Amino acid dipepetide frequency for Vibrio phage Va_178/90_p41

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.725AlaAla: 6.725 ± 0.757
0.536AlaCys: 0.536 ± 0.185
5.059AlaAsp: 5.059 ± 0.592
4.166AlaGlu: 4.166 ± 0.519
2.857AlaPhe: 2.857 ± 0.4
5.178AlaGly: 5.178 ± 0.76
1.012AlaHis: 1.012 ± 0.281
6.904AlaIle: 6.904 ± 0.767
6.427AlaLys: 6.427 ± 0.603
6.904AlaLeu: 6.904 ± 0.619
2.857AlaMet: 2.857 ± 0.435
3.987AlaAsn: 3.987 ± 0.342
1.904AlaPro: 1.904 ± 0.317
2.976AlaGln: 2.976 ± 0.401
3.273AlaArg: 3.273 ± 0.491
5.713AlaSer: 5.713 ± 0.88
3.749AlaThr: 3.749 ± 0.408
4.821AlaVal: 4.821 ± 0.544
1.19AlaTrp: 1.19 ± 0.242
2.559AlaTyr: 2.559 ± 0.43
0.0AlaXaa: 0.0 ± 0.0
Cys
0.714CysAla: 0.714 ± 0.191
0.417CysCys: 0.417 ± 0.158
1.131CysAsp: 1.131 ± 0.274
1.071CysGlu: 1.071 ± 0.317
0.417CysPhe: 0.417 ± 0.154
1.131CysGly: 1.131 ± 0.263
0.476CysHis: 0.476 ± 0.147
0.595CysIle: 0.595 ± 0.199
0.595CysLys: 0.595 ± 0.181
1.131CysLeu: 1.131 ± 0.328
0.476CysMet: 0.476 ± 0.171
0.417CysAsn: 0.417 ± 0.16
0.417CysPro: 0.417 ± 0.157
0.417CysGln: 0.417 ± 0.169
0.774CysArg: 0.774 ± 0.209
1.071CysSer: 1.071 ± 0.271
1.012CysThr: 1.012 ± 0.255
0.952CysVal: 0.952 ± 0.277
0.714CysTrp: 0.714 ± 0.205
0.774CysTyr: 0.774 ± 0.221
0.0CysXaa: 0.0 ± 0.0
Asp
4.583AspAla: 4.583 ± 0.568
0.833AspCys: 0.833 ± 0.318
3.749AspAsp: 3.749 ± 0.486
4.106AspGlu: 4.106 ± 0.572
2.559AspPhe: 2.559 ± 0.504
5.356AspGly: 5.356 ± 0.678
0.893AspHis: 0.893 ± 0.212
3.69AspIle: 3.69 ± 0.43
3.214AspLys: 3.214 ± 0.417
3.987AspLeu: 3.987 ± 0.396
1.369AspMet: 1.369 ± 0.29
2.857AspAsn: 2.857 ± 0.412
2.083AspPro: 2.083 ± 0.303
2.262AspGln: 2.262 ± 0.482
2.559AspArg: 2.559 ± 0.392
3.987AspSer: 3.987 ± 0.593
2.559AspThr: 2.559 ± 0.461
2.619AspVal: 2.619 ± 0.417
1.25AspTrp: 1.25 ± 0.233
2.381AspTyr: 2.381 ± 0.393
0.0AspXaa: 0.0 ± 0.0
Glu
4.285GluAla: 4.285 ± 0.675
0.833GluCys: 0.833 ± 0.212
2.678GluAsp: 2.678 ± 0.391
3.63GluGlu: 3.63 ± 0.507
3.035GluPhe: 3.035 ± 0.404
3.035GluGly: 3.035 ± 0.392
1.369GluHis: 1.369 ± 0.268
4.761GluIle: 4.761 ± 0.545
3.511GluLys: 3.511 ± 0.562
7.142GluLeu: 7.142 ± 0.733
2.44GluMet: 2.44 ± 0.434
2.916GluAsn: 2.916 ± 0.403
2.797GluPro: 2.797 ± 0.909
3.928GluGln: 3.928 ± 0.593
2.916GluArg: 2.916 ± 0.458
5.832GluSer: 5.832 ± 0.622
2.381GluThr: 2.381 ± 0.4
4.106GluVal: 4.106 ± 0.556
1.19GluTrp: 1.19 ± 0.241
1.488GluTyr: 1.488 ± 0.256
0.0GluXaa: 0.0 ± 0.0
Phe
2.559PheAla: 2.559 ± 0.406
0.595PheCys: 0.595 ± 0.203
2.678PheAsp: 2.678 ± 0.399
2.202PheGlu: 2.202 ± 0.381
1.428PhePhe: 1.428 ± 0.362
3.095PheGly: 3.095 ± 0.447
0.476PheHis: 0.476 ± 0.156
1.726PheIle: 1.726 ± 0.419
2.857PheLys: 2.857 ± 0.342
3.154PheLeu: 3.154 ± 0.479
0.714PheMet: 0.714 ± 0.25
2.023PheAsn: 2.023 ± 0.322
1.131PhePro: 1.131 ± 0.269
0.833PheGln: 0.833 ± 0.205
1.726PheArg: 1.726 ± 0.327
2.857PheSer: 2.857 ± 0.415
2.44PheThr: 2.44 ± 0.451
2.262PheVal: 2.262 ± 0.34
0.714PheTrp: 0.714 ± 0.228
1.309PheTyr: 1.309 ± 0.282
0.0PheXaa: 0.0 ± 0.0
Gly
5.713GlyAla: 5.713 ± 0.681
1.012GlyCys: 1.012 ± 0.274
3.749GlyAsp: 3.749 ± 0.654
4.285GlyGlu: 4.285 ± 0.472
2.797GlyPhe: 2.797 ± 0.374
5.416GlyGly: 5.416 ± 0.678
0.833GlyHis: 0.833 ± 0.213
4.523GlyIle: 4.523 ± 0.561
4.523GlyLys: 4.523 ± 0.585
5.237GlyLeu: 5.237 ± 0.61
1.964GlyMet: 1.964 ± 0.398
3.095GlyAsn: 3.095 ± 0.54
1.19GlyPro: 1.19 ± 0.246
2.321GlyGln: 2.321 ± 0.392
2.678GlyArg: 2.678 ± 0.408
4.94GlySer: 4.94 ± 0.633
4.344GlyThr: 4.344 ± 0.541
5.892GlyVal: 5.892 ± 0.586
1.369GlyTrp: 1.369 ± 0.242
2.797GlyTyr: 2.797 ± 0.464
0.0GlyXaa: 0.0 ± 0.0
His
1.071HisAla: 1.071 ± 0.349
0.536HisCys: 0.536 ± 0.156
1.25HisAsp: 1.25 ± 0.293
1.369HisGlu: 1.369 ± 0.332
0.774HisPhe: 0.774 ± 0.194
1.25HisGly: 1.25 ± 0.249
0.714HisHis: 0.714 ± 0.292
1.131HisIle: 1.131 ± 0.237
1.19HisLys: 1.19 ± 0.338
1.428HisLeu: 1.428 ± 0.284
0.476HisMet: 0.476 ± 0.228
0.655HisAsn: 0.655 ± 0.197
0.952HisPro: 0.952 ± 0.263
0.774HisGln: 0.774 ± 0.203
0.893HisArg: 0.893 ± 0.309
1.012HisSer: 1.012 ± 0.262
0.893HisThr: 0.893 ± 0.211
1.309HisVal: 1.309 ± 0.255
0.298HisTrp: 0.298 ± 0.126
0.476HisTyr: 0.476 ± 0.158
0.0HisXaa: 0.0 ± 0.0
Ile
6.308IleAla: 6.308 ± 0.663
1.19IleCys: 1.19 ± 0.27
4.225IleAsp: 4.225 ± 0.576
5.059IleGlu: 5.059 ± 0.618
1.666IlePhe: 1.666 ± 0.302
4.999IleGly: 4.999 ± 0.693
1.071IleHis: 1.071 ± 0.278
3.095IleIle: 3.095 ± 0.418
5.594IleLys: 5.594 ± 0.532
3.452IleLeu: 3.452 ± 0.513
1.012IleMet: 1.012 ± 0.26
4.166IleAsn: 4.166 ± 0.509
2.5IlePro: 2.5 ± 0.346
2.262IleGln: 2.262 ± 0.352
2.976IleArg: 2.976 ± 0.384
6.011IleSer: 6.011 ± 0.649
3.809IleThr: 3.809 ± 0.378
3.392IleVal: 3.392 ± 0.378
0.655IleTrp: 0.655 ± 0.172
2.321IleTyr: 2.321 ± 0.331
0.0IleXaa: 0.0 ± 0.0
Lys
7.201LysAla: 7.201 ± 0.901
1.25LysCys: 1.25 ± 0.324
2.857LysAsp: 2.857 ± 0.473
4.761LysGlu: 4.761 ± 0.705
2.262LysPhe: 2.262 ± 0.363
3.868LysGly: 3.868 ± 0.504
1.369LysHis: 1.369 ± 0.312
3.095LysIle: 3.095 ± 0.378
4.583LysLys: 4.583 ± 0.664
5.297LysLeu: 5.297 ± 0.692
2.023LysMet: 2.023 ± 0.323
2.857LysAsn: 2.857 ± 0.396
3.452LysPro: 3.452 ± 0.602
3.868LysGln: 3.868 ± 0.6
3.987LysArg: 3.987 ± 0.6
4.821LysSer: 4.821 ± 0.503
3.987LysThr: 3.987 ± 0.46
3.392LysVal: 3.392 ± 0.486
0.952LysTrp: 0.952 ± 0.182
1.726LysTyr: 1.726 ± 0.27
0.0LysXaa: 0.0 ± 0.0
Leu
6.546LeuAla: 6.546 ± 0.579
1.012LeuCys: 1.012 ± 0.221
3.987LeuAsp: 3.987 ± 0.385
5.118LeuGlu: 5.118 ± 0.717
2.321LeuPhe: 2.321 ± 0.398
4.166LeuGly: 4.166 ± 0.505
1.488LeuHis: 1.488 ± 0.287
5.654LeuIle: 5.654 ± 0.522
5.475LeuLys: 5.475 ± 0.572
5.475LeuLeu: 5.475 ± 0.48
2.44LeuMet: 2.44 ± 0.394
4.047LeuAsn: 4.047 ± 0.616
3.452LeuPro: 3.452 ± 0.435
2.738LeuGln: 2.738 ± 0.404
3.511LeuArg: 3.511 ± 0.495
6.725LeuSer: 6.725 ± 0.606
5.118LeuThr: 5.118 ± 0.512
5.416LeuVal: 5.416 ± 0.568
1.071LeuTrp: 1.071 ± 0.225
2.797LeuTyr: 2.797 ± 0.381
0.0LeuXaa: 0.0 ± 0.0
Met
2.202MetAla: 2.202 ± 0.36
0.298MetCys: 0.298 ± 0.117
1.369MetAsp: 1.369 ± 0.309
1.607MetGlu: 1.607 ± 0.342
0.833MetPhe: 0.833 ± 0.227
0.952MetGly: 0.952 ± 0.192
0.357MetHis: 0.357 ± 0.16
1.607MetIle: 1.607 ± 0.288
2.44MetLys: 2.44 ± 0.523
2.381MetLeu: 2.381 ± 0.373
0.774MetMet: 0.774 ± 0.216
1.428MetAsn: 1.428 ± 0.264
1.726MetPro: 1.726 ± 0.299
1.309MetGln: 1.309 ± 0.274
1.488MetArg: 1.488 ± 0.261
2.916MetSer: 2.916 ± 0.44
1.607MetThr: 1.607 ± 0.289
1.666MetVal: 1.666 ± 0.256
0.417MetTrp: 0.417 ± 0.149
0.476MetTyr: 0.476 ± 0.164
0.0MetXaa: 0.0 ± 0.0
Asn
4.166AsnAla: 4.166 ± 0.549
0.833AsnCys: 0.833 ± 0.274
2.678AsnAsp: 2.678 ± 0.551
2.5AsnGlu: 2.5 ± 0.324
1.309AsnPhe: 1.309 ± 0.254
4.523AsnGly: 4.523 ± 0.58
1.428AsnHis: 1.428 ± 0.344
2.857AsnIle: 2.857 ± 0.377
4.285AsnLys: 4.285 ± 0.625
3.452AsnLeu: 3.452 ± 0.483
1.25AsnMet: 1.25 ± 0.262
3.392AsnAsn: 3.392 ± 0.553
1.964AsnPro: 1.964 ± 0.403
2.5AsnGln: 2.5 ± 0.359
2.797AsnArg: 2.797 ± 0.468
2.738AsnSer: 2.738 ± 0.404
1.428AsnThr: 1.428 ± 0.273
3.63AsnVal: 3.63 ± 0.442
0.952AsnTrp: 0.952 ± 0.229
1.726AsnTyr: 1.726 ± 0.24
0.0AsnXaa: 0.0 ± 0.0
Pro
3.035ProAla: 3.035 ± 0.345
0.714ProCys: 0.714 ± 0.227
2.321ProAsp: 2.321 ± 0.346
3.809ProGlu: 3.809 ± 0.83
1.071ProPhe: 1.071 ± 0.205
1.547ProGly: 1.547 ± 0.31
0.952ProHis: 0.952 ± 0.195
2.202ProIle: 2.202 ± 0.464
1.845ProLys: 1.845 ± 0.354
2.738ProLeu: 2.738 ± 0.413
1.309ProMet: 1.309 ± 0.307
1.785ProAsn: 1.785 ± 0.348
1.607ProPro: 1.607 ± 0.402
1.309ProGln: 1.309 ± 0.272
1.904ProArg: 1.904 ± 0.395
3.809ProSer: 3.809 ± 0.56
2.44ProThr: 2.44 ± 0.467
2.44ProVal: 2.44 ± 0.329
0.298ProTrp: 0.298 ± 0.123
1.012ProTyr: 1.012 ± 0.236
0.0ProXaa: 0.0 ± 0.0
Gln
3.273GlnAla: 3.273 ± 0.391
0.357GlnCys: 0.357 ± 0.136
1.25GlnAsp: 1.25 ± 0.245
2.559GlnGlu: 2.559 ± 0.495
1.785GlnPhe: 1.785 ± 0.341
2.202GlnGly: 2.202 ± 0.367
0.536GlnHis: 0.536 ± 0.172
3.035GlnIle: 3.035 ± 0.462
2.381GlnLys: 2.381 ± 0.324
4.404GlnLeu: 4.404 ± 0.622
1.428GlnMet: 1.428 ± 0.275
2.083GlnAsn: 2.083 ± 0.379
1.666GlnPro: 1.666 ± 0.382
2.321GlnGln: 2.321 ± 0.621
1.607GlnArg: 1.607 ± 0.256
3.452GlnSer: 3.452 ± 0.405
1.845GlnThr: 1.845 ± 0.349
2.142GlnVal: 2.142 ± 0.338
0.417GlnTrp: 0.417 ± 0.153
1.904GlnTyr: 1.904 ± 0.303
0.0GlnXaa: 0.0 ± 0.0
Arg
3.392ArgAla: 3.392 ± 0.35
0.298ArgCys: 0.298 ± 0.146
2.321ArgAsp: 2.321 ± 0.351
3.154ArgGlu: 3.154 ± 0.504
2.381ArgPhe: 2.381 ± 0.473
2.262ArgGly: 2.262 ± 0.386
0.893ArgHis: 0.893 ± 0.253
4.047ArgIle: 4.047 ± 0.49
3.511ArgLys: 3.511 ± 0.503
4.821ArgLeu: 4.821 ± 0.615
1.666ArgMet: 1.666 ± 0.268
2.321ArgAsn: 2.321 ± 0.422
1.488ArgPro: 1.488 ± 0.389
1.25ArgGln: 1.25 ± 0.326
2.916ArgArg: 2.916 ± 0.486
3.928ArgSer: 3.928 ± 0.403
2.262ArgThr: 2.262 ± 0.405
3.154ArgVal: 3.154 ± 0.535
0.476ArgTrp: 0.476 ± 0.163
1.845ArgTyr: 1.845 ± 0.397
0.0ArgXaa: 0.0 ± 0.0
Ser
5.773SerAla: 5.773 ± 0.703
0.952SerCys: 0.952 ± 0.27
4.344SerAsp: 4.344 ± 0.525
5.416SerGlu: 5.416 ± 0.393
3.69SerPhe: 3.69 ± 0.481
7.261SerGly: 7.261 ± 0.77
1.309SerHis: 1.309 ± 0.297
6.13SerIle: 6.13 ± 0.709
4.463SerLys: 4.463 ± 0.595
5.475SerLeu: 5.475 ± 0.524
1.488SerMet: 1.488 ± 0.238
3.987SerAsn: 3.987 ± 0.444
2.916SerPro: 2.916 ± 0.478
3.035SerGln: 3.035 ± 0.432
3.63SerArg: 3.63 ± 0.535
5.832SerSer: 5.832 ± 0.632
3.69SerThr: 3.69 ± 0.541
4.94SerVal: 4.94 ± 0.62
0.774SerTrp: 0.774 ± 0.221
2.797SerTyr: 2.797 ± 0.319
0.0SerXaa: 0.0 ± 0.0
Thr
4.225ThrAla: 4.225 ± 0.513
0.714ThrCys: 0.714 ± 0.25
3.749ThrAsp: 3.749 ± 0.488
2.559ThrGlu: 2.559 ± 0.335
1.726ThrPhe: 1.726 ± 0.355
5.237ThrGly: 5.237 ± 0.542
1.012ThrHis: 1.012 ± 0.225
3.511ThrIle: 3.511 ± 0.439
3.095ThrLys: 3.095 ± 0.464
4.225ThrLeu: 4.225 ± 0.489
1.547ThrMet: 1.547 ± 0.335
2.678ThrAsn: 2.678 ± 0.561
2.738ThrPro: 2.738 ± 0.393
2.262ThrGln: 2.262 ± 0.351
2.381ThrArg: 2.381 ± 0.377
3.154ThrSer: 3.154 ± 0.492
2.916ThrThr: 2.916 ± 0.526
3.809ThrVal: 3.809 ± 0.576
0.476ThrTrp: 0.476 ± 0.171
1.904ThrTyr: 1.904 ± 0.324
0.0ThrXaa: 0.0 ± 0.0
Val
4.225ValAla: 4.225 ± 0.558
0.774ValCys: 0.774 ± 0.247
4.583ValAsp: 4.583 ± 0.568
3.987ValGlu: 3.987 ± 0.575
2.142ValPhe: 2.142 ± 0.334
4.523ValGly: 4.523 ± 0.685
1.131ValHis: 1.131 ± 0.27
3.749ValIle: 3.749 ± 0.451
4.88ValLys: 4.88 ± 0.531
3.868ValLeu: 3.868 ± 0.39
1.726ValMet: 1.726 ± 0.34
3.749ValAsn: 3.749 ± 0.428
2.321ValPro: 2.321 ± 0.392
1.785ValGln: 1.785 ± 0.334
3.273ValArg: 3.273 ± 0.427
4.821ValSer: 4.821 ± 0.587
4.344ValThr: 4.344 ± 0.623
3.809ValVal: 3.809 ± 0.524
1.012ValTrp: 1.012 ± 0.227
2.381ValTyr: 2.381 ± 0.295
0.0ValXaa: 0.0 ± 0.0
Trp
0.833TrpAla: 0.833 ± 0.192
0.536TrpCys: 0.536 ± 0.198
0.714TrpAsp: 0.714 ± 0.225
1.25TrpGlu: 1.25 ± 0.283
0.595TrpPhe: 0.595 ± 0.183
0.714TrpGly: 0.714 ± 0.226
0.357TrpHis: 0.357 ± 0.152
0.952TrpIle: 0.952 ± 0.231
1.19TrpLys: 1.19 ± 0.287
1.309TrpLeu: 1.309 ± 0.301
0.179TrpMet: 0.179 ± 0.088
0.595TrpAsn: 0.595 ± 0.205
0.714TrpPro: 0.714 ± 0.209
0.774TrpGln: 0.774 ± 0.194
0.952TrpArg: 0.952 ± 0.195
0.952TrpSer: 0.952 ± 0.206
0.774TrpThr: 0.774 ± 0.259
1.012TrpVal: 1.012 ± 0.274
0.536TrpTrp: 0.536 ± 0.216
0.417TrpTyr: 0.417 ± 0.166
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.964TyrAla: 1.964 ± 0.329
1.012TyrCys: 1.012 ± 0.256
2.202TyrAsp: 2.202 ± 0.32
1.666TyrGlu: 1.666 ± 0.348
1.131TyrPhe: 1.131 ± 0.329
2.023TyrGly: 2.023 ± 0.335
0.774TyrHis: 0.774 ± 0.225
2.5TyrIle: 2.5 ± 0.386
1.547TyrLys: 1.547 ± 0.288
2.678TyrLeu: 2.678 ± 0.357
0.655TyrMet: 0.655 ± 0.244
1.369TyrAsn: 1.369 ± 0.299
1.131TyrPro: 1.131 ± 0.247
1.726TyrGln: 1.726 ± 0.32
2.142TyrArg: 2.142 ± 0.381
3.333TyrSer: 3.333 ± 0.437
2.321TyrThr: 2.321 ± 0.394
2.321TyrVal: 2.321 ± 0.422
0.595TyrTrp: 0.595 ± 0.163
0.714TyrTyr: 0.714 ± 0.192
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 90 proteins (16804 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski