Amino acid dipepetide frequency for Photobacterium halotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.488AlaAla: 9.488 ± 0.118	1.058AlaCys: 1.058 ± 0.029	5.364AlaAsp: 5.364 ± 0.076	6.186AlaGlu: 6.186 ± 0.08	3.679AlaPhe: 3.679 ± 0.061	7.134AlaGly: 7.134 ± 0.09	1.806AlaHis: 1.806 ± 0.042	5.819AlaIle: 5.819 ± 0.081	4.239AlaLys: 4.239 ± 0.069	10.839AlaLeu: 10.839 ± 0.112	3.092AlaMet: 3.092 ± 0.056	3.202AlaAsn: 3.202 ± 0.056	3.208AlaPro: 3.208 ± 0.059	4.24AlaGln: 4.24 ± 0.073	4.656AlaArg: 4.656 ± 0.068	5.86AlaSer: 5.86 ± 0.066	4.689AlaThr: 4.689 ± 0.06	6.79AlaVal: 6.79 ± 0.076	1.129AlaTrp: 1.129 ± 0.032	2.466AlaTyr: 2.466 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.813CysAla: 0.813 ± 0.027	0.158CysCys: 0.158 ± 0.011	0.641CysAsp: 0.641 ± 0.024	0.59CysGlu: 0.59 ± 0.024	0.484CysPhe: 0.484 ± 0.021	0.958CysGly: 0.958 ± 0.033	0.406CysHis: 0.406 ± 0.021	0.561CysIle: 0.561 ± 0.025	0.347CysLys: 0.347 ± 0.019	1.059CysLeu: 1.059 ± 0.033	0.248CysMet: 0.248 ± 0.014	0.319CysAsn: 0.319 ± 0.016	0.474CysPro: 0.474 ± 0.02	0.605CysGln: 0.605 ± 0.024	0.609CysArg: 0.609 ± 0.024	0.673CysSer: 0.673 ± 0.024	0.482CysThr: 0.482 ± 0.023	0.67CysVal: 0.67 ± 0.022	0.166CysTrp: 0.166 ± 0.012	0.341CysTyr: 0.341 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.021AspAla: 5.021 ± 0.081	0.591AspCys: 0.591 ± 0.022	3.2AspAsp: 3.2 ± 0.062	3.698AspGlu: 3.698 ± 0.068	2.398AspPhe: 2.398 ± 0.047	3.875AspGly: 3.875 ± 0.087	1.253AspHis: 1.253 ± 0.035	3.754AspIle: 3.754 ± 0.067	2.918AspLys: 2.918 ± 0.048	5.255AspLeu: 5.255 ± 0.068	1.504AspMet: 1.504 ± 0.033	2.33AspAsn: 2.33 ± 0.049	2.361AspPro: 2.361 ± 0.05	2.314AspGln: 2.314 ± 0.046	2.497AspArg: 2.497 ± 0.048	3.297AspSer: 3.297 ± 0.062	2.914AspThr: 2.914 ± 0.057	3.759AspVal: 3.759 ± 0.056	0.954AspTrp: 0.954 ± 0.03	2.032AspTyr: 2.032 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.628GluAla: 5.628 ± 0.078	0.513GluCys: 0.513 ± 0.022	2.676GluAsp: 2.676 ± 0.052	3.444GluGlu: 3.444 ± 0.07	2.141GluPhe: 2.141 ± 0.04	3.534GluGly: 3.534 ± 0.06	1.542GluHis: 1.542 ± 0.039	3.44GluIle: 3.44 ± 0.058	3.366GluLys: 3.366 ± 0.058	6.598GluLeu: 6.598 ± 0.079	1.743GluMet: 1.743 ± 0.039	2.286GluAsn: 2.286 ± 0.041	2.218GluPro: 2.218 ± 0.046	3.891GluGln: 3.891 ± 0.062	3.459GluArg: 3.459 ± 0.054	3.33GluSer: 3.33 ± 0.065	3.184GluThr: 3.184 ± 0.05	4.099GluVal: 4.099 ± 0.06	0.774GluTrp: 0.774 ± 0.028	1.629GluTyr: 1.629 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.681PheAla: 3.681 ± 0.063	0.532PheCys: 0.532 ± 0.023	2.666PheAsp: 2.666 ± 0.052	2.266PheGlu: 2.266 ± 0.047	1.67PhePhe: 1.67 ± 0.045	3.115PheGly: 3.115 ± 0.053	0.872PheHis: 0.872 ± 0.028	2.478PheIle: 2.478 ± 0.052	1.471PheLys: 1.471 ± 0.036	3.459PheLeu: 3.459 ± 0.056	1.01PheMet: 1.01 ± 0.027	1.759PheAsn: 1.759 ± 0.037	1.49PhePro: 1.49 ± 0.034	1.356PheGln: 1.356 ± 0.027	1.774PheArg: 1.774 ± 0.039	3.26PheSer: 3.26 ± 0.064	2.379PheThr: 2.379 ± 0.045	2.676PheVal: 2.676 ± 0.057	0.544PheTrp: 0.544 ± 0.021	1.282PheTyr: 1.282 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	5.478GlyAla: 5.478 ± 0.081	0.957GlyCys: 0.957 ± 0.031	3.715GlyAsp: 3.715 ± 0.078	4.432GlyGlu: 4.432 ± 0.062	3.257GlyPhe: 3.257 ± 0.054	4.914GlyGly: 4.914 ± 0.087	1.658GlyHis: 1.658 ± 0.041	4.704GlyIle: 4.704 ± 0.073	3.761GlyLys: 3.761 ± 0.058	7.47GlyLeu: 7.47 ± 0.085	2.227GlyMet: 2.227 ± 0.044	2.605GlyAsn: 2.605 ± 0.058	1.907GlyPro: 1.907 ± 0.041	3.482GlyGln: 3.482 ± 0.059	3.518GlyArg: 3.518 ± 0.062	4.093GlySer: 4.093 ± 0.072	3.573GlyThr: 3.573 ± 0.065	5.277GlyVal: 5.277 ± 0.068	1.091GlyTrp: 1.091 ± 0.033	2.615GlyTyr: 2.615 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.834HisAla: 1.834 ± 0.039	0.366HisCys: 0.366 ± 0.017	1.2HisAsp: 1.2 ± 0.031	1.17HisGlu: 1.17 ± 0.033	1.14HisPhe: 1.14 ± 0.031	1.611HisGly: 1.611 ± 0.032	0.83HisHis: 0.83 ± 0.029	1.365HisIle: 1.365 ± 0.034	0.888HisLys: 0.888 ± 0.026	2.454HisLeu: 2.454 ± 0.048	0.54HisMet: 0.54 ± 0.021	0.799HisAsn: 0.799 ± 0.025	1.369HisPro: 1.369 ± 0.037	1.43HisGln: 1.43 ± 0.038	1.21HisArg: 1.21 ± 0.031	1.444HisSer: 1.444 ± 0.032	1.183HisThr: 1.183 ± 0.033	1.273HisVal: 1.273 ± 0.031	0.418HisTrp: 0.418 ± 0.021	0.883HisTyr: 0.883 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.245IleAla: 6.245 ± 0.08	0.633IleCys: 0.633 ± 0.022	3.668IleAsp: 3.668 ± 0.061	3.881IleGlu: 3.881 ± 0.064	1.966IlePhe: 1.966 ± 0.048	4.437IleGly: 4.437 ± 0.065	1.317IleHis: 1.317 ± 0.036	3.039IleIle: 3.039 ± 0.056	2.473IleLys: 2.473 ± 0.051	5.116IleLeu: 5.116 ± 0.075	1.254IleMet: 1.254 ± 0.036	2.464IleAsn: 2.464 ± 0.051	2.582IlePro: 2.582 ± 0.041	2.325IleGln: 2.325 ± 0.038	3.169IleArg: 3.169 ± 0.055	3.955IleSer: 3.955 ± 0.064	3.453IleThr: 3.453 ± 0.062	3.753IleVal: 3.753 ± 0.065	0.677IleTrp: 0.677 ± 0.026	1.509IleTyr: 1.509 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.688LysAla: 4.688 ± 0.076	0.267LysCys: 0.267 ± 0.014	2.41LysAsp: 2.41 ± 0.044	2.639LysGlu: 2.639 ± 0.051	1.248LysPhe: 1.248 ± 0.034	2.973LysGly: 2.973 ± 0.05	1.075LysHis: 1.075 ± 0.027	2.399LysIle: 2.399 ± 0.045	2.285LysLys: 2.285 ± 0.049	4.541LysLeu: 4.541 ± 0.058	1.22LysMet: 1.22 ± 0.031	1.657LysAsn: 1.657 ± 0.043	2.195LysPro: 2.195 ± 0.043	2.418LysGln: 2.418 ± 0.053	2.452LysArg: 2.452 ± 0.05	2.531LysSer: 2.531 ± 0.047	2.446LysThr: 2.446 ± 0.042	3.416LysVal: 3.416 ± 0.061	0.469LysTrp: 0.469 ± 0.019	1.114LysTyr: 1.114 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	11.428LeuAla: 11.428 ± 0.127	1.148LeuCys: 1.148 ± 0.033	6.07LeuAsp: 6.07 ± 0.097	5.78LeuGlu: 5.78 ± 0.08	4.189LeuPhe: 4.189 ± 0.071	7.255LeuGly: 7.255 ± 0.087	2.175LeuHis: 2.175 ± 0.046	6.121LeuIle: 6.121 ± 0.078	4.866LeuLys: 4.866 ± 0.072	11.322LeuLeu: 11.322 ± 0.151	2.978LeuMet: 2.978 ± 0.051	4.343LeuAsn: 4.343 ± 0.062	5.353LeuPro: 5.353 ± 0.078	3.953LeuGln: 3.953 ± 0.058	4.865LeuArg: 4.865 ± 0.075	8.22LeuSer: 8.22 ± 0.08	6.412LeuThr: 6.412 ± 0.08	7.122LeuVal: 7.122 ± 0.092	1.15LeuTrp: 1.15 ± 0.035	2.596LeuTyr: 2.596 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.994MetAla: 2.994 ± 0.061	0.212MetCys: 0.212 ± 0.014	1.348MetAsp: 1.348 ± 0.032	1.273MetGlu: 1.273 ± 0.031	0.903MetPhe: 0.903 ± 0.028	1.859MetGly: 1.859 ± 0.041	0.504MetHis: 0.504 ± 0.019	1.539MetIle: 1.539 ± 0.037	1.511MetLys: 1.511 ± 0.031	2.998MetLeu: 2.998 ± 0.059	0.865MetMet: 0.865 ± 0.029	1.09MetAsn: 1.09 ± 0.031	1.335MetPro: 1.335 ± 0.031	1.163MetGln: 1.163 ± 0.03	1.278MetArg: 1.278 ± 0.03	1.858MetSer: 1.858 ± 0.041	1.877MetThr: 1.877 ± 0.041	1.932MetVal: 1.932 ± 0.046	0.228MetTrp: 0.228 ± 0.013	0.565MetTyr: 0.565 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.299AsnAla: 3.299 ± 0.059	0.368AsnCys: 0.368 ± 0.016	2.026AsnAsp: 2.026 ± 0.041	1.979AsnGlu: 1.979 ± 0.041	1.322AsnPhe: 1.322 ± 0.031	2.831AsnGly: 2.831 ± 0.054	0.967AsnHis: 0.967 ± 0.03	2.221AsnIle: 2.221 ± 0.041	1.611AsnLys: 1.611 ± 0.038	3.762AsnLeu: 3.762 ± 0.053	0.92AsnMet: 0.92 ± 0.023	1.486AsnAsn: 1.486 ± 0.039	2.127AsnPro: 2.127 ± 0.04	2.042AsnGln: 2.042 ± 0.05	1.947AsnArg: 1.947 ± 0.037	1.965AsnSer: 1.965 ± 0.042	2.008AsnThr: 2.008 ± 0.046	2.286AsnVal: 2.286 ± 0.04	0.565AsnTrp: 0.565 ± 0.022	1.125AsnTyr: 1.125 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	4.273ProAla: 4.273 ± 0.074	0.373ProCys: 0.373 ± 0.017	2.942ProAsp: 2.942 ± 0.058	3.415ProGlu: 3.415 ± 0.052	1.76ProPhe: 1.76 ± 0.038	3.045ProGly: 3.045 ± 0.057	0.942ProHis: 0.942 ± 0.031	1.977ProIle: 1.977 ± 0.04	1.641ProLys: 1.641 ± 0.035	4.556ProLeu: 4.556 ± 0.068	1.102ProMet: 1.102 ± 0.03	1.4ProAsn: 1.4 ± 0.031	1.398ProPro: 1.398 ± 0.039	1.882ProGln: 1.882 ± 0.038	1.553ProArg: 1.553 ± 0.034	2.477ProSer: 2.477 ± 0.049	1.992ProThr: 1.992 ± 0.046	3.871ProVal: 3.871 ± 0.061	0.563ProTrp: 0.563 ± 0.024	1.339ProTyr: 1.339 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	5.321GlnAla: 5.321 ± 0.083	0.447GlnCys: 0.447 ± 0.022	2.312GlnAsp: 2.312 ± 0.045	2.448GlnGlu: 2.448 ± 0.047	1.787GlnPhe: 1.787 ± 0.038	3.436GlnGly: 3.436 ± 0.051	1.282GlnHis: 1.282 ± 0.033	2.536GlnIle: 2.536 ± 0.046	1.813GlnLys: 1.813 ± 0.042	5.633GlnLeu: 5.633 ± 0.08	1.151GlnMet: 1.151 ± 0.031	1.442GlnAsn: 1.442 ± 0.034	2.294GlnPro: 2.294 ± 0.045	3.539GlnGln: 3.539 ± 0.084	2.722GlnArg: 2.722 ± 0.053	3.033GlnSer: 3.033 ± 0.058	2.444GlnThr: 2.444 ± 0.05	3.388GlnVal: 3.388 ± 0.056	0.715GlnTrp: 0.715 ± 0.027	1.446GlnTyr: 1.446 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.864ArgAla: 3.864 ± 0.057	0.529ArgCys: 0.529 ± 0.021	2.749ArgAsp: 2.749 ± 0.053	3.345ArgGlu: 3.345 ± 0.055	2.433ArgPhe: 2.433 ± 0.046	2.802ArgGly: 2.802 ± 0.053	1.499ArgHis: 1.499 ± 0.037	3.096ArgIle: 3.096 ± 0.049	2.251ArgLys: 2.251 ± 0.043	5.752ArgLeu: 5.752 ± 0.071	1.382ArgMet: 1.382 ± 0.031	1.786ArgAsn: 1.786 ± 0.034	1.899ArgPro: 1.899 ± 0.04	3.181ArgGln: 3.181 ± 0.059	2.901ArgArg: 2.901 ± 0.053	2.588ArgSer: 2.588 ± 0.042	2.264ArgThr: 2.264 ± 0.043	3.369ArgVal: 3.369 ± 0.056	0.777ArgTrp: 0.777 ± 0.025	1.907ArgTyr: 1.907 ± 0.04	0.001ArgXaa: 0.001 ± 0.001
Ser	5.81SerAla: 5.81 ± 0.07	0.597SerCys: 0.597 ± 0.025	3.684SerAsp: 3.684 ± 0.062	3.791SerGlu: 3.791 ± 0.056	2.488SerPhe: 2.488 ± 0.043	5.158SerGly: 5.158 ± 0.077	1.569SerHis: 1.569 ± 0.037	3.222SerIle: 3.222 ± 0.055	2.528SerLys: 2.528 ± 0.044	7.092SerLeu: 7.092 ± 0.09	1.71SerMet: 1.71 ± 0.037	2.048SerAsn: 2.048 ± 0.04	2.682SerPro: 2.682 ± 0.046	3.274SerGln: 3.274 ± 0.06	3.287SerArg: 3.287 ± 0.051	3.609SerSer: 3.609 ± 0.06	3.013SerThr: 3.013 ± 0.055	4.62SerVal: 4.62 ± 0.077	0.855SerTrp: 0.855 ± 0.027	1.896SerTyr: 1.896 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	5.134ThrAla: 5.134 ± 0.065	0.49ThrCys: 0.49 ± 0.018	3.046ThrAsp: 3.046 ± 0.072	3.131ThrGlu: 3.131 ± 0.06	2.103ThrPhe: 2.103 ± 0.044	4.327ThrGly: 4.327 ± 0.067	1.246ThrHis: 1.246 ± 0.034	2.896ThrIle: 2.896 ± 0.052	1.754ThrLys: 1.754 ± 0.039	6.618ThrLeu: 6.618 ± 0.08	1.22ThrMet: 1.22 ± 0.029	1.632ThrAsn: 1.632 ± 0.04	2.722ThrPro: 2.722 ± 0.045	2.512ThrGln: 2.512 ± 0.046	2.478ThrArg: 2.478 ± 0.044	3.054ThrSer: 3.054 ± 0.052	2.742ThrThr: 2.742 ± 0.054	4.152ThrVal: 4.152 ± 0.07	0.578ThrTrp: 0.578 ± 0.023	1.469ThrTyr: 1.469 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	6.811ValAla: 6.811 ± 0.078	0.796ValCys: 0.796 ± 0.022	3.959ValAsp: 3.959 ± 0.068	4.074ValGlu: 4.074 ± 0.057	2.87ValPhe: 2.87 ± 0.051	4.525ValGly: 4.525 ± 0.067	1.265ValHis: 1.265 ± 0.031	4.622ValIle: 4.622 ± 0.066	3.2ValLys: 3.2 ± 0.06	7.309ValLeu: 7.309 ± 0.089	2.173ValMet: 2.173 ± 0.046	2.775ValAsn: 2.775 ± 0.055	2.934ValPro: 2.934 ± 0.059	2.404ValGln: 2.404 ± 0.046	3.345ValArg: 3.345 ± 0.052	5.107ValSer: 5.107 ± 0.068	4.26ValThr: 4.26 ± 0.087	5.33ValVal: 5.33 ± 0.07	0.799ValTrp: 0.799 ± 0.028	1.847ValTyr: 1.847 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.87TrpAla: 0.87 ± 0.028	0.154TrpCys: 0.154 ± 0.011	0.643TrpAsp: 0.643 ± 0.026	0.563TrpGlu: 0.563 ± 0.018	0.559TrpPhe: 0.559 ± 0.023	0.824TrpGly: 0.824 ± 0.026	0.384TrpHis: 0.384 ± 0.018	0.65TrpIle: 0.65 ± 0.024	0.46TrpLys: 0.46 ± 0.02	2.041TrpLeu: 2.041 ± 0.049	0.369TrpMet: 0.369 ± 0.018	0.426TrpAsn: 0.426 ± 0.017	0.553TrpPro: 0.553 ± 0.019	1.175TrpGln: 1.175 ± 0.035	0.764TrpArg: 0.764 ± 0.026	0.735TrpSer: 0.735 ± 0.025	0.503TrpThr: 0.503 ± 0.02	0.865TrpVal: 0.865 ± 0.028	0.21TrpTrp: 0.21 ± 0.014	0.369TrpTyr: 0.369 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.264TyrAla: 2.264 ± 0.049	0.417TyrCys: 0.417 ± 0.02	1.607TyrAsp: 1.607 ± 0.044	1.389TyrGlu: 1.389 ± 0.033	1.34TyrPhe: 1.34 ± 0.03	2.12TyrGly: 2.12 ± 0.043	0.816TyrHis: 0.816 ± 0.027	1.476TyrIle: 1.476 ± 0.031	1.06TyrLys: 1.06 ± 0.032	3.47TyrLeu: 3.47 ± 0.058	0.622TyrMet: 0.622 ± 0.025	1.008TyrAsn: 1.008 ± 0.03	1.404TyrPro: 1.404 ± 0.035	2.002TyrGln: 2.002 ± 0.046	1.892TyrArg: 1.892 ± 0.042	1.843TyrSer: 1.843 ± 0.049	1.484TyrThr: 1.484 ± 0.036	1.759TyrVal: 1.759 ± 0.032	0.456TyrTrp: 0.456 ± 0.02	1.003TyrTyr: 1.003 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3968 proteins (1261788 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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