Amino acid dipepetide frequency for Candidatus Thiodictyon syntrophicum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.1AlaAla: 20.1 ± 0.184	1.299AlaCys: 1.299 ± 0.033	7.728AlaAsp: 7.728 ± 0.069	6.74AlaGlu: 6.74 ± 0.072	3.721AlaPhe: 3.721 ± 0.046	11.243AlaGly: 11.243 ± 0.098	2.3AlaHis: 2.3 ± 0.033	5.162AlaIle: 5.162 ± 0.056	2.755AlaLys: 2.755 ± 0.052	15.272AlaLeu: 15.272 ± 0.127	2.581AlaMet: 2.581 ± 0.037	2.66AlaAsn: 2.66 ± 0.045	6.999AlaPro: 6.999 ± 0.087	5.197AlaGln: 5.197 ± 0.058	10.116AlaArg: 10.116 ± 0.088	4.978AlaSer: 4.978 ± 0.057	5.73AlaThr: 5.73 ± 0.065	8.735AlaVal: 8.735 ± 0.076	1.959AlaTrp: 1.959 ± 0.039	2.493AlaTyr: 2.493 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	1.298CysAla: 1.298 ± 0.031	0.166CysCys: 0.166 ± 0.01	0.588CysAsp: 0.588 ± 0.018	0.593CysGlu: 0.593 ± 0.017	0.373CysPhe: 0.373 ± 0.015	1.09CysGly: 1.09 ± 0.029	0.298CysHis: 0.298 ± 0.014	0.41CysIle: 0.41 ± 0.015	0.24CysLys: 0.24 ± 0.012	1.11CysLeu: 1.11 ± 0.028	0.172CysMet: 0.172 ± 0.009	0.256CysAsn: 0.256 ± 0.013	0.685CysPro: 0.685 ± 0.023	0.304CysGln: 0.304 ± 0.012	0.976CysArg: 0.976 ± 0.027	0.463CysSer: 0.463 ± 0.018	0.557CysThr: 0.557 ± 0.018	0.684CysVal: 0.684 ± 0.018	0.157CysTrp: 0.157 ± 0.014	0.266CysTyr: 0.266 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.832AspAla: 6.832 ± 0.066	0.73AspCys: 0.73 ± 0.023	3.12AspAsp: 3.12 ± 0.054	3.283AspGlu: 3.283 ± 0.051	2.065AspPhe: 2.065 ± 0.038	5.171AspGly: 5.171 ± 0.071	1.244AspHis: 1.244 ± 0.031	2.179AspIle: 2.179 ± 0.039	1.281AspLys: 1.281 ± 0.025	8.13AspLeu: 8.13 ± 0.075	0.907AspMet: 0.907 ± 0.023	1.221AspAsn: 1.221 ± 0.03	4.577AspPro: 4.577 ± 0.055	2.504AspGln: 2.504 ± 0.036	4.431AspArg: 4.431 ± 0.051	2.344AspSer: 2.344 ± 0.042	2.748AspThr: 2.748 ± 0.041	2.779AspVal: 2.779 ± 0.04	1.257AspTrp: 1.257 ± 0.026	1.773AspTyr: 1.773 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.453GluAla: 6.453 ± 0.072	0.456GluCys: 0.456 ± 0.016	2.508GluAsp: 2.508 ± 0.039	2.675GluGlu: 2.675 ± 0.044	1.653GluPhe: 1.653 ± 0.034	3.667GluGly: 3.667 ± 0.046	1.371GluHis: 1.371 ± 0.026	2.627GluIle: 2.627 ± 0.04	1.303GluLys: 1.303 ± 0.032	5.849GluLeu: 5.849 ± 0.067	0.971GluMet: 0.971 ± 0.023	1.102GluAsn: 1.102 ± 0.028	3.152GluPro: 3.152 ± 0.042	2.715GluGln: 2.715 ± 0.045	6.034GluArg: 6.034 ± 0.073	2.697GluSer: 2.697 ± 0.039	3.109GluThr: 3.109 ± 0.044	4.108GluVal: 4.108 ± 0.051	0.752GluTrp: 0.752 ± 0.021	1.088GluTyr: 1.088 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.997PheAla: 3.997 ± 0.048	0.379PheCys: 0.379 ± 0.014	2.413PheAsp: 2.413 ± 0.038	1.891PheGlu: 1.891 ± 0.031	1.23PhePhe: 1.23 ± 0.032	3.001PheGly: 3.001 ± 0.039	0.694PheHis: 0.694 ± 0.017	1.415PheIle: 1.415 ± 0.027	0.896PheLys: 0.896 ± 0.023	3.34PheLeu: 3.34 ± 0.044	0.593PheMet: 0.593 ± 0.019	0.955PheAsn: 0.955 ± 0.024	1.565PhePro: 1.565 ± 0.029	1.116PheGln: 1.116 ± 0.026	2.177PheArg: 2.177 ± 0.033	1.925PheSer: 1.925 ± 0.034	1.79PheThr: 1.79 ± 0.036	2.285PheVal: 2.285 ± 0.04	0.471PheTrp: 0.471 ± 0.015	0.883PheTyr: 0.883 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.535GlyAla: 9.535 ± 0.094	1.049GlyCys: 1.049 ± 0.029	4.613GlyAsp: 4.613 ± 0.058	4.699GlyGlu: 4.699 ± 0.051	3.158GlyPhe: 3.158 ± 0.048	7.073GlyGly: 7.073 ± 0.109	1.912GlyHis: 1.912 ± 0.032	3.792GlyIle: 3.792 ± 0.045	2.439GlyLys: 2.439 ± 0.046	10.099GlyLeu: 10.099 ± 0.079	1.679GlyMet: 1.679 ± 0.03	2.128GlyAsn: 2.128 ± 0.047	4.083GlyPro: 4.083 ± 0.057	3.314GlyGln: 3.314 ± 0.042	7.061GlyArg: 7.061 ± 0.062	4.328GlySer: 4.328 ± 0.056	4.799GlyThr: 4.799 ± 0.07	5.948GlyVal: 5.948 ± 0.061	1.466GlyTrp: 1.466 ± 0.033	2.295GlyTyr: 2.295 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.164HisAla: 2.164 ± 0.035	0.352HisCys: 0.352 ± 0.014	1.159HisAsp: 1.159 ± 0.024	1.029HisGlu: 1.029 ± 0.023	0.797HisPhe: 0.797 ± 0.02	1.926HisGly: 1.926 ± 0.039	0.574HisHis: 0.574 ± 0.02	0.751HisIle: 0.751 ± 0.022	0.416HisLys: 0.416 ± 0.014	2.651HisLeu: 2.651 ± 0.041	0.317HisMet: 0.317 ± 0.014	0.46HisAsn: 0.46 ± 0.016	1.729HisPro: 1.729 ± 0.037	0.906HisGln: 0.906 ± 0.023	1.877HisArg: 1.877 ± 0.03	0.894HisSer: 0.894 ± 0.02	0.909HisThr: 0.909 ± 0.021	1.011HisVal: 1.011 ± 0.023	0.513HisTrp: 0.513 ± 0.016	0.668HisTyr: 0.668 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.846IleAla: 5.846 ± 0.06	0.44IleCys: 0.44 ± 0.015	3.107IleAsp: 3.107 ± 0.043	3.091IleGlu: 3.091 ± 0.049	1.179IlePhe: 1.179 ± 0.026	3.964IleGly: 3.964 ± 0.05	0.922IleHis: 0.922 ± 0.02	1.609IleIle: 1.609 ± 0.031	1.252IleLys: 1.252 ± 0.029	4.159IleLeu: 4.159 ± 0.05	0.597IleMet: 0.597 ± 0.019	1.172IleAsn: 1.172 ± 0.026	2.357IlePro: 2.357 ± 0.034	1.364IleGln: 1.364 ± 0.026	3.037IleArg: 3.037 ± 0.044	1.921IleSer: 1.921 ± 0.034	2.2IleThr: 2.2 ± 0.036	2.654IleVal: 2.654 ± 0.037	0.463IleTrp: 0.463 ± 0.016	1.013IleTyr: 1.013 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	2.94LysAla: 2.94 ± 0.046	0.195LysCys: 0.195 ± 0.01	1.5LysAsp: 1.5 ± 0.032	1.374LysGlu: 1.374 ± 0.032	0.622LysPhe: 0.622 ± 0.018	2.045LysGly: 2.045 ± 0.038	0.488LysHis: 0.488 ± 0.016	1.006LysIle: 1.006 ± 0.026	0.811LysLys: 0.811 ± 0.026	2.386LysLeu: 2.386 ± 0.039	0.471LysMet: 0.471 ± 0.014	0.636LysAsn: 0.636 ± 0.019	1.515LysPro: 1.515 ± 0.028	0.919LysGln: 0.919 ± 0.023	1.918LysArg: 1.918 ± 0.04	1.318LysSer: 1.318 ± 0.025	1.561LysThr: 1.561 ± 0.031	1.769LysVal: 1.769 ± 0.032	0.278LysTrp: 0.278 ± 0.014	0.54LysTyr: 0.54 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	16.487LeuAla: 16.487 ± 0.149	1.237LeuCys: 1.237 ± 0.029	7.203LeuAsp: 7.203 ± 0.07	6.245LeuGlu: 6.245 ± 0.063	3.684LeuPhe: 3.684 ± 0.05	9.613LeuGly: 9.613 ± 0.08	2.336LeuHis: 2.336 ± 0.036	5.247LeuIle: 5.247 ± 0.051	3.171LeuLys: 3.171 ± 0.041	12.505LeuLeu: 12.505 ± 0.122	2.11LeuMet: 2.11 ± 0.039	2.488LeuAsn: 2.488 ± 0.038	6.621LeuPro: 6.621 ± 0.064	3.21LeuGln: 3.21 ± 0.043	9.167LeuArg: 9.167 ± 0.084	5.729LeuSer: 5.729 ± 0.058	6.558LeuThr: 6.558 ± 0.07	8.282LeuVal: 8.282 ± 0.075	1.489LeuTrp: 1.489 ± 0.037	2.431LeuTyr: 2.431 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	2.202MetAla: 2.202 ± 0.036	0.124MetCys: 0.124 ± 0.008	1.028MetAsp: 1.028 ± 0.026	0.899MetGlu: 0.899 ± 0.024	0.426MetPhe: 0.426 ± 0.014	1.367MetGly: 1.367 ± 0.028	0.408MetHis: 0.408 ± 0.015	0.852MetIle: 0.852 ± 0.022	0.65MetLys: 0.65 ± 0.019	1.812MetLeu: 1.812 ± 0.033	0.361MetMet: 0.361 ± 0.015	0.663MetAsn: 0.663 ± 0.019	1.108MetPro: 1.108 ± 0.025	0.73MetGln: 0.73 ± 0.02	1.394MetArg: 1.394 ± 0.027	1.15MetSer: 1.15 ± 0.029	1.325MetThr: 1.325 ± 0.031	1.288MetVal: 1.288 ± 0.025	0.121MetTrp: 0.121 ± 0.008	0.267MetTyr: 0.267 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.639AsnAla: 2.639 ± 0.045	0.279AsnCys: 0.279 ± 0.012	1.241AsnAsp: 1.241 ± 0.027	1.047AsnGlu: 1.047 ± 0.023	0.788AsnPhe: 0.788 ± 0.02	1.977AsnGly: 1.977 ± 0.05	0.478AsnHis: 0.478 ± 0.017	0.936AsnIle: 0.936 ± 0.022	0.563AsnLys: 0.563 ± 0.017	2.889AsnLeu: 2.889 ± 0.041	0.372AsnMet: 0.372 ± 0.014	0.616AsnAsn: 0.616 ± 0.021	1.934AsnPro: 1.934 ± 0.032	0.927AsnGln: 0.927 ± 0.025	1.953AsnArg: 1.953 ± 0.035	0.986AsnSer: 0.986 ± 0.022	1.114AsnThr: 1.114 ± 0.028	1.335AsnVal: 1.335 ± 0.031	0.407AsnTrp: 0.407 ± 0.016	0.639AsnTyr: 0.639 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	8.227ProAla: 8.227 ± 0.091	0.512ProCys: 0.512 ± 0.018	4.244ProAsp: 4.244 ± 0.052	3.608ProGlu: 3.608 ± 0.041	1.782ProPhe: 1.782 ± 0.032	5.997ProGly: 5.997 ± 0.07	1.044ProHis: 1.044 ± 0.025	2.11ProIle: 2.11 ± 0.037	1.28ProLys: 1.28 ± 0.028	5.858ProLeu: 5.858 ± 0.055	1.135ProMet: 1.135 ± 0.023	1.243ProAsn: 1.243 ± 0.028	4.008ProPro: 4.008 ± 0.054	2.02ProGln: 2.02 ± 0.034	4.045ProArg: 4.045 ± 0.045	2.595ProSer: 2.595 ± 0.036	3.096ProThr: 3.096 ± 0.044	4.516ProVal: 4.516 ± 0.056	0.975ProTrp: 0.975 ± 0.023	1.225ProTyr: 1.225 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	5.417GlnAla: 5.417 ± 0.065	0.342GlnCys: 0.342 ± 0.013	1.942GlnAsp: 1.942 ± 0.034	1.928GlnGlu: 1.928 ± 0.032	1.131GlnPhe: 1.131 ± 0.026	3.39GlnGly: 3.39 ± 0.041	0.738GlnHis: 0.738 ± 0.02	1.547GlnIle: 1.547 ± 0.028	0.678GlnLys: 0.678 ± 0.019	3.691GlnLeu: 3.691 ± 0.042	0.665GlnMet: 0.665 ± 0.018	0.657GlnAsn: 0.657 ± 0.019	2.089GlnPro: 2.089 ± 0.041	1.463GlnGln: 1.463 ± 0.032	3.241GlnArg: 3.241 ± 0.048	1.773GlnSer: 1.773 ± 0.031	2.036GlnThr: 2.036 ± 0.031	3.366GlnVal: 3.366 ± 0.048	0.604GlnTrp: 0.604 ± 0.017	0.742GlnTyr: 0.742 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.089ArgAla: 9.089 ± 0.091	0.855ArgCys: 0.855 ± 0.023	4.627ArgAsp: 4.627 ± 0.053	4.611ArgGlu: 4.611 ± 0.061	3.145ArgPhe: 3.145 ± 0.041	5.62ArgGly: 5.62 ± 0.057	1.967ArgHis: 1.967 ± 0.031	3.894ArgIle: 3.894 ± 0.053	1.785ArgLys: 1.785 ± 0.032	10.71ArgLeu: 10.71 ± 0.085	1.568ArgMet: 1.568 ± 0.03	1.719ArgAsn: 1.719 ± 0.032	4.478ArgPro: 4.478 ± 0.061	3.137ArgGln: 3.137 ± 0.043	7.433ArgArg: 7.433 ± 0.082	3.271ArgSer: 3.271 ± 0.044	3.858ArgThr: 3.858 ± 0.044	5.992ArgVal: 5.992 ± 0.061	1.374ArgTrp: 1.374 ± 0.027	2.244ArgTyr: 2.244 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	5.726SerAla: 5.726 ± 0.056	0.452SerCys: 0.452 ± 0.017	2.549SerAsp: 2.549 ± 0.042	2.259SerGlu: 2.259 ± 0.036	1.751SerPhe: 1.751 ± 0.028	4.732SerGly: 4.732 ± 0.066	0.991SerHis: 0.991 ± 0.023	2.071SerIle: 2.071 ± 0.034	1.072SerLys: 1.072 ± 0.024	5.312SerLeu: 5.312 ± 0.06	0.845SerMet: 0.845 ± 0.023	1.158SerAsn: 1.158 ± 0.028	2.923SerPro: 2.923 ± 0.046	1.575SerGln: 1.575 ± 0.029	3.522SerArg: 3.522 ± 0.041	2.168SerSer: 2.168 ± 0.045	2.304SerThr: 2.304 ± 0.039	3.223SerVal: 3.223 ± 0.044	0.654SerTrp: 0.654 ± 0.019	1.099SerTyr: 1.099 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	6.477ThrAla: 6.477 ± 0.075	0.494ThrCys: 0.494 ± 0.019	3.004ThrAsp: 3.004 ± 0.045	2.491ThrGlu: 2.491 ± 0.04	1.6ThrPhe: 1.6 ± 0.036	5.2ThrGly: 5.2 ± 0.065	1.097ThrHis: 1.097 ± 0.026	2.123ThrIle: 2.123 ± 0.038	1.087ThrLys: 1.087 ± 0.026	6.88ThrLeu: 6.88 ± 0.065	0.88ThrMet: 0.88 ± 0.02	1.213ThrAsn: 1.213 ± 0.028	3.62ThrPro: 3.62 ± 0.046	1.85ThrGln: 1.85 ± 0.035	3.772ThrArg: 3.772 ± 0.046	2.269ThrSer: 2.269 ± 0.04	2.698ThrThr: 2.698 ± 0.055	3.596ThrVal: 3.596 ± 0.06	0.78ThrTrp: 0.78 ± 0.02	1.209ThrTyr: 1.209 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.447ValAla: 8.447 ± 0.07	0.759ValCys: 0.759 ± 0.02	3.775ValAsp: 3.775 ± 0.05	3.859ValGlu: 3.859 ± 0.048	2.452ValPhe: 2.452 ± 0.04	5.377ValGly: 5.377 ± 0.055	1.351ValHis: 1.351 ± 0.03	3.197ValIle: 3.197 ± 0.04	1.784ValLys: 1.784 ± 0.035	8.148ValLeu: 8.148 ± 0.089	1.361ValMet: 1.361 ± 0.027	1.734ValAsn: 1.734 ± 0.035	3.9ValPro: 3.9 ± 0.047	2.376ValGln: 2.376 ± 0.031	5.502ValArg: 5.502 ± 0.063	3.53ValSer: 3.53 ± 0.042	4.064ValThr: 4.064 ± 0.06	5.139ValVal: 5.139 ± 0.059	0.95ValTrp: 0.95 ± 0.024	1.646ValTyr: 1.646 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.321TrpAla: 1.321 ± 0.029	0.208TrpCys: 0.208 ± 0.01	0.828TrpAsp: 0.828 ± 0.025	0.818TrpGlu: 0.818 ± 0.021	0.606TrpPhe: 0.606 ± 0.018	1.054TrpGly: 1.054 ± 0.027	0.355TrpHis: 0.355 ± 0.014	0.621TrpIle: 0.621 ± 0.019	0.337TrpLys: 0.337 ± 0.013	2.123TrpLeu: 2.123 ± 0.034	0.285TrpMet: 0.285 ± 0.011	0.399TrpAsn: 0.399 ± 0.014	0.842TrpPro: 0.842 ± 0.022	0.74TrpGln: 0.74 ± 0.02	1.313TrpArg: 1.313 ± 0.028	0.913TrpSer: 0.913 ± 0.023	0.791TrpThr: 0.791 ± 0.022	1.131TrpVal: 1.131 ± 0.023	0.292TrpTrp: 0.292 ± 0.011	0.378TrpTyr: 0.378 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.572TyrAla: 2.572 ± 0.03	0.356TyrCys: 0.356 ± 0.014	1.395TyrAsp: 1.395 ± 0.041	1.15TyrGlu: 1.15 ± 0.025	0.852TyrPhe: 0.852 ± 0.021	1.962TyrGly: 1.962 ± 0.039	0.535TyrHis: 0.535 ± 0.017	0.802TyrIle: 0.802 ± 0.022	0.492TyrLys: 0.492 ± 0.019	2.889TyrLeu: 2.889 ± 0.045	0.304TyrMet: 0.304 ± 0.013	0.642TyrAsn: 0.642 ± 0.021	1.333TyrPro: 1.333 ± 0.026	1.072TyrGln: 1.072 ± 0.026	2.407TyrArg: 2.407 ± 0.031	1.136TyrSer: 1.136 ± 0.025	1.095TyrThr: 1.095 ± 0.029	1.511TyrVal: 1.511 ± 0.028	0.393TyrTrp: 0.393 ± 0.014	0.679TyrTyr: 0.679 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6068 proteins (2008834 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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