Amino acid dipepetide frequency for Ewingella americana ATCC 33852

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.622AlaAla: 10.622 ± 0.118	0.977AlaCys: 0.977 ± 0.031	5.221AlaAsp: 5.221 ± 0.061	6.094AlaGlu: 6.094 ± 0.083	3.589AlaPhe: 3.589 ± 0.054	7.646AlaGly: 7.646 ± 0.102	1.777AlaHis: 1.777 ± 0.036	5.724AlaIle: 5.724 ± 0.068	4.349AlaLys: 4.349 ± 0.067	11.698AlaLeu: 11.698 ± 0.104	2.9AlaMet: 2.9 ± 0.052	3.309AlaAsn: 3.309 ± 0.055	3.754AlaPro: 3.754 ± 0.053	4.561AlaGln: 4.561 ± 0.067	4.854AlaArg: 4.854 ± 0.064	5.934AlaSer: 5.934 ± 0.073	4.935AlaThr: 4.935 ± 0.075	6.818AlaVal: 6.818 ± 0.082	1.266AlaTrp: 1.266 ± 0.032	2.221AlaTyr: 2.221 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.908CysAla: 0.908 ± 0.027	0.148CysCys: 0.148 ± 0.011	0.496CysAsp: 0.496 ± 0.018	0.493CysGlu: 0.493 ± 0.02	0.41CysPhe: 0.41 ± 0.018	0.947CysGly: 0.947 ± 0.028	0.306CysHis: 0.306 ± 0.016	0.528CysIle: 0.528 ± 0.023	0.311CysLys: 0.311 ± 0.013	0.937CysLeu: 0.937 ± 0.026	0.207CysMet: 0.207 ± 0.013	0.283CysAsn: 0.283 ± 0.013	0.408CysPro: 0.408 ± 0.016	0.43CysGln: 0.43 ± 0.02	0.526CysArg: 0.526 ± 0.02	0.614CysSer: 0.614 ± 0.025	0.441CysThr: 0.441 ± 0.017	0.66CysVal: 0.66 ± 0.023	0.155CysTrp: 0.155 ± 0.011	0.283CysTyr: 0.283 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.126AspAla: 5.126 ± 0.072	0.479AspCys: 0.479 ± 0.019	2.774AspAsp: 2.774 ± 0.052	3.28AspGlu: 3.28 ± 0.058	2.317AspPhe: 2.317 ± 0.041	3.898AspGly: 3.898 ± 0.083	1.047AspHis: 1.047 ± 0.028	3.403AspIle: 3.403 ± 0.044	2.605AspLys: 2.605 ± 0.047	4.913AspLeu: 4.913 ± 0.064	1.356AspMet: 1.356 ± 0.031	2.14AspAsn: 2.14 ± 0.051	2.286AspPro: 2.286 ± 0.041	1.967AspGln: 1.967 ± 0.036	2.513AspArg: 2.513 ± 0.042	3.098AspSer: 3.098 ± 0.048	2.454AspThr: 2.454 ± 0.048	3.767AspVal: 3.767 ± 0.053	0.84AspTrp: 0.84 ± 0.026	1.789AspTyr: 1.789 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.09GluAla: 5.09 ± 0.071	0.405GluCys: 0.405 ± 0.017	2.378GluAsp: 2.378 ± 0.052	3.267GluGlu: 3.267 ± 0.068	1.957GluPhe: 1.957 ± 0.039	3.46GluGly: 3.46 ± 0.056	1.334GluHis: 1.334 ± 0.033	3.275GluIle: 3.275 ± 0.051	3.119GluLys: 3.119 ± 0.05	5.96GluLeu: 5.96 ± 0.075	1.683GluMet: 1.683 ± 0.038	2.323GluAsn: 2.323 ± 0.047	2.076GluPro: 2.076 ± 0.041	3.572GluGln: 3.572 ± 0.065	3.335GluArg: 3.335 ± 0.057	3.106GluSer: 3.106 ± 0.052	2.686GluThr: 2.686 ± 0.044	3.789GluVal: 3.789 ± 0.065	0.779GluTrp: 0.779 ± 0.024	1.343GluTyr: 1.343 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.789PheAla: 3.789 ± 0.053	0.499PheCys: 0.499 ± 0.019	2.371PheAsp: 2.371 ± 0.045	1.873PheGlu: 1.873 ± 0.035	1.633PhePhe: 1.633 ± 0.044	3.415PheGly: 3.415 ± 0.054	0.774PheHis: 0.774 ± 0.023	2.578PheIle: 2.578 ± 0.051	1.432PheLys: 1.432 ± 0.034	3.316PheLeu: 3.316 ± 0.053	1.007PheMet: 1.007 ± 0.03	1.789PheAsn: 1.789 ± 0.037	1.562PhePro: 1.562 ± 0.034	1.161PheGln: 1.161 ± 0.028	1.775PheArg: 1.775 ± 0.034	3.202PheSer: 3.202 ± 0.055	2.37PheThr: 2.37 ± 0.04	2.545PheVal: 2.545 ± 0.054	0.562PheTrp: 0.562 ± 0.021	1.234PheTyr: 1.234 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	6.284GlyAla: 6.284 ± 0.09	0.9GlyCys: 0.9 ± 0.03	3.673GlyAsp: 3.673 ± 0.066	4.357GlyGlu: 4.357 ± 0.066	3.276GlyPhe: 3.276 ± 0.058	5.517GlyGly: 5.517 ± 0.101	1.641GlyHis: 1.641 ± 0.036	4.98GlyIle: 4.98 ± 0.065	4.078GlyLys: 4.078 ± 0.063	7.87GlyLeu: 7.87 ± 0.092	2.262GlyMet: 2.262 ± 0.041	2.774GlyAsn: 2.774 ± 0.083	2.175GlyPro: 2.175 ± 0.039	3.202GlyGln: 3.202 ± 0.06	3.684GlyArg: 3.684 ± 0.057	4.497GlySer: 4.497 ± 0.081	3.824GlyThr: 3.824 ± 0.087	5.896GlyVal: 5.896 ± 0.073	1.227GlyTrp: 1.227 ± 0.032	2.576GlyTyr: 2.576 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	1.905HisAla: 1.905 ± 0.037	0.308HisCys: 0.308 ± 0.015	1.134HisAsp: 1.134 ± 0.027	1.061HisGlu: 1.061 ± 0.028	1.05HisPhe: 1.05 ± 0.028	1.729HisGly: 1.729 ± 0.042	0.724HisHis: 0.724 ± 0.027	1.244HisIle: 1.244 ± 0.03	0.777HisLys: 0.777 ± 0.023	2.229HisLeu: 2.229 ± 0.047	0.551HisMet: 0.551 ± 0.02	0.788HisAsn: 0.788 ± 0.024	1.299HisPro: 1.299 ± 0.035	1.212HisGln: 1.212 ± 0.029	1.212HisArg: 1.212 ± 0.029	1.322HisSer: 1.322 ± 0.027	0.994HisThr: 0.994 ± 0.028	1.216HisVal: 1.216 ± 0.031	0.431HisTrp: 0.431 ± 0.018	0.795HisTyr: 0.795 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.389IleAla: 6.389 ± 0.069	0.598IleCys: 0.598 ± 0.023	3.581IleAsp: 3.581 ± 0.056	3.378IleGlu: 3.378 ± 0.062	2.062IlePhe: 2.062 ± 0.045	4.852IleGly: 4.852 ± 0.073	1.155IleHis: 1.155 ± 0.033	3.194IleIle: 3.194 ± 0.059	2.472IleLys: 2.472 ± 0.052	4.98IleLeu: 4.98 ± 0.076	1.234IleMet: 1.234 ± 0.037	2.677IleAsn: 2.677 ± 0.055	2.648IlePro: 2.648 ± 0.045	1.858IleGln: 1.858 ± 0.035	2.819IleArg: 2.819 ± 0.046	4.089IleSer: 4.089 ± 0.054	3.391IleThr: 3.391 ± 0.056	3.816IleVal: 3.816 ± 0.057	0.608IleTrp: 0.608 ± 0.021	1.546IleTyr: 1.546 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.372LysAla: 4.372 ± 0.065	0.229LysCys: 0.229 ± 0.013	2.2LysAsp: 2.2 ± 0.045	2.397LysGlu: 2.397 ± 0.052	1.21LysPhe: 1.21 ± 0.028	2.979LysGly: 2.979 ± 0.051	0.93LysHis: 0.93 ± 0.028	2.426LysIle: 2.426 ± 0.048	2.294LysLys: 2.294 ± 0.057	4.58LysLeu: 4.58 ± 0.063	1.295LysMet: 1.295 ± 0.033	1.816LysAsn: 1.816 ± 0.037	2.266LysPro: 2.266 ± 0.043	2.281LysGln: 2.281 ± 0.046	2.42LysArg: 2.42 ± 0.041	2.588LysSer: 2.588 ± 0.048	2.542LysThr: 2.542 ± 0.048	3.289LysVal: 3.289 ± 0.055	0.482LysTrp: 0.482 ± 0.019	1.113LysTyr: 1.113 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	11.638LeuAla: 11.638 ± 0.103	1.133LeuCys: 1.133 ± 0.027	5.63LeuAsp: 5.63 ± 0.073	5.453LeuGlu: 5.453 ± 0.08	4.277LeuPhe: 4.277 ± 0.06	7.689LeuGly: 7.689 ± 0.089	2.274LeuHis: 2.274 ± 0.045	6.013LeuIle: 6.013 ± 0.076	4.648LeuLys: 4.648 ± 0.061	12.147LeuLeu: 12.147 ± 0.155	2.986LeuMet: 2.986 ± 0.057	4.325LeuAsn: 4.325 ± 0.074	5.788LeuPro: 5.788 ± 0.064	4.534LeuGln: 4.534 ± 0.061	5.941LeuArg: 5.941 ± 0.089	7.898LeuSer: 7.898 ± 0.076	6.406LeuThr: 6.406 ± 0.077	7.331LeuVal: 7.331 ± 0.089	1.267LeuTrp: 1.267 ± 0.034	2.568LeuTyr: 2.568 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.875MetAla: 2.875 ± 0.052	0.173MetCys: 0.173 ± 0.012	1.142MetAsp: 1.142 ± 0.026	1.138MetGlu: 1.138 ± 0.03	0.89MetPhe: 0.89 ± 0.027	1.824MetGly: 1.824 ± 0.041	0.53MetHis: 0.53 ± 0.019	1.432MetIle: 1.432 ± 0.036	1.336MetLys: 1.336 ± 0.031	3.17MetLeu: 3.17 ± 0.058	0.836MetMet: 0.836 ± 0.026	1.063MetAsn: 1.063 ± 0.026	1.356MetPro: 1.356 ± 0.031	1.18MetGln: 1.18 ± 0.029	1.41MetArg: 1.41 ± 0.033	2.026MetSer: 2.026 ± 0.036	1.742MetThr: 1.742 ± 0.037	1.885MetVal: 1.885 ± 0.041	0.261MetTrp: 0.261 ± 0.014	0.5MetTyr: 0.5 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.672AsnAla: 3.672 ± 0.058	0.319AsnCys: 0.319 ± 0.014	2.034AsnAsp: 2.034 ± 0.041	1.781AsnGlu: 1.781 ± 0.039	1.388AsnPhe: 1.388 ± 0.031	3.028AsnGly: 3.028 ± 0.067	0.81AsnHis: 0.81 ± 0.027	2.358AsnIle: 2.358 ± 0.044	1.652AsnLys: 1.652 ± 0.041	3.774AsnLeu: 3.774 ± 0.059	0.896AsnMet: 0.896 ± 0.026	1.695AsnAsn: 1.695 ± 0.048	2.117AsnPro: 2.117 ± 0.045	1.836AsnGln: 1.836 ± 0.037	1.967AsnArg: 1.967 ± 0.042	2.284AsnSer: 2.284 ± 0.054	1.961AsnThr: 1.961 ± 0.048	2.593AsnVal: 2.593 ± 0.058	0.566AsnTrp: 0.566 ± 0.021	1.179AsnTyr: 1.179 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	4.637ProAla: 4.637 ± 0.065	0.329ProCys: 0.329 ± 0.017	2.63ProAsp: 2.63 ± 0.047	3.306ProGlu: 3.306 ± 0.058	1.794ProPhe: 1.794 ± 0.041	3.067ProGly: 3.067 ± 0.053	1.047ProHis: 1.047 ± 0.029	2.125ProIle: 2.125 ± 0.038	1.724ProLys: 1.724 ± 0.033	5.256ProLeu: 5.256 ± 0.058	1.141ProMet: 1.141 ± 0.03	1.506ProAsn: 1.506 ± 0.035	1.672ProPro: 1.672 ± 0.039	2.475ProGln: 2.475 ± 0.046	1.957ProArg: 1.957 ± 0.038	2.504ProSer: 2.504 ± 0.041	2.269ProThr: 2.269 ± 0.046	3.627ProVal: 3.627 ± 0.064	0.647ProTrp: 0.647 ± 0.023	1.296ProTyr: 1.296 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.854GlnAla: 4.854 ± 0.067	0.346GlnCys: 0.346 ± 0.017	2.027GlnAsp: 2.027 ± 0.039	2.127GlnGlu: 2.127 ± 0.046	1.588GlnPhe: 1.588 ± 0.034	3.425GlnGly: 3.425 ± 0.052	1.239GlnHis: 1.239 ± 0.034	2.463GlnIle: 2.463 ± 0.044	1.946GlnLys: 1.946 ± 0.039	5.492GlnLeu: 5.492 ± 0.076	1.169GlnMet: 1.169 ± 0.029	1.577GlnAsn: 1.577 ± 0.04	2.447GlnPro: 2.447 ± 0.049	3.748GlnGln: 3.748 ± 0.084	3.126GlnArg: 3.126 ± 0.057	2.625GlnSer: 2.625 ± 0.048	2.262GlnThr: 2.262 ± 0.046	3.277GlnVal: 3.277 ± 0.049	0.737GlnTrp: 0.737 ± 0.027	1.17GlnTyr: 1.17 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	4.439ArgAla: 4.439 ± 0.065	0.487ArgCys: 0.487 ± 0.02	2.835ArgAsp: 2.835 ± 0.047	3.357ArgGlu: 3.357 ± 0.062	2.427ArgPhe: 2.427 ± 0.049	3.269ArgGly: 3.269 ± 0.052	1.374ArgHis: 1.374 ± 0.03	3.101ArgIle: 3.101 ± 0.053	2.173ArgLys: 2.173 ± 0.038	6.178ArgLeu: 6.178 ± 0.078	1.396ArgMet: 1.396 ± 0.03	1.894ArgAsn: 1.894 ± 0.04	2.078ArgPro: 2.078 ± 0.039	2.947ArgGln: 2.947 ± 0.055	3.165ArgArg: 3.165 ± 0.057	2.84ArgSer: 2.84 ± 0.051	2.367ArgThr: 2.367 ± 0.045	3.768ArgVal: 3.768 ± 0.061	0.868ArgTrp: 0.868 ± 0.031	1.935ArgTyr: 1.935 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.141SerAla: 6.141 ± 0.072	0.548SerCys: 0.548 ± 0.018	3.269SerAsp: 3.269 ± 0.051	3.246SerGlu: 3.246 ± 0.051	2.509SerPhe: 2.509 ± 0.048	5.64SerGly: 5.64 ± 0.078	1.502SerHis: 1.502 ± 0.033	3.276SerIle: 3.276 ± 0.056	2.487SerLys: 2.487 ± 0.041	7.321SerLeu: 7.321 ± 0.079	1.639SerMet: 1.639 ± 0.031	2.086SerAsn: 2.086 ± 0.044	2.826SerPro: 2.826 ± 0.048	3.046SerGln: 3.046 ± 0.06	3.367SerArg: 3.367 ± 0.049	4.133SerSer: 4.133 ± 0.064	3.198SerThr: 3.198 ± 0.057	4.445SerVal: 4.445 ± 0.062	0.942SerTrp: 0.942 ± 0.026	1.771SerTyr: 1.771 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	4.965ThrAla: 4.965 ± 0.069	0.428ThrCys: 0.428 ± 0.018	2.702ThrAsp: 2.702 ± 0.06	2.597ThrGlu: 2.597 ± 0.043	2.002ThrPhe: 2.002 ± 0.04	4.269ThrGly: 4.269 ± 0.078	1.218ThrHis: 1.218 ± 0.031	2.684ThrIle: 2.684 ± 0.07	1.72ThrLys: 1.72 ± 0.037	7.305ThrLeu: 7.305 ± 0.078	1.074ThrMet: 1.074 ± 0.031	1.625ThrAsn: 1.625 ± 0.038	3.283ThrPro: 3.283 ± 0.056	2.425ThrGln: 2.425 ± 0.049	2.736ThrArg: 2.736 ± 0.044	3.205ThrSer: 3.205 ± 0.055	2.909ThrThr: 2.909 ± 0.071	3.784ThrVal: 3.784 ± 0.103	0.621ThrTrp: 0.621 ± 0.023	1.353ThrTyr: 1.353 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	7.171ValAla: 7.171 ± 0.081	0.701ValCys: 0.701 ± 0.023	3.789ValAsp: 3.789 ± 0.054	4.032ValGlu: 4.032 ± 0.064	2.661ValPhe: 2.661 ± 0.046	5.013ValGly: 5.013 ± 0.08	1.194ValHis: 1.194 ± 0.026	4.459ValIle: 4.459 ± 0.067	3.161ValLys: 3.161 ± 0.049	7.467ValLeu: 7.467 ± 0.083	2.15ValMet: 2.15 ± 0.042	2.758ValAsn: 2.758 ± 0.05	2.969ValPro: 2.969 ± 0.051	2.442ValGln: 2.442 ± 0.041	3.413ValArg: 3.413 ± 0.051	4.846ValSer: 4.846 ± 0.06	4.31ValThr: 4.31 ± 0.086	5.652ValVal: 5.652 ± 0.073	0.889ValTrp: 0.889 ± 0.024	1.676ValTyr: 1.676 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.027TrpAla: 1.027 ± 0.032	0.148TrpCys: 0.148 ± 0.01	0.641TrpAsp: 0.641 ± 0.023	0.554TrpGlu: 0.554 ± 0.018	0.607TrpPhe: 0.607 ± 0.023	0.858TrpGly: 0.858 ± 0.029	0.407TrpHis: 0.407 ± 0.017	0.662TrpIle: 0.662 ± 0.023	0.5TrpLys: 0.5 ± 0.019	2.158TrpLeu: 2.158 ± 0.041	0.409TrpMet: 0.409 ± 0.019	0.471TrpAsn: 0.471 ± 0.018	0.613TrpPro: 0.613 ± 0.02	1.053TrpGln: 1.053 ± 0.028	0.89TrpArg: 0.89 ± 0.03	0.776TrpSer: 0.776 ± 0.027	0.524TrpThr: 0.524 ± 0.023	0.918TrpVal: 0.918 ± 0.026	0.212TrpTrp: 0.212 ± 0.012	0.37TrpTyr: 0.37 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.344TyrAla: 2.344 ± 0.043	0.333TyrCys: 0.333 ± 0.014	1.526TyrAsp: 1.526 ± 0.037	1.147TyrGlu: 1.147 ± 0.028	1.242TyrPhe: 1.242 ± 0.029	2.168TyrGly: 2.168 ± 0.039	0.698TyrHis: 0.698 ± 0.022	1.42TyrIle: 1.42 ± 0.033	0.926TyrLys: 0.926 ± 0.026	3.196TyrLeu: 3.196 ± 0.052	0.578TyrMet: 0.578 ± 0.02	1.01TyrAsn: 1.01 ± 0.028	1.386TyrPro: 1.386 ± 0.033	1.715TyrGln: 1.715 ± 0.041	1.787TyrArg: 1.787 ± 0.036	1.803TyrSer: 1.803 ± 0.04	1.321TyrThr: 1.321 ± 0.031	1.677TyrVal: 1.677 ± 0.036	0.438TyrTrp: 0.438 ± 0.02	0.917TyrTyr: 0.917 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4395 proteins (1403935 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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