Amino acid dipepetide frequency for Streptococcus satellite phage Javan230

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.419AlaAla: 0.419 ± 0.408
1.256AlaCys: 1.256 ± 0.606
3.35AlaAsp: 3.35 ± 1.2
5.863AlaGlu: 5.863 ± 2.461
2.094AlaPhe: 2.094 ± 0.919
2.931AlaGly: 2.931 ± 1.183
0.419AlaHis: 0.419 ± 0.383
4.606AlaIle: 4.606 ± 1.054
8.375AlaLys: 8.375 ± 2.538
2.931AlaLeu: 2.931 ± 1.108
0.838AlaMet: 0.838 ± 0.63
4.606AlaAsn: 4.606 ± 1.323
0.419AlaPro: 0.419 ± 0.543
2.931AlaGln: 2.931 ± 1.558
2.094AlaArg: 2.094 ± 1.151
4.188AlaSer: 4.188 ± 1.185
5.025AlaThr: 5.025 ± 1.815
1.256AlaVal: 1.256 ± 0.625
0.0AlaTrp: 0.0 ± 0.0
3.769AlaTyr: 3.769 ± 1.273
0.0AlaXaa: 0.0 ± 0.0
Cys
0.838CysAla: 0.838 ± 0.492
0.0CysCys: 0.0 ± 0.0
0.838CysAsp: 0.838 ± 1.005
0.0CysGlu: 0.0 ± 0.0
0.419CysPhe: 0.419 ± 0.383
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.419CysIle: 0.419 ± 0.385
0.0CysLys: 0.0 ± 0.0
0.419CysLeu: 0.419 ± 0.422
0.0CysMet: 0.0 ± 0.0
1.256CysAsn: 1.256 ± 0.756
1.256CysPro: 1.256 ± 0.779
0.838CysGln: 0.838 ± 0.587
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.419CysTyr: 0.419 ± 0.521
0.0CysXaa: 0.0 ± 0.0
Asp
1.256AspAla: 1.256 ± 0.657
0.419AspCys: 0.419 ± 0.521
6.281AspAsp: 6.281 ± 2.059
4.188AspGlu: 4.188 ± 1.188
2.931AspPhe: 2.931 ± 0.557
1.675AspGly: 1.675 ± 0.791
0.0AspHis: 0.0 ± 0.0
3.35AspIle: 3.35 ± 0.969
9.213AspLys: 9.213 ± 1.542
5.025AspLeu: 5.025 ± 0.912
1.256AspMet: 1.256 ± 0.708
2.094AspAsn: 2.094 ± 1.218
0.419AspPro: 0.419 ± 0.383
0.838AspGln: 0.838 ± 0.51
4.188AspArg: 4.188 ± 1.752
2.094AspSer: 2.094 ± 0.582
3.35AspThr: 3.35 ± 1.148
4.188AspVal: 4.188 ± 1.394
1.256AspTrp: 1.256 ± 0.526
4.188AspTyr: 4.188 ± 1.094
0.0AspXaa: 0.0 ± 0.0
Glu
3.35GluAla: 3.35 ± 1.227
1.256GluCys: 1.256 ± 0.681
1.675GluAsp: 1.675 ± 0.822
5.025GluGlu: 5.025 ± 1.921
3.35GluPhe: 3.35 ± 0.847
2.931GluGly: 2.931 ± 1.375
0.838GluHis: 0.838 ± 0.454
6.7GluIle: 6.7 ± 2.183
6.281GluLys: 6.281 ± 1.529
12.144GluLeu: 12.144 ± 3.14
0.838GluMet: 0.838 ± 0.456
4.606GluAsn: 4.606 ± 1.237
1.675GluPro: 1.675 ± 0.778
4.606GluGln: 4.606 ± 1.301
4.188GluArg: 4.188 ± 1.474
2.931GluSer: 2.931 ± 1.136
1.256GluThr: 1.256 ± 0.776
5.444GluVal: 5.444 ± 1.111
0.838GluTrp: 0.838 ± 0.601
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
1.256PheAla: 1.256 ± 0.681
0.419PheCys: 0.419 ± 0.367
3.769PheAsp: 3.769 ± 1.183
3.35PheGlu: 3.35 ± 0.98
1.256PhePhe: 1.256 ± 0.542
2.513PheGly: 2.513 ± 0.548
0.838PheHis: 0.838 ± 0.497
5.025PheIle: 5.025 ± 1.262
2.931PheLys: 2.931 ± 1.389
3.769PheLeu: 3.769 ± 1.052
0.419PheMet: 0.419 ± 0.374
0.838PheAsn: 0.838 ± 0.765
0.838PhePro: 0.838 ± 0.765
0.838PheGln: 0.838 ± 0.454
0.419PheArg: 0.419 ± 0.466
3.35PheSer: 3.35 ± 0.86
1.675PheThr: 1.675 ± 0.734
1.675PheVal: 1.675 ± 0.897
0.0PheTrp: 0.0 ± 0.0
0.838PheTyr: 0.838 ± 0.648
0.0PheXaa: 0.0 ± 0.0
Gly
4.188GlyAla: 4.188 ± 1.282
0.419GlyCys: 0.419 ± 0.385
1.256GlyAsp: 1.256 ± 0.796
2.094GlyGlu: 2.094 ± 0.879
2.094GlyPhe: 2.094 ± 1.083
1.675GlyGly: 1.675 ± 0.847
0.838GlyHis: 0.838 ± 0.499
4.188GlyIle: 4.188 ± 1.27
3.769GlyLys: 3.769 ± 1.506
4.188GlyLeu: 4.188 ± 1.683
0.419GlyMet: 0.419 ± 0.367
2.094GlyAsn: 2.094 ± 1.183
0.0GlyPro: 0.0 ± 0.0
0.838GlyGln: 0.838 ± 0.67
2.513GlyArg: 2.513 ± 0.852
0.838GlySer: 0.838 ± 0.492
2.931GlyThr: 2.931 ± 1.022
7.538GlyVal: 7.538 ± 1.596
0.419GlyTrp: 0.419 ± 0.367
4.188GlyTyr: 4.188 ± 0.916
0.0GlyXaa: 0.0 ± 0.0
His
0.838HisAla: 0.838 ± 0.799
0.0HisCys: 0.0 ± 0.0
0.419HisAsp: 0.419 ± 0.383
0.419HisGlu: 0.419 ± 0.385
0.419HisPhe: 0.419 ± 0.4
0.419HisGly: 0.419 ± 0.4
0.419HisHis: 0.419 ± 0.383
1.256HisIle: 1.256 ± 0.674
0.838HisLys: 0.838 ± 0.475
1.256HisLeu: 1.256 ± 0.895
0.0HisMet: 0.0 ± 0.0
2.513HisAsn: 2.513 ± 0.88
0.419HisPro: 0.419 ± 0.383
0.0HisGln: 0.0 ± 0.0
0.419HisArg: 0.419 ± 0.4
0.419HisSer: 0.419 ± 0.4
0.419HisThr: 0.419 ± 0.4
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.419HisTyr: 0.419 ± 0.383
0.0HisXaa: 0.0 ± 0.0
Ile
2.513IleAla: 2.513 ± 1.213
0.0IleCys: 0.0 ± 0.0
4.606IleAsp: 4.606 ± 0.981
3.769IleGlu: 3.769 ± 1.772
1.675IlePhe: 1.675 ± 0.588
4.606IleGly: 4.606 ± 1.884
0.0IleHis: 0.0 ± 0.0
5.025IleIle: 5.025 ± 1.689
9.213IleLys: 9.213 ± 2.657
7.119IleLeu: 7.119 ± 1.642
2.513IleMet: 2.513 ± 0.922
7.119IleAsn: 7.119 ± 1.777
2.094IlePro: 2.094 ± 0.866
2.931IleGln: 2.931 ± 1.244
2.513IleArg: 2.513 ± 0.908
8.375IleSer: 8.375 ± 1.478
4.606IleThr: 4.606 ± 1.199
2.513IleVal: 2.513 ± 1.159
0.419IleTrp: 0.419 ± 0.383
0.838IleTyr: 0.838 ± 0.589
0.0IleXaa: 0.0 ± 0.0
Lys
8.794LysAla: 8.794 ± 2.05
0.419LysCys: 0.419 ± 0.383
5.444LysAsp: 5.444 ± 1.774
9.213LysGlu: 9.213 ± 1.998
2.931LysPhe: 2.931 ± 1.065
5.444LysGly: 5.444 ± 1.538
0.838LysHis: 0.838 ± 0.5
3.769LysIle: 3.769 ± 1.147
9.213LysLys: 9.213 ± 2.861
12.563LysLeu: 12.563 ± 2.286
2.094LysMet: 2.094 ± 0.97
5.444LysAsn: 5.444 ± 1.856
3.35LysPro: 3.35 ± 0.874
8.794LysGln: 8.794 ± 2.009
5.863LysArg: 5.863 ± 1.888
4.188LysSer: 4.188 ± 1.373
6.7LysThr: 6.7 ± 1.588
4.606LysVal: 4.606 ± 0.938
1.256LysTrp: 1.256 ± 0.55
3.35LysTyr: 3.35 ± 0.789
0.0LysXaa: 0.0 ± 0.0
Leu
5.025LeuAla: 5.025 ± 1.305
0.838LeuCys: 0.838 ± 0.62
10.05LeuAsp: 10.05 ± 1.565
10.888LeuGlu: 10.888 ± 1.74
2.931LeuPhe: 2.931 ± 1.054
4.188LeuGly: 4.188 ± 1.399
0.838LeuHis: 0.838 ± 0.5
5.025LeuIle: 5.025 ± 1.987
9.213LeuLys: 9.213 ± 2.187
9.631LeuLeu: 9.631 ± 1.397
1.675LeuMet: 1.675 ± 0.807
6.281LeuAsn: 6.281 ± 1.415
3.769LeuPro: 3.769 ± 1.152
3.769LeuGln: 3.769 ± 1.019
3.769LeuArg: 3.769 ± 1.217
5.863LeuSer: 5.863 ± 1.843
9.631LeuThr: 9.631 ± 1.565
3.35LeuVal: 3.35 ± 1.399
0.838LeuTrp: 0.838 ± 0.5
3.35LeuTyr: 3.35 ± 0.844
0.0LeuXaa: 0.0 ± 0.0
Met
1.675MetAla: 1.675 ± 0.879
0.0MetCys: 0.0 ± 0.0
0.838MetAsp: 0.838 ± 0.575
2.094MetGlu: 2.094 ± 1.141
0.0MetPhe: 0.0 ± 0.0
0.419MetGly: 0.419 ± 0.466
0.0MetHis: 0.0 ± 0.0
1.675MetIle: 1.675 ± 0.673
0.838MetLys: 0.838 ± 0.454
2.094MetLeu: 2.094 ± 0.922
0.0MetMet: 0.0 ± 0.0
0.838MetAsn: 0.838 ± 0.527
0.419MetPro: 0.419 ± 0.383
0.838MetGln: 0.838 ± 0.497
0.419MetArg: 0.419 ± 0.385
0.419MetSer: 0.419 ± 0.424
3.769MetThr: 3.769 ± 1.699
1.675MetVal: 1.675 ± 1.334
0.419MetTrp: 0.419 ± 0.521
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.188AsnAla: 4.188 ± 1.271
0.0AsnCys: 0.0 ± 0.0
2.931AsnAsp: 2.931 ± 1.02
2.513AsnGlu: 2.513 ± 1.161
0.838AsnPhe: 0.838 ± 0.554
3.35AsnGly: 3.35 ± 0.965
0.838AsnHis: 0.838 ± 0.697
2.931AsnIle: 2.931 ± 1.122
5.025AsnLys: 5.025 ± 1.256
6.281AsnLeu: 6.281 ± 1.243
1.675AsnMet: 1.675 ± 1.021
5.444AsnAsn: 5.444 ± 1.14
2.094AsnPro: 2.094 ± 0.823
1.675AsnGln: 1.675 ± 0.99
2.513AsnArg: 2.513 ± 0.898
5.863AsnSer: 5.863 ± 1.877
5.863AsnThr: 5.863 ± 2.255
4.606AsnVal: 4.606 ± 1.305
0.419AsnTrp: 0.419 ± 0.385
4.606AsnTyr: 4.606 ± 0.747
0.0AsnXaa: 0.0 ± 0.0
Pro
1.256ProAla: 1.256 ± 0.611
0.0ProCys: 0.0 ± 0.0
1.256ProAsp: 1.256 ± 0.746
2.931ProGlu: 2.931 ± 1.216
2.094ProPhe: 2.094 ± 0.89
0.0ProGly: 0.0 ± 0.0
0.0ProHis: 0.0 ± 0.0
2.513ProIle: 2.513 ± 0.919
4.188ProLys: 4.188 ± 1.165
0.0ProLeu: 0.0 ± 0.0
0.0ProMet: 0.0 ± 0.0
2.094ProAsn: 2.094 ± 0.762
1.675ProPro: 1.675 ± 0.625
0.0ProGln: 0.0 ± 0.0
0.838ProArg: 0.838 ± 0.491
3.35ProSer: 3.35 ± 1.155
1.256ProThr: 1.256 ± 0.555
2.931ProVal: 2.931 ± 0.948
0.0ProTrp: 0.0 ± 0.0
0.419ProTyr: 0.419 ± 0.383
0.0ProXaa: 0.0 ± 0.0
Gln
4.606GlnAla: 4.606 ± 2.143
0.0GlnCys: 0.0 ± 0.0
1.256GlnAsp: 1.256 ± 0.604
3.769GlnGlu: 3.769 ± 0.813
0.838GlnPhe: 0.838 ± 0.618
0.838GlnGly: 0.838 ± 0.754
1.256GlnHis: 1.256 ± 0.821
2.513GlnIle: 2.513 ± 1.348
4.606GlnLys: 4.606 ± 1.392
5.025GlnLeu: 5.025 ± 1.04
0.419GlnMet: 0.419 ± 0.514
1.256GlnAsn: 1.256 ± 0.542
2.513GlnPro: 2.513 ± 1.076
4.606GlnGln: 4.606 ± 1.562
0.419GlnArg: 0.419 ± 0.503
5.025GlnSer: 5.025 ± 0.987
4.606GlnThr: 4.606 ± 1.521
2.094GlnVal: 2.094 ± 0.882
0.0GlnTrp: 0.0 ± 0.0
2.094GlnTyr: 2.094 ± 0.886
0.0GlnXaa: 0.0 ± 0.0
Arg
4.188ArgAla: 4.188 ± 1.025
0.0ArgCys: 0.0 ± 0.0
2.094ArgAsp: 2.094 ± 0.868
1.256ArgGlu: 1.256 ± 0.543
0.838ArgPhe: 0.838 ± 0.454
1.675ArgGly: 1.675 ± 0.641
0.838ArgHis: 0.838 ± 0.5
2.931ArgIle: 2.931 ± 1.237
6.281ArgLys: 6.281 ± 1.425
3.35ArgLeu: 3.35 ± 1.598
1.675ArgMet: 1.675 ± 0.718
1.675ArgAsn: 1.675 ± 0.695
0.0ArgPro: 0.0 ± 0.0
2.931ArgGln: 2.931 ± 0.831
2.094ArgArg: 2.094 ± 0.929
2.931ArgSer: 2.931 ± 0.724
1.675ArgThr: 1.675 ± 0.946
2.931ArgVal: 2.931 ± 1.526
0.838ArgTrp: 0.838 ± 0.639
3.35ArgTyr: 3.35 ± 1.33
0.0ArgXaa: 0.0 ± 0.0
Ser
2.513SerAla: 2.513 ± 0.815
0.838SerCys: 0.838 ± 1.005
4.606SerAsp: 4.606 ± 1.149
5.444SerGlu: 5.444 ± 1.327
3.35SerPhe: 3.35 ± 1.456
3.35SerGly: 3.35 ± 1.193
0.419SerHis: 0.419 ± 0.367
7.538SerIle: 7.538 ± 1.785
5.863SerLys: 5.863 ± 1.621
5.444SerLeu: 5.444 ± 1.447
0.838SerMet: 0.838 ± 0.507
2.513SerAsn: 2.513 ± 0.813
0.838SerPro: 0.838 ± 0.554
2.094SerGln: 2.094 ± 0.877
4.606SerArg: 4.606 ± 0.845
1.675SerSer: 1.675 ± 0.951
3.35SerThr: 3.35 ± 0.788
2.513SerVal: 2.513 ± 1.077
1.256SerTrp: 1.256 ± 0.563
2.931SerTyr: 2.931 ± 0.861
0.0SerXaa: 0.0 ± 0.0
Thr
4.188ThrAla: 4.188 ± 1.275
0.0ThrCys: 0.0 ± 0.0
5.025ThrAsp: 5.025 ± 1.843
2.931ThrGlu: 2.931 ± 1.079
3.35ThrPhe: 3.35 ± 1.132
6.281ThrGly: 6.281 ± 1.157
0.419ThrHis: 0.419 ± 0.4
7.956ThrIle: 7.956 ± 1.328
7.538ThrLys: 7.538 ± 2.264
7.119ThrLeu: 7.119 ± 1.1
1.256ThrMet: 1.256 ± 0.63
1.675ThrAsn: 1.675 ± 0.697
2.094ThrPro: 2.094 ± 0.859
3.769ThrGln: 3.769 ± 1.454
1.256ThrArg: 1.256 ± 0.746
2.094ThrSer: 2.094 ± 1.1
4.606ThrThr: 4.606 ± 0.915
2.513ThrVal: 2.513 ± 1.002
0.419ThrTrp: 0.419 ± 0.385
2.513ThrTyr: 2.513 ± 0.903
0.0ThrXaa: 0.0 ± 0.0
Val
1.675ValAla: 1.675 ± 0.883
0.838ValCys: 0.838 ± 0.492
1.256ValAsp: 1.256 ± 0.692
2.513ValGlu: 2.513 ± 1.476
2.094ValPhe: 2.094 ± 1.195
2.513ValGly: 2.513 ± 0.83
1.675ValHis: 1.675 ± 0.982
2.513ValIle: 2.513 ± 0.75
6.281ValLys: 6.281 ± 1.69
6.7ValLeu: 6.7 ± 1.506
1.675ValMet: 1.675 ± 1.141
5.444ValAsn: 5.444 ± 1.411
2.931ValPro: 2.931 ± 0.825
1.256ValGln: 1.256 ± 0.611
3.35ValArg: 3.35 ± 1.747
4.606ValSer: 4.606 ± 0.903
2.931ValThr: 2.931 ± 0.861
4.606ValVal: 4.606 ± 1.537
0.0ValTrp: 0.0 ± 0.0
2.094ValTyr: 2.094 ± 0.847
0.0ValXaa: 0.0 ± 0.0
Trp
0.838TrpAla: 0.838 ± 0.51
0.0TrpCys: 0.0 ± 0.0
0.838TrpAsp: 0.838 ± 0.563
0.838TrpGlu: 0.838 ± 0.527
0.419TrpPhe: 0.419 ± 0.422
0.0TrpGly: 0.0 ± 0.0
0.419TrpHis: 0.419 ± 0.383
0.0TrpIle: 0.0 ± 0.0
0.419TrpLys: 0.419 ± 0.385
1.256TrpLeu: 1.256 ± 0.87
0.0TrpMet: 0.0 ± 0.0
0.838TrpAsn: 0.838 ± 0.492
0.0TrpPro: 0.0 ± 0.0
1.256TrpGln: 1.256 ± 0.592
0.0TrpArg: 0.0 ± 0.0
0.419TrpSer: 0.419 ± 0.4
0.0TrpThr: 0.0 ± 0.0
1.256TrpVal: 1.256 ± 0.704
0.419TrpTrp: 0.419 ± 0.4
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.769TyrAla: 3.769 ± 1.55
0.0TyrCys: 0.0 ± 0.0
0.419TyrAsp: 0.419 ± 0.383
0.838TyrGlu: 0.838 ± 0.499
2.094TyrPhe: 2.094 ± 0.926
1.675TyrGly: 1.675 ± 0.759
0.0TyrHis: 0.0 ± 0.0
2.513TyrIle: 2.513 ± 1.142
4.188TyrLys: 4.188 ± 1.61
4.606TyrLeu: 4.606 ± 1.132
0.419TyrMet: 0.419 ± 0.445
5.025TyrAsn: 5.025 ± 1.51
0.0TyrPro: 0.0 ± 0.0
2.931TyrGln: 2.931 ± 0.854
2.094TyrArg: 2.094 ± 0.876
3.35TyrSer: 3.35 ± 0.911
3.35TyrThr: 3.35 ± 1.108
1.675TyrVal: 1.675 ± 0.837
0.419TyrTrp: 0.419 ± 0.383
2.094TyrTyr: 2.094 ± 1.187
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 16 proteins (2389 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski