Amino acid dipepetide frequency for Flavobacterium marinum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.097AlaAla: 4.097 ± 0.093	0.573AlaCys: 0.573 ± 0.029	3.497AlaAsp: 3.497 ± 0.07	4.073AlaGlu: 4.073 ± 0.078	3.293AlaPhe: 3.293 ± 0.06	4.058AlaGly: 4.058 ± 0.088	1.073AlaHis: 1.073 ± 0.034	4.924AlaIle: 4.924 ± 0.096	4.689AlaLys: 4.689 ± 0.086	6.152AlaLeu: 6.152 ± 0.089	1.513AlaMet: 1.513 ± 0.043	3.5AlaAsn: 3.5 ± 0.076	1.762AlaPro: 1.762 ± 0.044	2.626AlaGln: 2.626 ± 0.052	1.919AlaArg: 1.919 ± 0.055	3.606AlaSer: 3.606 ± 0.063	3.908AlaThr: 3.908 ± 0.094	4.521AlaVal: 4.521 ± 0.089	0.501AlaTrp: 0.501 ± 0.025	2.562AlaTyr: 2.562 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.44CysAla: 0.44 ± 0.024	0.116CysCys: 0.116 ± 0.014	0.397CysAsp: 0.397 ± 0.023	0.5CysGlu: 0.5 ± 0.026	0.447CysPhe: 0.447 ± 0.022	0.617CysGly: 0.617 ± 0.031	0.157CysHis: 0.157 ± 0.014	0.576CysIle: 0.576 ± 0.023	0.541CysLys: 0.541 ± 0.027	0.644CysLeu: 0.644 ± 0.029	0.145CysMet: 0.145 ± 0.012	0.443CysAsn: 0.443 ± 0.023	0.323CysPro: 0.323 ± 0.024	0.213CysGln: 0.213 ± 0.016	0.212CysArg: 0.212 ± 0.015	0.523CysSer: 0.523 ± 0.025	0.466CysThr: 0.466 ± 0.024	0.454CysVal: 0.454 ± 0.022	0.064CysTrp: 0.064 ± 0.009	0.326CysTyr: 0.326 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.545AspAla: 3.545 ± 0.071	0.449AspCys: 0.449 ± 0.023	2.743AspAsp: 2.743 ± 0.074	4.074AspGlu: 4.074 ± 0.084	3.673AspPhe: 3.673 ± 0.067	3.04AspGly: 3.04 ± 0.072	0.873AspHis: 0.873 ± 0.034	4.126AspIle: 4.126 ± 0.073	4.43AspLys: 4.43 ± 0.079	5.33AspLeu: 5.33 ± 0.085	1.125AspMet: 1.125 ± 0.035	2.858AspAsn: 2.858 ± 0.059	1.522AspPro: 1.522 ± 0.045	1.568AspGln: 1.568 ± 0.043	1.903AspArg: 1.903 ± 0.043	2.616AspSer: 2.616 ± 0.048	2.79AspThr: 2.79 ± 0.052	3.531AspVal: 3.531 ± 0.07	0.688AspTrp: 0.688 ± 0.027	2.911AspTyr: 2.911 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	4.063GluAla: 4.063 ± 0.096	0.31GluCys: 0.31 ± 0.021	3.147GluAsp: 3.147 ± 0.069	4.976GluGlu: 4.976 ± 0.085	2.95GluPhe: 2.95 ± 0.061	3.355GluGly: 3.355 ± 0.063	1.208GluHis: 1.208 ± 0.038	6.016GluIle: 6.016 ± 0.099	6.303GluLys: 6.303 ± 0.108	6.258GluLeu: 6.258 ± 0.087	1.707GluMet: 1.707 ± 0.04	5.085GluAsn: 5.085 ± 0.077	1.664GluPro: 1.664 ± 0.045	2.859GluGln: 2.859 ± 0.061	2.532GluArg: 2.532 ± 0.058	2.982GluSer: 2.982 ± 0.062	4.0GluThr: 4.0 ± 0.07	4.197GluVal: 4.197 ± 0.075	0.662GluTrp: 0.662 ± 0.029	2.588GluTyr: 2.588 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.098PheAla: 3.098 ± 0.059	0.495PheCys: 0.495 ± 0.023	3.296PheAsp: 3.296 ± 0.066	3.383PheGlu: 3.383 ± 0.064	2.846PhePhe: 2.846 ± 0.071	3.489PheGly: 3.489 ± 0.065	0.857PheHis: 0.857 ± 0.031	4.232PheIle: 4.232 ± 0.086	3.848PheLys: 3.848 ± 0.063	4.918PheLeu: 4.918 ± 0.09	1.159PheMet: 1.159 ± 0.041	3.472PheAsn: 3.472 ± 0.061	1.657PhePro: 1.657 ± 0.044	1.644PheGln: 1.644 ± 0.046	1.553PheArg: 1.553 ± 0.047	3.897PheSer: 3.897 ± 0.068	3.1PheThr: 3.1 ± 0.066	3.384PheVal: 3.384 ± 0.062	0.542PheTrp: 0.542 ± 0.026	2.437PheTyr: 2.437 ± 0.055	0.0PheXaa: 0.0 ± 0.0
Gly	3.84GlyAla: 3.84 ± 0.081	0.573GlyCys: 0.573 ± 0.034	2.862GlyAsp: 2.862 ± 0.059	3.215GlyGlu: 3.215 ± 0.065	3.586GlyPhe: 3.586 ± 0.068	3.996GlyGly: 3.996 ± 0.092	0.996GlyHis: 0.996 ± 0.037	5.285GlyIle: 5.285 ± 0.088	4.837GlyLys: 4.837 ± 0.082	5.359GlyLeu: 5.359 ± 0.087	1.615GlyMet: 1.615 ± 0.047	3.544GlyAsn: 3.544 ± 0.072	1.035GlyPro: 1.035 ± 0.037	1.802GlyGln: 1.802 ± 0.043	1.852GlyArg: 1.852 ± 0.052	3.788GlySer: 3.788 ± 0.074	4.138GlyThr: 4.138 ± 0.093	3.869GlyVal: 3.869 ± 0.074	0.642GlyTrp: 0.642 ± 0.025	2.752GlyTyr: 2.752 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	0.927HisAla: 0.927 ± 0.034	0.178HisCys: 0.178 ± 0.015	0.853HisAsp: 0.853 ± 0.033	0.868HisGlu: 0.868 ± 0.031	1.307HisPhe: 1.307 ± 0.041	0.937HisGly: 0.937 ± 0.031	0.526HisHis: 0.526 ± 0.027	1.438HisIle: 1.438 ± 0.045	1.203HisLys: 1.203 ± 0.034	1.961HisLeu: 1.961 ± 0.047	0.302HisMet: 0.302 ± 0.019	1.022HisAsn: 1.022 ± 0.034	0.833HisPro: 0.833 ± 0.031	0.804HisGln: 0.804 ± 0.029	0.63HisArg: 0.63 ± 0.028	1.165HisSer: 1.165 ± 0.044	1.074HisThr: 1.074 ± 0.031	0.755HisVal: 0.755 ± 0.03	0.195HisTrp: 0.195 ± 0.016	0.864HisTyr: 0.864 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	5.504IleAla: 5.504 ± 0.084	0.68IleCys: 0.68 ± 0.032	5.005IleAsp: 5.005 ± 0.072	5.764IleGlu: 5.764 ± 0.098	3.513IlePhe: 3.513 ± 0.074	4.883IleGly: 4.883 ± 0.082	1.364IleHis: 1.364 ± 0.042	6.136IleIle: 6.136 ± 0.106	5.949IleLys: 5.949 ± 0.104	6.893IleLeu: 6.893 ± 0.107	1.346IleMet: 1.346 ± 0.043	5.008IleAsn: 5.008 ± 0.086	3.277IlePro: 3.277 ± 0.065	2.908IleGln: 2.908 ± 0.062	2.529IleArg: 2.529 ± 0.048	5.285IleSer: 5.285 ± 0.082	4.768IleThr: 4.768 ± 0.071	5.032IleVal: 5.032 ± 0.078	0.692IleTrp: 0.692 ± 0.031	2.937IleTyr: 2.937 ± 0.062	0.0IleXaa: 0.0 ± 0.0
Lys	5.002LysAla: 5.002 ± 0.086	0.374LysCys: 0.374 ± 0.023	4.435LysAsp: 4.435 ± 0.081	6.375LysGlu: 6.375 ± 0.117	3.113LysPhe: 3.113 ± 0.058	4.302LysGly: 4.302 ± 0.077	1.38LysHis: 1.38 ± 0.042	6.52LysIle: 6.52 ± 0.101	7.048LysLys: 7.048 ± 0.104	6.377LysLeu: 6.377 ± 0.1	2.259LysMet: 2.259 ± 0.05	5.857LysAsn: 5.857 ± 0.091	2.501LysPro: 2.501 ± 0.054	3.321LysGln: 3.321 ± 0.068	2.756LysArg: 2.756 ± 0.071	4.441LysSer: 4.441 ± 0.082	4.901LysThr: 4.901 ± 0.077	4.75LysVal: 4.75 ± 0.075	0.763LysTrp: 0.763 ± 0.034	3.227LysTyr: 3.227 ± 0.069	0.0LysXaa: 0.0 ± 0.0
Leu	5.651LeuAla: 5.651 ± 0.099	0.686LeuCys: 0.686 ± 0.031	4.568LeuAsp: 4.568 ± 0.083	5.731LeuGlu: 5.731 ± 0.087	5.102LeuPhe: 5.102 ± 0.088	5.338LeuGly: 5.338 ± 0.092	1.687LeuHis: 1.687 ± 0.046	7.067LeuIle: 7.067 ± 0.111	7.948LeuLys: 7.948 ± 0.119	8.884LeuLeu: 8.884 ± 0.134	2.214LeuMet: 2.214 ± 0.042	6.176LeuAsn: 6.176 ± 0.091	3.588LeuPro: 3.588 ± 0.064	3.735LeuGln: 3.735 ± 0.071	3.059LeuArg: 3.059 ± 0.069	6.372LeuSer: 6.372 ± 0.092	5.454LeuThr: 5.454 ± 0.071	5.164LeuVal: 5.164 ± 0.08	0.799LeuTrp: 0.799 ± 0.029	3.449LeuTyr: 3.449 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	1.557MetAla: 1.557 ± 0.045	0.142MetCys: 0.142 ± 0.011	1.118MetAsp: 1.118 ± 0.037	1.425MetGlu: 1.425 ± 0.042	0.97MetPhe: 0.97 ± 0.031	1.406MetGly: 1.406 ± 0.051	0.391MetHis: 0.391 ± 0.021	1.66MetIle: 1.66 ± 0.043	2.378MetLys: 2.378 ± 0.054	1.999MetLeu: 1.999 ± 0.046	0.644MetMet: 0.644 ± 0.03	1.496MetAsn: 1.496 ± 0.043	0.834MetPro: 0.834 ± 0.027	0.921MetGln: 0.921 ± 0.033	0.88MetArg: 0.88 ± 0.033	1.289MetSer: 1.289 ± 0.042	1.138MetThr: 1.138 ± 0.031	1.402MetVal: 1.402 ± 0.035	0.174MetTrp: 0.174 ± 0.015	0.865MetTyr: 0.865 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	4.081AsnAla: 4.081 ± 0.073	0.446AsnCys: 0.446 ± 0.024	3.776AsnAsp: 3.776 ± 0.073	4.552AsnGlu: 4.552 ± 0.074	3.085AsnPhe: 3.085 ± 0.06	4.121AsnGly: 4.121 ± 0.088	1.199AsnHis: 1.199 ± 0.036	5.033AsnIle: 5.033 ± 0.079	4.882AsnLys: 4.882 ± 0.087	5.401AsnLeu: 5.401 ± 0.085	1.285AsnMet: 1.285 ± 0.038	4.478AsnAsn: 4.478 ± 0.105	2.706AsnPro: 2.706 ± 0.048	2.685AsnGln: 2.685 ± 0.064	2.295AsnArg: 2.295 ± 0.058	3.391AsnSer: 3.391 ± 0.068	3.641AsnThr: 3.641 ± 0.08	3.847AsnVal: 3.847 ± 0.066	0.739AsnTrp: 0.739 ± 0.029	2.931AsnTyr: 2.931 ± 0.076	0.0AsnXaa: 0.0 ± 0.0
Pro	1.976ProAla: 1.976 ± 0.057	0.211ProCys: 0.211 ± 0.018	1.947ProAsp: 1.947 ± 0.043	2.691ProGlu: 2.691 ± 0.055	1.901ProPhe: 1.901 ± 0.046	1.726ProGly: 1.726 ± 0.055	0.61ProHis: 0.61 ± 0.032	2.348ProIle: 2.348 ± 0.052	2.456ProLys: 2.456 ± 0.061	2.933ProLeu: 2.933 ± 0.058	0.747ProMet: 0.747 ± 0.026	2.109ProAsn: 2.109 ± 0.058	0.729ProPro: 0.729 ± 0.033	1.195ProGln: 1.195 ± 0.035	0.833ProArg: 0.833 ± 0.032	1.936ProSer: 1.936 ± 0.054	2.015ProThr: 2.015 ± 0.056	2.659ProVal: 2.659 ± 0.062	0.268ProTrp: 0.268 ± 0.019	1.448ProTyr: 1.448 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.229GlnAla: 2.229 ± 0.054	0.171GlnCys: 0.171 ± 0.016	1.636GlnAsp: 1.636 ± 0.043	2.404GlnGlu: 2.404 ± 0.058	1.965GlnPhe: 1.965 ± 0.044	1.839GlnGly: 1.839 ± 0.045	0.735GlnHis: 0.735 ± 0.029	3.009GlnIle: 3.009 ± 0.052	3.303GlnLys: 3.303 ± 0.078	3.997GlnLeu: 3.997 ± 0.067	0.923GlnMet: 0.923 ± 0.031	2.747GlnAsn: 2.747 ± 0.062	1.293GlnPro: 1.293 ± 0.036	2.019GlnGln: 2.019 ± 0.062	1.308GlnArg: 1.308 ± 0.033	2.09GlnSer: 2.09 ± 0.051	2.381GlnThr: 2.381 ± 0.065	2.062GlnVal: 2.062 ± 0.044	0.416GlnTrp: 0.416 ± 0.019	1.533GlnTyr: 1.533 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	1.814ArgAla: 1.814 ± 0.049	0.197ArgCys: 0.197 ± 0.013	1.479ArgAsp: 1.479 ± 0.048	2.167ArgGlu: 2.167 ± 0.048	1.948ArgPhe: 1.948 ± 0.05	1.664ArgGly: 1.664 ± 0.043	0.574ArgHis: 0.574 ± 0.027	2.888ArgIle: 2.888 ± 0.062	2.858ArgLys: 2.858 ± 0.059	3.342ArgLeu: 3.342 ± 0.062	0.956ArgMet: 0.956 ± 0.037	2.138ArgAsn: 2.138 ± 0.053	1.004ArgPro: 1.004 ± 0.032	1.08ArgGln: 1.08 ± 0.037	1.201ArgArg: 1.201 ± 0.036	1.811ArgSer: 1.811 ± 0.052	1.888ArgThr: 1.888 ± 0.048	1.918ArgVal: 1.918 ± 0.046	0.378ArgTrp: 0.378 ± 0.018	1.532ArgTyr: 1.532 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	3.59SerAla: 3.59 ± 0.07	0.679SerCys: 0.679 ± 0.028	3.134SerAsp: 3.134 ± 0.065	3.705SerGlu: 3.705 ± 0.067	3.694SerPhe: 3.694 ± 0.072	4.166SerGly: 4.166 ± 0.076	1.022SerHis: 1.022 ± 0.035	4.633SerIle: 4.633 ± 0.074	4.544SerLys: 4.544 ± 0.071	5.623SerLeu: 5.623 ± 0.09	1.244SerMet: 1.244 ± 0.038	3.611SerAsn: 3.611 ± 0.079	1.726SerPro: 1.726 ± 0.047	2.083SerGln: 2.083 ± 0.052	1.834SerArg: 1.834 ± 0.052	3.646SerSer: 3.646 ± 0.076	3.477SerThr: 3.477 ± 0.079	4.17SerVal: 4.17 ± 0.074	0.523SerTrp: 0.523 ± 0.026	2.761SerTyr: 2.761 ± 0.064	0.0SerXaa: 0.0 ± 0.0
Thr	4.158ThrAla: 4.158 ± 0.078	0.335ThrCys: 0.335 ± 0.022	3.635ThrAsp: 3.635 ± 0.072	3.916ThrGlu: 3.916 ± 0.068	3.143ThrPhe: 3.143 ± 0.063	3.9ThrGly: 3.9 ± 0.089	1.055ThrHis: 1.055 ± 0.035	4.921ThrIle: 4.921 ± 0.079	3.989ThrLys: 3.989 ± 0.068	5.329ThrLeu: 5.329 ± 0.081	1.092ThrMet: 1.092 ± 0.042	3.599ThrAsn: 3.599 ± 0.085	2.434ThrPro: 2.434 ± 0.063	2.1ThrGln: 2.1 ± 0.051	1.516ThrArg: 1.516 ± 0.044	3.594ThrSer: 3.594 ± 0.083	3.779ThrThr: 3.779 ± 0.098	4.185ThrVal: 4.185 ± 0.086	0.491ThrTrp: 0.491 ± 0.028	2.509ThrTyr: 2.509 ± 0.07	0.0ThrXaa: 0.0 ± 0.0
Val	4.265ValAla: 4.265 ± 0.086	0.546ValCys: 0.546 ± 0.027	3.361ValAsp: 3.361 ± 0.06	3.891ValGlu: 3.891 ± 0.071	3.525ValPhe: 3.525 ± 0.06	3.653ValGly: 3.653 ± 0.072	0.99ValHis: 0.99 ± 0.033	4.797ValIle: 4.797 ± 0.084	4.537ValLys: 4.537 ± 0.081	6.285ValLeu: 6.285 ± 0.082	1.32ValMet: 1.32 ± 0.04	3.82ValAsn: 3.82 ± 0.059	2.143ValPro: 2.143 ± 0.049	2.173ValGln: 2.173 ± 0.048	2.088ValArg: 2.088 ± 0.048	4.348ValSer: 4.348 ± 0.069	3.845ValThr: 3.845 ± 0.099	4.395ValVal: 4.395 ± 0.089	0.569ValTrp: 0.569 ± 0.026	2.7ValTyr: 2.7 ± 0.063	0.0ValXaa: 0.0 ± 0.0
Trp	0.572TrpAla: 0.572 ± 0.029	0.088TrpCys: 0.088 ± 0.01	0.522TrpAsp: 0.522 ± 0.023	0.6TrpGlu: 0.6 ± 0.029	0.574TrpPhe: 0.574 ± 0.027	0.549TrpGly: 0.549 ± 0.026	0.203TrpHis: 0.203 ± 0.013	0.791TrpIle: 0.791 ± 0.028	0.744TrpLys: 0.744 ± 0.029	0.927TrpLeu: 0.927 ± 0.035	0.299TrpMet: 0.299 ± 0.021	0.744TrpAsn: 0.744 ± 0.031	0.172TrpPro: 0.172 ± 0.014	0.459TrpGln: 0.459 ± 0.023	0.323TrpArg: 0.323 ± 0.02	0.533TrpSer: 0.533 ± 0.024	0.468TrpThr: 0.468 ± 0.024	0.561TrpVal: 0.561 ± 0.027	0.115TrpTrp: 0.115 ± 0.011	0.457TrpTyr: 0.457 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.437TyrAla: 2.437 ± 0.045	0.355TyrCys: 0.355 ± 0.018	2.385TyrAsp: 2.385 ± 0.063	2.553TyrGlu: 2.553 ± 0.058	2.671TyrPhe: 2.671 ± 0.066	2.549TyrGly: 2.549 ± 0.05	0.942TyrHis: 0.942 ± 0.035	3.073TyrIle: 3.073 ± 0.07	3.215TyrLys: 3.215 ± 0.066	4.061TyrLeu: 4.061 ± 0.075	0.795TyrMet: 0.795 ± 0.03	2.867TyrAsn: 2.867 ± 0.073	1.534TyrPro: 1.534 ± 0.043	1.864TyrGln: 1.864 ± 0.048	1.61TyrArg: 1.61 ± 0.047	2.555TyrSer: 2.555 ± 0.068	2.45TyrThr: 2.45 ± 0.069	2.395TyrVal: 2.395 ± 0.053	0.479TyrTrp: 0.479 ± 0.021	2.129TyrTyr: 2.129 ± 0.058	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2850 proteins (896829 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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