Amino acid dipepetide frequency for Mastacembelus armatus (zig-zag eel)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.656AlaAla: 5.656 ± 0.021	1.289AlaCys: 1.289 ± 0.007	3.113AlaAsp: 3.113 ± 0.011	4.43AlaGlu: 4.43 ± 0.017	2.425AlaPhe: 2.425 ± 0.009	4.03AlaGly: 4.03 ± 0.012	1.465AlaHis: 1.465 ± 0.006	2.922AlaIle: 2.922 ± 0.009	3.386AlaLys: 3.386 ± 0.015	6.484AlaLeu: 6.484 ± 0.018	1.614AlaMet: 1.614 ± 0.007	2.214AlaAsn: 2.214 ± 0.008	3.087AlaPro: 3.087 ± 0.012	2.88AlaGln: 2.88 ± 0.012	3.014AlaArg: 3.014 ± 0.009	5.012AlaSer: 5.012 ± 0.014	3.438AlaThr: 3.438 ± 0.011	4.848AlaVal: 4.848 ± 0.013	0.665AlaTrp: 0.665 ± 0.005	1.619AlaTyr: 1.619 ± 0.007	0.0AlaXaa: 0.0 ± 0.0
Cys	1.187CysAla: 1.187 ± 0.007	0.664CysCys: 0.664 ± 0.007	1.19CysAsp: 1.19 ± 0.01	1.258CysGlu: 1.258 ± 0.009	0.996CysPhe: 0.996 ± 0.006	1.521CysGly: 1.521 ± 0.009	0.691CysHis: 0.691 ± 0.005	1.114CysIle: 1.114 ± 0.008	1.196CysLys: 1.196 ± 0.007	2.32CysLeu: 2.32 ± 0.01	0.495CysMet: 0.495 ± 0.004	0.874CysAsn: 0.874 ± 0.006	1.286CysPro: 1.286 ± 0.009	1.093CysGln: 1.093 ± 0.009	1.277CysArg: 1.277 ± 0.006	2.087CysSer: 2.087 ± 0.011	1.235CysThr: 1.235 ± 0.007	1.664CysVal: 1.664 ± 0.009	0.301CysTrp: 0.301 ± 0.003	0.675CysTyr: 0.675 ± 0.005	0.0CysXaa: 0.0 ± 0.0
Asp	2.851AspAla: 2.851 ± 0.009	1.183AspCys: 1.183 ± 0.008	3.082AspAsp: 3.082 ± 0.016	3.672AspGlu: 3.672 ± 0.014	2.223AspPhe: 2.223 ± 0.008	3.541AspGly: 3.541 ± 0.012	1.258AspHis: 1.258 ± 0.006	2.941AspIle: 2.941 ± 0.012	2.83AspLys: 2.83 ± 0.009	5.078AspLeu: 5.078 ± 0.012	1.354AspMet: 1.354 ± 0.006	2.085AspAsn: 2.085 ± 0.01	2.874AspPro: 2.874 ± 0.01	2.009AspGln: 2.009 ± 0.008	2.731AspArg: 2.731 ± 0.012	4.281AspSer: 4.281 ± 0.013	2.741AspThr: 2.741 ± 0.011	3.305AspVal: 3.305 ± 0.012	0.711AspTrp: 0.711 ± 0.005	1.65AspTyr: 1.65 ± 0.008	0.0AspXaa: 0.0 ± 0.0
Glu	4.561GluAla: 4.561 ± 0.017	1.268GluCys: 1.268 ± 0.01	4.25GluAsp: 4.25 ± 0.013	7.107GluGlu: 7.107 ± 0.033	2.049GluPhe: 2.049 ± 0.008	4.036GluGly: 4.036 ± 0.012	1.494GluHis: 1.494 ± 0.007	3.029GluIle: 3.029 ± 0.009	4.635GluLys: 4.635 ± 0.02	6.358GluLeu: 6.358 ± 0.019	1.76GluMet: 1.76 ± 0.008	2.785GluAsn: 2.785 ± 0.01	2.562GluPro: 2.562 ± 0.01	3.067GluGln: 3.067 ± 0.012	4.058GluArg: 4.058 ± 0.015	4.083GluSer: 4.083 ± 0.014	3.353GluThr: 3.353 ± 0.012	4.335GluVal: 4.335 ± 0.012	0.72GluTrp: 0.72 ± 0.005	1.7GluTyr: 1.7 ± 0.007	0.0GluXaa: 0.0 ± 0.0
Phe	2.024PheAla: 2.024 ± 0.008	1.01PheCys: 1.01 ± 0.006	1.88PheAsp: 1.88 ± 0.008	1.968PheGlu: 1.968 ± 0.008	1.803PhePhe: 1.803 ± 0.009	2.275PheGly: 2.275 ± 0.01	1.071PheHis: 1.071 ± 0.005	2.137PheIle: 2.137 ± 0.009	1.898PheLys: 1.898 ± 0.008	4.127PheLeu: 4.127 ± 0.015	0.868PheMet: 0.868 ± 0.005	1.591PheAsn: 1.591 ± 0.007	1.85PhePro: 1.85 ± 0.007	1.688PheGln: 1.688 ± 0.007	1.883PheArg: 1.883 ± 0.008	3.479PheSer: 3.479 ± 0.01	2.439PheThr: 2.439 ± 0.01	2.383PheVal: 2.383 ± 0.01	0.492PheTrp: 0.492 ± 0.004	1.325PheTyr: 1.325 ± 0.006	0.0PheXaa: 0.0 ± 0.0
Gly	3.778GlyAla: 3.778 ± 0.014	1.238GlyCys: 1.238 ± 0.008	3.168GlyAsp: 3.168 ± 0.012	3.925GlyGlu: 3.925 ± 0.013	2.453GlyPhe: 2.453 ± 0.01	4.908GlyGly: 4.908 ± 0.021	1.671GlyHis: 1.671 ± 0.009	2.786GlyIle: 2.786 ± 0.009	3.61GlyLys: 3.61 ± 0.013	5.469GlyLeu: 5.469 ± 0.015	1.508GlyMet: 1.508 ± 0.008	2.464GlyAsn: 2.464 ± 0.009	3.032GlyPro: 3.032 ± 0.021	2.738GlyGln: 2.738 ± 0.011	3.44GlyArg: 3.44 ± 0.014	5.328GlySer: 5.328 ± 0.017	3.477GlyThr: 3.477 ± 0.013	3.95GlyVal: 3.95 ± 0.016	0.777GlyTrp: 0.777 ± 0.006	1.955GlyTyr: 1.955 ± 0.009	0.0GlyXaa: 0.0 ± 0.0
His	1.328HisAla: 1.328 ± 0.006	0.819HisCys: 0.819 ± 0.006	1.029HisAsp: 1.029 ± 0.005	1.262HisGlu: 1.262 ± 0.006	1.108HisPhe: 1.108 ± 0.006	1.557HisGly: 1.557 ± 0.008	1.002HisHis: 1.002 ± 0.009	1.47HisIle: 1.47 ± 0.006	1.32HisLys: 1.32 ± 0.006	2.78HisLeu: 2.78 ± 0.01	0.666HisMet: 0.666 ± 0.004	1.086HisAsn: 1.086 ± 0.006	1.548HisPro: 1.548 ± 0.008	1.261HisGln: 1.261 ± 0.008	1.601HisArg: 1.601 ± 0.006	2.398HisSer: 2.398 ± 0.01	1.675HisThr: 1.675 ± 0.008	1.504HisVal: 1.504 ± 0.007	0.36HisTrp: 0.36 ± 0.003	0.919HisTyr: 0.919 ± 0.005	0.0HisXaa: 0.0 ± 0.0
Ile	2.717IleAla: 2.717 ± 0.009	1.169IleCys: 1.169 ± 0.006	2.322IleAsp: 2.322 ± 0.009	2.579IleGlu: 2.579 ± 0.01	2.024IlePhe: 2.024 ± 0.009	2.444IleGly: 2.444 ± 0.01	1.403IleHis: 1.403 ± 0.007	2.74IleIle: 2.74 ± 0.009	2.77IleLys: 2.77 ± 0.008	4.682IleLeu: 4.682 ± 0.014	1.185IleMet: 1.185 ± 0.006	2.173IleAsn: 2.173 ± 0.009	2.555IlePro: 2.555 ± 0.009	2.355IleGln: 2.355 ± 0.009	2.596IleArg: 2.596 ± 0.008	3.934IleSer: 3.934 ± 0.011	2.999IleThr: 2.999 ± 0.01	2.797IleVal: 2.797 ± 0.011	0.513IleTrp: 0.513 ± 0.004	1.587IleTyr: 1.587 ± 0.007	0.0IleXaa: 0.0 ± 0.0
Lys	3.743LysAla: 3.743 ± 0.015	1.057LysCys: 1.057 ± 0.007	3.31LysAsp: 3.31 ± 0.013	4.683LysGlu: 4.683 ± 0.019	1.729LysPhe: 1.729 ± 0.007	3.176LysGly: 3.176 ± 0.014	1.471LysHis: 1.471 ± 0.006	2.705LysIle: 2.705 ± 0.009	4.386LysLys: 4.386 ± 0.02	5.217LysLeu: 5.217 ± 0.016	1.492LysMet: 1.492 ± 0.008	2.42LysAsn: 2.42 ± 0.009	2.763LysPro: 2.763 ± 0.011	2.594LysGln: 2.594 ± 0.011	3.252LysArg: 3.252 ± 0.011	3.716LysSer: 3.716 ± 0.015	3.215LysThr: 3.215 ± 0.012	3.702LysVal: 3.702 ± 0.011	0.605LysTrp: 0.605 ± 0.004	1.626LysTyr: 1.626 ± 0.007	0.0LysXaa: 0.0 ± 0.0
Leu	6.156LeuAla: 6.156 ± 0.016	2.357LeuCys: 2.357 ± 0.01	5.045LeuAsp: 5.045 ± 0.014	6.502LeuGlu: 6.502 ± 0.025	3.714LeuPhe: 3.714 ± 0.013	5.214LeuGly: 5.214 ± 0.014	2.816LeuHis: 2.816 ± 0.01	4.174LeuIle: 4.174 ± 0.013	5.776LeuLys: 5.776 ± 0.016	10.341LeuLeu: 10.341 ± 0.032	2.247LeuMet: 2.247 ± 0.008	3.816LeuAsn: 3.816 ± 0.01	5.147LeuPro: 5.147 ± 0.016	5.518LeuGln: 5.518 ± 0.017	5.588LeuArg: 5.588 ± 0.015	8.268LeuSer: 8.268 ± 0.022	5.429LeuThr: 5.429 ± 0.015	5.682LeuVal: 5.682 ± 0.016	1.113LeuTrp: 1.113 ± 0.007	2.84LeuTyr: 2.84 ± 0.01	0.0LeuXaa: 0.0 ± 0.0
Met	1.909MetAla: 1.909 ± 0.008	0.537MetCys: 0.537 ± 0.004	1.466MetAsp: 1.466 ± 0.006	2.001MetGlu: 2.001 ± 0.008	0.927MetPhe: 0.927 ± 0.005	1.438MetGly: 1.438 ± 0.008	0.514MetHis: 0.514 ± 0.004	0.958MetIle: 0.958 ± 0.005	1.519MetLys: 1.519 ± 0.006	2.213MetLeu: 2.213 ± 0.008	0.708MetMet: 0.708 ± 0.005	0.965MetAsn: 0.965 ± 0.005	1.07MetPro: 1.07 ± 0.007	1.03MetGln: 1.03 ± 0.006	1.194MetArg: 1.194 ± 0.006	1.868MetSer: 1.868 ± 0.008	1.321MetThr: 1.321 ± 0.005	1.667MetVal: 1.667 ± 0.007	0.283MetTrp: 0.283 ± 0.003	0.694MetTyr: 0.694 ± 0.004	0.0MetXaa: 0.0 ± 0.0
Asn	2.166AsnAla: 2.166 ± 0.009	0.932AsnCys: 0.932 ± 0.006	1.768AsnAsp: 1.768 ± 0.009	2.153AsnGlu: 2.153 ± 0.007	1.527AsnPhe: 1.527 ± 0.007	2.749AsnGly: 2.749 ± 0.012	1.047AsnHis: 1.047 ± 0.005	2.381AsnIle: 2.381 ± 0.008	2.313AsnLys: 2.313 ± 0.009	3.82AsnLeu: 3.82 ± 0.011	1.1AsnMet: 1.1 ± 0.005	1.875AsnAsn: 1.875 ± 0.009	2.315AsnPro: 2.315 ± 0.011	1.816AsnGln: 1.816 ± 0.01	1.997AsnArg: 1.997 ± 0.007	3.224AsnSer: 3.224 ± 0.011	2.406AsnThr: 2.406 ± 0.01	2.37AsnVal: 2.37 ± 0.008	0.474AsnTrp: 0.474 ± 0.004	1.252AsnTyr: 1.252 ± 0.007	0.0AsnXaa: 0.0 ± 0.0
Pro	3.653ProAla: 3.653 ± 0.014	1.066ProCys: 1.066 ± 0.009	2.857ProAsp: 2.857 ± 0.011	3.595ProGlu: 3.595 ± 0.011	1.798ProPhe: 1.798 ± 0.008	3.783ProGly: 3.783 ± 0.02	1.467ProHis: 1.467 ± 0.008	1.97ProIle: 1.97 ± 0.008	2.455ProLys: 2.455 ± 0.013	4.738ProLeu: 4.738 ± 0.014	1.021ProMet: 1.021 ± 0.006	1.92ProAsn: 1.92 ± 0.008	4.824ProPro: 4.824 ± 0.042	2.51ProGln: 2.51 ± 0.013	2.498ProArg: 2.498 ± 0.009	5.005ProSer: 5.005 ± 0.018	2.941ProThr: 2.941 ± 0.013	3.658ProVal: 3.658 ± 0.015	0.558ProTrp: 0.558 ± 0.004	1.447ProTyr: 1.447 ± 0.008	0.0ProXaa: 0.0 ± 0.0
Gln	3.177GlnAla: 3.177 ± 0.013	1.066GlnCys: 1.066 ± 0.008	2.346GlnAsp: 2.346 ± 0.008	3.441GlnGlu: 3.441 ± 0.014	1.476GlnPhe: 1.476 ± 0.007	2.738GlnGly: 2.738 ± 0.011	1.376GlnHis: 1.376 ± 0.007	2.073GlnIle: 2.073 ± 0.008	2.609GlnLys: 2.609 ± 0.011	4.626GlnLeu: 4.626 ± 0.015	1.17GlnMet: 1.17 ± 0.006	1.799GlnAsn: 1.799 ± 0.008	2.411GlnPro: 2.411 ± 0.012	3.231GlnGln: 3.231 ± 0.025	2.965GlnArg: 2.965 ± 0.011	3.341GlnSer: 3.341 ± 0.011	2.516GlnThr: 2.516 ± 0.01	2.953GlnVal: 2.953 ± 0.011	0.582GlnTrp: 0.582 ± 0.004	1.361GlnTyr: 1.361 ± 0.006	0.0GlnXaa: 0.0 ± 0.0
Arg	3.267ArgAla: 3.267 ± 0.01	1.256ArgCys: 1.256 ± 0.008	2.916ArgAsp: 2.916 ± 0.01	3.752ArgGlu: 3.752 ± 0.015	1.997ArgPhe: 1.997 ± 0.008	3.218ArgGly: 3.218 ± 0.013	1.514ArgHis: 1.514 ± 0.007	2.531ArgIle: 2.531 ± 0.009	3.453ArgLys: 3.453 ± 0.011	5.323ArgLeu: 5.323 ± 0.016	1.299ArgMet: 1.299 ± 0.006	2.158ArgAsn: 2.158 ± 0.008	2.698ArgPro: 2.698 ± 0.011	2.666ArgGln: 2.666 ± 0.01	3.906ArgArg: 3.906 ± 0.014	4.079ArgSer: 4.079 ± 0.014	2.831ArgThr: 2.831 ± 0.009	3.318ArgVal: 3.318 ± 0.011	0.675ArgTrp: 0.675 ± 0.005	1.6ArgTyr: 1.6 ± 0.007	0.0ArgXaa: 0.0 ± 0.0
Ser	5.12SerAla: 5.12 ± 0.014	1.946SerCys: 1.946 ± 0.012	4.212SerAsp: 4.212 ± 0.014	4.632SerGlu: 4.632 ± 0.013	3.094SerPhe: 3.094 ± 0.011	5.328SerGly: 5.328 ± 0.017	2.188SerHis: 2.188 ± 0.009	3.49SerIle: 3.49 ± 0.01	3.919SerLys: 3.919 ± 0.013	8.15SerLeu: 8.15 ± 0.02	1.819SerMet: 1.819 ± 0.007	3.01SerAsn: 3.01 ± 0.01	5.312SerPro: 5.312 ± 0.023	3.737SerGln: 3.737 ± 0.012	4.185SerArg: 4.185 ± 0.013	9.244SerSer: 9.244 ± 0.034	4.715SerThr: 4.715 ± 0.014	5.388SerVal: 5.388 ± 0.015	0.977SerTrp: 0.977 ± 0.006	2.192SerTyr: 2.192 ± 0.008	0.0SerXaa: 0.0 ± 0.0
Thr	3.937ThrAla: 3.937 ± 0.012	1.415ThrCys: 1.415 ± 0.011	2.994ThrAsp: 2.994 ± 0.011	3.72ThrGlu: 3.72 ± 0.012	2.219ThrPhe: 2.219 ± 0.008	3.761ThrGly: 3.761 ± 0.013	1.489ThrHis: 1.489 ± 0.007	2.634ThrIle: 2.634 ± 0.009	2.729ThrLys: 2.729 ± 0.01	5.539ThrLeu: 5.539 ± 0.013	1.274ThrMet: 1.274 ± 0.005	2.028ThrAsn: 2.028 ± 0.008	3.462ThrPro: 3.462 ± 0.015	2.402ThrGln: 2.402 ± 0.01	2.432ThrArg: 2.432 ± 0.008	4.668ThrSer: 4.668 ± 0.015	3.396ThrThr: 3.396 ± 0.028	4.331ThrVal: 4.331 ± 0.012	0.691ThrTrp: 0.691 ± 0.005	1.572ThrTyr: 1.572 ± 0.008	0.0ThrXaa: 0.0 ± 0.0
Val	4.169ValAla: 4.169 ± 0.013	1.794ValCys: 1.794 ± 0.009	3.305ValAsp: 3.305 ± 0.013	4.039ValGlu: 4.039 ± 0.012	2.822ValPhe: 2.822 ± 0.012	3.567ValGly: 3.567 ± 0.011	1.632ValHis: 1.632 ± 0.006	3.224ValIle: 3.224 ± 0.009	3.7ValLys: 3.7 ± 0.013	6.41ValLeu: 6.41 ± 0.014	1.609ValMet: 1.609 ± 0.008	2.584ValAsn: 2.584 ± 0.01	3.195ValPro: 3.195 ± 0.012	2.824ValGln: 2.824 ± 0.01	3.354ValArg: 3.354 ± 0.01	5.278ValSer: 5.278 ± 0.016	4.05ValThr: 4.05 ± 0.013	4.517ValVal: 4.517 ± 0.014	0.813ValTrp: 0.813 ± 0.006	1.939ValTyr: 1.939 ± 0.007	0.0ValXaa: 0.0 ± 0.0
Trp	0.7TrpAla: 0.7 ± 0.005	0.275TrpCys: 0.275 ± 0.003	0.677TrpAsp: 0.677 ± 0.006	0.773TrpGlu: 0.773 ± 0.005	0.483TrpPhe: 0.483 ± 0.004	0.627TrpGly: 0.627 ± 0.004	0.278TrpHis: 0.278 ± 0.003	0.591TrpIle: 0.591 ± 0.004	0.748TrpLys: 0.748 ± 0.005	1.207TrpLeu: 1.207 ± 0.007	0.355TrpMet: 0.355 ± 0.003	0.54TrpAsn: 0.54 ± 0.004	0.441TrpPro: 0.441 ± 0.004	0.525TrpGln: 0.525 ± 0.004	0.723TrpArg: 0.723 ± 0.005	0.954TrpSer: 0.954 ± 0.006	0.73TrpThr: 0.73 ± 0.005	0.737TrpVal: 0.737 ± 0.006	0.209TrpTrp: 0.209 ± 0.003	0.369TrpTyr: 0.369 ± 0.003	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.496TyrAla: 1.496 ± 0.007	0.784TyrCys: 0.784 ± 0.005	1.469TyrAsp: 1.469 ± 0.008	1.718TyrGlu: 1.718 ± 0.007	1.322TyrPhe: 1.322 ± 0.006	1.764TyrGly: 1.764 ± 0.01	0.845TyrHis: 0.845 ± 0.004	1.673TyrIle: 1.673 ± 0.008	1.609TyrLys: 1.609 ± 0.008	2.863TyrLeu: 2.863 ± 0.01	0.741TyrMet: 0.741 ± 0.004	1.296TyrAsn: 1.296 ± 0.006	1.334TyrPro: 1.334 ± 0.007	1.314TyrGln: 1.314 ± 0.006	1.761TyrArg: 1.761 ± 0.009	2.41TyrSer: 2.41 ± 0.009	1.785TyrThr: 1.785 ± 0.008	1.715TyrVal: 1.715 ± 0.007	0.421TyrTrp: 0.421 ± 0.004	1.081TyrTyr: 1.081 ± 0.006	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 59116 proteins (40357664 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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