Amino acid dipepetide frequency for Apple geminivirus PL-2015

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.625AlaAla: 4.625 ± 1.404
0.925AlaCys: 0.925 ± 0.903
0.0AlaAsp: 0.0 ± 0.0
5.55AlaGlu: 5.55 ± 2.087
0.0AlaPhe: 0.0 ± 0.0
2.775AlaGly: 2.775 ± 2.458
0.925AlaHis: 0.925 ± 0.726
2.775AlaIle: 2.775 ± 2.477
5.55AlaLys: 5.55 ± 1.728
6.475AlaLeu: 6.475 ± 2.021
0.925AlaMet: 0.925 ± 0.819
3.7AlaAsn: 3.7 ± 2.241
4.625AlaPro: 4.625 ± 2.256
1.85AlaGln: 1.85 ± 1.639
10.176AlaArg: 10.176 ± 2.545
5.55AlaSer: 5.55 ± 2.045
0.925AlaThr: 0.925 ± 0.819
3.7AlaVal: 3.7 ± 1.096
1.85AlaTrp: 1.85 ± 1.398
0.925AlaTyr: 0.925 ± 0.811
0.0AlaXaa: 0.0 ± 0.0
Cys
1.85CysAla: 1.85 ± 1.183
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
1.85CysGlu: 1.85 ± 1.518
0.0CysPhe: 0.0 ± 0.0
2.775CysGly: 2.775 ± 1.397
0.0CysHis: 0.0 ± 0.0
1.85CysIle: 1.85 ± 0.925
0.0CysLys: 0.0 ± 0.0
0.925CysLeu: 0.925 ± 0.808
0.0CysMet: 0.0 ± 0.0
0.925CysAsn: 0.925 ± 0.726
0.925CysPro: 0.925 ± 0.903
0.925CysGln: 0.925 ± 0.903
1.85CysArg: 1.85 ± 0.958
3.7CysSer: 3.7 ± 1.915
0.925CysThr: 0.925 ± 0.726
1.85CysVal: 1.85 ± 1.518
0.925CysTrp: 0.925 ± 0.811
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.775AspAla: 2.775 ± 2.179
0.925AspCys: 0.925 ± 0.903
5.55AspAsp: 5.55 ± 1.438
2.775AspGlu: 2.775 ± 0.709
0.925AspPhe: 0.925 ± 0.819
2.775AspGly: 2.775 ± 1.043
0.925AspHis: 0.925 ± 0.726
0.925AspIle: 0.925 ± 0.903
0.925AspLys: 0.925 ± 0.819
4.625AspLeu: 4.625 ± 0.89
2.775AspMet: 2.775 ± 1.28
0.925AspAsn: 0.925 ± 0.903
4.625AspPro: 4.625 ± 2.494
1.85AspGln: 1.85 ± 1.011
0.0AspArg: 0.0 ± 0.0
3.7AspSer: 3.7 ± 1.814
0.0AspThr: 0.0 ± 0.0
3.7AspVal: 3.7 ± 1.469
3.7AspTrp: 3.7 ± 1.438
0.925AspTyr: 0.925 ± 0.903
0.0AspXaa: 0.0 ± 0.0
Glu
6.475GluAla: 6.475 ± 4.386
1.85GluCys: 1.85 ± 1.518
2.775GluAsp: 2.775 ± 0.857
5.55GluGlu: 5.55 ± 2.776
4.625GluPhe: 4.625 ± 1.238
7.401GluGly: 7.401 ± 3.164
0.925GluHis: 0.925 ± 0.903
0.925GluIle: 0.925 ± 0.819
6.475GluLys: 6.475 ± 1.94
4.625GluLeu: 4.625 ± 1.884
0.925GluMet: 0.925 ± 1.201
0.925GluAsn: 0.925 ± 0.819
5.55GluPro: 5.55 ± 2.137
2.775GluGln: 2.775 ± 1.236
0.0GluArg: 0.0 ± 0.0
2.775GluSer: 2.775 ± 1.943
1.85GluThr: 1.85 ± 0.689
3.7GluVal: 3.7 ± 0.99
1.85GluTrp: 1.85 ± 1.453
1.85GluTyr: 1.85 ± 1.089
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
0.925PheCys: 0.925 ± 0.726
1.85PheAsp: 1.85 ± 1.453
1.85PheGlu: 1.85 ± 0.925
2.775PhePhe: 2.775 ± 1.329
1.85PheGly: 1.85 ± 1.639
2.775PheHis: 2.775 ± 0.857
1.85PheIle: 1.85 ± 0.689
1.85PheLys: 1.85 ± 1.453
5.55PheLeu: 5.55 ± 2.575
0.925PheMet: 0.925 ± 0.726
3.7PheAsn: 3.7 ± 1.096
0.0PhePro: 0.0 ± 0.0
1.85PheGln: 1.85 ± 0.689
2.775PheArg: 2.775 ± 1.043
3.7PheSer: 3.7 ± 1.727
1.85PheThr: 1.85 ± 1.094
3.7PheVal: 3.7 ± 1.152
0.0PheTrp: 0.0 ± 0.0
1.85PheTyr: 1.85 ± 0.689
0.0PheXaa: 0.0 ± 0.0
Gly
3.7GlyAla: 3.7 ± 1.495
0.925GlyCys: 0.925 ± 0.903
0.0GlyAsp: 0.0 ± 0.0
6.475GlyGlu: 6.475 ± 2.311
1.85GlyPhe: 1.85 ± 1.089
4.625GlyGly: 4.625 ± 1.361
1.85GlyHis: 1.85 ± 0.689
0.925GlyIle: 0.925 ± 0.726
4.625GlyLys: 4.625 ± 1.578
1.85GlyLeu: 1.85 ± 1.133
0.0GlyMet: 0.0 ± 0.0
4.625GlyAsn: 4.625 ± 2.185
4.625GlyPro: 4.625 ± 1.43
3.7GlyGln: 3.7 ± 1.123
2.775GlyArg: 2.775 ± 1.784
6.475GlySer: 6.475 ± 2.641
0.925GlyThr: 0.925 ± 1.201
5.55GlyVal: 5.55 ± 1.936
0.0GlyTrp: 0.0 ± 0.0
0.925GlyTyr: 0.925 ± 0.819
0.0GlyXaa: 0.0 ± 0.0
His
0.925HisAla: 0.925 ± 0.808
0.0HisCys: 0.0 ± 0.0
0.925HisAsp: 0.925 ± 0.819
2.775HisGlu: 2.775 ± 1.043
2.775HisPhe: 2.775 ± 1.495
0.925HisGly: 0.925 ± 0.726
0.0HisHis: 0.0 ± 0.0
1.85HisIle: 1.85 ± 1.116
0.925HisLys: 0.925 ± 0.811
6.475HisLeu: 6.475 ± 1.721
0.925HisMet: 0.925 ± 0.714
3.7HisAsn: 3.7 ± 1.415
0.925HisPro: 0.925 ± 0.726
0.0HisGln: 0.0 ± 0.0
1.85HisArg: 1.85 ± 1.807
2.775HisSer: 2.775 ± 2.71
0.925HisThr: 0.925 ± 0.819
1.85HisVal: 1.85 ± 0.689
0.0HisTrp: 0.0 ± 0.0
0.925HisTyr: 0.925 ± 0.726
0.0HisXaa: 0.0 ± 0.0
Ile
0.925IleAla: 0.925 ± 0.819
2.775IleCys: 2.775 ± 2.191
4.625IleAsp: 4.625 ± 1.052
3.7IleGlu: 3.7 ± 1.916
3.7IlePhe: 3.7 ± 2.033
0.0IleGly: 0.0 ± 0.0
0.925IleHis: 0.925 ± 0.903
3.7IleIle: 3.7 ± 1.915
3.7IleLys: 3.7 ± 1.376
1.85IleLeu: 1.85 ± 1.068
0.925IleMet: 0.925 ± 0.809
2.775IleAsn: 2.775 ± 1.242
0.925IlePro: 0.925 ± 0.726
1.85IleGln: 1.85 ± 1.068
1.85IleArg: 1.85 ± 1.094
5.55IleSer: 5.55 ± 2.991
3.7IleThr: 3.7 ± 2.011
0.925IleVal: 0.925 ± 0.726
0.925IleTrp: 0.925 ± 0.811
5.55IleTyr: 5.55 ± 1.683
0.0IleXaa: 0.0 ± 0.0
Lys
3.7LysAla: 3.7 ± 1.927
1.85LysCys: 1.85 ± 1.621
1.85LysAsp: 1.85 ± 1.133
4.625LysGlu: 4.625 ± 2.672
2.775LysPhe: 2.775 ± 0.857
5.55LysGly: 5.55 ± 1.482
1.85LysHis: 1.85 ± 0.689
3.7LysIle: 3.7 ± 1.221
3.7LysLys: 3.7 ± 1.096
1.85LysLeu: 1.85 ± 1.404
0.925LysMet: 0.925 ± 1.131
4.625LysAsn: 4.625 ± 1.724
1.85LysPro: 1.85 ± 0.689
0.925LysGln: 0.925 ± 0.819
2.775LysArg: 2.775 ± 1.826
2.775LysSer: 2.775 ± 1.155
3.7LysThr: 3.7 ± 1.803
2.775LysVal: 2.775 ± 1.155
0.0LysTrp: 0.0 ± 0.0
3.7LysTyr: 3.7 ± 0.935
0.0LysXaa: 0.0 ± 0.0
Leu
4.625LeuAla: 4.625 ± 1.955
1.85LeuCys: 1.85 ± 1.453
8.326LeuAsp: 8.326 ± 2.459
3.7LeuGlu: 3.7 ± 1.353
1.85LeuPhe: 1.85 ± 0.925
4.625LeuGly: 4.625 ± 1.758
6.475LeuHis: 6.475 ± 1.747
4.625LeuIle: 4.625 ± 1.242
5.55LeuLys: 5.55 ± 0.963
2.775LeuLeu: 2.775 ± 0.857
1.85LeuMet: 1.85 ± 1.094
4.625LeuAsn: 4.625 ± 0.921
1.85LeuPro: 1.85 ± 1.404
2.775LeuGln: 2.775 ± 1.043
5.55LeuArg: 5.55 ± 2.636
8.326LeuSer: 8.326 ± 2.821
4.625LeuThr: 4.625 ± 1.436
3.7LeuVal: 3.7 ± 1.123
0.925LeuTrp: 0.925 ± 0.819
3.7LeuTyr: 3.7 ± 0.83
0.0LeuXaa: 0.0 ± 0.0
Met
1.85MetAla: 1.85 ± 0.689
0.0MetCys: 0.0 ± 0.0
1.85MetAsp: 1.85 ± 1.094
3.7MetGlu: 3.7 ± 2.631
0.0MetPhe: 0.0 ± 0.0
0.925MetGly: 0.925 ± 0.808
0.0MetHis: 0.0 ± 0.0
0.925MetIle: 0.925 ± 0.819
1.85MetLys: 1.85 ± 1.639
0.925MetLeu: 0.925 ± 0.811
0.0MetMet: 0.0 ± 0.0
0.925MetAsn: 0.925 ± 0.811
4.625MetPro: 4.625 ± 1.5
0.0MetGln: 0.0 ± 0.0
0.925MetArg: 0.925 ± 0.819
1.85MetSer: 1.85 ± 1.011
0.925MetThr: 0.925 ± 0.819
0.925MetVal: 0.925 ± 0.811
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
5.55AsnAla: 5.55 ± 2.068
1.85AsnCys: 1.85 ± 1.807
2.775AsnAsp: 2.775 ± 1.412
1.85AsnGlu: 1.85 ± 1.404
0.925AsnPhe: 0.925 ± 0.808
1.85AsnGly: 1.85 ± 1.404
1.85AsnHis: 1.85 ± 1.398
2.775AsnIle: 2.775 ± 0.709
0.925AsnLys: 0.925 ± 0.726
4.625AsnLeu: 4.625 ± 0.89
0.0AsnMet: 0.0 ± 0.0
0.925AsnAsn: 0.925 ± 0.726
3.7AsnPro: 3.7 ± 1.749
2.775AsnGln: 2.775 ± 0.709
1.85AsnArg: 1.85 ± 1.404
4.625AsnSer: 4.625 ± 1.67
2.775AsnThr: 2.775 ± 2.179
3.7AsnVal: 3.7 ± 1.803
1.85AsnTrp: 1.85 ± 0.689
5.55AsnTyr: 5.55 ± 3.239
0.0AsnXaa: 0.0 ± 0.0
Pro
5.55ProAla: 5.55 ± 2.33
0.0ProCys: 0.0 ± 0.0
4.625ProAsp: 4.625 ± 1.313
4.625ProGlu: 4.625 ± 1.884
1.85ProPhe: 1.85 ± 0.689
0.925ProGly: 0.925 ± 0.726
3.7ProHis: 3.7 ± 2.026
1.85ProIle: 1.85 ± 1.011
3.7ProLys: 3.7 ± 2.033
6.475ProLeu: 6.475 ± 3.047
1.85ProMet: 1.85 ± 1.038
5.55ProAsn: 5.55 ± 0.985
1.85ProPro: 1.85 ± 0.925
3.7ProGln: 3.7 ± 2.707
2.775ProArg: 2.775 ± 2.179
4.625ProSer: 4.625 ± 2.724
6.475ProThr: 6.475 ± 2.885
0.925ProVal: 0.925 ± 1.201
0.0ProTrp: 0.0 ± 0.0
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
2.775GlnAla: 2.775 ± 1.083
0.0GlnCys: 0.0 ± 0.0
0.0GlnAsp: 0.0 ± 0.0
3.7GlnGlu: 3.7 ± 2.174
0.925GlnPhe: 0.925 ± 0.726
3.7GlnGly: 3.7 ± 1.352
1.85GlnHis: 1.85 ± 1.068
2.775GlnIle: 2.775 ± 2.179
0.925GlnLys: 0.925 ± 0.903
4.625GlnLeu: 4.625 ± 2.679
0.0GlnMet: 0.0 ± 0.0
0.0GlnAsn: 0.0 ± 0.0
3.7GlnPro: 3.7 ± 2.259
1.85GlnGln: 1.85 ± 1.398
2.775GlnArg: 2.775 ± 1.155
0.925GlnSer: 0.925 ± 0.726
1.85GlnThr: 1.85 ± 1.116
3.7GlnVal: 3.7 ± 1.927
0.0GlnTrp: 0.0 ± 0.0
1.85GlnTyr: 1.85 ± 0.689
0.0GlnXaa: 0.0 ± 0.0
Arg
2.775ArgAla: 2.775 ± 2.06
1.85ArgCys: 1.85 ± 1.453
0.925ArgAsp: 0.925 ± 0.726
4.625ArgGlu: 4.625 ± 2.196
2.775ArgPhe: 2.775 ± 1.155
4.625ArgGly: 4.625 ± 1.688
1.85ArgHis: 1.85 ± 1.639
4.625ArgIle: 4.625 ± 2.108
3.7ArgLys: 3.7 ± 2.512
1.85ArgLeu: 1.85 ± 1.089
2.775ArgMet: 2.775 ± 2.458
1.85ArgAsn: 1.85 ± 1.089
8.326ArgPro: 8.326 ± 1.833
0.925ArgGln: 0.925 ± 0.819
10.176ArgArg: 10.176 ± 3.281
5.55ArgSer: 5.55 ± 1.977
3.7ArgThr: 3.7 ± 1.519
2.775ArgVal: 2.775 ± 0.709
0.925ArgTrp: 0.925 ± 0.819
0.0ArgTyr: 0.0 ± 0.0
0.0ArgXaa: 0.0 ± 0.0
Ser
9.251SerAla: 9.251 ± 2.975
1.85SerCys: 1.85 ± 1.518
3.7SerAsp: 3.7 ± 0.935
2.775SerGlu: 2.775 ± 1.943
2.775SerPhe: 2.775 ± 0.709
1.85SerGly: 1.85 ± 1.639
1.85SerHis: 1.85 ± 1.518
5.55SerIle: 5.55 ± 2.158
3.7SerLys: 3.7 ± 0.902
12.026SerLeu: 12.026 ± 2.268
1.85SerMet: 1.85 ± 1.318
5.55SerAsn: 5.55 ± 1.862
4.625SerPro: 4.625 ± 1.88
3.7SerGln: 3.7 ± 1.749
7.401SerArg: 7.401 ± 2.863
11.101SerSer: 11.101 ± 1.708
5.55SerThr: 5.55 ± 2.762
2.775SerVal: 2.775 ± 1.083
0.0SerTrp: 0.0 ± 0.0
1.85SerTyr: 1.85 ± 0.689
0.0SerXaa: 0.0 ± 0.0
Thr
0.925ThrAla: 0.925 ± 1.201
2.775ThrCys: 2.775 ± 1.114
1.85ThrAsp: 1.85 ± 1.094
2.775ThrGlu: 2.775 ± 1.329
2.775ThrPhe: 2.775 ± 1.329
4.625ThrGly: 4.625 ± 1.097
0.925ThrHis: 0.925 ± 0.808
2.775ThrIle: 2.775 ± 1.083
0.925ThrLys: 0.925 ± 0.726
1.85ThrLeu: 1.85 ± 1.639
2.775ThrMet: 2.775 ± 1.784
2.775ThrAsn: 2.775 ± 1.155
3.7ThrPro: 3.7 ± 0.83
0.925ThrGln: 0.925 ± 0.726
2.775ThrArg: 2.775 ± 2.179
5.55ThrSer: 5.55 ± 1.714
3.7ThrThr: 3.7 ± 1.376
1.85ThrVal: 1.85 ± 1.639
1.85ThrTrp: 1.85 ± 1.011
2.775ThrTyr: 2.775 ± 1.638
0.0ThrXaa: 0.0 ± 0.0
Val
1.85ValAla: 1.85 ± 1.639
0.925ValCys: 0.925 ± 0.726
2.775ValAsp: 2.775 ± 1.678
0.925ValGlu: 0.925 ± 0.811
4.625ValPhe: 4.625 ± 2.672
1.85ValGly: 1.85 ± 1.398
0.925ValHis: 0.925 ± 0.811
2.775ValIle: 2.775 ± 1.619
4.625ValLys: 4.625 ± 1.623
6.475ValLeu: 6.475 ± 1.803
0.0ValMet: 0.0 ± 0.0
3.7ValAsn: 3.7 ± 1.353
1.85ValPro: 1.85 ± 1.133
4.625ValGln: 4.625 ± 1.07
4.625ValArg: 4.625 ± 1.417
7.401ValSer: 7.401 ± 2.477
0.0ValThr: 0.0 ± 0.0
0.925ValVal: 0.925 ± 0.819
0.925ValTrp: 0.925 ± 0.819
2.775ValTyr: 2.775 ± 0.857
0.0ValXaa: 0.0 ± 0.0
Trp
1.85TrpAla: 1.85 ± 1.453
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
1.85TrpIle: 1.85 ± 1.398
0.925TrpLys: 0.925 ± 0.903
0.925TrpLeu: 0.925 ± 0.726
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.925TrpGln: 0.925 ± 0.726
0.925TrpArg: 0.925 ± 0.819
2.775TrpSer: 2.775 ± 1.755
1.85TrpThr: 1.85 ± 1.094
2.775TrpVal: 2.775 ± 1.236
0.0TrpTrp: 0.0 ± 0.0
0.925TrpTyr: 0.925 ± 0.808
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.85TyrAla: 1.85 ± 0.958
0.0TyrCys: 0.0 ± 0.0
0.925TyrAsp: 0.925 ± 0.903
0.0TyrGlu: 0.0 ± 0.0
3.7TyrPhe: 3.7 ± 1.376
2.775TyrGly: 2.775 ± 0.709
1.85TyrHis: 1.85 ± 0.689
1.85TyrIle: 1.85 ± 0.925
1.85TyrLys: 1.85 ± 0.689
5.55TyrLeu: 5.55 ± 1.397
1.85TyrMet: 1.85 ± 1.517
0.925TyrAsn: 0.925 ± 0.726
2.775TyrPro: 2.775 ± 1.004
0.0TyrGln: 0.0 ± 0.0
2.775TyrArg: 2.775 ± 1.784
0.0TyrSer: 0.0 ± 0.0
4.625TyrThr: 4.625 ± 0.89
2.775TyrVal: 2.775 ± 1.816
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1082 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski