Amino acid dipepetide frequency for Sitophilus oryzae (Rice weevil) (Curculio oryzae)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.384AlaAla: 4.384 ± 0.046	1.031AlaCys: 1.031 ± 0.02	2.768AlaAsp: 2.768 ± 0.021	3.803AlaGlu: 3.803 ± 0.029	2.004AlaPhe: 2.004 ± 0.016	3.053AlaGly: 3.053 ± 0.026	1.21AlaHis: 1.21 ± 0.011	3.13AlaIle: 3.13 ± 0.022	3.731AlaLys: 3.731 ± 0.038	5.193AlaLeu: 5.193 ± 0.034	1.181AlaMet: 1.181 ± 0.013	2.529AlaAsn: 2.529 ± 0.019	2.868AlaPro: 2.868 ± 0.03	2.388AlaGln: 2.388 ± 0.02	2.583AlaArg: 2.583 ± 0.016	4.469AlaSer: 4.469 ± 0.028	3.24AlaThr: 3.24 ± 0.028	3.632AlaVal: 3.632 ± 0.024	0.494AlaTrp: 0.494 ± 0.007	1.567AlaTyr: 1.567 ± 0.013	0.001AlaXaa: 0.001 ± 0.0
Cys	0.981CysAla: 0.981 ± 0.015	0.471CysCys: 0.471 ± 0.009	1.229CysAsp: 1.229 ± 0.016	1.131CysGlu: 1.131 ± 0.015	0.73CysPhe: 0.73 ± 0.009	1.213CysGly: 1.213 ± 0.027	0.487CysHis: 0.487 ± 0.007	1.119CysIle: 1.119 ± 0.021	1.278CysLys: 1.278 ± 0.02	1.75CysLeu: 1.75 ± 0.021	0.358CysMet: 0.358 ± 0.006	1.045CysAsn: 1.045 ± 0.015	1.042CysPro: 1.042 ± 0.024	0.781CysGln: 0.781 ± 0.014	0.94CysArg: 0.94 ± 0.02	1.685CysSer: 1.685 ± 0.029	1.025CysThr: 1.025 ± 0.017	1.119CysVal: 1.119 ± 0.02	0.192CysTrp: 0.192 ± 0.004	0.594CysTyr: 0.594 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	2.677AspAla: 2.677 ± 0.026	1.0AspCys: 1.0 ± 0.017	3.686AspAsp: 3.686 ± 0.024	4.339AspGlu: 4.339 ± 0.035	2.332AspPhe: 2.332 ± 0.015	2.916AspGly: 2.916 ± 0.02	1.181AspHis: 1.181 ± 0.011	4.0AspIle: 4.0 ± 0.024	3.784AspLys: 3.784 ± 0.031	5.128AspLeu: 5.128 ± 0.024	1.203AspMet: 1.203 ± 0.013	3.021AspAsn: 3.021 ± 0.022	2.381AspPro: 2.381 ± 0.026	1.916AspGln: 1.916 ± 0.015	2.485AspArg: 2.485 ± 0.02	4.569AspSer: 4.569 ± 0.025	2.92AspThr: 2.92 ± 0.02	3.434AspVal: 3.434 ± 0.021	0.572AspTrp: 0.572 ± 0.009	1.891AspTyr: 1.891 ± 0.015	0.001AspXaa: 0.001 ± 0.0
Glu	3.884GluAla: 3.884 ± 0.029	1.194GluCys: 1.194 ± 0.028	4.442GluAsp: 4.442 ± 0.031	7.121GluGlu: 7.121 ± 0.136	2.247GluPhe: 2.247 ± 0.016	3.042GluGly: 3.042 ± 0.041	1.543GluHis: 1.543 ± 0.019	4.554GluIle: 4.554 ± 0.042	6.213GluLys: 6.213 ± 0.066	6.151GluLeu: 6.151 ± 0.046	1.482GluMet: 1.482 ± 0.014	4.655GluAsn: 4.655 ± 0.034	2.837GluPro: 2.837 ± 0.038	3.015GluGln: 3.015 ± 0.035	3.64GluArg: 3.64 ± 0.03	4.918GluSer: 4.918 ± 0.037	3.904GluThr: 3.904 ± 0.054	3.994GluVal: 3.994 ± 0.035	0.587GluTrp: 0.587 ± 0.008	2.067GluTyr: 2.067 ± 0.018	0.001GluXaa: 0.001 ± 0.0
Phe	1.982PheAla: 1.982 ± 0.016	0.807PheCys: 0.807 ± 0.009	2.144PheAsp: 2.144 ± 0.015	2.333PheGlu: 2.333 ± 0.016	1.613PhePhe: 1.613 ± 0.017	2.25PheGly: 2.25 ± 0.021	0.879PheHis: 0.879 ± 0.011	2.253PheIle: 2.253 ± 0.02	2.544PheLys: 2.544 ± 0.02	3.625PheLeu: 3.625 ± 0.029	0.801PheMet: 0.801 ± 0.009	2.039PheAsn: 2.039 ± 0.018	1.609PhePro: 1.609 ± 0.014	1.503PheGln: 1.503 ± 0.013	1.808PheArg: 1.808 ± 0.016	3.085PheSer: 3.085 ± 0.022	2.103PheThr: 2.103 ± 0.018	2.36PheVal: 2.36 ± 0.018	0.442PheTrp: 0.442 ± 0.007	1.396PheTyr: 1.396 ± 0.015	0.001PheXaa: 0.001 ± 0.0
Gly	2.972GlyAla: 2.972 ± 0.026	0.915GlyCys: 0.915 ± 0.012	2.848GlyAsp: 2.848 ± 0.022	3.074GlyGlu: 3.074 ± 0.027	2.165GlyPhe: 2.165 ± 0.018	3.932GlyGly: 3.932 ± 0.054	1.356GlyHis: 1.356 ± 0.015	3.06GlyIle: 3.06 ± 0.021	3.527GlyLys: 3.527 ± 0.033	4.243GlyLeu: 4.243 ± 0.03	1.048GlyMet: 1.048 ± 0.012	2.639GlyAsn: 2.639 ± 0.019	2.472GlyPro: 2.472 ± 0.036	2.229GlyGln: 2.229 ± 0.036	2.591GlyArg: 2.591 ± 0.02	4.635GlySer: 4.635 ± 0.053	2.989GlyThr: 2.989 ± 0.022	3.034GlyVal: 3.034 ± 0.022	0.591GlyTrp: 0.591 ± 0.008	1.969GlyTyr: 1.969 ± 0.021	0.002GlyXaa: 0.002 ± 0.0
His	1.084HisAla: 1.084 ± 0.011	0.605HisCys: 0.605 ± 0.011	1.061HisAsp: 1.061 ± 0.025	1.32HisGlu: 1.32 ± 0.01	1.019HisPhe: 1.019 ± 0.011	1.193HisGly: 1.193 ± 0.011	0.91HisHis: 0.91 ± 0.016	1.56HisIle: 1.56 ± 0.013	1.547HisLys: 1.547 ± 0.013	2.45HisLeu: 2.45 ± 0.026	0.587HisMet: 0.587 ± 0.01	1.176HisAsn: 1.176 ± 0.011	1.285HisPro: 1.285 ± 0.015	1.115HisGln: 1.115 ± 0.012	1.219HisArg: 1.219 ± 0.012	1.938HisSer: 1.938 ± 0.019	1.299HisThr: 1.299 ± 0.014	1.333HisVal: 1.333 ± 0.013	0.249HisTrp: 0.249 ± 0.004	0.835HisTyr: 0.835 ± 0.008	0.001HisXaa: 0.001 ± 0.0
Ile	3.18IleAla: 3.18 ± 0.019	1.298IleCys: 1.298 ± 0.017	3.39IleAsp: 3.39 ± 0.021	4.196IleGlu: 4.196 ± 0.037	2.493IlePhe: 2.493 ± 0.024	2.809IleGly: 2.809 ± 0.018	1.442IleHis: 1.442 ± 0.013	3.701IleIle: 3.701 ± 0.024	4.505IleLys: 4.505 ± 0.039	5.503IleLeu: 5.503 ± 0.038	1.172IleMet: 1.172 ± 0.011	3.303IleAsn: 3.303 ± 0.026	3.078IlePro: 3.078 ± 0.023	2.576IleGln: 2.576 ± 0.02	2.778IleArg: 2.778 ± 0.018	4.923IleSer: 4.923 ± 0.026	3.443IleThr: 3.443 ± 0.03	3.506IleVal: 3.506 ± 0.025	0.562IleTrp: 0.562 ± 0.008	1.945IleTyr: 1.945 ± 0.014	0.001IleXaa: 0.001 ± 0.0
Lys	3.696LysAla: 3.696 ± 0.03	1.463LysCys: 1.463 ± 0.02	4.03LysAsp: 4.03 ± 0.04	5.837LysGlu: 5.837 ± 0.067	2.398LysPhe: 2.398 ± 0.02	3.129LysGly: 3.129 ± 0.029	1.721LysHis: 1.721 ± 0.014	4.732LysIle: 4.732 ± 0.033	6.768LysLys: 6.768 ± 0.106	6.427LysLeu: 6.427 ± 0.036	1.533LysMet: 1.533 ± 0.011	4.252LysAsn: 4.252 ± 0.03	3.614LysPro: 3.614 ± 0.065	3.096LysGln: 3.096 ± 0.023	3.954LysArg: 3.954 ± 0.027	5.52LysSer: 5.52 ± 0.05	4.138LysThr: 4.138 ± 0.027	4.042LysVal: 4.042 ± 0.03	0.72LysTrp: 0.72 ± 0.01	2.573LysTyr: 2.573 ± 0.015	0.002LysXaa: 0.002 ± 0.0
Leu	5.245LeuAla: 5.245 ± 0.032	1.642LeuCys: 1.642 ± 0.018	4.92LeuAsp: 4.92 ± 0.03	6.695LeuGlu: 6.695 ± 0.049	3.233LeuPhe: 3.233 ± 0.025	4.318LeuGly: 4.318 ± 0.025	2.144LeuHis: 2.144 ± 0.02	4.662LeuIle: 4.662 ± 0.028	7.077LeuLys: 7.077 ± 0.038	8.115LeuLeu: 8.115 ± 0.057	1.759LeuMet: 1.759 ± 0.017	4.973LeuAsn: 4.973 ± 0.032	4.546LeuPro: 4.546 ± 0.032	4.371LeuGln: 4.371 ± 0.028	4.598LeuArg: 4.598 ± 0.031	6.971LeuSer: 6.971 ± 0.04	5.043LeuThr: 5.043 ± 0.026	4.835LeuVal: 4.835 ± 0.029	0.854LeuTrp: 0.854 ± 0.01	2.715LeuTyr: 2.715 ± 0.02	0.003LeuXaa: 0.003 ± 0.0
Met	1.366MetAla: 1.366 ± 0.01	0.404MetCys: 0.404 ± 0.007	1.255MetAsp: 1.255 ± 0.01	1.57MetGlu: 1.57 ± 0.012	0.854MetPhe: 0.854 ± 0.01	1.151MetGly: 1.151 ± 0.014	0.462MetHis: 0.462 ± 0.007	0.986MetIle: 0.986 ± 0.01	1.427MetLys: 1.427 ± 0.012	1.746MetLeu: 1.746 ± 0.016	0.507MetMet: 0.507 ± 0.008	0.993MetAsn: 0.993 ± 0.011	0.956MetPro: 0.956 ± 0.011	0.861MetGln: 0.861 ± 0.009	0.954MetArg: 0.954 ± 0.01	1.729MetSer: 1.729 ± 0.015	1.087MetThr: 1.087 ± 0.011	1.195MetVal: 1.195 ± 0.011	0.214MetTrp: 0.214 ± 0.004	0.674MetTyr: 0.674 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.737AsnAla: 2.737 ± 0.021	1.039AsnCys: 1.039 ± 0.015	2.864AsnAsp: 2.864 ± 0.02	3.681AsnGlu: 3.681 ± 0.025	2.2AsnPhe: 2.2 ± 0.019	2.958AsnGly: 2.958 ± 0.024	1.287AsnHis: 1.287 ± 0.015	4.08AsnIle: 4.08 ± 0.029	4.022AsnLys: 4.022 ± 0.029	5.086AsnLeu: 5.086 ± 0.031	1.202AsnMet: 1.202 ± 0.01	3.642AsnAsn: 3.642 ± 0.031	2.421AsnPro: 2.421 ± 0.026	2.339AsnGln: 2.339 ± 0.029	2.426AsnArg: 2.426 ± 0.019	4.657AsnSer: 4.657 ± 0.031	3.015AsnThr: 3.015 ± 0.018	3.354AsnVal: 3.354 ± 0.018	0.5AsnTrp: 0.5 ± 0.006	1.865AsnTyr: 1.865 ± 0.016	0.001AsnXaa: 0.001 ± 0.0
Pro	2.84ProAla: 2.84 ± 0.024	0.796ProCys: 0.796 ± 0.032	2.628ProAsp: 2.628 ± 0.018	3.805ProGlu: 3.805 ± 0.075	1.663ProPhe: 1.663 ± 0.014	2.952ProGly: 2.952 ± 0.052	1.158ProHis: 1.158 ± 0.012	2.699ProIle: 2.699 ± 0.02	3.546ProLys: 3.546 ± 0.043	4.105ProLeu: 4.105 ± 0.025	0.886ProMet: 0.886 ± 0.011	2.557ProAsn: 2.557 ± 0.022	4.629ProPro: 4.629 ± 0.051	2.271ProGln: 2.271 ± 0.023	2.276ProArg: 2.276 ± 0.018	4.597ProSer: 4.597 ± 0.04	3.127ProThr: 3.127 ± 0.025	3.314ProVal: 3.314 ± 0.026	0.424ProTrp: 0.424 ± 0.007	1.576ProTyr: 1.576 ± 0.016	0.001ProXaa: 0.001 ± 0.0
Gln	2.481GlnAla: 2.481 ± 0.019	0.814GlnCys: 0.814 ± 0.018	2.05GlnAsp: 2.05 ± 0.014	3.241GlnGlu: 3.241 ± 0.036	1.449GlnPhe: 1.449 ± 0.013	1.973GlnGly: 1.973 ± 0.02	1.134GlnHis: 1.134 ± 0.013	2.505GlnIle: 2.505 ± 0.017	3.125GlnLys: 3.125 ± 0.021	3.776GlnLeu: 3.776 ± 0.029	0.941GlnMet: 0.941 ± 0.011	2.713GlnAsn: 2.713 ± 0.025	2.298GlnPro: 2.298 ± 0.037	3.085GlnGln: 3.085 ± 0.054	2.243GlnArg: 2.243 ± 0.017	3.149GlnSer: 3.149 ± 0.026	2.461GlnThr: 2.461 ± 0.02	2.463GlnVal: 2.463 ± 0.019	0.436GlnTrp: 0.436 ± 0.006	1.451GlnTyr: 1.451 ± 0.018	0.001GlnXaa: 0.001 ± 0.0
Arg	2.598ArgAla: 2.598 ± 0.018	0.954ArgCys: 0.954 ± 0.016	2.583ArgAsp: 2.583 ± 0.019	3.226ArgGlu: 3.226 ± 0.026	1.811ArgPhe: 1.811 ± 0.015	2.437ArgGly: 2.437 ± 0.023	1.406ArgHis: 1.406 ± 0.015	2.797ArgIle: 2.797 ± 0.014	4.106ArgLys: 4.106 ± 0.024	4.21ArgLeu: 4.21 ± 0.028	0.99ArgMet: 0.99 ± 0.01	2.845ArgAsn: 2.845 ± 0.019	2.416ArgPro: 2.416 ± 0.025	2.242ArgGln: 2.242 ± 0.018	3.488ArgArg: 3.488 ± 0.029	3.847ArgSer: 3.847 ± 0.035	2.611ArgThr: 2.611 ± 0.016	2.552ArgVal: 2.552 ± 0.019	0.511ArgTrp: 0.511 ± 0.007	1.586ArgTyr: 1.586 ± 0.012	0.001ArgXaa: 0.001 ± 0.0
Ser	4.306SerAla: 4.306 ± 0.033	1.434SerCys: 1.434 ± 0.025	4.829SerAsp: 4.829 ± 0.034	5.411SerGlu: 5.411 ± 0.044	2.931SerPhe: 2.931 ± 0.02	4.695SerGly: 4.695 ± 0.049	1.782SerHis: 1.782 ± 0.016	4.372SerIle: 4.372 ± 0.025	5.557SerLys: 5.557 ± 0.048	6.95SerLeu: 6.95 ± 0.04	1.577SerMet: 1.577 ± 0.014	4.517SerAsn: 4.517 ± 0.03	4.679SerPro: 4.679 ± 0.057	3.409SerGln: 3.409 ± 0.027	3.962SerArg: 3.962 ± 0.03	9.014SerSer: 9.014 ± 0.084	5.349SerThr: 5.349 ± 0.043	4.848SerVal: 4.848 ± 0.026	0.756SerTrp: 0.756 ± 0.01	2.39SerTyr: 2.39 ± 0.021	0.001SerXaa: 0.001 ± 0.0
Thr	3.265ThrAla: 3.265 ± 0.024	1.117ThrCys: 1.117 ± 0.02	3.187ThrAsp: 3.187 ± 0.021	4.08ThrGlu: 4.08 ± 0.049	2.168ThrPhe: 2.168 ± 0.015	3.115ThrGly: 3.115 ± 0.023	1.219ThrHis: 1.219 ± 0.011	3.397ThrIle: 3.397 ± 0.027	3.813ThrLys: 3.813 ± 0.027	4.998ThrLeu: 4.998 ± 0.024	1.053ThrMet: 1.053 ± 0.011	3.04ThrAsn: 3.04 ± 0.019	3.533ThrPro: 3.533 ± 0.027	2.185ThrGln: 2.185 ± 0.019	2.385ThrArg: 2.385 ± 0.014	5.172ThrSer: 5.172 ± 0.046	4.258ThrThr: 4.258 ± 0.058	3.848ThrVal: 3.848 ± 0.054	0.55ThrTrp: 0.55 ± 0.008	1.746ThrTyr: 1.746 ± 0.014	0.001ThrXaa: 0.001 ± 0.0
Val	3.544ValAla: 3.544 ± 0.024	1.24ValCys: 1.24 ± 0.015	3.226ValAsp: 3.226 ± 0.02	4.095ValGlu: 4.095 ± 0.044	2.323ValPhe: 2.323 ± 0.019	2.823ValGly: 2.823 ± 0.021	1.374ValHis: 1.374 ± 0.013	3.624ValIle: 3.624 ± 0.035	4.137ValLys: 4.137 ± 0.034	5.348ValLeu: 5.348 ± 0.031	1.169ValMet: 1.169 ± 0.01	3.04ValAsn: 3.04 ± 0.019	3.309ValPro: 3.309 ± 0.031	2.553ValGln: 2.553 ± 0.021	2.652ValArg: 2.652 ± 0.017	4.609ValSer: 4.609 ± 0.022	3.709ValThr: 3.709 ± 0.045	3.919ValVal: 3.919 ± 0.033	0.596ValTrp: 0.596 ± 0.008	1.856ValTyr: 1.856 ± 0.015	0.001ValXaa: 0.001 ± 0.0
Trp	0.483TrpAla: 0.483 ± 0.007	0.188TrpCys: 0.188 ± 0.004	0.568TrpAsp: 0.568 ± 0.008	0.567TrpGlu: 0.567 ± 0.008	0.445TrpPhe: 0.445 ± 0.007	0.479TrpGly: 0.479 ± 0.007	0.227TrpHis: 0.227 ± 0.005	0.607TrpIle: 0.607 ± 0.009	0.729TrpLys: 0.729 ± 0.01	0.974TrpLeu: 0.974 ± 0.011	0.252TrpMet: 0.252 ± 0.005	0.575TrpAsn: 0.575 ± 0.008	0.397TrpPro: 0.397 ± 0.007	0.404TrpGln: 0.404 ± 0.006	0.554TrpArg: 0.554 ± 0.007	0.746TrpSer: 0.746 ± 0.01	0.575TrpThr: 0.575 ± 0.008	0.499TrpVal: 0.499 ± 0.008	0.166TrpTrp: 0.166 ± 0.004	0.356TrpTyr: 0.356 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.556TyrAla: 1.556 ± 0.014	0.757TyrCys: 0.757 ± 0.009	1.725TyrAsp: 1.725 ± 0.016	1.964TyrGlu: 1.964 ± 0.017	1.5TyrPhe: 1.5 ± 0.014	1.851TyrGly: 1.851 ± 0.019	0.865TyrHis: 0.865 ± 0.009	1.966TyrIle: 1.966 ± 0.014	2.206TyrLys: 2.206 ± 0.016	2.939TyrLeu: 2.939 ± 0.02	0.69TyrMet: 0.69 ± 0.009	1.82TyrAsn: 1.82 ± 0.016	1.476TyrPro: 1.476 ± 0.016	1.448TyrGln: 1.448 ± 0.017	1.68TyrArg: 1.68 ± 0.015	2.534TyrSer: 2.534 ± 0.02	1.833TyrThr: 1.833 ± 0.016	1.865TyrVal: 1.865 ± 0.014	0.376TyrTrp: 0.376 ± 0.007	1.292TyrTyr: 1.292 ± 0.014	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.002XaaPhe: 0.002 ± 0.0	0.002XaaGly: 0.002 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.003XaaLys: 0.003 ± 0.0	0.002XaaLeu: 0.002 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.002XaaAsn: 0.002 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.001XaaGln: 0.001 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.002XaaSer: 0.002 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 20351 proteins (12485201 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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