Amino acid dipepetide frequency for Cyclobacterium marinum (strain ATCC 25205 / DSM 745 / LMG 13164 / NCIMB 1802) (Flectobacillus marinus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.641AlaAla: 4.641 ± 0.062	0.583AlaCys: 0.583 ± 0.018	3.36AlaAsp: 3.36 ± 0.049	4.103AlaGlu: 4.103 ± 0.053	3.414AlaPhe: 3.414 ± 0.046	4.633AlaGly: 4.633 ± 0.058	1.128AlaHis: 1.128 ± 0.027	5.259AlaIle: 5.259 ± 0.058	4.314AlaLys: 4.314 ± 0.056	6.47AlaLeu: 6.47 ± 0.076	1.685AlaMet: 1.685 ± 0.033	3.239AlaAsn: 3.239 ± 0.05	2.227AlaPro: 2.227 ± 0.042	2.264AlaGln: 2.264 ± 0.035	2.12AlaArg: 2.12 ± 0.037	4.364AlaSer: 4.364 ± 0.045	3.339AlaThr: 3.339 ± 0.054	4.002AlaVal: 4.002 ± 0.052	0.767AlaTrp: 0.767 ± 0.02	2.775AlaTyr: 2.775 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.388CysAla: 0.388 ± 0.015	0.103CysCys: 0.103 ± 0.008	0.357CysAsp: 0.357 ± 0.016	0.436CysGlu: 0.436 ± 0.018	0.395CysPhe: 0.395 ± 0.016	0.537CysGly: 0.537 ± 0.021	0.208CysHis: 0.208 ± 0.014	0.483CysIle: 0.483 ± 0.018	0.439CysLys: 0.439 ± 0.017	0.694CysLeu: 0.694 ± 0.021	0.171CysMet: 0.171 ± 0.01	0.337CysAsn: 0.337 ± 0.015	0.323CysPro: 0.323 ± 0.014	0.272CysGln: 0.272 ± 0.011	0.263CysArg: 0.263 ± 0.012	0.478CysSer: 0.478 ± 0.018	0.361CysThr: 0.361 ± 0.014	0.355CysVal: 0.355 ± 0.013	0.088CysTrp: 0.088 ± 0.007	0.26CysTyr: 0.26 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.24AspAla: 3.24 ± 0.048	0.375AspCys: 0.375 ± 0.013	2.461AspAsp: 2.461 ± 0.044	3.705AspGlu: 3.705 ± 0.05	3.489AspPhe: 3.489 ± 0.043	3.956AspGly: 3.956 ± 0.068	1.153AspHis: 1.153 ± 0.027	3.915AspIle: 3.915 ± 0.054	3.92AspLys: 3.92 ± 0.054	5.773AspLeu: 5.773 ± 0.054	1.246AspMet: 1.246 ± 0.028	2.825AspAsn: 2.825 ± 0.041	2.493AspPro: 2.493 ± 0.041	2.255AspGln: 2.255 ± 0.034	2.175AspArg: 2.175 ± 0.036	2.916AspSer: 2.916 ± 0.048	2.143AspThr: 2.143 ± 0.034	2.927AspVal: 2.927 ± 0.046	0.969AspTrp: 0.969 ± 0.027	2.493AspTyr: 2.493 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	4.779GluAla: 4.779 ± 0.063	0.306GluCys: 0.306 ± 0.014	3.772GluAsp: 3.772 ± 0.048	5.619GluGlu: 5.619 ± 0.066	2.696GluPhe: 2.696 ± 0.042	4.794GluGly: 4.794 ± 0.057	0.988GluHis: 0.988 ± 0.03	5.519GluIle: 5.519 ± 0.058	6.2GluLys: 6.2 ± 0.077	6.268GluLeu: 6.268 ± 0.065	1.911GluMet: 1.911 ± 0.038	4.701GluAsn: 4.701 ± 0.055	1.79GluPro: 1.79 ± 0.04	2.223GluGln: 2.223 ± 0.037	2.647GluArg: 2.647 ± 0.041	3.625GluSer: 3.625 ± 0.045	3.27GluThr: 3.27 ± 0.048	4.576GluVal: 4.576 ± 0.058	0.808GluTrp: 0.808 ± 0.023	2.2GluTyr: 2.2 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	2.847PheAla: 2.847 ± 0.044	0.398PheCys: 0.398 ± 0.014	3.185PheAsp: 3.185 ± 0.044	3.351PheGlu: 3.351 ± 0.044	2.738PhePhe: 2.738 ± 0.043	3.716PheGly: 3.716 ± 0.047	0.938PheHis: 0.938 ± 0.026	3.678PheIle: 3.678 ± 0.051	3.14PheLys: 3.14 ± 0.045	4.97PheLeu: 4.97 ± 0.068	1.157PheMet: 1.157 ± 0.021	2.932PheAsn: 2.932 ± 0.043	2.007PhePro: 2.007 ± 0.033	1.745PheGln: 1.745 ± 0.03	1.896PheArg: 1.896 ± 0.037	4.131PheSer: 4.131 ± 0.05	2.882PheThr: 2.882 ± 0.047	2.84PheVal: 2.84 ± 0.043	0.686PheTrp: 0.686 ± 0.023	2.139PheTyr: 2.139 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	4.42GlyAla: 4.42 ± 0.06	0.518GlyCys: 0.518 ± 0.02	3.654GlyAsp: 3.654 ± 0.054	4.561GlyGlu: 4.561 ± 0.057	3.833GlyPhe: 3.833 ± 0.056	4.895GlyGly: 4.895 ± 0.076	1.304GlyHis: 1.304 ± 0.031	5.549GlyIle: 5.549 ± 0.067	5.44GlyLys: 5.44 ± 0.058	6.895GlyLeu: 6.895 ± 0.077	1.962GlyMet: 1.962 ± 0.034	3.862GlyAsn: 3.862 ± 0.054	1.872GlyPro: 1.872 ± 0.036	2.359GlyGln: 2.359 ± 0.041	2.645GlyArg: 2.645 ± 0.039	4.248GlySer: 4.248 ± 0.06	3.76GlyThr: 3.76 ± 0.05	4.541GlyVal: 4.541 ± 0.059	0.998GlyTrp: 0.998 ± 0.021	3.048GlyTyr: 3.048 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.12HisAla: 1.12 ± 0.028	0.187HisCys: 0.187 ± 0.011	0.819HisAsp: 0.819 ± 0.023	1.037HisGlu: 1.037 ± 0.028	1.136HisPhe: 1.136 ± 0.026	1.266HisGly: 1.266 ± 0.029	0.522HisHis: 0.522 ± 0.022	1.225HisIle: 1.225 ± 0.031	1.049HisLys: 1.049 ± 0.026	2.004HisLeu: 2.004 ± 0.033	0.399HisMet: 0.399 ± 0.016	0.856HisAsn: 0.856 ± 0.022	1.058HisPro: 1.058 ± 0.025	0.841HisGln: 0.841 ± 0.022	0.724HisArg: 0.724 ± 0.023	1.156HisSer: 1.156 ± 0.029	0.925HisThr: 0.925 ± 0.026	0.986HisVal: 0.986 ± 0.026	0.32HisTrp: 0.32 ± 0.015	0.831HisTyr: 0.831 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.14IleAla: 5.14 ± 0.059	0.592IleCys: 0.592 ± 0.02	4.339IleAsp: 4.339 ± 0.052	4.82IleGlu: 4.82 ± 0.066	3.352IlePhe: 3.352 ± 0.049	5.278IleGly: 5.278 ± 0.07	1.448IleHis: 1.448 ± 0.029	5.157IleIle: 5.157 ± 0.065	5.116IleLys: 5.116 ± 0.063	6.764IleLeu: 6.764 ± 0.067	1.416IleMet: 1.416 ± 0.029	4.453IleAsn: 4.453 ± 0.058	3.464IlePro: 3.464 ± 0.044	2.637IleGln: 2.637 ± 0.037	2.926IleArg: 2.926 ± 0.043	5.619IleSer: 5.619 ± 0.06	3.957IleThr: 3.957 ± 0.049	4.094IleVal: 4.094 ± 0.055	0.806IleTrp: 0.806 ± 0.022	2.594IleTyr: 2.594 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.921LysAla: 4.921 ± 0.062	0.333LysCys: 0.333 ± 0.017	4.07LysAsp: 4.07 ± 0.054	5.936LysGlu: 5.936 ± 0.063	2.623LysPhe: 2.623 ± 0.04	4.787LysGly: 4.787 ± 0.049	1.245LysHis: 1.245 ± 0.029	5.491LysIle: 5.491 ± 0.063	5.686LysLys: 5.686 ± 0.078	6.133LysLeu: 6.133 ± 0.064	1.918LysMet: 1.918 ± 0.041	4.354LysAsn: 4.354 ± 0.056	2.64LysPro: 2.64 ± 0.041	2.18LysGln: 2.18 ± 0.042	2.721LysArg: 2.721 ± 0.042	4.305LysSer: 4.305 ± 0.052	3.641LysThr: 3.641 ± 0.048	4.693LysVal: 4.693 ± 0.055	0.901LysTrp: 0.901 ± 0.026	2.594LysTyr: 2.594 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	6.565LeuAla: 6.565 ± 0.072	0.665LeuCys: 0.665 ± 0.021	5.361LeuAsp: 5.361 ± 0.062	6.613LeuGlu: 6.613 ± 0.071	4.921LeuPhe: 4.921 ± 0.061	6.531LeuGly: 6.531 ± 0.078	1.595LeuHis: 1.595 ± 0.03	7.131LeuIle: 7.131 ± 0.075	7.169LeuLys: 7.169 ± 0.079	9.632LeuLeu: 9.632 ± 0.103	2.435LeuMet: 2.435 ± 0.042	5.409LeuAsn: 5.409 ± 0.067	4.339LeuPro: 4.339 ± 0.05	3.134LeuGln: 3.134 ± 0.042	3.446LeuArg: 3.446 ± 0.045	7.214LeuSer: 7.214 ± 0.069	5.063LeuThr: 5.063 ± 0.051	5.819LeuVal: 5.819 ± 0.069	1.021LeuTrp: 1.021 ± 0.024	3.252LeuTyr: 3.252 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.046MetAla: 2.046 ± 0.035	0.126MetCys: 0.126 ± 0.009	1.593MetAsp: 1.593 ± 0.03	1.883MetGlu: 1.883 ± 0.039	0.813MetPhe: 0.813 ± 0.021	1.767MetGly: 1.767 ± 0.033	0.455MetHis: 0.455 ± 0.015	1.551MetIle: 1.551 ± 0.031	2.057MetLys: 2.057 ± 0.037	2.039MetLeu: 2.039 ± 0.041	0.648MetMet: 0.648 ± 0.025	1.334MetAsn: 1.334 ± 0.026	1.011MetPro: 1.011 ± 0.025	0.779MetGln: 0.779 ± 0.023	0.894MetArg: 0.894 ± 0.023	1.35MetSer: 1.35 ± 0.027	1.147MetThr: 1.147 ± 0.025	1.831MetVal: 1.831 ± 0.038	0.196MetTrp: 0.196 ± 0.01	0.654MetTyr: 0.654 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.377AsnAla: 3.377 ± 0.042	0.36AsnCys: 0.36 ± 0.015	2.785AsnAsp: 2.785 ± 0.041	3.599AsnGlu: 3.599 ± 0.048	2.954AsnPhe: 2.954 ± 0.049	3.996AsnGly: 3.996 ± 0.061	1.104AsnHis: 1.104 ± 0.026	4.14AsnIle: 4.14 ± 0.058	3.824AsnLys: 3.824 ± 0.052	5.546AsnLeu: 5.546 ± 0.063	1.226AsnMet: 1.226 ± 0.026	3.241AsnAsn: 3.241 ± 0.058	2.934AsnPro: 2.934 ± 0.039	2.43AsnGln: 2.43 ± 0.041	2.371AsnArg: 2.371 ± 0.039	3.544AsnSer: 3.544 ± 0.055	2.895AsnThr: 2.895 ± 0.045	2.961AsnVal: 2.961 ± 0.04	0.889AsnTrp: 0.889 ± 0.028	2.52AsnTyr: 2.52 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	2.256ProAla: 2.256 ± 0.036	0.212ProCys: 0.212 ± 0.012	2.598ProAsp: 2.598 ± 0.045	3.714ProGlu: 3.714 ± 0.053	2.109ProPhe: 2.109 ± 0.034	2.733ProGly: 2.733 ± 0.039	0.715ProHis: 0.715 ± 0.022	2.849ProIle: 2.849 ± 0.042	2.494ProLys: 2.494 ± 0.04	3.622ProLeu: 3.622 ± 0.05	0.893ProMet: 0.893 ± 0.025	2.282ProAsn: 2.282 ± 0.041	1.091ProPro: 1.091 ± 0.026	1.224ProGln: 1.224 ± 0.026	1.168ProArg: 1.168 ± 0.023	2.65ProSer: 2.65 ± 0.04	1.961ProThr: 1.961 ± 0.037	2.724ProVal: 2.724 ± 0.041	0.511ProTrp: 0.511 ± 0.018	1.646ProTyr: 1.646 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	2.357GlnAla: 2.357 ± 0.037	0.176GlnCys: 0.176 ± 0.011	1.644GlnAsp: 1.644 ± 0.032	2.554GlnGlu: 2.554 ± 0.039	1.673GlnPhe: 1.673 ± 0.031	2.174GlnGly: 2.174 ± 0.031	0.574GlnHis: 0.574 ± 0.019	2.444GlnIle: 2.444 ± 0.043	2.581GlnLys: 2.581 ± 0.038	3.684GlnLeu: 3.684 ± 0.049	0.935GlnMet: 0.935 ± 0.022	2.061GlnAsn: 2.061 ± 0.043	1.247GlnPro: 1.247 ± 0.025	1.394GlnGln: 1.394 ± 0.037	1.337GlnArg: 1.337 ± 0.028	2.267GlnSer: 2.267 ± 0.033	1.783GlnThr: 1.783 ± 0.03	2.386GlnVal: 2.386 ± 0.035	0.462GlnTrp: 0.462 ± 0.016	1.306GlnTyr: 1.306 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.175ArgAla: 2.175 ± 0.044	0.204ArgCys: 0.204 ± 0.011	1.967ArgAsp: 1.967 ± 0.032	2.564ArgGlu: 2.564 ± 0.041	2.063ArgPhe: 2.063 ± 0.033	2.238ArgGly: 2.238 ± 0.042	0.66ArgHis: 0.66 ± 0.02	2.93ArgIle: 2.93 ± 0.043	2.916ArgLys: 2.916 ± 0.044	3.679ArgLeu: 3.679 ± 0.049	1.069ArgMet: 1.069 ± 0.026	2.238ArgAsn: 2.238 ± 0.035	1.385ArgPro: 1.385 ± 0.031	1.301ArgGln: 1.301 ± 0.028	1.547ArgArg: 1.547 ± 0.033	2.295ArgSer: 2.295 ± 0.04	1.835ArgThr: 1.835 ± 0.036	2.361ArgVal: 2.361 ± 0.033	0.571ArgTrp: 0.571 ± 0.021	1.627ArgTyr: 1.627 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	3.745SerAla: 3.745 ± 0.045	0.606SerCys: 0.606 ± 0.021	3.304SerAsp: 3.304 ± 0.042	3.981SerGlu: 3.981 ± 0.047	3.929SerPhe: 3.929 ± 0.046	5.218SerGly: 5.218 ± 0.07	1.19SerHis: 1.19 ± 0.029	5.103SerIle: 5.103 ± 0.06	4.363SerLys: 4.363 ± 0.051	6.826SerLeu: 6.826 ± 0.07	1.481SerMet: 1.481 ± 0.028	3.581SerAsn: 3.581 ± 0.061	2.744SerPro: 2.744 ± 0.038	2.321SerGln: 2.321 ± 0.039	2.539SerArg: 2.539 ± 0.038	4.537SerSer: 4.537 ± 0.056	3.381SerThr: 3.381 ± 0.046	3.6SerVal: 3.6 ± 0.046	0.853SerTrp: 0.853 ± 0.023	2.638SerTyr: 2.638 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	3.478ThrAla: 3.478 ± 0.044	0.355ThrCys: 0.355 ± 0.017	2.906ThrAsp: 2.906 ± 0.042	3.103ThrGlu: 3.103 ± 0.043	2.773ThrPhe: 2.773 ± 0.042	4.13ThrGly: 4.13 ± 0.057	0.957ThrHis: 0.957 ± 0.023	3.976ThrIle: 3.976 ± 0.05	2.961ThrLys: 2.961 ± 0.039	4.972ThrLeu: 4.972 ± 0.053	0.974ThrMet: 0.974 ± 0.027	2.61ThrAsn: 2.61 ± 0.04	2.161ThrPro: 2.161 ± 0.033	1.637ThrGln: 1.637 ± 0.034	1.633ThrArg: 1.633 ± 0.029	3.459ThrSer: 3.459 ± 0.046	2.574ThrThr: 2.574 ± 0.045	3.25ThrVal: 3.25 ± 0.048	0.653ThrTrp: 0.653 ± 0.024	2.187ThrTyr: 2.187 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	4.013ValAla: 4.013 ± 0.057	0.449ValCys: 0.449 ± 0.017	3.316ValAsp: 3.316 ± 0.05	3.764ValGlu: 3.764 ± 0.053	3.467ValPhe: 3.467 ± 0.046	3.983ValGly: 3.983 ± 0.055	1.089ValHis: 1.089 ± 0.023	4.45ValIle: 4.45 ± 0.053	4.145ValLys: 4.145 ± 0.058	6.019ValLeu: 6.019 ± 0.063	1.477ValMet: 1.477 ± 0.027	3.519ValAsn: 3.519 ± 0.052	2.505ValPro: 2.505 ± 0.034	1.802ValGln: 1.802 ± 0.032	2.222ValArg: 2.222 ± 0.043	4.293ValSer: 4.293 ± 0.053	3.122ValThr: 3.122 ± 0.046	3.842ValVal: 3.842 ± 0.055	0.754ValTrp: 0.754 ± 0.022	2.299ValTyr: 2.299 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	0.807TrpAla: 0.807 ± 0.022	0.081TrpCys: 0.081 ± 0.007	0.771TrpAsp: 0.771 ± 0.022	0.999TrpGlu: 0.999 ± 0.024	0.592TrpPhe: 0.592 ± 0.02	0.868TrpGly: 0.868 ± 0.027	0.291TrpHis: 0.291 ± 0.016	0.834TrpIle: 0.834 ± 0.022	0.935TrpLys: 0.935 ± 0.025	1.225TrpLeu: 1.225 ± 0.031	0.402TrpMet: 0.402 ± 0.015	0.698TrpAsn: 0.698 ± 0.022	0.449TrpPro: 0.449 ± 0.017	0.54TrpGln: 0.54 ± 0.018	0.559TrpArg: 0.559 ± 0.017	0.741TrpSer: 0.741 ± 0.02	0.677TrpThr: 0.677 ± 0.023	0.866TrpVal: 0.866 ± 0.023	0.2TrpTrp: 0.2 ± 0.011	0.498TrpTyr: 0.498 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.37TyrAla: 2.37 ± 0.04	0.318TyrCys: 0.318 ± 0.014	2.167TyrAsp: 2.167 ± 0.038	2.35TyrGlu: 2.35 ± 0.036	2.405TyrPhe: 2.405 ± 0.038	2.864TyrGly: 2.864 ± 0.041	0.894TyrHis: 0.894 ± 0.026	2.287TyrIle: 2.287 ± 0.04	2.424TyrLys: 2.424 ± 0.039	4.104TyrLeu: 4.104 ± 0.049	0.769TyrMet: 0.769 ± 0.022	2.162TyrAsn: 2.162 ± 0.045	1.713TyrPro: 1.713 ± 0.032	1.699TyrGln: 1.699 ± 0.034	1.793TyrArg: 1.793 ± 0.032	2.749TyrSer: 2.749 ± 0.036	2.035TyrThr: 2.035 ± 0.036	1.877TyrVal: 1.877 ± 0.032	0.58TyrTrp: 0.58 ± 0.017	1.788TyrTyr: 1.788 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4983 proteins (1776705 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---