Amino acid dipepetide frequency for Melghirimyces algeriensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.516AlaAla: 5.516 ± 0.086	0.715AlaCys: 0.715 ± 0.027	3.691AlaAsp: 3.691 ± 0.071	4.915AlaGlu: 4.915 ± 0.074	3.101AlaPhe: 3.101 ± 0.069	5.81AlaGly: 5.81 ± 0.101	1.445AlaHis: 1.445 ± 0.042	4.82AlaIle: 4.82 ± 0.078	4.034AlaLys: 4.034 ± 0.061	7.658AlaLeu: 7.658 ± 0.101	2.047AlaMet: 2.047 ± 0.049	2.205AlaAsn: 2.205 ± 0.054	2.247AlaPro: 2.247 ± 0.053	2.641AlaGln: 2.641 ± 0.055	3.532AlaArg: 3.532 ± 0.066	3.994AlaSer: 3.994 ± 0.065	3.36AlaThr: 3.36 ± 0.059	6.256AlaVal: 6.256 ± 0.094	0.899AlaTrp: 0.899 ± 0.037	2.227AlaTyr: 2.227 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.537CysAla: 0.537 ± 0.024	0.134CysCys: 0.134 ± 0.013	0.462CysAsp: 0.462 ± 0.022	0.466CysGlu: 0.466 ± 0.024	0.409CysPhe: 0.409 ± 0.024	0.803CysGly: 0.803 ± 0.033	0.258CysHis: 0.258 ± 0.016	0.525CysIle: 0.525 ± 0.02	0.37CysLys: 0.37 ± 0.02	0.859CysLeu: 0.859 ± 0.034	0.207CysMet: 0.207 ± 0.015	0.287CysAsn: 0.287 ± 0.017	0.495CysPro: 0.495 ± 0.023	0.36CysGln: 0.36 ± 0.021	0.565CysArg: 0.565 ± 0.024	0.556CysSer: 0.556 ± 0.023	0.442CysThr: 0.442 ± 0.023	0.454CysVal: 0.454 ± 0.024	0.114CysTrp: 0.114 ± 0.011	0.296CysTyr: 0.296 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.435AspAla: 3.435 ± 0.066	0.48AspCys: 0.48 ± 0.02	2.21AspAsp: 2.21 ± 0.047	3.879AspGlu: 3.879 ± 0.075	2.028AspPhe: 2.028 ± 0.042	3.756AspGly: 3.756 ± 0.079	1.494AspHis: 1.494 ± 0.038	3.005AspIle: 3.005 ± 0.057	2.218AspLys: 2.218 ± 0.055	5.627AspLeu: 5.627 ± 0.08	1.291AspMet: 1.291 ± 0.037	1.18AspAsn: 1.18 ± 0.041	2.827AspPro: 2.827 ± 0.058	2.793AspGln: 2.793 ± 0.053	3.501AspArg: 3.501 ± 0.066	2.608AspSer: 2.608 ± 0.053	2.29AspThr: 2.29 ± 0.054	3.757AspVal: 3.757 ± 0.06	0.921AspTrp: 0.921 ± 0.032	1.74AspTyr: 1.74 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	5.791GluAla: 5.791 ± 0.087	0.477GluCys: 0.477 ± 0.023	3.422GluAsp: 3.422 ± 0.063	7.103GluGlu: 7.103 ± 0.108	1.74GluPhe: 1.74 ± 0.044	5.003GluGly: 5.003 ± 0.078	1.537GluHis: 1.537 ± 0.043	4.598GluIle: 4.598 ± 0.09	6.065GluLys: 6.065 ± 0.092	6.304GluLeu: 6.304 ± 0.103	2.351GluMet: 2.351 ± 0.049	2.684GluAsn: 2.684 ± 0.053	2.365GluPro: 2.365 ± 0.053	3.515GluGln: 3.515 ± 0.065	4.695GluArg: 4.695 ± 0.098	3.687GluSer: 3.687 ± 0.066	3.846GluThr: 3.846 ± 0.064	5.298GluVal: 5.298 ± 0.078	1.137GluTrp: 1.137 ± 0.037	1.884GluTyr: 1.884 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	2.829PheAla: 2.829 ± 0.057	0.414PheCys: 0.414 ± 0.019	1.983PheAsp: 1.983 ± 0.05	2.155PheGlu: 2.155 ± 0.051	2.132PhePhe: 2.132 ± 0.056	3.106PheGly: 3.106 ± 0.064	1.206PheHis: 1.206 ± 0.035	2.604PheIle: 2.604 ± 0.061	1.423PheLys: 1.423 ± 0.04	4.309PheLeu: 4.309 ± 0.082	1.016PheMet: 1.016 ± 0.034	1.208PheAsn: 1.208 ± 0.035	1.859PhePro: 1.859 ± 0.048	1.807PheGln: 1.807 ± 0.039	2.189PheArg: 2.189 ± 0.053	2.888PheSer: 2.888 ± 0.056	2.157PheThr: 2.157 ± 0.049	2.703PheVal: 2.703 ± 0.052	0.517PheTrp: 0.517 ± 0.025	1.43PheTyr: 1.43 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	5.023GlyAla: 5.023 ± 0.098	0.777GlyCys: 0.777 ± 0.03	3.543GlyAsp: 3.543 ± 0.069	5.174GlyGlu: 5.174 ± 0.08	3.267GlyPhe: 3.267 ± 0.071	5.625GlyGly: 5.625 ± 0.09	1.505GlyHis: 1.505 ± 0.041	5.423GlyIle: 5.423 ± 0.076	5.069GlyLys: 5.069 ± 0.08	7.341GlyLeu: 7.341 ± 0.106	2.586GlyMet: 2.586 ± 0.05	2.433GlyAsn: 2.433 ± 0.054	2.149GlyPro: 2.149 ± 0.054	2.482GlyGln: 2.482 ± 0.054	3.824GlyArg: 3.824 ± 0.054	4.199GlySer: 4.199 ± 0.068	4.24GlyThr: 4.24 ± 0.075	6.149GlyVal: 6.149 ± 0.091	1.21GlyTrp: 1.21 ± 0.034	2.657GlyTyr: 2.657 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	1.544HisAla: 1.544 ± 0.039	0.281HisCys: 0.281 ± 0.018	0.911HisAsp: 0.911 ± 0.034	1.249HisGlu: 1.249 ± 0.036	1.124HisPhe: 1.124 ± 0.037	1.668HisGly: 1.668 ± 0.044	0.864HisHis: 0.864 ± 0.032	1.481HisIle: 1.481 ± 0.041	0.922HisLys: 0.922 ± 0.033	2.792HisLeu: 2.792 ± 0.064	0.621HisMet: 0.621 ± 0.025	0.606HisAsn: 0.606 ± 0.027	1.825HisPro: 1.825 ± 0.056	1.245HisGln: 1.245 ± 0.039	1.587HisArg: 1.587 ± 0.044	1.376HisSer: 1.376 ± 0.04	1.165HisThr: 1.165 ± 0.034	1.536HisVal: 1.536 ± 0.04	0.356HisTrp: 0.356 ± 0.017	0.848HisTyr: 0.848 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	4.972IleAla: 4.972 ± 0.084	0.629IleCys: 0.629 ± 0.027	3.17IleAsp: 3.17 ± 0.062	3.633IleGlu: 3.633 ± 0.067	2.33IlePhe: 2.33 ± 0.059	5.074IleGly: 5.074 ± 0.083	2.006IleHis: 2.006 ± 0.048	3.294IleIle: 3.294 ± 0.075	2.785IleLys: 2.785 ± 0.064	6.482IleLeu: 6.482 ± 0.095	1.317IleMet: 1.317 ± 0.044	1.985IleAsn: 1.985 ± 0.049	3.486IlePro: 3.486 ± 0.067	3.483IleGln: 3.483 ± 0.059	4.394IleArg: 4.394 ± 0.067	4.052IleSer: 4.052 ± 0.071	3.357IleThr: 3.357 ± 0.064	4.167IleVal: 4.167 ± 0.067	0.737IleTrp: 0.737 ± 0.029	1.845IleTyr: 1.845 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.333LysAla: 4.333 ± 0.063	0.296LysCys: 0.296 ± 0.018	3.021LysAsp: 3.021 ± 0.065	6.287LysGlu: 6.287 ± 0.097	1.169LysPhe: 1.169 ± 0.034	4.589LysGly: 4.589 ± 0.068	1.25LysHis: 1.25 ± 0.037	2.995LysIle: 2.995 ± 0.055	5.113LysLys: 5.113 ± 0.11	4.339LysLeu: 4.339 ± 0.074	1.794LysMet: 1.794 ± 0.046	2.318LysAsn: 2.318 ± 0.048	2.364LysPro: 2.364 ± 0.055	2.877LysGln: 2.877 ± 0.058	4.024LysArg: 4.024 ± 0.067	2.797LysSer: 2.797 ± 0.054	3.123LysThr: 3.123 ± 0.058	4.124LysVal: 4.124 ± 0.074	0.858LysTrp: 0.858 ± 0.03	1.516LysTyr: 1.516 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	7.581LeuAla: 7.581 ± 0.094	0.876LeuCys: 0.876 ± 0.034	5.416LeuAsp: 5.416 ± 0.087	6.828LeuGlu: 6.828 ± 0.091	4.809LeuPhe: 4.809 ± 0.091	7.021LeuGly: 7.021 ± 0.101	2.246LeuHis: 2.246 ± 0.054	6.271LeuIle: 6.271 ± 0.104	6.234LeuLys: 6.234 ± 0.079	10.367LeuLeu: 10.367 ± 0.157	2.622LeuMet: 2.622 ± 0.056	3.634LeuAsn: 3.634 ± 0.058	4.502LeuPro: 4.502 ± 0.077	3.773LeuGln: 3.773 ± 0.078	4.888LeuArg: 4.888 ± 0.075	7.031LeuSer: 7.031 ± 0.085	5.541LeuThr: 5.541 ± 0.068	6.699LeuVal: 6.699 ± 0.097	1.073LeuTrp: 1.073 ± 0.035	2.931LeuTyr: 2.931 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.23MetAla: 2.23 ± 0.057	0.152MetCys: 0.152 ± 0.013	1.882MetAsp: 1.882 ± 0.043	2.553MetGlu: 2.553 ± 0.053	0.878MetPhe: 0.878 ± 0.032	2.243MetGly: 2.243 ± 0.051	0.448MetHis: 0.448 ± 0.024	2.027MetIle: 2.027 ± 0.051	2.254MetLys: 2.254 ± 0.044	2.332MetLeu: 2.332 ± 0.046	0.964MetMet: 0.964 ± 0.033	1.293MetAsn: 1.293 ± 0.038	0.96MetPro: 0.96 ± 0.03	0.933MetGln: 0.933 ± 0.028	1.25MetArg: 1.25 ± 0.041	1.512MetSer: 1.512 ± 0.04	1.526MetThr: 1.526 ± 0.038	2.306MetVal: 2.306 ± 0.05	0.21MetTrp: 0.21 ± 0.015	0.618MetTyr: 0.618 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.23AsnAla: 2.23 ± 0.05	0.256AsnCys: 0.256 ± 0.018	1.592AsnAsp: 1.592 ± 0.044	2.31AsnGlu: 2.31 ± 0.05	0.956AsnPhe: 0.956 ± 0.028	2.696AsnGly: 2.696 ± 0.061	1.044AsnHis: 1.044 ± 0.034	2.217AsnIle: 2.217 ± 0.051	1.718AsnLys: 1.718 ± 0.047	3.155AsnLeu: 3.155 ± 0.056	0.892AsnMet: 0.892 ± 0.032	1.105AsnAsn: 1.105 ± 0.036	2.104AsnPro: 2.104 ± 0.052	1.794AsnGln: 1.794 ± 0.047	2.759AsnArg: 2.759 ± 0.052	1.457AsnSer: 1.457 ± 0.042	1.584AsnThr: 1.584 ± 0.046	2.446AsnVal: 2.446 ± 0.062	0.444AsnTrp: 0.444 ± 0.023	0.888AsnTyr: 0.888 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	2.661ProAla: 2.661 ± 0.058	0.306ProCys: 0.306 ± 0.018	2.95ProAsp: 2.95 ± 0.07	3.74ProGlu: 3.74 ± 0.065	2.107ProPhe: 2.107 ± 0.051	3.112ProGly: 3.112 ± 0.063	1.081ProHis: 1.081 ± 0.032	2.514ProIle: 2.514 ± 0.046	2.245ProLys: 2.245 ± 0.053	4.224ProLeu: 4.224 ± 0.073	1.078ProMet: 1.078 ± 0.032	1.408ProAsn: 1.408 ± 0.035	1.555ProPro: 1.555 ± 0.046	1.561ProGln: 1.561 ± 0.045	1.877ProArg: 1.877 ± 0.052	2.827ProSer: 2.827 ± 0.062	2.053ProThr: 2.053 ± 0.049	3.728ProVal: 3.728 ± 0.065	0.618ProTrp: 0.618 ± 0.032	1.477ProTyr: 1.477 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	3.35GlnAla: 3.35 ± 0.065	0.298GlnCys: 0.298 ± 0.017	1.845GlnAsp: 1.845 ± 0.048	3.395GlnGlu: 3.395 ± 0.085	1.415GlnPhe: 1.415 ± 0.043	2.876GlnGly: 2.876 ± 0.054	0.91GlnHis: 0.91 ± 0.031	2.483GlnIle: 2.483 ± 0.058	2.866GlnLys: 2.866 ± 0.059	4.249GlnLeu: 4.249 ± 0.067	1.375GlnMet: 1.375 ± 0.044	1.436GlnAsn: 1.436 ± 0.04	1.845GlnPro: 1.845 ± 0.045	2.004GlnGln: 2.004 ± 0.061	2.356GlnArg: 2.356 ± 0.054	2.418GlnSer: 2.418 ± 0.045	2.393GlnThr: 2.393 ± 0.06	3.306GlnVal: 3.306 ± 0.064	0.639GlnTrp: 0.639 ± 0.025	1.29GlnTyr: 1.29 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.096ArgAla: 3.096 ± 0.053	0.466ArgCys: 0.466 ± 0.022	2.664ArgAsp: 2.664 ± 0.053	4.591ArgGlu: 4.591 ± 0.078	2.644ArgPhe: 2.644 ± 0.056	3.387ArgGly: 3.387 ± 0.059	1.227ArgHis: 1.227 ± 0.038	3.93ArgIle: 3.93 ± 0.066	3.977ArgLys: 3.977 ± 0.066	6.361ArgLeu: 6.361 ± 0.104	2.056ArgMet: 2.056 ± 0.043	2.171ArgAsn: 2.171 ± 0.043	2.093ArgPro: 2.093 ± 0.046	2.334ArgGln: 2.334 ± 0.048	3.492ArgArg: 3.492 ± 0.068	3.202ArgSer: 3.202 ± 0.052	2.669ArgThr: 2.669 ± 0.057	4.03ArgVal: 4.03 ± 0.067	0.976ArgTrp: 0.976 ± 0.031	2.091ArgTyr: 2.091 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	3.704SerAla: 3.704 ± 0.067	0.494SerCys: 0.494 ± 0.023	2.93SerAsp: 2.93 ± 0.054	3.732SerGlu: 3.732 ± 0.068	2.747SerPhe: 2.747 ± 0.055	4.722SerGly: 4.722 ± 0.073	1.409SerHis: 1.409 ± 0.037	3.828SerIle: 3.828 ± 0.068	2.928SerLys: 2.928 ± 0.066	6.371SerLeu: 6.371 ± 0.086	1.736SerMet: 1.736 ± 0.038	1.844SerAsn: 1.844 ± 0.046	2.691SerPro: 2.691 ± 0.062	2.258SerGln: 2.258 ± 0.044	3.304SerArg: 3.304 ± 0.056	3.691SerSer: 3.691 ± 0.081	2.805SerThr: 2.805 ± 0.054	4.425SerVal: 4.425 ± 0.072	0.763SerTrp: 0.763 ± 0.027	1.794SerTyr: 1.794 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	4.014ThrAla: 4.014 ± 0.064	0.43ThrCys: 0.43 ± 0.023	2.83ThrAsp: 2.83 ± 0.063	3.404ThrGlu: 3.404 ± 0.066	2.21ThrPhe: 2.21 ± 0.043	4.667ThrGly: 4.667 ± 0.067	1.191ThrHis: 1.191 ± 0.033	3.232ThrIle: 3.232 ± 0.055	2.244ThrLys: 2.244 ± 0.054	5.523ThrLeu: 5.523 ± 0.077	1.288ThrMet: 1.288 ± 0.035	1.57ThrAsn: 1.57 ± 0.045	2.633ThrPro: 2.633 ± 0.049	1.774ThrGln: 1.774 ± 0.045	2.37ThrArg: 2.37 ± 0.047	2.854ThrSer: 2.854 ± 0.052	2.543ThrThr: 2.543 ± 0.069	4.45ThrVal: 4.45 ± 0.069	0.621ThrTrp: 0.621 ± 0.027	1.748ThrTyr: 1.748 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	5.525ValAla: 5.525 ± 0.083	0.687ValCys: 0.687 ± 0.029	4.149ValAsp: 4.149 ± 0.07	5.291ValGlu: 5.291 ± 0.094	2.912ValPhe: 2.912 ± 0.065	5.174ValGly: 5.174 ± 0.096	1.718ValHis: 1.718 ± 0.05	5.042ValIle: 5.042 ± 0.081	4.37ValLys: 4.37 ± 0.086	7.287ValLeu: 7.287 ± 0.096	2.011ValMet: 2.011 ± 0.048	2.66ValAsn: 2.66 ± 0.057	3.108ValPro: 3.108 ± 0.062	3.059ValGln: 3.059 ± 0.052	3.902ValArg: 3.902 ± 0.075	4.592ValSer: 4.592 ± 0.078	4.194ValThr: 4.194 ± 0.073	5.642ValVal: 5.642 ± 0.101	0.861ValTrp: 0.861 ± 0.033	2.265ValTyr: 2.265 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.721TrpAla: 0.721 ± 0.029	0.115TrpCys: 0.115 ± 0.012	0.652TrpAsp: 0.652 ± 0.028	0.982TrpGlu: 0.982 ± 0.033	0.628TrpPhe: 0.628 ± 0.026	0.91TrpGly: 0.91 ± 0.039	0.268TrpHis: 0.268 ± 0.018	1.045TrpIle: 1.045 ± 0.036	1.034TrpLys: 1.034 ± 0.034	1.513TrpLeu: 1.513 ± 0.043	0.573TrpMet: 0.573 ± 0.028	0.607TrpAsn: 0.607 ± 0.028	0.34TrpPro: 0.34 ± 0.02	0.424TrpGln: 0.424 ± 0.026	0.616TrpArg: 0.616 ± 0.025	0.791TrpSer: 0.791 ± 0.03	0.698TrpThr: 0.698 ± 0.027	1.064TrpVal: 1.064 ± 0.035	0.251TrpTrp: 0.251 ± 0.016	0.393TrpTyr: 0.393 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.021TyrAla: 2.021 ± 0.047	0.317TyrCys: 0.317 ± 0.018	1.721TyrAsp: 1.721 ± 0.057	1.814TyrGlu: 1.814 ± 0.043	1.329TyrPhe: 1.329 ± 0.04	2.434TyrGly: 2.434 ± 0.053	0.895TyrHis: 0.895 ± 0.028	1.862TyrIle: 1.862 ± 0.046	1.319TyrLys: 1.319 ± 0.037	3.248TyrLeu: 3.248 ± 0.06	0.746TyrMet: 0.746 ± 0.031	1.009TyrAsn: 1.009 ± 0.036	1.674TyrPro: 1.674 ± 0.043	1.63TyrGln: 1.63 ± 0.047	2.334TyrArg: 2.334 ± 0.053	1.642TyrSer: 1.642 ± 0.042	1.611TyrThr: 1.611 ± 0.04	1.911TyrVal: 1.911 ± 0.05	0.423TyrTrp: 0.423 ± 0.02	1.079TyrTyr: 1.079 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3293 proteins (984518 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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