Amino acid dipepetide frequency for Ostreococcus lucimarinus virus OlV3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.159AlaAla: 4.159 ± 0.399
0.868AlaCys: 0.868 ± 0.153
3.454AlaAsp: 3.454 ± 0.261
3.056AlaGlu: 3.056 ± 0.307
2.152AlaPhe: 2.152 ± 0.242
3.363AlaGly: 3.363 ± 0.311
1.175AlaHis: 1.175 ± 0.132
3.707AlaIle: 3.707 ± 0.265
4.376AlaLys: 4.376 ± 0.519
5.244AlaLeu: 5.244 ± 0.357
1.772AlaMet: 1.772 ± 0.194
3.165AlaAsn: 3.165 ± 0.565
1.917AlaPro: 1.917 ± 0.22
2.55AlaGln: 2.55 ± 0.329
2.948AlaArg: 2.948 ± 0.393
3.309AlaSer: 3.309 ± 0.306
4.195AlaThr: 4.195 ± 0.471
3.707AlaVal: 3.707 ± 0.273
0.452AlaTrp: 0.452 ± 0.097
2.061AlaTyr: 2.061 ± 0.21
0.0AlaXaa: 0.0 ± 0.0
Cys
0.759CysAla: 0.759 ± 0.119
0.47CysCys: 0.47 ± 0.105
1.121CysAsp: 1.121 ± 0.177
1.465CysGlu: 1.465 ± 0.213
0.561CysPhe: 0.561 ± 0.119
1.121CysGly: 1.121 ± 0.166
0.344CysHis: 0.344 ± 0.09
0.886CysIle: 0.886 ± 0.143
1.085CysLys: 1.085 ± 0.142
1.139CysLeu: 1.139 ± 0.146
0.579CysMet: 0.579 ± 0.101
0.687CysAsn: 0.687 ± 0.127
1.085CysPro: 1.085 ± 0.173
0.344CysGln: 0.344 ± 0.076
0.904CysArg: 0.904 ± 0.139
0.976CysSer: 0.976 ± 0.146
0.687CysThr: 0.687 ± 0.123
0.995CysVal: 0.995 ± 0.153
0.127CysTrp: 0.127 ± 0.055
0.759CysTyr: 0.759 ± 0.12
0.0CysXaa: 0.0 ± 0.0
Asp
3.689AspAla: 3.689 ± 0.258
0.976AspCys: 0.976 ± 0.152
3.942AspAsp: 3.942 ± 0.309
4.684AspGlu: 4.684 ± 0.341
2.749AspPhe: 2.749 ± 0.221
3.743AspGly: 3.743 ± 0.339
1.121AspHis: 1.121 ± 0.17
4.087AspIle: 4.087 ± 0.257
3.146AspLys: 3.146 ± 0.234
5.552AspLeu: 5.552 ± 0.322
1.736AspMet: 1.736 ± 0.161
2.387AspAsn: 2.387 ± 0.216
2.206AspPro: 2.206 ± 0.179
1.32AspGln: 1.32 ± 0.134
3.092AspArg: 3.092 ± 0.234
2.966AspSer: 2.966 ± 0.264
3.743AspThr: 3.743 ± 0.356
3.906AspVal: 3.906 ± 0.317
0.778AspTrp: 0.778 ± 0.133
3.11AspTyr: 3.11 ± 0.299
0.0AspXaa: 0.0 ± 0.0
Glu
4.213GluAla: 4.213 ± 0.485
1.175GluCys: 1.175 ± 0.157
4.304GluAsp: 4.304 ± 0.358
5.931GluGlu: 5.931 ± 0.446
2.929GluPhe: 2.929 ± 0.199
3.219GluGly: 3.219 ± 0.241
1.483GluHis: 1.483 ± 0.159
4.629GluIle: 4.629 ± 0.338
5.57GluLys: 5.57 ± 0.401
5.515GluLeu: 5.515 ± 0.348
2.025GluMet: 2.025 ± 0.176
3.906GluAsn: 3.906 ± 0.268
2.604GluPro: 2.604 ± 0.322
1.989GluGln: 1.989 ± 0.228
3.562GluArg: 3.562 ± 0.377
3.454GluSer: 3.454 ± 0.321
3.617GluThr: 3.617 ± 0.272
4.087GluVal: 4.087 ± 0.309
0.922GluTrp: 0.922 ± 0.14
3.11GluTyr: 3.11 ± 0.247
0.0GluXaa: 0.0 ± 0.0
Phe
2.459PheAla: 2.459 ± 0.3
0.796PheCys: 0.796 ± 0.15
3.002PheAsp: 3.002 ± 0.245
2.749PheGlu: 2.749 ± 0.252
1.953PhePhe: 1.953 ± 0.21
2.441PheGly: 2.441 ± 0.213
1.193PheHis: 1.193 ± 0.155
2.441PheIle: 2.441 ± 0.249
3.11PheLys: 3.11 ± 0.236
3.291PheLeu: 3.291 ± 0.274
1.555PheMet: 1.555 ± 0.188
2.405PheAsn: 2.405 ± 0.228
1.483PhePro: 1.483 ± 0.164
0.922PheGln: 0.922 ± 0.118
1.826PheArg: 1.826 ± 0.178
3.038PheSer: 3.038 ± 0.303
2.188PheThr: 2.188 ± 0.202
3.562PheVal: 3.562 ± 0.294
0.362PheTrp: 0.362 ± 0.082
1.718PheTyr: 1.718 ± 0.177
0.0PheXaa: 0.0 ± 0.0
Gly
3.49GlyAla: 3.49 ± 0.477
0.958GlyCys: 0.958 ± 0.159
3.725GlyAsp: 3.725 ± 0.411
3.707GlyGlu: 3.707 ± 0.243
2.875GlyPhe: 2.875 ± 0.234
4.973GlyGly: 4.973 ± 0.599
1.356GlyHis: 1.356 ± 0.17
3.906GlyIle: 3.906 ± 0.38
4.539GlyLys: 4.539 ± 0.315
4.81GlyLeu: 4.81 ± 0.341
1.555GlyMet: 1.555 ± 0.184
3.653GlyAsn: 3.653 ± 0.472
2.188GlyPro: 2.188 ± 0.246
1.989GlyGln: 1.989 ± 0.208
2.911GlyArg: 2.911 ± 0.257
3.761GlySer: 3.761 ± 0.329
3.924GlyThr: 3.924 ± 0.4
3.924GlyVal: 3.924 ± 0.513
0.633GlyTrp: 0.633 ± 0.11
2.17GlyTyr: 2.17 ± 0.178
0.0GlyXaa: 0.0 ± 0.0
His
1.193HisAla: 1.193 ± 0.167
0.362HisCys: 0.362 ± 0.072
0.995HisAsp: 0.995 ± 0.137
1.392HisGlu: 1.392 ± 0.175
0.904HisPhe: 0.904 ± 0.149
1.609HisGly: 1.609 ± 0.179
0.814HisHis: 0.814 ± 0.133
1.718HisIle: 1.718 ± 0.182
1.537HisLys: 1.537 ± 0.193
1.844HisLeu: 1.844 ± 0.203
0.579HisMet: 0.579 ± 0.11
1.049HisAsn: 1.049 ± 0.153
1.085HisPro: 1.085 ± 0.143
0.669HisGln: 0.669 ± 0.125
1.23HisArg: 1.23 ± 0.172
1.121HisSer: 1.121 ± 0.162
1.501HisThr: 1.501 ± 0.192
1.212HisVal: 1.212 ± 0.178
0.307HisTrp: 0.307 ± 0.078
0.976HisTyr: 0.976 ± 0.137
0.0HisXaa: 0.0 ± 0.0
Ile
3.309IleAla: 3.309 ± 0.237
0.759IleCys: 0.759 ± 0.119
4.25IleAsp: 4.25 ± 0.325
4.738IleGlu: 4.738 ± 0.32
2.26IlePhe: 2.26 ± 0.211
3.707IleGly: 3.707 ± 0.306
1.808IleHis: 1.808 ± 0.211
3.599IleIle: 3.599 ± 0.3
5.154IleLys: 5.154 ± 0.293
5.353IleLeu: 5.353 ± 0.35
1.881IleMet: 1.881 ± 0.206
3.635IleAsn: 3.635 ± 0.259
3.056IlePro: 3.056 ± 0.261
2.785IleGln: 2.785 ± 0.21
2.984IleArg: 2.984 ± 0.222
3.653IleSer: 3.653 ± 0.259
3.906IleThr: 3.906 ± 0.368
4.213IleVal: 4.213 ± 0.336
0.561IleTrp: 0.561 ± 0.101
2.387IleTyr: 2.387 ± 0.215
0.0IleXaa: 0.0 ± 0.0
Lys
3.888LysAla: 3.888 ± 0.373
1.519LysCys: 1.519 ± 0.205
4.051LysAsp: 4.051 ± 0.309
4.864LysGlu: 4.864 ± 0.381
3.635LysPhe: 3.635 ± 0.309
3.797LysGly: 3.797 ± 0.28
1.627LysHis: 1.627 ± 0.194
5.154LysIle: 5.154 ± 0.35
7.324LysLys: 7.324 ± 0.749
5.986LysLeu: 5.986 ± 0.451
2.495LysMet: 2.495 ± 0.237
5.244LysAsn: 5.244 ± 0.621
2.875LysPro: 2.875 ± 0.255
3.002LysGln: 3.002 ± 0.29
4.557LysArg: 4.557 ± 0.513
4.34LysSer: 4.34 ± 0.332
5.045LysThr: 5.045 ± 0.313
4.792LysVal: 4.792 ± 0.338
0.759LysTrp: 0.759 ± 0.105
3.255LysTyr: 3.255 ± 0.285
0.0LysXaa: 0.0 ± 0.0
Leu
4.756LeuAla: 4.756 ± 0.357
1.23LeuCys: 1.23 ± 0.169
4.629LeuAsp: 4.629 ± 0.334
6.184LeuGlu: 6.184 ± 0.354
2.658LeuPhe: 2.658 ± 0.208
4.105LeuGly: 4.105 ± 0.294
1.465LeuHis: 1.465 ± 0.145
5.154LeuIle: 5.154 ± 0.305
7.396LeuLys: 7.396 ± 0.454
6.166LeuLeu: 6.166 ± 0.359
2.116LeuMet: 2.116 ± 0.21
5.316LeuAsn: 5.316 ± 0.862
3.11LeuPro: 3.11 ± 0.219
2.495LeuGln: 2.495 ± 0.337
4.774LeuArg: 4.774 ± 0.322
4.955LeuSer: 4.955 ± 0.248
4.629LeuThr: 4.629 ± 0.3
5.335LeuVal: 5.335 ± 0.324
0.868LeuTrp: 0.868 ± 0.135
3.237LeuTyr: 3.237 ± 0.276
0.0LeuXaa: 0.0 ± 0.0
Met
1.519MetAla: 1.519 ± 0.182
0.597MetCys: 0.597 ± 0.115
1.537MetAsp: 1.537 ± 0.19
1.863MetGlu: 1.863 ± 0.154
1.664MetPhe: 1.664 ± 0.166
1.772MetGly: 1.772 ± 0.195
0.597MetHis: 0.597 ± 0.098
1.7MetIle: 1.7 ± 0.195
2.712MetLys: 2.712 ± 0.264
2.061MetLeu: 2.061 ± 0.209
0.886MetMet: 0.886 ± 0.143
2.007MetAsn: 2.007 ± 0.277
0.904MetPro: 0.904 ± 0.125
0.687MetGln: 0.687 ± 0.106
1.392MetArg: 1.392 ± 0.168
2.532MetSer: 2.532 ± 0.226
1.41MetThr: 1.41 ± 0.152
1.664MetVal: 1.664 ± 0.17
0.38MetTrp: 0.38 ± 0.09
1.302MetTyr: 1.302 ± 0.164
0.0MetXaa: 0.0 ± 0.0
Asn
4.304AsnAla: 4.304 ± 0.798
0.615AsnCys: 0.615 ± 0.108
2.948AsnAsp: 2.948 ± 0.223
3.599AsnGlu: 3.599 ± 0.228
2.749AsnPhe: 2.749 ± 0.273
3.599AsnGly: 3.599 ± 0.331
1.302AsnHis: 1.302 ± 0.18
3.779AsnIle: 3.779 ± 0.26
4.286AsnLys: 4.286 ± 0.611
5.063AsnLeu: 5.063 ± 0.388
1.79AsnMet: 1.79 ± 0.158
3.327AsnAsn: 3.327 ± 0.454
2.17AsnPro: 2.17 ± 0.189
1.881AsnGln: 1.881 ± 0.242
2.731AsnArg: 2.731 ± 0.572
3.165AsnSer: 3.165 ± 0.295
4.069AsnThr: 4.069 ± 0.624
4.901AsnVal: 4.901 ± 0.579
0.651AsnTrp: 0.651 ± 0.099
2.297AsnTyr: 2.297 ± 0.227
0.0AsnXaa: 0.0 ± 0.0
Pro
1.736ProAla: 1.736 ± 0.183
0.651ProCys: 0.651 ± 0.114
2.405ProAsp: 2.405 ± 0.22
3.201ProGlu: 3.201 ± 0.283
1.646ProPhe: 1.646 ± 0.188
2.658ProGly: 2.658 ± 0.27
0.687ProHis: 0.687 ± 0.129
2.098ProIle: 2.098 ± 0.197
3.382ProLys: 3.382 ± 0.317
2.568ProLeu: 2.568 ± 0.23
1.212ProMet: 1.212 ± 0.132
2.405ProAsn: 2.405 ± 0.211
2.405ProPro: 2.405 ± 0.291
1.881ProGln: 1.881 ± 0.195
1.736ProArg: 1.736 ± 0.192
2.785ProSer: 2.785 ± 0.388
2.839ProThr: 2.839 ± 0.254
2.315ProVal: 2.315 ± 0.237
0.344ProTrp: 0.344 ± 0.07
1.32ProTyr: 1.32 ± 0.163
0.0ProXaa: 0.0 ± 0.0
Gln
1.555GlnAla: 1.555 ± 0.167
0.542GlnCys: 0.542 ± 0.089
1.935GlnAsp: 1.935 ± 0.188
2.134GlnGlu: 2.134 ± 0.258
1.555GlnPhe: 1.555 ± 0.194
1.591GlnGly: 1.591 ± 0.196
0.705GlnHis: 0.705 ± 0.116
2.351GlnIle: 2.351 ± 0.228
2.857GlnLys: 2.857 ± 0.362
3.237GlnLeu: 3.237 ± 0.253
0.995GlnMet: 0.995 ± 0.147
1.754GlnAsn: 1.754 ± 0.225
1.718GlnPro: 1.718 ± 0.176
1.555GlnGln: 1.555 ± 0.209
1.989GlnArg: 1.989 ± 0.233
1.844GlnSer: 1.844 ± 0.175
1.953GlnThr: 1.953 ± 0.169
1.718GlnVal: 1.718 ± 0.186
0.38GlnTrp: 0.38 ± 0.092
1.121GlnTyr: 1.121 ± 0.155
0.0GlnXaa: 0.0 ± 0.0
Arg
2.911ArgAla: 2.911 ± 0.307
0.669ArgCys: 0.669 ± 0.13
3.309ArgAsp: 3.309 ± 0.247
3.816ArgGlu: 3.816 ± 0.397
2.025ArgPhe: 2.025 ± 0.194
2.929ArgGly: 2.929 ± 0.219
1.139ArgHis: 1.139 ± 0.152
3.146ArgIle: 3.146 ± 0.242
3.725ArgLys: 3.725 ± 0.511
3.779ArgLeu: 3.779 ± 0.265
1.483ArgMet: 1.483 ± 0.188
2.785ArgAsn: 2.785 ± 0.304
1.899ArgPro: 1.899 ± 0.191
1.79ArgGln: 1.79 ± 0.204
2.966ArgArg: 2.966 ± 0.266
3.02ArgSer: 3.02 ± 0.227
2.532ArgThr: 2.532 ± 0.262
4.123ArgVal: 4.123 ± 0.32
0.651ArgTrp: 0.651 ± 0.109
2.116ArgTyr: 2.116 ± 0.202
0.0ArgXaa: 0.0 ± 0.0
Ser
3.58SerAla: 3.58 ± 0.341
0.85SerCys: 0.85 ± 0.138
3.219SerAsp: 3.219 ± 0.265
4.159SerGlu: 4.159 ± 0.378
2.694SerPhe: 2.694 ± 0.253
4.81SerGly: 4.81 ± 0.532
1.266SerHis: 1.266 ± 0.169
3.544SerIle: 3.544 ± 0.253
3.978SerLys: 3.978 ± 0.267
4.828SerLeu: 4.828 ± 0.313
1.429SerMet: 1.429 ± 0.159
4.448SerAsn: 4.448 ± 0.608
2.061SerPro: 2.061 ± 0.218
2.152SerGln: 2.152 ± 0.187
2.803SerArg: 2.803 ± 0.244
3.942SerSer: 3.942 ± 0.438
3.924SerThr: 3.924 ± 0.326
4.087SerVal: 4.087 ± 0.345
0.687SerTrp: 0.687 ± 0.116
1.844SerTyr: 1.844 ± 0.194
0.0SerXaa: 0.0 ± 0.0
Thr
3.562ThrAla: 3.562 ± 0.326
0.868ThrCys: 0.868 ± 0.143
3.562ThrAsp: 3.562 ± 0.402
3.382ThrGlu: 3.382 ± 0.278
2.477ThrPhe: 2.477 ± 0.221
4.485ThrGly: 4.485 ± 0.578
1.591ThrHis: 1.591 ± 0.199
3.852ThrIle: 3.852 ± 0.24
4.901ThrLys: 4.901 ± 0.262
4.828ThrLeu: 4.828 ± 0.284
1.573ThrMet: 1.573 ± 0.193
4.358ThrAsn: 4.358 ± 0.472
2.875ThrPro: 2.875 ± 0.297
2.025ThrGln: 2.025 ± 0.185
3.092ThrArg: 3.092 ± 0.274
3.924ThrSer: 3.924 ± 0.414
4.123ThrThr: 4.123 ± 0.646
3.363ThrVal: 3.363 ± 0.359
0.597ThrTrp: 0.597 ± 0.08
2.387ThrTyr: 2.387 ± 0.229
0.0ThrXaa: 0.0 ± 0.0
Val
3.779ValAla: 3.779 ± 0.292
1.41ValCys: 1.41 ± 0.183
3.508ValAsp: 3.508 ± 0.277
3.978ValGlu: 3.978 ± 0.238
2.694ValPhe: 2.694 ± 0.257
3.779ValGly: 3.779 ± 0.533
1.392ValHis: 1.392 ± 0.158
4.159ValIle: 4.159 ± 0.389
5.353ValLys: 5.353 ± 0.338
4.702ValLeu: 4.702 ± 0.271
1.772ValMet: 1.772 ± 0.189
3.689ValAsn: 3.689 ± 0.519
3.002ValPro: 3.002 ± 0.251
2.043ValGln: 2.043 ± 0.177
3.183ValArg: 3.183 ± 0.26
4.322ValSer: 4.322 ± 0.341
4.539ValThr: 4.539 ± 0.618
4.033ValVal: 4.033 ± 0.322
0.778ValTrp: 0.778 ± 0.119
2.767ValTyr: 2.767 ± 0.263
0.0ValXaa: 0.0 ± 0.0
Trp
0.344TrpAla: 0.344 ± 0.077
0.325TrpCys: 0.325 ± 0.081
0.542TrpAsp: 0.542 ± 0.106
0.759TrpGlu: 0.759 ± 0.12
0.561TrpPhe: 0.561 ± 0.109
0.759TrpGly: 0.759 ± 0.113
0.253TrpHis: 0.253 ± 0.076
0.958TrpIle: 0.958 ± 0.142
0.904TrpLys: 0.904 ± 0.141
0.85TrpLeu: 0.85 ± 0.132
0.217TrpMet: 0.217 ± 0.06
0.759TrpAsn: 0.759 ± 0.124
0.289TrpPro: 0.289 ± 0.082
0.307TrpGln: 0.307 ± 0.071
0.38TrpArg: 0.38 ± 0.092
0.85TrpSer: 0.85 ± 0.12
0.506TrpThr: 0.506 ± 0.098
0.669TrpVal: 0.669 ± 0.122
0.163TrpTrp: 0.163 ± 0.056
0.325TrpTyr: 0.325 ± 0.073
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.423TyrAla: 2.423 ± 0.29
0.452TyrCys: 0.452 ± 0.097
2.495TyrAsp: 2.495 ± 0.228
2.586TyrGlu: 2.586 ± 0.254
1.754TyrPhe: 1.754 ± 0.205
2.586TyrGly: 2.586 ± 0.228
0.778TyrHis: 0.778 ± 0.136
3.128TyrIle: 3.128 ± 0.302
2.875TyrLys: 2.875 ± 0.286
3.761TyrLeu: 3.761 ± 0.276
1.519TyrMet: 1.519 ± 0.166
2.242TyrAsn: 2.242 ± 0.189
1.338TyrPro: 1.338 ± 0.168
1.103TyrGln: 1.103 ± 0.131
1.754TyrArg: 1.754 ± 0.187
2.369TyrSer: 2.369 ± 0.225
2.495TyrThr: 2.495 ± 0.256
2.278TyrVal: 2.278 ± 0.193
0.325TyrTrp: 0.325 ± 0.08
1.682TyrTyr: 1.682 ± 0.204
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 246 proteins (55301 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski