Amino acid dipepetide frequency for Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129 / PRD-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.135AlaAla: 18.135 ± 0.283	0.986AlaCys: 0.986 ± 0.035	4.314AlaAsp: 4.314 ± 0.071	8.28AlaGlu: 8.28 ± 0.116	3.923AlaPhe: 3.923 ± 0.072	13.724AlaGly: 13.724 ± 0.16	1.848AlaHis: 1.848 ± 0.047	3.959AlaIle: 3.959 ± 0.07	1.865AlaLys: 1.865 ± 0.043	15.042AlaLeu: 15.042 ± 0.208	2.297AlaMet: 2.297 ± 0.051	1.869AlaAsn: 1.869 ± 0.044	5.141AlaPro: 5.141 ± 0.074	2.199AlaGln: 2.199 ± 0.05	11.497AlaArg: 11.497 ± 0.13	5.755AlaSer: 5.755 ± 0.075	4.409AlaThr: 4.409 ± 0.081	10.233AlaVal: 10.233 ± 0.131	1.261AlaTrp: 1.261 ± 0.037	2.713AlaTyr: 2.713 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.967CysAla: 0.967 ± 0.038	0.132CysCys: 0.132 ± 0.012	0.386CysAsp: 0.386 ± 0.023	0.54CysGlu: 0.54 ± 0.022	0.236CysPhe: 0.236 ± 0.015	1.192CysGly: 1.192 ± 0.036	0.169CysHis: 0.169 ± 0.012	0.26CysIle: 0.26 ± 0.016	0.127CysLys: 0.127 ± 0.01	0.738CysLeu: 0.738 ± 0.033	0.157CysMet: 0.157 ± 0.013	0.134CysAsn: 0.134 ± 0.012	0.527CysPro: 0.527 ± 0.021	0.129CysGln: 0.129 ± 0.012	0.706CysArg: 0.706 ± 0.029	0.44CysSer: 0.44 ± 0.02	0.351CysThr: 0.351 ± 0.021	0.594CysVal: 0.594 ± 0.025	0.094CysTrp: 0.094 ± 0.011	0.201CysTyr: 0.201 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.04AspAla: 5.04 ± 0.079	0.285AspCys: 0.285 ± 0.018	1.661AspAsp: 1.661 ± 0.051	3.411AspGlu: 3.411 ± 0.071	1.576AspPhe: 1.576 ± 0.042	4.386AspGly: 4.386 ± 0.073	0.907AspHis: 0.907 ± 0.032	1.827AspIle: 1.827 ± 0.048	0.618AspLys: 0.618 ± 0.025	5.237AspLeu: 5.237 ± 0.077	0.727AspMet: 0.727 ± 0.029	0.706AspAsn: 0.706 ± 0.028	3.857AspPro: 3.857 ± 0.07	0.77AspGln: 0.77 ± 0.032	3.873AspArg: 3.873 ± 0.066	1.5AspSer: 1.5 ± 0.035	1.657AspThr: 1.657 ± 0.048	3.574AspVal: 3.574 ± 0.059	0.647AspTrp: 0.647 ± 0.03	1.321AspTyr: 1.321 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	10.348GluAla: 10.348 ± 0.117	0.388GluCys: 0.388 ± 0.021	3.722GluAsp: 3.722 ± 0.067	9.222GluGlu: 9.222 ± 0.131	1.973GluPhe: 1.973 ± 0.046	8.244GluGly: 8.244 ± 0.11	1.659GluHis: 1.659 ± 0.041	3.45GluIle: 3.45 ± 0.066	1.986GluLys: 1.986 ± 0.051	8.411GluLeu: 8.411 ± 0.114	1.523GluMet: 1.523 ± 0.046	1.747GluAsn: 1.747 ± 0.049	3.972GluPro: 3.972 ± 0.061	1.927GluGln: 1.927 ± 0.047	9.793GluArg: 9.793 ± 0.134	2.803GluSer: 2.803 ± 0.06	2.861GluThr: 2.861 ± 0.063	7.054GluVal: 7.054 ± 0.089	0.82GluTrp: 0.82 ± 0.031	1.601GluTyr: 1.601 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.94PheAla: 3.94 ± 0.071	0.367PheCys: 0.367 ± 0.021	1.801PheAsp: 1.801 ± 0.047	2.438PheGlu: 2.438 ± 0.051	1.416PhePhe: 1.416 ± 0.049	3.804PheGly: 3.804 ± 0.066	0.56PheHis: 0.56 ± 0.025	1.087PheIle: 1.087 ± 0.035	0.578PheLys: 0.578 ± 0.023	3.334PheLeu: 3.334 ± 0.064	0.6PheMet: 0.6 ± 0.028	0.7PheAsn: 0.7 ± 0.028	1.621PhePro: 1.621 ± 0.033	0.613PheGln: 0.613 ± 0.027	2.574PheArg: 2.574 ± 0.055	1.9PheSer: 1.9 ± 0.05	1.375PheThr: 1.375 ± 0.039	3.081PheVal: 3.081 ± 0.054	0.546PheTrp: 0.546 ± 0.029	0.953PheTyr: 0.953 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	11.566GlyAla: 11.566 ± 0.126	0.981GlyCys: 0.981 ± 0.034	4.145GlyAsp: 4.145 ± 0.069	8.944GlyGlu: 8.944 ± 0.114	3.781GlyPhe: 3.781 ± 0.066	10.919GlyGly: 10.919 ± 0.129	1.784GlyHis: 1.784 ± 0.045	4.124GlyIle: 4.124 ± 0.072	2.17GlyLys: 2.17 ± 0.048	10.674GlyLeu: 10.674 ± 0.119	2.556GlyMet: 2.556 ± 0.05	1.65GlyAsn: 1.65 ± 0.046	4.655GlyPro: 4.655 ± 0.073	1.981GlyGln: 1.981 ± 0.047	10.24GlyArg: 10.24 ± 0.108	5.172GlySer: 5.172 ± 0.077	4.44GlyThr: 4.44 ± 0.077	8.607GlyVal: 8.607 ± 0.092	1.617GlyTrp: 1.617 ± 0.042	3.006GlyTyr: 3.006 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.95HisAla: 1.95 ± 0.05	0.179HisCys: 0.179 ± 0.014	0.791HisAsp: 0.791 ± 0.031	1.221HisGlu: 1.221 ± 0.035	0.595HisPhe: 0.595 ± 0.025	1.667HisGly: 1.667 ± 0.047	0.487HisHis: 0.487 ± 0.023	0.682HisIle: 0.682 ± 0.028	0.293HisLys: 0.293 ± 0.019	2.035HisLeu: 2.035 ± 0.047	0.283HisMet: 0.283 ± 0.018	0.381HisAsn: 0.381 ± 0.019	1.566HisPro: 1.566 ± 0.037	0.36HisGln: 0.36 ± 0.019	1.659HisArg: 1.659 ± 0.041	0.736HisSer: 0.736 ± 0.026	0.821HisThr: 0.821 ± 0.03	1.289HisVal: 1.289 ± 0.039	0.203HisTrp: 0.203 ± 0.014	0.524HisTyr: 0.524 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	4.043IleAla: 4.043 ± 0.07	0.33IleCys: 0.33 ± 0.02	1.728IleAsp: 1.728 ± 0.045	2.959IleGlu: 2.959 ± 0.063	1.315IlePhe: 1.315 ± 0.043	3.453IleGly: 3.453 ± 0.068	0.683IleHis: 0.683 ± 0.026	1.47IleIle: 1.47 ± 0.047	0.95IleLys: 0.95 ± 0.033	3.762IleLeu: 3.762 ± 0.068	0.617IleMet: 0.617 ± 0.027	0.908IleAsn: 0.908 ± 0.034	2.256IlePro: 2.256 ± 0.046	0.801IleGln: 0.801 ± 0.026	2.98IleArg: 2.98 ± 0.056	2.62IleSer: 2.62 ± 0.046	1.996IleThr: 1.996 ± 0.046	2.949IleVal: 2.949 ± 0.055	0.338IleTrp: 0.338 ± 0.018	0.871IleTyr: 0.871 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	2.085LysAla: 2.085 ± 0.052	0.112LysCys: 0.112 ± 0.011	1.017LysAsp: 1.017 ± 0.031	1.726LysGlu: 1.726 ± 0.053	0.462LysPhe: 0.462 ± 0.021	1.846LysGly: 1.846 ± 0.051	0.342LysHis: 0.342 ± 0.021	0.98LysIle: 0.98 ± 0.037	0.8LysLys: 0.8 ± 0.032	1.871LysLeu: 1.871 ± 0.042	0.437LysMet: 0.437 ± 0.024	0.555LysAsn: 0.555 ± 0.025	1.084LysPro: 1.084 ± 0.041	0.461LysGln: 0.461 ± 0.022	1.859LysArg: 1.859 ± 0.04	0.979LysSer: 0.979 ± 0.033	1.189LysThr: 1.189 ± 0.034	1.843LysVal: 1.843 ± 0.046	0.175LysTrp: 0.175 ± 0.013	0.46LysTyr: 0.46 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.404LeuAla: 14.404 ± 0.171	0.992LeuCys: 0.992 ± 0.034	5.007LeuAsp: 5.007 ± 0.075	8.845LeuGlu: 8.845 ± 0.113	3.559LeuPhe: 3.559 ± 0.072	10.966LeuGly: 10.966 ± 0.121	1.765LeuHis: 1.765 ± 0.047	3.506LeuIle: 3.506 ± 0.066	2.349LeuLys: 2.349 ± 0.053	12.873LeuLeu: 12.873 ± 0.196	1.815LeuMet: 1.815 ± 0.042	1.753LeuAsn: 1.753 ± 0.042	6.054LeuPro: 6.054 ± 0.085	2.185LeuGln: 2.185 ± 0.047	10.504LeuArg: 10.504 ± 0.131	6.515LeuSer: 6.515 ± 0.088	4.044LeuThr: 4.044 ± 0.067	8.816LeuVal: 8.816 ± 0.113	1.318LeuTrp: 1.318 ± 0.044	2.75LeuTyr: 2.75 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.21MetAla: 2.21 ± 0.05	0.141MetCys: 0.141 ± 0.01	0.919MetAsp: 0.919 ± 0.031	1.451MetGlu: 1.451 ± 0.043	0.505MetPhe: 0.505 ± 0.024	1.825MetGly: 1.825 ± 0.046	0.346MetHis: 0.346 ± 0.02	0.805MetIle: 0.805 ± 0.032	0.53MetLys: 0.53 ± 0.024	1.966MetLeu: 1.966 ± 0.044	0.391MetMet: 0.391 ± 0.021	0.459MetAsn: 0.459 ± 0.023	1.088MetPro: 1.088 ± 0.035	0.549MetGln: 0.549 ± 0.025	1.983MetArg: 1.983 ± 0.048	1.243MetSer: 1.243 ± 0.034	0.911MetThr: 0.911 ± 0.032	1.573MetVal: 1.573 ± 0.042	0.196MetTrp: 0.196 ± 0.012	0.365MetTyr: 0.365 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.209AsnAla: 2.209 ± 0.051	0.159AsnCys: 0.159 ± 0.014	0.729AsnAsp: 0.729 ± 0.03	1.005AsnGlu: 1.005 ± 0.037	0.703AsnPhe: 0.703 ± 0.032	1.534AsnGly: 1.534 ± 0.041	0.363AsnHis: 0.363 ± 0.02	0.917AsnIle: 0.917 ± 0.029	0.338AsnLys: 0.338 ± 0.019	2.259AsnLeu: 2.259 ± 0.049	0.343AsnMet: 0.343 ± 0.017	0.436AsnAsn: 0.436 ± 0.021	1.573AsnPro: 1.573 ± 0.04	0.406AsnGln: 0.406 ± 0.021	1.524AsnArg: 1.524 ± 0.045	0.76AsnSer: 0.76 ± 0.03	0.911AsnThr: 0.911 ± 0.03	1.662AsnVal: 1.662 ± 0.041	0.229AsnTrp: 0.229 ± 0.017	0.52AsnTyr: 0.52 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.084ProAla: 6.084 ± 0.098	0.339ProCys: 0.339 ± 0.019	3.03ProAsp: 3.03 ± 0.062	6.446ProGlu: 6.446 ± 0.086	1.825ProPhe: 1.825 ± 0.048	6.538ProGly: 6.538 ± 0.085	0.999ProHis: 0.999 ± 0.034	1.455ProIle: 1.455 ± 0.04	1.094ProLys: 1.094 ± 0.04	5.399ProLeu: 5.399 ± 0.08	0.95ProMet: 0.95 ± 0.027	1.019ProAsn: 1.019 ± 0.033	3.688ProPro: 3.688 ± 0.074	1.391ProGln: 1.391 ± 0.037	4.227ProArg: 4.227 ± 0.063	2.671ProSer: 2.671 ± 0.057	1.941ProThr: 1.941 ± 0.043	4.756ProVal: 4.756 ± 0.067	0.714ProTrp: 0.714 ± 0.03	1.457ProTyr: 1.457 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	2.315GlnAla: 2.315 ± 0.058	0.092GlnCys: 0.092 ± 0.01	0.95GlnAsp: 0.95 ± 0.03	1.747GlnGlu: 1.747 ± 0.049	0.588GlnPhe: 0.588 ± 0.026	1.746GlnGly: 1.746 ± 0.045	0.351GlnHis: 0.351 ± 0.02	1.065GlnIle: 1.065 ± 0.035	0.699GlnLys: 0.699 ± 0.03	2.02GlnLeu: 2.02 ± 0.05	0.506GlnMet: 0.506 ± 0.025	0.577GlnAsn: 0.577 ± 0.024	1.018GlnPro: 1.018 ± 0.032	0.784GlnGln: 0.784 ± 0.04	2.079GlnArg: 2.079 ± 0.042	0.991GlnSer: 0.991 ± 0.038	1.057GlnThr: 1.057 ± 0.034	1.64GlnVal: 1.64 ± 0.042	0.219GlnTrp: 0.219 ± 0.016	0.493GlnTyr: 0.493 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	10.437ArgAla: 10.437 ± 0.111	0.697ArgCys: 0.697 ± 0.029	3.909ArgAsp: 3.909 ± 0.069	9.677ArgGlu: 9.677 ± 0.13	3.118ArgPhe: 3.118 ± 0.062	8.256ArgGly: 8.256 ± 0.102	1.674ArgHis: 1.674 ± 0.042	3.535ArgIle: 3.535 ± 0.067	2.038ArgLys: 2.038 ± 0.044	10.803ArgLeu: 10.803 ± 0.141	2.229ArgMet: 2.229 ± 0.049	1.574ArgAsn: 1.574 ± 0.042	5.109ArgPro: 5.109 ± 0.071	2.11ArgGln: 2.11 ± 0.051	11.637ArgArg: 11.637 ± 0.148	4.454ArgSer: 4.454 ± 0.068	3.535ArgThr: 3.535 ± 0.056	7.956ArgVal: 7.956 ± 0.099	1.381ArgTrp: 1.381 ± 0.043	2.611ArgTyr: 2.611 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.196SerAla: 5.196 ± 0.07	0.441SerCys: 0.441 ± 0.022	1.934SerAsp: 1.934 ± 0.047	3.217SerGlu: 3.217 ± 0.058	1.878SerPhe: 1.878 ± 0.045	6.632SerGly: 6.632 ± 0.093	0.829SerHis: 0.829 ± 0.031	1.709SerIle: 1.709 ± 0.05	0.87SerLys: 0.87 ± 0.03	5.196SerLeu: 5.196 ± 0.081	1.035SerMet: 1.035 ± 0.032	0.865SerAsn: 0.865 ± 0.032	3.468SerPro: 3.468 ± 0.064	0.955SerGln: 0.955 ± 0.029	4.6SerArg: 4.6 ± 0.067	2.709SerSer: 2.709 ± 0.054	2.125SerThr: 2.125 ± 0.054	3.917SerVal: 3.917 ± 0.064	0.734SerTrp: 0.734 ± 0.026	1.322SerTyr: 1.322 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	4.381ThrAla: 4.381 ± 0.069	0.289ThrCys: 0.289 ± 0.017	1.832ThrAsp: 1.832 ± 0.043	2.38ThrGlu: 2.38 ± 0.044	1.549ThrPhe: 1.549 ± 0.042	4.771ThrGly: 4.771 ± 0.07	0.794ThrHis: 0.794 ± 0.028	1.674ThrIle: 1.674 ± 0.037	0.767ThrLys: 0.767 ± 0.033	4.751ThrLeu: 4.751 ± 0.076	0.786ThrMet: 0.786 ± 0.033	0.868ThrAsn: 0.868 ± 0.03	2.619ThrPro: 2.619 ± 0.055	0.811ThrGln: 0.811 ± 0.029	2.971ThrArg: 2.971 ± 0.061	2.043ThrSer: 2.043 ± 0.043	1.964ThrThr: 1.964 ± 0.05	3.773ThrVal: 3.773 ± 0.069	0.403ThrTrp: 0.403 ± 0.02	1.097ThrTyr: 1.097 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.862ValAla: 9.862 ± 0.118	0.867ValCys: 0.867 ± 0.032	3.826ValAsp: 3.826 ± 0.062	7.095ValGlu: 7.095 ± 0.096	2.947ValPhe: 2.947 ± 0.056	7.674ValGly: 7.674 ± 0.094	1.411ValHis: 1.411 ± 0.041	3.195ValIle: 3.195 ± 0.063	1.534ValLys: 1.534 ± 0.042	9.429ValLeu: 9.429 ± 0.114	1.49ValMet: 1.49 ± 0.039	1.557ValAsn: 1.557 ± 0.042	4.71ValPro: 4.71 ± 0.07	1.607ValGln: 1.607 ± 0.046	8.131ValArg: 8.131 ± 0.099	4.483ValSer: 4.483 ± 0.072	3.31ValThr: 3.31 ± 0.06	8.044ValVal: 8.044 ± 0.104	0.958ValTrp: 0.958 ± 0.039	2.128ValTyr: 2.128 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	1.282TrpAla: 1.282 ± 0.038	0.101TrpCys: 0.101 ± 0.012	0.574TrpAsp: 0.574 ± 0.025	0.988TrpGlu: 0.988 ± 0.038	0.427TrpPhe: 0.427 ± 0.022	1.097TrpGly: 1.097 ± 0.039	0.238TrpHis: 0.238 ± 0.016	0.48TrpIle: 0.48 ± 0.022	0.261TrpLys: 0.261 ± 0.016	1.388TrpLeu: 1.388 ± 0.046	0.293TrpMet: 0.293 ± 0.016	0.304TrpAsn: 0.304 ± 0.018	0.565TrpPro: 0.565 ± 0.026	0.364TrpGln: 0.364 ± 0.022	1.333TrpArg: 1.333 ± 0.033	0.66TrpSer: 0.66 ± 0.024	0.527TrpThr: 0.527 ± 0.023	0.97TrpVal: 0.97 ± 0.033	0.223TrpTrp: 0.223 ± 0.016	0.325TrpTyr: 0.325 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.995TyrAla: 2.995 ± 0.062	0.206TyrCys: 0.206 ± 0.016	1.304TyrAsp: 1.304 ± 0.042	1.914TyrGlu: 1.914 ± 0.043	0.913TyrPhe: 0.913 ± 0.027	2.735TyrGly: 2.735 ± 0.057	0.512TyrHis: 0.512 ± 0.02	0.848TyrIle: 0.848 ± 0.03	0.421TyrLys: 0.421 ± 0.023	2.83TyrLeu: 2.83 ± 0.051	0.419TyrMet: 0.419 ± 0.02	0.518TyrAsn: 0.518 ± 0.023	1.451TyrPro: 1.451 ± 0.041	0.536TyrGln: 0.536 ± 0.026	2.569TyrArg: 2.569 ± 0.06	1.198TyrSer: 1.198 ± 0.037	1.098TyrThr: 1.098 ± 0.034	1.925TyrVal: 1.925 ± 0.044	0.326TyrTrp: 0.326 ± 0.017	0.767TyrTyr: 0.767 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3127 proteins (982021 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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