0.68 ± 0.245
3.959AspAsp: 3.959 ± 0.525
4.33AspGlu: 4.33 ± 0.559
2.66AspPhe: 2.66 ± 0.467
6.0AspGly: 6.0 ± 0.695
1.546AspHis: 1.546 ± 0.348
3.464AspIle: 3.464 ± 0.391
2.351AspLys: 2.351 ± 0.385
5.629AspLeu: 5.629 ± 0.685
1.979AspMet: 1.979 ± 0.349
1.237AspAsn: 1.237 ± 0.275
4.949AspPro: 4.949 ± 0.708
1.485AspGln: 1.485 ± 0.302
3.217AspArg: 3.217 ± 0.462
2.845AspSer: 2.845 ± 0.455
3.65AspThr: 3.65 ± 0.563
4.516AspVal: 4.516 ± 0.634
1.175AspTrp: 1.175 ± 0.261
2.351AspTyr: 2.351 ± 0.4
0.0AspXaa: 0.0 ± 0.0
Glu
8.413GluAla: 8.413 ± 0.909
0.309GluCys: 0.309 ± 0.136
4.578GluAsp: 4.578 ± 0.812
5.505GluGlu: 5.505 ± 0.733
2.907GluPhe: 2.907 ± 0.399
4.639GluGly: 4.639 ± 0.589
1.608GluHis: 1.608 ± 0.285
3.464GluIle: 3.464 ± 0.462
2.041GluLys: 2.041 ± 0.35
7.299GluLeu: 7.299 ± 0.657
2.103GluMet: 2.103 ± 0.342
2.165GluAsn: 2.165 ± 0.359
2.969GluPro: 2.969 ± 0.426
2.722GluGln: 2.722 ± 0.424
4.578GluArg: 4.578 ± 0.608
2.722GluSer: 2.722 ± 0.419
3.897GluThr: 3.897 ± 0.456
5.196GluVal: 5.196 ± 0.537
1.546GluTrp: 1.546 ± 0.28
1.794GluTyr: 1.794 ± 0.295
0.0GluXaa: 0.0 ± 0.0
Phe
3.217PheAla: 3.217 ± 0.467
0.495PheCys: 0.495 ± 0.199
2.351PheAsp: 2.351 ± 0.432
3.526PheGlu: 3.526 ± 0.491
0.99PhePhe: 0.99 ± 0.253
3.402PheGly: 3.402 ± 0.446
0.804PheHis: 0.804 ± 0.279
1.918PheIle: 1.918 ± 0.331
1.423PheLys: 1.423 ± 0.352
2.598PheLeu: 2.598 ± 0.467
0.495PheMet: 0.495 ± 0.183
1.67PheAsn: 1.67 ± 0.359
2.041PhePro: 2.041 ± 0.415
1.175PheGln: 1.175 ± 0.32
1.794PheArg: 1.794 ± 0.328
2.165PheSer: 2.165 ± 0.359
2.165PheThr: 2.165 ± 0.332
2.289PheVal: 2.289 ± 0.389
0.371PheTrp: 0.371 ± 0.131
0.742PheTyr: 0.742 ± 0.227
0.0PheXaa: 0.0 ± 0.0
Gly
7.299GlyAla: 7.299 ± 0.884
0.68GlyCys: 0.68 ± 0.198
7.114GlyAsp: 7.114 ± 1.002
5.444GlyGlu: 5.444 ± 0.766
3.402GlyPhe: 3.402 ± 0.509
6.928GlyGly: 6.928 ± 0.945
1.608GlyHis: 1.608 ± 0.316
3.959GlyIle: 3.959 ± 0.536
3.773GlyLys: 3.773 ± 0.466
6.248GlyLeu: 6.248 ± 0.744
2.227GlyMet: 2.227 ± 0.478
3.402GlyAsn: 3.402 ± 0.427
5.877GlyPro: 5.877 ± 2.119
2.784GlyGln: 2.784 ± 0.425
4.268GlyArg: 4.268 ± 0.44
3.588GlySer: 3.588 ± 0.587
5.011GlyThr: 5.011 ± 0.703
6.866GlyVal: 6.866 ± 0.674
1.175GlyTrp: 1.175 ± 0.32
2.784GlyTyr: 2.784 ± 0.393
0.0GlyXaa: 0.0 ± 0.0
His
1.918HisAla: 1.918 ± 0.319
0.309HisCys: 0.309 ± 0.123
1.237HisAsp: 1.237 ± 0.305
1.67HisGlu: 1.67 ± 0.383
0.557HisPhe: 0.557 ± 0.191
1.546HisGly: 1.546 ± 0.362
0.742HisHis: 0.742 ± 0.216
1.175HisIle: 1.175 ± 0.275
1.237HisLys: 1.237 ± 0.291
1.67HisLeu: 1.67 ± 0.309
0.186HisMet: 0.186 ± 0.098
0.619HisAsn: 0.619 ± 0.188
1.423HisPro: 1.423 ± 0.279
0.742HisGln: 0.742 ± 0.268
1.485HisArg: 1.485 ± 0.346
0.619HisSer: 0.619 ± 0.202
0.928HisThr: 0.928 ± 0.224
1.175HisVal: 1.175 ± 0.346
0.495HisTrp: 0.495 ± 0.195
0.495HisTyr: 0.495 ± 0.235
0.0HisXaa: 0.0 ± 0.0
Ile
5.32IleAla: 5.32 ± 0.549
0.495IleCys: 0.495 ± 0.176
3.402IleAsp: 3.402 ± 0.469
4.578IleGlu: 4.578 ± 0.526
1.423IlePhe: 1.423 ± 0.247
4.825IleGly: 4.825 ± 0.758
0.99IleHis: 0.99 ± 0.257
2.041IleIle: 2.041 ± 0.34
2.351IleLys: 2.351 ± 0.454
3.402IleLeu: 3.402 ± 0.418
0.742IleMet: 0.742 ± 0.207
2.103IleAsn: 2.103 ± 0.39
3.278IlePro: 3.278 ± 0.43
1.237IleGln: 1.237 ± 0.252
2.722IleArg: 2.722 ± 0.422
2.412IleSer: 2.412 ± 0.377
3.773IleThr: 3.773 ± 0.447
2.907IleVal: 2.907 ± 0.409
0.619IleTrp: 0.619 ± 0.169
0.742IleTyr: 0.742 ± 0.226
0.0IleXaa: 0.0 ± 0.0
Lys
4.763LysAla: 4.763 ± 0.704
0.124LysCys: 0.124 ± 0.067
2.474LysAsp: 2.474 ± 0.43
2.103LysGlu: 2.103 ± 0.365
1.299LysPhe: 1.299 ± 0.274
4.145LysGly: 4.145 ± 0.916
0.309LysHis: 0.309 ± 0.127
2.227LysIle: 2.227 ± 0.409
2.907LysLys: 2.907 ± 0.563
3.711LysLeu: 3.711 ± 0.496
0.866LysMet: 0.866 ± 0.242
1.175LysAsn: 1.175 ± 0.245
3.278LysPro: 3.278 ± 0.586
1.113LysGln: 1.113 ± 0.288
3.093LysArg: 3.093 ± 0.526
2.041LysSer: 2.041 ± 0.348
2.722LysThr: 2.722 ± 0.43
3.588LysVal: 3.588 ± 0.511
0.619LysTrp: 0.619 ± 0.216
1.052LysTyr: 1.052 ± 0.198
0.0LysXaa: 0.0 ± 0.0
Leu
9.155LeuAla: 9.155 ± 1.028
0.495LeuCys: 0.495 ± 0.19
5.382LeuAsp: 5.382 ± 0.57
6.31LeuGlu: 6.31 ± 0.7
2.845LeuPhe: 2.845 ± 0.366
5.815LeuGly: 5.815 ± 0.699
1.918LeuHis: 1.918 ± 0.422
4.145LeuIle: 4.145 ± 0.615
2.907LeuLys: 2.907 ± 0.415
5.629LeuLeu: 5.629 ± 0.597
2.412LeuMet: 2.412 ± 0.378
2.536LeuAsn: 2.536 ± 0.483
4.887LeuPro: 4.887 ± 0.575
3.278LeuGln: 3.278 ± 0.696
5.567LeuArg: 5.567 ± 0.669
4.701LeuSer: 4.701 ± 0.561
4.949LeuThr: 4.949 ± 0.714
4.454LeuVal: 4.454 ± 0.601
2.103LeuTrp: 2.103 ± 0.349
2.103LeuTyr: 2.103 ± 0.375
0.0LeuXaa: 0.0 ± 0.0
Met
2.722MetAla: 2.722 ± 0.403
0.124MetCys: 0.124 ± 0.079
1.052MetAsp: 1.052 ± 0.294
1.485MetGlu: 1.485 ± 0.262
0.433MetPhe: 0.433 ± 0.138
1.608MetGly: 1.608 ± 0.328
0.557MetHis: 0.557 ± 0.169
1.299MetIle: 1.299 ± 0.265
1.67MetLys: 1.67 ± 0.393
1.794MetLeu: 1.794 ± 0.426
0.495MetMet: 0.495 ± 0.188
0.866MetAsn: 0.866 ± 0.246
1.299MetPro: 1.299 ± 0.428
1.113MetGln: 1.113 ± 0.25
1.423MetArg: 1.423 ± 0.236
2.66MetSer: 2.66 ± 0.418
2.351MetThr: 2.351 ± 0.35
1.608MetVal: 1.608 ± 0.291
0.371MetTrp: 0.371 ± 0.13
0.742MetTyr: 0.742 ± 0.215
0.0MetXaa: 0.0 ± 0.0
Asn
3.093AsnAla: 3.093 ± 0.42
0.557AsnCys: 0.557 ± 0.147
1.918AsnAsp: 1.918 ± 0.343
2.041AsnGlu: 2.041 ± 0.403
0.866AsnPhe: 0.866 ± 0.292
3.897AsnGly: 3.897 ± 0.536
1.052AsnHis: 1.052 ± 0.224
1.485AsnIle: 1.485 ± 0.365
0.99AsnLys: 0.99 ± 0.224
2.536AsnLeu: 2.536 ± 0.453
0.68AsnMet: 0.68 ± 0.203
0.68AsnAsn: 0.68 ± 0.181
2.536AsnPro: 2.536 ± 0.374
0.619AsnGln: 0.619 ± 0.195
1.67AsnArg: 1.67 ± 0.4
1.361AsnSer: 1.361 ± 0.212
1.732AsnThr: 1.732 ± 0.411
2.351AsnVal: 2.351 ± 0.393
1.113AsnTrp: 1.113 ± 0.279
0.866AsnTyr: 0.866 ± 0.206
0.0AsnXaa: 0.0 ± 0.0
Pro
6.557ProAla: 6.557 ± 0.774
0.433ProCys: 0.433 ± 0.188
4.021ProAsp: 4.021 ± 0.555
4.268ProGlu: 4.268 ± 0.572
1.856ProPhe: 1.856 ± 0.364
4.949ProGly: 4.949 ± 0.683
0.99ProHis: 0.99 ± 0.224
2.722ProIle: 2.722 ± 0.286
3.031ProLys: 3.031 ± 0.68
3.278ProLeu: 3.278 ± 0.46
1.546ProMet: 1.546 ± 0.34
2.289ProAsn: 2.289 ± 0.427
2.474ProPro: 2.474 ± 0.475
2.907ProGln: 2.907 ± 0.896
3.711ProArg: 3.711 ± 0.646
2.598ProSer: 2.598 ± 0.343
3.402ProThr: 3.402 ± 0.435
3.464ProVal: 3.464 ± 0.302
0.99ProTrp: 0.99 ± 0.375
1.546ProTyr: 1.546 ± 0.325
0.0ProXaa: 0.0 ± 0.0
Gln
4.516GlnAla: 4.516 ± 0.606
0.247GlnCys: 0.247 ± 0.113
1.361GlnAsp: 1.361 ± 0.269
2.041GlnGlu: 2.041 ± 0.385
1.608GlnPhe: 1.608 ± 0.437
4.206GlnGly: 4.206 ± 1.538
0.804GlnHis: 0.804 ± 0.225
2.103GlnIle: 2.103 ± 0.35
1.732GlnLys: 1.732 ± 0.347
3.278GlnLeu: 3.278 ± 0.712
0.804GlnMet: 0.804 ± 0.226
0.619GlnAsn: 0.619 ± 0.199
1.237GlnPro: 1.237 ± 0.282
1.856GlnGln: 1.856 ± 0.396
2.598GlnArg: 2.598 ± 0.428
1.485GlnSer: 1.485 ± 0.315
1.918GlnThr: 1.918 ± 0.376
2.474GlnVal: 2.474 ± 0.372
0.742GlnTrp: 0.742 ± 0.217
0.68GlnTyr: 0.68 ± 0.218
0.0GlnXaa: 0.0 ± 0.0
Arg
4.701ArgAla: 4.701 ± 0.705
0.99ArgCys: 0.99 ± 0.297
4.392ArgAsp: 4.392 ± 0.495
4.763ArgGlu: 4.763 ± 0.73
2.66ArgPhe: 2.66 ± 0.509
4.887ArgGly: 4.887 ± 0.713
1.546ArgHis: 1.546 ± 0.294
3.65ArgIle: 3.65 ± 0.481
2.351ArgLys: 2.351 ± 0.392
5.382ArgLeu: 5.382 ± 0.639
2.165ArgMet: 2.165 ± 0.387
1.979ArgAsn: 1.979 ± 0.347
2.474ArgPro: 2.474 ± 0.354
2.103ArgGln: 2.103 ± 0.398
5.258ArgArg: 5.258 ± 0.569
3.278ArgSer: 3.278 ± 0.437
2.474ArgThr: 2.474 ± 0.408
4.639ArgVal: 4.639 ± 0.546
1.299ArgTrp: 1.299 ± 0.254
2.227ArgTyr: 2.227 ± 0.38
0.0ArgXaa: 0.0 ± 0.0
Ser
4.33SerAla: 4.33 ± 0.453
0.495SerCys: 0.495 ± 0.172
3.031SerAsp: 3.031 ± 0.373
2.845SerGlu: 2.845 ± 0.417
2.289SerPhe: 2.289 ± 0.415
4.083SerGly: 4.083 ± 0.627
0.742SerHis: 0.742 ± 0.201
2.907SerIle: 2.907 ± 0.417
2.289SerLys: 2.289 ± 0.424
4.145SerLeu: 4.145 ± 0.672
1.299SerMet: 1.299 ± 0.248
1.175SerAsn: 1.175 ± 0.229
2.722SerPro: 2.722 ± 0.355
2.536SerGln: 2.536 ± 0.381
3.773SerArg: 3.773 ± 0.467
2.227SerSer: 2.227 ± 0.417
3.217SerThr: 3.217 ± 0.409
3.402SerVal: 3.402 ± 0.467
0.742SerTrp: 0.742 ± 0.217
1.608SerTyr: 1.608 ± 0.319
0.0SerXaa: 0.0 ± 0.0
Thr
5.567ThrAla: 5.567 ± 0.617
0.433ThrCys: 0.433 ± 0.153
3.155ThrAsp: 3.155 ± 0.51
3.835ThrGlu: 3.835 ± 0.418
2.165ThrPhe: 2.165 ± 0.266
5.567ThrGly: 5.567 ± 0.855
0.742ThrHis: 0.742 ± 0.224
2.784ThrIle: 2.784 ± 0.435
2.722ThrLys: 2.722 ± 0.424
4.701ThrLeu: 4.701 ± 0.615
1.423ThrMet: 1.423 ± 0.291
1.67ThrAsn: 1.67 ± 0.313
4.763ThrPro: 4.763 ± 0.653
2.474ThrGln: 2.474 ± 0.397
2.722ThrArg: 2.722 ± 0.414
2.969ThrSer: 2.969 ± 0.452
3.155ThrThr: 3.155 ± 0.449
4.083ThrVal: 4.083 ± 0.55
1.361ThrTrp: 1.361 ± 0.254
2.351ThrTyr: 2.351 ± 0.364
0.0ThrXaa: 0.0 ± 0.0
Val
5.938ValAla: 5.938 ± 0.74
0.495ValCys: 0.495 ± 0.171
5.382ValAsp: 5.382 ± 0.42
4.206ValGlu: 4.206 ± 0.612
2.227ValPhe: 2.227 ± 0.41
5.196ValGly: 5.196 ± 0.579
1.361ValHis: 1.361 ± 0.268
3.278ValIle: 3.278 ± 0.516
3.278ValLys: 3.278 ± 0.416
5.877ValLeu: 5.877 ± 0.593
1.732ValMet: 1.732 ± 0.378
2.474ValAsn: 2.474 ± 0.364
3.526ValPro: 3.526 ± 0.564
2.474ValGln: 2.474 ± 0.393
4.578ValArg: 4.578 ± 0.53
3.773ValSer: 3.773 ± 0.639
5.011ValThr: 5.011 ± 0.637
5.072ValVal: 5.072 ± 0.556
1.485ValTrp: 1.485 ± 0.326
2.598ValTyr: 2.598 ± 0.464
0.0ValXaa: 0.0 ± 0.0
Trp
1.732TrpAla: 1.732 ± 0.329
0.247TrpCys: 0.247 ± 0.148
1.237TrpAsp: 1.237 ± 0.281
1.299TrpGlu: 1.299 ± 0.267
0.495TrpPhe: 0.495 ± 0.201
1.361TrpGly: 1.361 ± 0.323
0.742TrpHis: 0.742 ± 0.23
0.804TrpIle: 0.804 ± 0.241
0.433TrpLys: 0.433 ± 0.155
1.546TrpLeu: 1.546 ± 0.333
0.433TrpMet: 0.433 ± 0.142
0.99TrpAsn: 0.99 ± 0.247
0.866TrpPro: 0.866 ± 0.253
1.052TrpGln: 1.052 ± 0.24
1.299TrpArg: 1.299 ± 0.257
1.175TrpSer: 1.175 ± 0.312
0.99TrpThr: 0.99 ± 0.223
1.299TrpVal: 1.299 ± 0.249
0.495TrpTrp: 0.495 ± 0.175
0.495TrpTyr: 0.495 ± 0.175
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.784TyrAla: 2.784 ± 0.417
0.247TyrCys: 0.247 ± 0.122
2.351TyrAsp: 2.351 ± 0.335
2.103TyrGlu: 2.103 ± 0.375
0.742TyrPhe: 0.742 ± 0.185
2.041TyrGly: 2.041 ± 0.362
0.433TyrHis: 0.433 ± 0.137
1.423TyrIle: 1.423 ± 0.248
0.557TyrLys: 0.557 ± 0.176
2.66TyrLeu: 2.66 ± 0.358
0.619TyrMet: 0.619 ± 0.197
1.113TyrAsn: 1.113 ± 0.242
1.546TyrPro: 1.546 ± 0.321
0.742TyrGln: 0.742 ± 0.2
2.536TyrArg: 2.536 ± 0.464
1.918TyrSer: 1.918 ± 0.374
1.485TyrThr: 1.485 ± 0.283
2.722TyrVal: 2.722 ± 0.461
0.557TyrTrp: 0.557 ± 0.251
0.804TyrTyr: 0.804 ± 0.196
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 92 proteins (16167 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski