Amino acid dipepetide frequency for Mycoplasma canadense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.203AlaAla: 2.203 ± 0.164
0.287AlaCys: 0.287 ± 0.036
1.767AlaAsp: 1.767 ± 0.1
2.602AlaGlu: 2.602 ± 0.147
2.413AlaPhe: 2.413 ± 0.133
2.044AlaGly: 2.044 ± 0.135
0.62AlaHis: 0.62 ± 0.071
5.394AlaIle: 5.394 ± 0.195
5.809AlaLys: 5.809 ± 0.226
4.231AlaLeu: 4.231 ± 0.177
0.871AlaMet: 0.871 ± 0.078
3.555AlaAsn: 3.555 ± 0.149
1.086AlaPro: 1.086 ± 0.083
1.511AlaGln: 1.511 ± 0.106
1.547AlaArg: 1.547 ± 0.098
2.981AlaSer: 2.981 ± 0.164
2.587AlaThr: 2.587 ± 0.132
1.931AlaVal: 1.931 ± 0.13
0.297AlaTrp: 0.297 ± 0.044
1.88AlaTyr: 1.88 ± 0.106
0.0AlaXaa: 0.0 ± 0.0
Cys
0.302CysAla: 0.302 ± 0.042
0.102CysCys: 0.102 ± 0.021
0.302CysAsp: 0.302 ± 0.038
0.369CysGlu: 0.369 ± 0.044
0.348CysPhe: 0.348 ± 0.054
0.338CysGly: 0.338 ± 0.04
0.087CysHis: 0.087 ± 0.024
0.389CysIle: 0.389 ± 0.054
0.42CysLys: 0.42 ± 0.052
0.558CysLeu: 0.558 ± 0.061
0.041CysMet: 0.041 ± 0.014
0.277CysAsn: 0.277 ± 0.044
0.179CysPro: 0.179 ± 0.031
0.138CysGln: 0.138 ± 0.027
0.097CysArg: 0.097 ± 0.026
0.43CysSer: 0.43 ± 0.047
0.154CysThr: 0.154 ± 0.031
0.236CysVal: 0.236 ± 0.036
0.041CysTrp: 0.041 ± 0.015
0.133CysTyr: 0.133 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
2.438AspAla: 2.438 ± 0.146
0.169AspCys: 0.169 ± 0.031
2.459AspAsp: 2.459 ± 0.126
4.252AspGlu: 4.252 ± 0.17
3.975AspPhe: 3.975 ± 0.179
2.228AspGly: 2.228 ± 0.135
0.645AspHis: 0.645 ± 0.053
5.245AspIle: 5.245 ± 0.174
5.415AspLys: 5.415 ± 0.209
5.886AspLeu: 5.886 ± 0.224
0.656AspMet: 0.656 ± 0.06
4.298AspAsn: 4.298 ± 0.156
1.48AspPro: 1.48 ± 0.088
1.455AspGln: 1.455 ± 0.108
1.204AspArg: 1.204 ± 0.075
3.12AspSer: 3.12 ± 0.135
2.198AspThr: 2.198 ± 0.113
2.561AspVal: 2.561 ± 0.129
0.604AspTrp: 0.604 ± 0.058
2.52AspTyr: 2.52 ± 0.117
0.0AspXaa: 0.0 ± 0.0
Glu
3.888GluAla: 3.888 ± 0.233
0.21GluCys: 0.21 ± 0.036
3.56GluAsp: 3.56 ± 0.159
6.173GluGlu: 6.173 ± 0.303
4.067GluPhe: 4.067 ± 0.134
2.536GluGly: 2.536 ± 0.118
0.743GluHis: 0.743 ± 0.061
9.728GluIle: 9.728 ± 0.338
9.482GluLys: 9.482 ± 0.277
6.972GluLeu: 6.972 ± 0.271
1.168GluMet: 1.168 ± 0.09
7.161GluAsn: 7.161 ± 0.26
1.342GluPro: 1.342 ± 0.085
2.479GluGln: 2.479 ± 0.137
1.772GluArg: 1.772 ± 0.116
3.366GluSer: 3.366 ± 0.146
3.35GluThr: 3.35 ± 0.13
3.237GluVal: 3.237 ± 0.16
0.594GluTrp: 0.594 ± 0.059
3.079GluTyr: 3.079 ± 0.123
0.0GluXaa: 0.0 ± 0.0
Phe
2.459PheAla: 2.459 ± 0.12
0.451PheCys: 0.451 ± 0.054
3.698PheAsp: 3.698 ± 0.155
4.405PheGlu: 4.405 ± 0.152
3.15PhePhe: 3.15 ± 0.181
2.613PheGly: 2.613 ± 0.139
0.507PheHis: 0.507 ± 0.055
5.466PheIle: 5.466 ± 0.25
6.132PheLys: 6.132 ± 0.226
5.645PheLeu: 5.645 ± 0.278
0.727PheMet: 0.727 ± 0.058
4.784PheAsn: 4.784 ± 0.195
1.081PhePro: 1.081 ± 0.083
1.347PheGln: 1.347 ± 0.09
1.24PheArg: 1.24 ± 0.067
4.298PheSer: 4.298 ± 0.213
2.136PheThr: 2.136 ± 0.13
2.705PheVal: 2.705 ± 0.117
0.543PheTrp: 0.543 ± 0.068
2.172PheTyr: 2.172 ± 0.129
0.0PheXaa: 0.0 ± 0.0
Gly
2.182GlyAla: 2.182 ± 0.138
0.174GlyCys: 0.174 ± 0.032
2.095GlyAsp: 2.095 ± 0.13
2.331GlyGlu: 2.331 ± 0.117
2.525GlyPhe: 2.525 ± 0.101
2.597GlyGly: 2.597 ± 0.156
0.943GlyHis: 0.943 ± 0.082
4.492GlyIle: 4.492 ± 0.159
4.272GlyLys: 4.272 ± 0.177
3.739GlyLeu: 3.739 ± 0.19
0.794GlyMet: 0.794 ± 0.06
2.484GlyAsn: 2.484 ± 0.111
0.866GlyPro: 0.866 ± 0.08
1.378GlyGln: 1.378 ± 0.084
1.337GlyArg: 1.337 ± 0.105
2.904GlySer: 2.904 ± 0.149
2.029GlyThr: 2.029 ± 0.105
2.433GlyVal: 2.433 ± 0.154
0.405GlyTrp: 0.405 ± 0.043
1.993GlyTyr: 1.993 ± 0.116
0.0GlyXaa: 0.0 ± 0.0
His
0.671HisAla: 0.671 ± 0.052
0.072HisCys: 0.072 ± 0.021
0.599HisAsp: 0.599 ± 0.058
0.871HisGlu: 0.871 ± 0.069
0.635HisPhe: 0.635 ± 0.057
0.686HisGly: 0.686 ± 0.058
0.231HisHis: 0.231 ± 0.036
1.229HisIle: 1.229 ± 0.065
1.178HisLys: 1.178 ± 0.077
1.183HisLeu: 1.183 ± 0.076
0.164HisMet: 0.164 ± 0.026
0.886HisAsn: 0.886 ± 0.063
0.451HisPro: 0.451 ± 0.055
0.348HisGln: 0.348 ± 0.047
0.369HisArg: 0.369 ± 0.038
0.907HisSer: 0.907 ± 0.067
0.528HisThr: 0.528 ± 0.058
0.61HisVal: 0.61 ± 0.063
0.19HisTrp: 0.19 ± 0.032
0.543HisTyr: 0.543 ± 0.055
0.0HisXaa: 0.0 ± 0.0
Ile
4.959IleAla: 4.959 ± 0.178
0.645IleCys: 0.645 ± 0.065
6.352IleAsp: 6.352 ± 0.226
8.078IleGlu: 8.078 ± 0.223
5.783IlePhe: 5.783 ± 0.268
4.226IleGly: 4.226 ± 0.173
1.183IleHis: 1.183 ± 0.074
10.081IleIle: 10.081 ± 0.341
12.263IleLys: 12.263 ± 0.325
9.764IleLeu: 9.764 ± 0.324
1.357IleMet: 1.357 ± 0.084
10.076IleAsn: 10.076 ± 0.318
3.058IlePro: 3.058 ± 0.164
2.889IleGln: 2.889 ± 0.12
2.423IleArg: 2.423 ± 0.124
8.278IleSer: 8.278 ± 0.26
4.738IleThr: 4.738 ± 0.181
4.979IleVal: 4.979 ± 0.197
0.743IleTrp: 0.743 ± 0.077
3.903IleTyr: 3.903 ± 0.13
0.0IleXaa: 0.0 ± 0.0
Lys
4.503LysAla: 4.503 ± 0.17
0.374LysCys: 0.374 ± 0.054
6.075LysAsp: 6.075 ± 0.24
10.455LysGlu: 10.455 ± 0.378
5.056LysPhe: 5.056 ± 0.162
3.115LysGly: 3.115 ± 0.132
1.224LysHis: 1.224 ± 0.084
13.57LysIle: 13.57 ± 0.359
14.2LysLys: 14.2 ± 0.385
9.764LysLeu: 9.764 ± 0.284
2.587LysMet: 2.587 ± 0.123
13.052LysAsn: 13.052 ± 0.444
2.628LysPro: 2.628 ± 0.129
4.252LysGln: 4.252 ± 0.184
3.176LysArg: 3.176 ± 0.148
6.08LysSer: 6.08 ± 0.196
5.824LysThr: 5.824 ± 0.183
4.39LysVal: 4.39 ± 0.144
1.019LysTrp: 1.019 ± 0.094
5.128LysTyr: 5.128 ± 0.158
0.0LysXaa: 0.0 ± 0.0
Leu
4.554LeuAla: 4.554 ± 0.16
0.471LeuCys: 0.471 ± 0.048
5.548LeuAsp: 5.548 ± 0.185
7.213LeuGlu: 7.213 ± 0.28
5.292LeuPhe: 5.292 ± 0.226
4.277LeuGly: 4.277 ± 0.179
1.122LeuHis: 1.122 ± 0.078
10.091LeuIle: 10.091 ± 0.328
11.013LeuLys: 11.013 ± 0.285
8.591LeuLeu: 8.591 ± 0.231
1.347LeuMet: 1.347 ± 0.097
8.883LeuAsn: 8.883 ± 0.309
2.546LeuPro: 2.546 ± 0.115
2.213LeuGln: 2.213 ± 0.093
2.459LeuArg: 2.459 ± 0.108
6.997LeuSer: 6.997 ± 0.186
4.749LeuThr: 4.749 ± 0.166
5.133LeuVal: 5.133 ± 0.175
0.558LeuTrp: 0.558 ± 0.057
2.812LeuTyr: 2.812 ± 0.118
0.0LeuXaa: 0.0 ± 0.0
Met
0.953MetAla: 0.953 ± 0.081
0.061MetCys: 0.061 ± 0.017
0.661MetAsp: 0.661 ± 0.068
0.82MetGlu: 0.82 ± 0.071
0.82MetPhe: 0.82 ± 0.066
0.615MetGly: 0.615 ± 0.065
0.231MetHis: 0.231 ± 0.038
1.465MetIle: 1.465 ± 0.109
1.988MetLys: 1.988 ± 0.1
1.434MetLeu: 1.434 ± 0.1
0.318MetMet: 0.318 ± 0.039
1.163MetAsn: 1.163 ± 0.081
0.651MetPro: 0.651 ± 0.053
0.517MetGln: 0.517 ± 0.059
0.43MetArg: 0.43 ± 0.055
1.183MetSer: 1.183 ± 0.083
0.717MetThr: 0.717 ± 0.061
0.722MetVal: 0.722 ± 0.08
0.159MetTrp: 0.159 ± 0.028
0.502MetTyr: 0.502 ± 0.057
0.0MetXaa: 0.0 ± 0.0
Asn
3.253AsnAla: 3.253 ± 0.14
0.287AsnCys: 0.287 ± 0.04
4.82AsnAsp: 4.82 ± 0.187
7.218AsnGlu: 7.218 ± 0.262
4.907AsnPhe: 4.907 ± 0.195
3.155AsnGly: 3.155 ± 0.137
0.943AsnHis: 0.943 ± 0.064
9.031AsnIle: 9.031 ± 0.255
12.012AsnLys: 12.012 ± 0.376
9.405AsnLeu: 9.405 ± 0.381
1.076AsnMet: 1.076 ± 0.076
8.724AsnAsn: 8.724 ± 0.367
2.464AsnPro: 2.464 ± 0.12
3.125AsnGln: 3.125 ± 0.121
1.465AsnArg: 1.465 ± 0.102
5.66AsnSer: 5.66 ± 0.201
3.109AsnThr: 3.109 ± 0.15
3.509AsnVal: 3.509 ± 0.131
0.855AsnTrp: 0.855 ± 0.07
3.658AsnTyr: 3.658 ± 0.146
0.0AsnXaa: 0.0 ± 0.0
Pro
1.158ProAla: 1.158 ± 0.084
0.174ProCys: 0.174 ± 0.037
1.24ProAsp: 1.24 ± 0.082
2.003ProGlu: 2.003 ± 0.115
1.419ProPhe: 1.419 ± 0.09
1.219ProGly: 1.219 ± 0.079
0.4ProHis: 0.4 ± 0.04
2.705ProIle: 2.705 ± 0.127
2.648ProLys: 2.648 ± 0.125
2.274ProLeu: 2.274 ± 0.122
0.307ProMet: 0.307 ± 0.037
1.921ProAsn: 1.921 ± 0.094
0.476ProPro: 0.476 ± 0.055
0.82ProGln: 0.82 ± 0.073
0.599ProArg: 0.599 ± 0.061
1.69ProSer: 1.69 ± 0.099
1.644ProThr: 1.644 ± 0.097
1.255ProVal: 1.255 ± 0.098
0.302ProTrp: 0.302 ± 0.043
1.081ProTyr: 1.081 ± 0.076
0.0ProXaa: 0.0 ± 0.0
Gln
1.45GlnAla: 1.45 ± 0.097
0.072GlnCys: 0.072 ± 0.02
1.486GlnAsp: 1.486 ± 0.1
2.274GlnGlu: 2.274 ± 0.121
1.552GlnPhe: 1.552 ± 0.09
1.05GlnGly: 1.05 ± 0.068
0.359GlnHis: 0.359 ± 0.044
3.514GlnIle: 3.514 ± 0.171
4.359GlnLys: 4.359 ± 0.193
2.618GlnLeu: 2.618 ± 0.117
0.497GlnMet: 0.497 ± 0.052
2.925GlnAsn: 2.925 ± 0.133
0.599GlnPro: 0.599 ± 0.062
0.896GlnGln: 0.896 ± 0.068
1.009GlnArg: 1.009 ± 0.07
1.465GlnSer: 1.465 ± 0.076
1.798GlnThr: 1.798 ± 0.105
1.27GlnVal: 1.27 ± 0.091
0.241GlnTrp: 0.241 ± 0.037
1.265GlnTyr: 1.265 ± 0.076
0.0GlnXaa: 0.0 ± 0.0
Arg
1.296ArgAla: 1.296 ± 0.083
0.159ArgCys: 0.159 ± 0.026
1.281ArgAsp: 1.281 ± 0.095
1.778ArgGlu: 1.778 ± 0.12
1.183ArgPhe: 1.183 ± 0.086
1.255ArgGly: 1.255 ± 0.105
0.353ArgHis: 0.353 ± 0.044
2.623ArgIle: 2.623 ± 0.129
2.782ArgLys: 2.782 ± 0.12
2.469ArgLeu: 2.469 ± 0.121
0.487ArgMet: 0.487 ± 0.061
2.07ArgAsn: 2.07 ± 0.107
0.656ArgPro: 0.656 ± 0.053
0.943ArgGln: 0.943 ± 0.059
0.932ArgArg: 0.932 ± 0.083
1.501ArgSer: 1.501 ± 0.094
1.178ArgThr: 1.178 ± 0.08
1.486ArgVal: 1.486 ± 0.092
0.195ArgTrp: 0.195 ± 0.031
1.117ArgTyr: 1.117 ± 0.076
0.0ArgXaa: 0.0 ± 0.0
Ser
2.572SerAla: 2.572 ± 0.134
0.517SerCys: 0.517 ± 0.056
3.294SerAsp: 3.294 ± 0.145
4.544SerGlu: 4.544 ± 0.177
4.472SerPhe: 4.472 ± 0.215
2.945SerGly: 2.945 ± 0.158
0.763SerHis: 0.763 ± 0.063
6.562SerIle: 6.562 ± 0.225
7.756SerLys: 7.756 ± 0.204
7.033SerLeu: 7.033 ± 0.234
0.881SerMet: 0.881 ± 0.067
5.035SerAsn: 5.035 ± 0.177
1.757SerPro: 1.757 ± 0.095
2.136SerGln: 2.136 ± 0.109
1.757SerArg: 1.757 ± 0.101
4.923SerSer: 4.923 ± 0.216
2.92SerThr: 2.92 ± 0.117
2.889SerVal: 2.889 ± 0.15
0.553SerTrp: 0.553 ± 0.051
2.597SerTyr: 2.597 ± 0.129
0.0SerXaa: 0.0 ± 0.0
Thr
1.982ThrAla: 1.982 ± 0.113
0.149ThrCys: 0.149 ± 0.026
1.993ThrAsp: 1.993 ± 0.096
2.73ThrGlu: 2.73 ± 0.146
2.628ThrPhe: 2.628 ± 0.139
2.28ThrGly: 2.28 ± 0.135
0.804ThrHis: 0.804 ± 0.063
5.276ThrIle: 5.276 ± 0.158
5.194ThrLys: 5.194 ± 0.176
4.718ThrLeu: 4.718 ± 0.159
0.666ThrMet: 0.666 ± 0.06
3.996ThrAsn: 3.996 ± 0.154
1.532ThrPro: 1.532 ± 0.093
1.393ThrGln: 1.393 ± 0.089
1.368ThrArg: 1.368 ± 0.091
3.273ThrSer: 3.273 ± 0.157
2.582ThrThr: 2.582 ± 0.133
2.049ThrVal: 2.049 ± 0.116
0.348ThrTrp: 0.348 ± 0.045
1.737ThrTyr: 1.737 ± 0.091
0.0ThrXaa: 0.0 ± 0.0
Val
2.556ValAla: 2.556 ± 0.145
0.297ValCys: 0.297 ± 0.042
2.741ValAsp: 2.741 ± 0.149
3.335ValGlu: 3.335 ± 0.137
2.443ValPhe: 2.443 ± 0.126
2.474ValGly: 2.474 ± 0.137
0.528ValHis: 0.528 ± 0.057
4.539ValIle: 4.539 ± 0.153
4.339ValLys: 4.339 ± 0.169
4.462ValLeu: 4.462 ± 0.168
0.748ValMet: 0.748 ± 0.066
3.371ValAsn: 3.371 ± 0.138
1.142ValPro: 1.142 ± 0.083
1.229ValGln: 1.229 ± 0.075
1.214ValArg: 1.214 ± 0.081
3.514ValSer: 3.514 ± 0.148
2.239ValThr: 2.239 ± 0.122
2.797ValVal: 2.797 ± 0.136
0.471ValTrp: 0.471 ± 0.054
1.947ValTyr: 1.947 ± 0.109
0.0ValXaa: 0.0 ± 0.0
Trp
0.348TrpAla: 0.348 ± 0.045
0.036TrpCys: 0.036 ± 0.013
0.497TrpAsp: 0.497 ± 0.05
0.476TrpGlu: 0.476 ± 0.052
0.482TrpPhe: 0.482 ± 0.053
0.405TrpGly: 0.405 ± 0.049
0.102TrpHis: 0.102 ± 0.024
0.927TrpIle: 0.927 ± 0.079
0.917TrpLys: 0.917 ± 0.068
0.814TrpLeu: 0.814 ± 0.067
0.236TrpMet: 0.236 ± 0.034
0.814TrpAsn: 0.814 ± 0.076
0.241TrpPro: 0.241 ± 0.039
0.215TrpGln: 0.215 ± 0.032
0.246TrpArg: 0.246 ± 0.037
0.523TrpSer: 0.523 ± 0.055
0.441TrpThr: 0.441 ± 0.05
0.502TrpVal: 0.502 ± 0.056
0.087TrpTrp: 0.087 ± 0.02
0.359TrpTyr: 0.359 ± 0.039
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.89TyrAla: 1.89 ± 0.109
0.236TyrCys: 0.236 ± 0.041
2.341TyrAsp: 2.341 ± 0.116
2.981TyrGlu: 2.981 ± 0.099
2.408TyrPhe: 2.408 ± 0.13
1.916TyrGly: 1.916 ± 0.108
0.563TyrHis: 0.563 ± 0.046
3.453TyrIle: 3.453 ± 0.134
4.293TyrLys: 4.293 ± 0.15
4.308TyrLeu: 4.308 ± 0.146
0.476TyrMet: 0.476 ± 0.049
3.202TyrAsn: 3.202 ± 0.128
1.101TyrPro: 1.101 ± 0.073
1.419TyrGln: 1.419 ± 0.086
1.096TyrArg: 1.096 ± 0.072
2.812TyrSer: 2.812 ± 0.122
1.778TyrThr: 1.778 ± 0.088
1.69TyrVal: 1.69 ± 0.107
0.461TyrTrp: 0.461 ± 0.054
1.778TyrTyr: 1.778 ± 0.125
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 481 proteins (195216 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski