Amino acid dipepetide frequency for Clostridium baratii str. Sullivan

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.264AlaAla: 3.264 ± 0.081	0.69AlaCys: 0.69 ± 0.024	2.348AlaAsp: 2.348 ± 0.055	3.021AlaGlu: 3.021 ± 0.07	2.532AlaPhe: 2.532 ± 0.066	3.378AlaGly: 3.378 ± 0.067	0.728AlaHis: 0.728 ± 0.032	5.806AlaIle: 5.806 ± 0.085	4.783AlaLys: 4.783 ± 0.077	5.791AlaLeu: 5.791 ± 0.092	1.529AlaMet: 1.529 ± 0.044	2.787AlaAsn: 2.787 ± 0.052	1.425AlaPro: 1.425 ± 0.042	1.177AlaGln: 1.177 ± 0.045	1.773AlaArg: 1.773 ± 0.054	3.232AlaSer: 3.232 ± 0.065	2.794AlaThr: 2.794 ± 0.062	3.703AlaVal: 3.703 ± 0.06	0.373AlaTrp: 0.373 ± 0.021	2.046AlaTyr: 2.046 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.57CysAla: 0.57 ± 0.026	0.161CysCys: 0.161 ± 0.016	0.734CysAsp: 0.734 ± 0.03	0.716CysGlu: 0.716 ± 0.031	0.429CysPhe: 0.429 ± 0.022	1.037CysGly: 1.037 ± 0.036	0.199CysHis: 0.199 ± 0.013	1.157CysIle: 1.157 ± 0.037	1.059CysLys: 1.059 ± 0.036	0.84CysLeu: 0.84 ± 0.026	0.28CysMet: 0.28 ± 0.016	0.833CysAsn: 0.833 ± 0.026	0.423CysPro: 0.423 ± 0.023	0.183CysGln: 0.183 ± 0.014	0.352CysArg: 0.352 ± 0.02	0.773CysSer: 0.773 ± 0.029	0.569CysThr: 0.569 ± 0.024	0.613CysVal: 0.613 ± 0.024	0.053CysTrp: 0.053 ± 0.007	0.424CysTyr: 0.424 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	2.611AspAla: 2.611 ± 0.055	0.637AspCys: 0.637 ± 0.031	3.083AspAsp: 3.083 ± 0.065	4.966AspGlu: 4.966 ± 0.094	2.901AspPhe: 2.901 ± 0.061	3.694AspGly: 3.694 ± 0.071	0.598AspHis: 0.598 ± 0.026	6.297AspIle: 6.297 ± 0.087	5.943AspLys: 5.943 ± 0.099	5.118AspLeu: 5.118 ± 0.083	1.517AspMet: 1.517 ± 0.044	3.753AspAsn: 3.753 ± 0.073	1.353AspPro: 1.353 ± 0.043	0.733AspGln: 0.733 ± 0.029	1.913AspArg: 1.913 ± 0.051	3.347AspSer: 3.347 ± 0.067	2.618AspThr: 2.618 ± 0.048	3.718AspVal: 3.718 ± 0.071	0.359AspTrp: 0.359 ± 0.02	2.804AspTyr: 2.804 ± 0.07	0.0AspXaa: 0.0 ± 0.0
Glu	4.221GluAla: 4.221 ± 0.082	0.772GluCys: 0.772 ± 0.033	4.788GluAsp: 4.788 ± 0.079	7.706GluGlu: 7.706 ± 0.124	3.303GluPhe: 3.303 ± 0.069	4.571GluGly: 4.571 ± 0.077	0.921GluHis: 0.921 ± 0.032	7.213GluIle: 7.213 ± 0.087	7.789GluLys: 7.789 ± 0.107	6.862GluLeu: 6.862 ± 0.111	1.954GluMet: 1.954 ± 0.05	5.708GluAsn: 5.708 ± 0.091	1.367GluPro: 1.367 ± 0.034	1.433GluGln: 1.433 ± 0.046	2.662GluArg: 2.662 ± 0.054	3.686GluSer: 3.686 ± 0.067	2.896GluThr: 2.896 ± 0.055	5.202GluVal: 5.202 ± 0.092	0.449GluTrp: 0.449 ± 0.024	3.359GluTyr: 3.359 ± 0.062	0.0GluXaa: 0.0 ± 0.0
Phe	2.184PheAla: 2.184 ± 0.057	0.48PheCys: 0.48 ± 0.023	2.639PheAsp: 2.639 ± 0.066	2.853PheGlu: 2.853 ± 0.056	2.03PhePhe: 2.03 ± 0.056	3.002PheGly: 3.002 ± 0.068	0.491PheHis: 0.491 ± 0.023	4.978PheIle: 4.978 ± 0.094	4.485PheLys: 4.485 ± 0.08	3.973PheLeu: 3.973 ± 0.077	1.187PheMet: 1.187 ± 0.036	3.31PheAsn: 3.31 ± 0.066	1.061PhePro: 1.061 ± 0.035	0.746PheGln: 0.746 ± 0.029	1.348PheArg: 1.348 ± 0.038	2.891PheSer: 2.891 ± 0.063	2.404PheThr: 2.404 ± 0.05	2.616PheVal: 2.616 ± 0.052	0.285PheTrp: 0.285 ± 0.021	1.844PheTyr: 1.844 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.094GlyAla: 4.094 ± 0.078	0.895GlyCys: 0.895 ± 0.036	3.523GlyAsp: 3.523 ± 0.065	4.507GlyGlu: 4.507 ± 0.073	3.103GlyPhe: 3.103 ± 0.06	4.415GlyGly: 4.415 ± 0.093	0.901GlyHis: 0.901 ± 0.034	6.862GlyIle: 6.862 ± 0.092	5.539GlyLys: 5.539 ± 0.075	5.457GlyLeu: 5.457 ± 0.081	1.774GlyMet: 1.774 ± 0.048	3.337GlyAsn: 3.337 ± 0.067	1.304GlyPro: 1.304 ± 0.089	1.257GlyGln: 1.257 ± 0.037	2.261GlyArg: 2.261 ± 0.052	3.751GlySer: 3.751 ± 0.075	3.467GlyThr: 3.467 ± 0.07	4.959GlyVal: 4.959 ± 0.079	0.5GlyTrp: 0.5 ± 0.03	2.973GlyTyr: 2.973 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	0.602HisAla: 0.602 ± 0.024	0.185HisCys: 0.185 ± 0.015	0.665HisAsp: 0.665 ± 0.025	0.785HisGlu: 0.785 ± 0.028	0.636HisPhe: 0.636 ± 0.028	0.946HisGly: 0.946 ± 0.032	0.254HisHis: 0.254 ± 0.016	1.176HisIle: 1.176 ± 0.034	1.049HisLys: 1.049 ± 0.036	1.057HisLeu: 1.057 ± 0.035	0.323HisMet: 0.323 ± 0.018	0.803HisAsn: 0.803 ± 0.032	0.546HisPro: 0.546 ± 0.026	0.261HisGln: 0.261 ± 0.018	0.489HisArg: 0.489 ± 0.022	0.803HisSer: 0.803 ± 0.031	0.638HisThr: 0.638 ± 0.027	0.692HisVal: 0.692 ± 0.031	0.078HisTrp: 0.078 ± 0.009	0.521HisTyr: 0.521 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.664IleAla: 5.664 ± 0.079	1.213IleCys: 1.213 ± 0.034	6.094IleAsp: 6.094 ± 0.079	7.336IleGlu: 7.336 ± 0.1	4.468IlePhe: 4.468 ± 0.092	6.369IleGly: 6.369 ± 0.097	1.129IleHis: 1.129 ± 0.035	9.935IleIle: 9.935 ± 0.143	9.529IleLys: 9.529 ± 0.117	9.419IleLeu: 9.419 ± 0.119	2.249IleMet: 2.249 ± 0.053	6.771IleAsn: 6.771 ± 0.102	3.25IlePro: 3.25 ± 0.069	1.888IleGln: 1.888 ± 0.045	3.074IleArg: 3.074 ± 0.063	6.83IleSer: 6.83 ± 0.097	4.983IleThr: 4.983 ± 0.079	6.281IleVal: 6.281 ± 0.087	0.493IleTrp: 0.493 ± 0.025	3.752IleTyr: 3.752 ± 0.08	0.0IleXaa: 0.0 ± 0.0
Lys	4.785LysAla: 4.785 ± 0.074	0.936LysCys: 0.936 ± 0.033	7.028LysAsp: 7.028 ± 0.105	10.451LysGlu: 10.451 ± 0.146	3.532LysPhe: 3.532 ± 0.064	5.542LysGly: 5.542 ± 0.07	1.117LysHis: 1.117 ± 0.041	8.452LysIle: 8.452 ± 0.096	8.9LysLys: 8.9 ± 0.099	7.859LysLeu: 7.859 ± 0.097	2.412LysMet: 2.412 ± 0.054	6.904LysAsn: 6.904 ± 0.103	2.049LysPro: 2.049 ± 0.054	1.692LysGln: 1.692 ± 0.044	3.313LysArg: 3.313 ± 0.065	5.119LysSer: 5.119 ± 0.073	3.991LysThr: 3.991 ± 0.065	6.126LysVal: 6.126 ± 0.088	0.605LysTrp: 0.605 ± 0.03	4.28LysTyr: 4.28 ± 0.079	0.0LysXaa: 0.0 ± 0.0
Leu	4.885LeuAla: 4.885 ± 0.08	1.032LeuCys: 1.032 ± 0.035	5.328LeuAsp: 5.328 ± 0.083	6.644LeuGlu: 6.644 ± 0.083	3.693LeuPhe: 3.693 ± 0.068	5.973LeuGly: 5.973 ± 0.089	1.047LeuHis: 1.047 ± 0.032	8.694LeuIle: 8.694 ± 0.115	8.935LeuLys: 8.935 ± 0.111	7.669LeuLeu: 7.669 ± 0.113	2.28LeuMet: 2.28 ± 0.048	6.634LeuAsn: 6.634 ± 0.103	2.538LeuPro: 2.538 ± 0.047	1.695LeuGln: 1.695 ± 0.047	2.95LeuArg: 2.95 ± 0.067	6.232LeuSer: 6.232 ± 0.085	4.389LeuThr: 4.389 ± 0.072	5.45LeuVal: 5.45 ± 0.081	0.532LeuTrp: 0.532 ± 0.02	3.252LeuTyr: 3.252 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	1.615MetAla: 1.615 ± 0.042	0.249MetCys: 0.249 ± 0.015	1.493MetAsp: 1.493 ± 0.036	1.777MetGlu: 1.777 ± 0.045	1.031MetPhe: 1.031 ± 0.032	1.837MetGly: 1.837 ± 0.047	0.324MetHis: 0.324 ± 0.022	2.283MetIle: 2.283 ± 0.047	2.508MetLys: 2.508 ± 0.051	2.147MetLeu: 2.147 ± 0.04	0.665MetMet: 0.665 ± 0.029	1.692MetAsn: 1.692 ± 0.046	0.921MetPro: 0.921 ± 0.034	0.617MetGln: 0.617 ± 0.024	0.903MetArg: 0.903 ± 0.03	1.548MetSer: 1.548 ± 0.046	1.168MetThr: 1.168 ± 0.035	1.522MetVal: 1.522 ± 0.037	0.183MetTrp: 0.183 ± 0.014	0.887MetTyr: 0.887 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	2.883AsnAla: 2.883 ± 0.058	0.662AsnCys: 0.662 ± 0.027	3.524AsnAsp: 3.524 ± 0.07	5.01AsnGlu: 5.01 ± 0.081	2.749AsnPhe: 2.749 ± 0.065	4.059AsnGly: 4.059 ± 0.071	0.822AsnHis: 0.822 ± 0.032	7.649AsnIle: 7.649 ± 0.122	7.145AsnLys: 7.145 ± 0.106	5.837AsnLeu: 5.837 ± 0.088	1.685AsnMet: 1.685 ± 0.043	5.113AsnAsn: 5.113 ± 0.106	2.04AsnPro: 2.04 ± 0.042	1.161AsnGln: 1.161 ± 0.035	2.129AsnArg: 2.129 ± 0.047	4.108AsnSer: 4.108 ± 0.08	3.05AsnThr: 3.05 ± 0.061	3.79AsnVal: 3.79 ± 0.066	0.412AsnTrp: 0.412 ± 0.02	2.893AsnTyr: 2.893 ± 0.066	0.0AsnXaa: 0.0 ± 0.0
Pro	1.329ProAla: 1.329 ± 0.04	0.281ProCys: 0.281 ± 0.017	1.28ProAsp: 1.28 ± 0.04	2.061ProGlu: 2.061 ± 0.064	1.455ProPhe: 1.455 ± 0.045	1.601ProGly: 1.601 ± 0.05	0.427ProHis: 0.427 ± 0.019	2.625ProIle: 2.625 ± 0.056	2.268ProLys: 2.268 ± 0.047	2.392ProLeu: 2.392 ± 0.055	0.711ProMet: 0.711 ± 0.03	1.564ProAsn: 1.564 ± 0.036	0.553ProPro: 0.553 ± 0.034	0.655ProGln: 0.655 ± 0.028	0.82ProArg: 0.82 ± 0.038	1.735ProSer: 1.735 ± 0.035	1.422ProThr: 1.422 ± 0.041	1.934ProVal: 1.934 ± 0.052	0.205ProTrp: 0.205 ± 0.015	1.25ProTyr: 1.25 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	1.072GlnAla: 1.072 ± 0.035	0.204GlnCys: 0.204 ± 0.015	1.059GlnAsp: 1.059 ± 0.034	1.387GlnGlu: 1.387 ± 0.045	0.846GlnPhe: 0.846 ± 0.033	1.35GlnGly: 1.35 ± 0.052	0.209GlnHis: 0.209 ± 0.015	1.763GlnIle: 1.763 ± 0.042	1.7GlnLys: 1.7 ± 0.044	1.553GlnLeu: 1.553 ± 0.042	0.559GlnMet: 0.559 ± 0.025	1.321GlnAsn: 1.321 ± 0.037	0.46GlnPro: 0.46 ± 0.023	0.445GlnGln: 0.445 ± 0.025	0.783GlnArg: 0.783 ± 0.035	1.099GlnSer: 1.099 ± 0.039	0.933GlnThr: 0.933 ± 0.037	1.212GlnVal: 1.212 ± 0.032	0.168GlnTrp: 0.168 ± 0.012	0.864GlnTyr: 0.864 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	1.735ArgAla: 1.735 ± 0.049	0.405ArgCys: 0.405 ± 0.024	2.019ArgAsp: 2.019 ± 0.045	3.197ArgGlu: 3.197 ± 0.068	1.472ArgPhe: 1.472 ± 0.039	2.07ArgGly: 2.07 ± 0.057	0.415ArgHis: 0.415 ± 0.02	3.198ArgIle: 3.198 ± 0.055	3.145ArgLys: 3.145 ± 0.062	2.795ArgLeu: 2.795 ± 0.056	0.921ArgMet: 0.921 ± 0.033	2.024ArgAsn: 2.024 ± 0.049	0.807ArgPro: 0.807 ± 0.032	0.688ArgGln: 0.688 ± 0.022	1.515ArgArg: 1.515 ± 0.046	1.534ArgSer: 1.534 ± 0.041	1.507ArgThr: 1.507 ± 0.04	2.319ArgVal: 2.319 ± 0.047	0.211ArgTrp: 0.211 ± 0.015	1.434ArgTyr: 1.434 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	2.939SerAla: 2.939 ± 0.066	0.587SerCys: 0.587 ± 0.025	3.174SerAsp: 3.174 ± 0.07	3.923SerGlu: 3.923 ± 0.065	3.077SerPhe: 3.077 ± 0.062	4.214SerGly: 4.214 ± 0.076	0.816SerHis: 0.816 ± 0.026	6.606SerIle: 6.606 ± 0.094	6.211SerLys: 6.211 ± 0.081	5.887SerLeu: 5.887 ± 0.093	1.527SerMet: 1.527 ± 0.041	4.08SerAsn: 4.08 ± 0.071	1.495SerPro: 1.495 ± 0.041	1.233SerGln: 1.233 ± 0.036	1.982SerArg: 1.982 ± 0.046	3.986SerSer: 3.986 ± 0.086	3.087SerThr: 3.087 ± 0.062	3.583SerVal: 3.583 ± 0.066	0.387SerTrp: 0.387 ± 0.022	2.544SerTyr: 2.544 ± 0.065	0.0SerXaa: 0.0 ± 0.0
Thr	2.772ThrAla: 2.772 ± 0.066	0.502ThrCys: 0.502 ± 0.025	2.393ThrAsp: 2.393 ± 0.052	2.968ThrGlu: 2.968 ± 0.057	2.347ThrPhe: 2.347 ± 0.047	3.514ThrGly: 3.514 ± 0.059	0.738ThrHis: 0.738 ± 0.029	4.92ThrIle: 4.92 ± 0.087	3.917ThrLys: 3.917 ± 0.065	4.817ThrLeu: 4.817 ± 0.073	1.092ThrMet: 1.092 ± 0.039	2.864ThrAsn: 2.864 ± 0.062	1.756ThrPro: 1.756 ± 0.045	0.954ThrGln: 0.954 ± 0.032	1.476ThrArg: 1.476 ± 0.035	3.15ThrSer: 3.15 ± 0.066	2.568ThrThr: 2.568 ± 0.057	3.359ThrVal: 3.359 ± 0.063	0.306ThrTrp: 0.306 ± 0.022	1.784ThrTyr: 1.784 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	3.762ValAla: 3.762 ± 0.073	0.937ValCys: 0.937 ± 0.037	3.838ValAsp: 3.838 ± 0.071	4.187ValGlu: 4.187 ± 0.077	2.89ValPhe: 2.89 ± 0.059	4.199ValGly: 4.199 ± 0.082	0.778ValHis: 0.778 ± 0.025	6.435ValIle: 6.435 ± 0.091	5.597ValLys: 5.597 ± 0.091	6.078ValLeu: 6.078 ± 0.084	1.534ValMet: 1.534 ± 0.041	3.847ValAsn: 3.847 ± 0.071	1.933ValPro: 1.933 ± 0.05	1.286ValGln: 1.286 ± 0.04	1.958ValArg: 1.958 ± 0.042	4.384ValSer: 4.384 ± 0.07	3.404ValThr: 3.404 ± 0.071	4.416ValVal: 4.416 ± 0.094	0.411ValTrp: 0.411 ± 0.021	2.424ValTyr: 2.424 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.323TrpAla: 0.323 ± 0.017	0.105TrpCys: 0.105 ± 0.011	0.397TrpAsp: 0.397 ± 0.02	0.379TrpGlu: 0.379 ± 0.022	0.302TrpPhe: 0.302 ± 0.017	0.483TrpGly: 0.483 ± 0.023	0.122TrpHis: 0.122 ± 0.013	0.609TrpIle: 0.609 ± 0.024	0.462TrpLys: 0.462 ± 0.025	0.518TrpLeu: 0.518 ± 0.026	0.18TrpMet: 0.18 ± 0.014	0.434TrpAsn: 0.434 ± 0.022	0.144TrpPro: 0.144 ± 0.013	0.198TrpGln: 0.198 ± 0.016	0.225TrpArg: 0.225 ± 0.015	0.402TrpSer: 0.402 ± 0.02	0.348TrpThr: 0.348 ± 0.023	0.389TrpVal: 0.389 ± 0.021	0.071TrpTrp: 0.071 ± 0.01	0.271TrpTyr: 0.271 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.869TyrAla: 1.869 ± 0.049	0.47TyrCys: 0.47 ± 0.027	2.557TyrAsp: 2.557 ± 0.052	2.989TyrGlu: 2.989 ± 0.066	2.008TyrPhe: 2.008 ± 0.049	2.627TyrGly: 2.627 ± 0.049	0.471TyrHis: 0.471 ± 0.021	4.068TyrIle: 4.068 ± 0.081	4.13TyrLys: 4.13 ± 0.075	3.784TyrLeu: 3.784 ± 0.07	0.989TyrMet: 0.989 ± 0.034	2.945TyrAsn: 2.945 ± 0.064	1.146TyrPro: 1.146 ± 0.035	0.687TyrGln: 0.687 ± 0.03	1.483TyrArg: 1.483 ± 0.04	2.729TyrSer: 2.729 ± 0.063	1.96TyrThr: 1.96 ± 0.053	2.414TyrVal: 2.414 ± 0.052	0.281TyrTrp: 0.281 ± 0.018	1.87TyrTyr: 1.87 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3167 proteins (965364 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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