Amino acid dipepetide frequency for Flavobacterium gilvum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.214AlaAla: 4.214 ± 0.088	0.56AlaCys: 0.56 ± 0.024	3.296AlaAsp: 3.296 ± 0.059	3.897AlaGlu: 3.897 ± 0.073	3.175AlaPhe: 3.175 ± 0.058	4.294AlaGly: 4.294 ± 0.084	1.0AlaHis: 1.0 ± 0.03	5.279AlaIle: 5.279 ± 0.078	5.248AlaLys: 5.248 ± 0.092	5.853AlaLeu: 5.853 ± 0.075	1.497AlaMet: 1.497 ± 0.041	3.843AlaAsn: 3.843 ± 0.058	2.048AlaPro: 2.048 ± 0.065	2.433AlaGln: 2.433 ± 0.051	1.849AlaArg: 1.849 ± 0.044	4.22AlaSer: 4.22 ± 0.062	4.103AlaThr: 4.103 ± 0.103	4.359AlaVal: 4.359 ± 0.084	0.647AlaTrp: 0.647 ± 0.024	2.385AlaTyr: 2.385 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.494CysAla: 0.494 ± 0.025	0.109CysCys: 0.109 ± 0.011	0.469CysAsp: 0.469 ± 0.024	0.527CysGlu: 0.527 ± 0.027	0.485CysPhe: 0.485 ± 0.018	0.61CysGly: 0.61 ± 0.024	0.192CysHis: 0.192 ± 0.014	0.639CysIle: 0.639 ± 0.024	0.514CysLys: 0.514 ± 0.021	0.704CysLeu: 0.704 ± 0.024	0.147CysMet: 0.147 ± 0.012	0.469CysAsn: 0.469 ± 0.021	0.351CysPro: 0.351 ± 0.02	0.26CysGln: 0.26 ± 0.016	0.218CysArg: 0.218 ± 0.013	0.651CysSer: 0.651 ± 0.03	0.526CysThr: 0.526 ± 0.03	0.491CysVal: 0.491 ± 0.019	0.079CysTrp: 0.079 ± 0.009	0.332CysTyr: 0.332 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.561AspAla: 3.561 ± 0.068	0.457AspCys: 0.457 ± 0.026	2.433AspAsp: 2.433 ± 0.054	3.405AspGlu: 3.405 ± 0.06	3.646AspPhe: 3.646 ± 0.062	3.704AspGly: 3.704 ± 0.094	0.773AspHis: 0.773 ± 0.028	4.047AspIle: 4.047 ± 0.062	4.487AspLys: 4.487 ± 0.078	5.004AspLeu: 5.004 ± 0.073	1.056AspMet: 1.056 ± 0.031	3.233AspAsn: 3.233 ± 0.063	1.716AspPro: 1.716 ± 0.041	1.424AspGln: 1.424 ± 0.03	1.738AspArg: 1.738 ± 0.043	3.142AspSer: 3.142 ± 0.056	2.563AspThr: 2.563 ± 0.057	3.408AspVal: 3.408 ± 0.061	0.841AspTrp: 0.841 ± 0.03	2.807AspTyr: 2.807 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	4.029GluAla: 4.029 ± 0.069	0.381GluCys: 0.381 ± 0.018	3.005GluAsp: 3.005 ± 0.055	4.172GluGlu: 4.172 ± 0.089	2.824GluPhe: 2.824 ± 0.045	3.524GluGly: 3.524 ± 0.063	0.976GluHis: 0.976 ± 0.033	5.621GluIle: 5.621 ± 0.091	6.369GluLys: 6.369 ± 0.1	5.688GluLeu: 5.688 ± 0.09	1.686GluMet: 1.686 ± 0.042	4.759GluAsn: 4.759 ± 0.078	1.546GluPro: 1.546 ± 0.037	2.186GluGln: 2.186 ± 0.044	2.137GluArg: 2.137 ± 0.05	3.35GluSer: 3.35 ± 0.057	3.593GluThr: 3.593 ± 0.056	3.817GluVal: 3.817 ± 0.064	0.644GluTrp: 0.644 ± 0.025	2.293GluTyr: 2.293 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.13PheAla: 3.13 ± 0.053	0.525PheCys: 0.525 ± 0.024	3.261PheAsp: 3.261 ± 0.056	3.523PheGlu: 3.523 ± 0.063	2.92PhePhe: 2.92 ± 0.057	3.723PheGly: 3.723 ± 0.066	0.843PheHis: 0.843 ± 0.028	3.711PheIle: 3.711 ± 0.074	3.718PheLys: 3.718 ± 0.063	4.699PheLeu: 4.699 ± 0.069	1.197PheMet: 1.197 ± 0.032	3.211PheAsn: 3.211 ± 0.06	1.838PhePro: 1.838 ± 0.037	1.582PheGln: 1.582 ± 0.032	1.657PheArg: 1.657 ± 0.038	4.021PheSer: 4.021 ± 0.067	3.033PheThr: 3.033 ± 0.059	3.276PheVal: 3.276 ± 0.055	0.631PheTrp: 0.631 ± 0.023	2.172PheTyr: 2.172 ± 0.048	0.001PheXaa: 0.001 ± 0.001
Gly	4.092GlyAla: 4.092 ± 0.077	0.663GlyCys: 0.663 ± 0.031	3.197GlyAsp: 3.197 ± 0.07	3.437GlyGlu: 3.437 ± 0.058	3.737GlyPhe: 3.737 ± 0.06	4.676GlyGly: 4.676 ± 0.087	1.102GlyHis: 1.102 ± 0.03	5.589GlyIle: 5.589 ± 0.067	5.503GlyLys: 5.503 ± 0.082	5.641GlyLeu: 5.641 ± 0.078	1.611GlyMet: 1.611 ± 0.039	4.02GlyAsn: 4.02 ± 0.078	1.354GlyPro: 1.354 ± 0.035	1.993GlyGln: 1.993 ± 0.041	2.0GlyArg: 2.0 ± 0.044	4.205GlySer: 4.205 ± 0.086	4.26GlyThr: 4.26 ± 0.139	4.324GlyVal: 4.324 ± 0.076	0.883GlyTrp: 0.883 ± 0.028	2.898GlyTyr: 2.898 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	0.899HisAla: 0.899 ± 0.026	0.16HisCys: 0.16 ± 0.011	0.882HisAsp: 0.882 ± 0.028	0.909HisGlu: 0.909 ± 0.027	1.185HisPhe: 1.185 ± 0.033	1.051HisGly: 1.051 ± 0.033	0.431HisHis: 0.431 ± 0.023	1.292HisIle: 1.292 ± 0.032	1.081HisLys: 1.081 ± 0.03	1.655HisLeu: 1.655 ± 0.039	0.291HisMet: 0.291 ± 0.016	0.954HisAsn: 0.954 ± 0.028	0.857HisPro: 0.857 ± 0.031	0.704HisGln: 0.704 ± 0.026	0.532HisArg: 0.532 ± 0.021	1.039HisSer: 1.039 ± 0.03	0.875HisThr: 0.875 ± 0.03	0.815HisVal: 0.815 ± 0.024	0.224HisTrp: 0.224 ± 0.013	0.784HisTyr: 0.784 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.625IleAla: 5.625 ± 0.081	0.724IleCys: 0.724 ± 0.024	4.75IleAsp: 4.75 ± 0.062	5.272IleGlu: 5.272 ± 0.093	3.477IlePhe: 3.477 ± 0.054	5.128IleGly: 5.128 ± 0.073	1.392IleHis: 1.392 ± 0.039	6.027IleIle: 6.027 ± 0.088	6.202IleLys: 6.202 ± 0.077	6.711IleLeu: 6.711 ± 0.086	1.489IleMet: 1.489 ± 0.039	4.843IleAsn: 4.843 ± 0.067	3.379IlePro: 3.379 ± 0.054	2.774IleGln: 2.774 ± 0.051	2.49IleArg: 2.49 ± 0.046	5.507IleSer: 5.507 ± 0.077	4.931IleThr: 4.931 ± 0.093	4.862IleVal: 4.862 ± 0.068	0.742IleTrp: 0.742 ± 0.028	2.772IleTyr: 2.772 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	5.323LysAla: 5.323 ± 0.083	0.443LysCys: 0.443 ± 0.02	4.538LysAsp: 4.538 ± 0.064	6.134LysGlu: 6.134 ± 0.099	3.088LysPhe: 3.088 ± 0.054	4.993LysGly: 4.993 ± 0.063	1.24LysHis: 1.24 ± 0.038	7.099LysIle: 7.099 ± 0.091	7.458LysLys: 7.458 ± 0.11	6.556LysLeu: 6.556 ± 0.088	2.326LysMet: 2.326 ± 0.048	5.909LysAsn: 5.909 ± 0.097	2.748LysPro: 2.748 ± 0.046	2.742LysGln: 2.742 ± 0.047	2.528LysArg: 2.528 ± 0.045	4.95LysSer: 4.95 ± 0.066	5.174LysThr: 5.174 ± 0.069	4.92LysVal: 4.92 ± 0.062	0.916LysTrp: 0.916 ± 0.027	3.284LysTyr: 3.284 ± 0.059	0.0LysXaa: 0.0 ± 0.0
Leu	5.612LeuAla: 5.612 ± 0.078	0.756LeuCys: 0.756 ± 0.024	4.792LeuAsp: 4.792 ± 0.055	5.595LeuGlu: 5.595 ± 0.092	4.98LeuPhe: 4.98 ± 0.083	5.565LeuGly: 5.565 ± 0.079	1.519LeuHis: 1.519 ± 0.037	6.468LeuIle: 6.468 ± 0.089	7.736LeuLys: 7.736 ± 0.094	8.076LeuLeu: 8.076 ± 0.114	2.023LeuMet: 2.023 ± 0.046	5.604LeuAsn: 5.604 ± 0.078	3.624LeuPro: 3.624 ± 0.059	3.026LeuGln: 3.026 ± 0.052	2.776LeuArg: 2.776 ± 0.048	6.391LeuSer: 6.391 ± 0.086	5.056LeuThr: 5.056 ± 0.089	5.253LeuVal: 5.253 ± 0.073	0.821LeuTrp: 0.821 ± 0.026	3.161LeuTyr: 3.161 ± 0.067	0.0LeuXaa: 0.0 ± 0.0
Met	1.581MetAla: 1.581 ± 0.037	0.175MetCys: 0.175 ± 0.012	1.165MetAsp: 1.165 ± 0.029	1.337MetGlu: 1.337 ± 0.034	0.885MetPhe: 0.885 ± 0.029	1.498MetGly: 1.498 ± 0.037	0.423MetHis: 0.423 ± 0.02	1.641MetIle: 1.641 ± 0.039	2.274MetLys: 2.274 ± 0.043	1.843MetLeu: 1.843 ± 0.04	0.633MetMet: 0.633 ± 0.022	1.436MetAsn: 1.436 ± 0.034	0.931MetPro: 0.931 ± 0.028	0.811MetGln: 0.811 ± 0.023	0.809MetArg: 0.809 ± 0.025	1.477MetSer: 1.477 ± 0.036	1.245MetThr: 1.245 ± 0.032	1.37MetVal: 1.37 ± 0.036	0.197MetTrp: 0.197 ± 0.011	0.725MetTyr: 0.725 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.99AsnAla: 3.99 ± 0.063	0.583AsnCys: 0.583 ± 0.03	3.384AsnAsp: 3.384 ± 0.07	3.9AsnGlu: 3.9 ± 0.055	3.219AsnPhe: 3.219 ± 0.053	4.436AsnGly: 4.436 ± 0.09	1.131AsnHis: 1.131 ± 0.032	4.771AsnIle: 4.771 ± 0.073	4.837AsnLys: 4.837 ± 0.083	5.65AsnLeu: 5.65 ± 0.082	1.278AsnMet: 1.278 ± 0.03	4.045AsnAsn: 4.045 ± 0.07	3.164AsnPro: 3.164 ± 0.055	2.381AsnGln: 2.381 ± 0.052	2.104AsnArg: 2.104 ± 0.04	4.28AsnSer: 4.28 ± 0.068	3.612AsnThr: 3.612 ± 0.083	3.735AsnVal: 3.735 ± 0.073	0.903AsnTrp: 0.903 ± 0.034	3.018AsnTyr: 3.018 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	2.261ProAla: 2.261 ± 0.051	0.21ProCys: 0.21 ± 0.014	2.059ProAsp: 2.059 ± 0.043	2.773ProGlu: 2.773 ± 0.055	2.045ProPhe: 2.045 ± 0.042	2.119ProGly: 2.119 ± 0.047	0.575ProHis: 0.575 ± 0.023	2.74ProIle: 2.74 ± 0.051	2.879ProLys: 2.879 ± 0.046	2.993ProLeu: 2.993 ± 0.053	0.752ProMet: 0.752 ± 0.023	2.487ProAsn: 2.487 ± 0.057	0.86ProPro: 0.86 ± 0.045	1.136ProGln: 1.136 ± 0.032	0.877ProArg: 0.877 ± 0.027	2.404ProSer: 2.404 ± 0.055	2.231ProThr: 2.231 ± 0.066	2.563ProVal: 2.563 ± 0.053	0.393ProTrp: 0.393 ± 0.018	1.464ProTyr: 1.464 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	1.935GlnAla: 1.935 ± 0.039	0.194GlnCys: 0.194 ± 0.013	1.518GlnAsp: 1.518 ± 0.032	2.18GlnGlu: 2.18 ± 0.05	1.69GlnPhe: 1.69 ± 0.036	1.741GlnGly: 1.741 ± 0.033	0.523GlnHis: 0.523 ± 0.021	2.757GlnIle: 2.757 ± 0.055	3.199GlnLys: 3.199 ± 0.061	3.304GlnLeu: 3.304 ± 0.061	0.832GlnMet: 0.832 ± 0.028	2.506GlnAsn: 2.506 ± 0.048	1.137GlnPro: 1.137 ± 0.032	1.282GlnGln: 1.282 ± 0.036	1.114GlnArg: 1.114 ± 0.034	2.032GlnSer: 2.032 ± 0.038	1.935GlnThr: 1.935 ± 0.042	1.893GlnVal: 1.893 ± 0.041	0.417GlnTrp: 0.417 ± 0.019	1.448GlnTyr: 1.448 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	1.91ArgAla: 1.91 ± 0.039	0.222ArgCys: 0.222 ± 0.015	1.603ArgAsp: 1.603 ± 0.038	2.054ArgGlu: 2.054 ± 0.047	1.799ArgPhe: 1.799 ± 0.044	1.796ArgGly: 1.796 ± 0.042	0.515ArgHis: 0.515 ± 0.02	2.758ArgIle: 2.758 ± 0.057	2.59ArgLys: 2.59 ± 0.053	2.895ArgLeu: 2.895 ± 0.044	0.836ArgMet: 0.836 ± 0.028	2.08ArgAsn: 2.08 ± 0.046	1.061ArgPro: 1.061 ± 0.032	0.993ArgGln: 0.993 ± 0.029	1.058ArgArg: 1.058 ± 0.034	1.625ArgSer: 1.625 ± 0.04	1.729ArgThr: 1.729 ± 0.04	1.858ArgVal: 1.858 ± 0.04	0.412ArgTrp: 0.412 ± 0.018	1.385ArgTyr: 1.385 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	3.942SerAla: 3.942 ± 0.079	0.642SerCys: 0.642 ± 0.025	3.558SerAsp: 3.558 ± 0.06	3.727SerGlu: 3.727 ± 0.054	3.911SerPhe: 3.911 ± 0.061	4.753SerGly: 4.753 ± 0.089	1.141SerHis: 1.141 ± 0.035	5.17SerIle: 5.17 ± 0.072	5.267SerLys: 5.267 ± 0.078	5.831SerLeu: 5.831 ± 0.08	1.304SerMet: 1.304 ± 0.033	4.062SerAsn: 4.062 ± 0.084	2.276SerPro: 2.276 ± 0.05	2.261SerGln: 2.261 ± 0.047	1.994SerArg: 1.994 ± 0.043	4.218SerSer: 4.218 ± 0.076	3.502SerThr: 3.502 ± 0.072	4.167SerVal: 4.167 ± 0.068	0.808SerTrp: 0.808 ± 0.031	2.753SerTyr: 2.753 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.125ThrAla: 4.125 ± 0.102	0.369ThrCys: 0.369 ± 0.027	3.125ThrAsp: 3.125 ± 0.053	3.287ThrGlu: 3.287 ± 0.058	3.031ThrPhe: 3.031 ± 0.048	4.203ThrGly: 4.203 ± 0.093	0.906ThrHis: 0.906 ± 0.029	5.154ThrIle: 5.154 ± 0.106	4.259ThrLys: 4.259 ± 0.058	5.199ThrLeu: 5.199 ± 0.078	1.019ThrMet: 1.019 ± 0.037	3.645ThrAsn: 3.645 ± 0.079	2.695ThrPro: 2.695 ± 0.071	1.902ThrGln: 1.902 ± 0.042	1.514ThrArg: 1.514 ± 0.03	3.676ThrSer: 3.676 ± 0.08	3.778ThrThr: 3.778 ± 0.1	4.213ThrVal: 4.213 ± 0.114	0.628ThrTrp: 0.628 ± 0.024	2.275ThrTyr: 2.275 ± 0.074	0.0ThrXaa: 0.0 ± 0.0
Val	4.305ValAla: 4.305 ± 0.065	0.595ValCys: 0.595 ± 0.024	3.363ValAsp: 3.363 ± 0.062	3.534ValGlu: 3.534 ± 0.061	3.499ValPhe: 3.499 ± 0.052	3.813ValGly: 3.813 ± 0.074	0.934ValHis: 0.934 ± 0.025	4.791ValIle: 4.791 ± 0.064	4.746ValLys: 4.746 ± 0.072	5.837ValLeu: 5.837 ± 0.073	1.368ValMet: 1.368 ± 0.034	3.838ValAsn: 3.838 ± 0.075	2.343ValPro: 2.343 ± 0.053	1.807ValGln: 1.807 ± 0.038	1.871ValArg: 1.871 ± 0.048	4.541ValSer: 4.541 ± 0.069	3.85ValThr: 3.85 ± 0.092	4.378ValVal: 4.378 ± 0.075	0.676ValTrp: 0.676 ± 0.028	2.442ValTyr: 2.442 ± 0.042	0.001ValXaa: 0.001 ± 0.001
Trp	0.711TrpAla: 0.711 ± 0.025	0.122TrpCys: 0.122 ± 0.011	0.685TrpAsp: 0.685 ± 0.025	0.715TrpGlu: 0.715 ± 0.028	0.596TrpPhe: 0.596 ± 0.025	0.832TrpGly: 0.832 ± 0.028	0.238TrpHis: 0.238 ± 0.013	0.865TrpIle: 0.865 ± 0.03	0.913TrpLys: 0.913 ± 0.031	0.987TrpLeu: 0.987 ± 0.03	0.298TrpMet: 0.298 ± 0.016	0.856TrpAsn: 0.856 ± 0.032	0.297TrpPro: 0.297 ± 0.018	0.407TrpGln: 0.407 ± 0.018	0.417TrpArg: 0.417 ± 0.019	0.713TrpSer: 0.713 ± 0.031	0.636TrpThr: 0.636 ± 0.024	0.633TrpVal: 0.633 ± 0.023	0.192TrpTrp: 0.192 ± 0.014	0.491TrpTyr: 0.491 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.461TyrAla: 2.461 ± 0.046	0.377TyrCys: 0.377 ± 0.016	2.362TyrAsp: 2.362 ± 0.046	2.222TyrGlu: 2.222 ± 0.038	2.482TyrPhe: 2.482 ± 0.047	2.724TyrGly: 2.724 ± 0.052	0.767TyrHis: 0.767 ± 0.026	2.677TyrIle: 2.677 ± 0.049	3.086TyrLys: 3.086 ± 0.056	3.708TyrLeu: 3.708 ± 0.063	0.811TyrMet: 0.811 ± 0.03	2.622TyrAsn: 2.622 ± 0.051	1.598TyrPro: 1.598 ± 0.036	1.533TyrGln: 1.533 ± 0.035	1.497TyrArg: 1.497 ± 0.04	2.844TyrSer: 2.844 ± 0.058	2.373TyrThr: 2.373 ± 0.08	2.198TyrVal: 2.198 ± 0.042	0.549TyrTrp: 0.549 ± 0.026	1.879TyrTyr: 1.879 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3653 proteins (1237433 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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