Amino acid dipepetide frequency for Bacteroidales bacterium CF

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.24AlaAla: 5.24 ± 0.087
0.771AlaCys: 0.771 ± 0.033
3.563AlaAsp: 3.563 ± 0.065
4.311AlaGlu: 4.311 ± 0.09
2.955AlaPhe: 2.955 ± 0.06
5.319AlaGly: 5.319 ± 0.092
1.026AlaHis: 1.026 ± 0.036
5.307AlaIle: 5.307 ± 0.096
4.416AlaLys: 4.416 ± 0.081
6.529AlaLeu: 6.529 ± 0.108
1.696AlaMet: 1.696 ± 0.046
3.035AlaAsn: 3.035 ± 0.071
2.039AlaPro: 2.039 ± 0.053
2.057AlaGln: 2.057 ± 0.057
2.843AlaArg: 2.843 ± 0.074
4.502AlaSer: 4.502 ± 0.079
3.63AlaThr: 3.63 ± 0.068
4.632AlaVal: 4.632 ± 0.08
0.572AlaTrp: 0.572 ± 0.024
2.594AlaTyr: 2.594 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.607CysAla: 0.607 ± 0.029
0.155CysCys: 0.155 ± 0.013
0.593CysAsp: 0.593 ± 0.027
0.678CysGlu: 0.678 ± 0.028
0.454CysPhe: 0.454 ± 0.028
1.002CysGly: 1.002 ± 0.038
0.229CysHis: 0.229 ± 0.018
0.746CysIle: 0.746 ± 0.031
0.667CysLys: 0.667 ± 0.029
0.746CysLeu: 0.746 ± 0.031
0.244CysMet: 0.244 ± 0.017
0.525CysAsn: 0.525 ± 0.027
0.464CysPro: 0.464 ± 0.024
0.254CysGln: 0.254 ± 0.018
0.52CysArg: 0.52 ± 0.023
0.837CysSer: 0.837 ± 0.033
0.623CysThr: 0.623 ± 0.028
0.58CysVal: 0.58 ± 0.032
0.087CysTrp: 0.087 ± 0.012
0.434CysTyr: 0.434 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
3.276AspAla: 3.276 ± 0.068
0.496AspCys: 0.496 ± 0.025
2.307AspAsp: 2.307 ± 0.065
3.402AspGlu: 3.402 ± 0.077
3.039AspPhe: 3.039 ± 0.063
3.552AspGly: 3.552 ± 0.077
0.739AspHis: 0.739 ± 0.029
4.757AspIle: 4.757 ± 0.082
4.316AspLys: 4.316 ± 0.077
4.818AspLeu: 4.818 ± 0.085
1.428AspMet: 1.428 ± 0.04
3.054AspAsn: 3.054 ± 0.069
1.988AspPro: 1.988 ± 0.056
1.368AspGln: 1.368 ± 0.046
2.227AspArg: 2.227 ± 0.059
3.616AspSer: 3.616 ± 0.089
2.663AspThr: 2.663 ± 0.059
3.262AspVal: 3.262 ± 0.062
0.622AspTrp: 0.622 ± 0.031
2.761AspTyr: 2.761 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
4.206GluAla: 4.206 ± 0.085
0.593GluCys: 0.593 ± 0.032
2.955GluAsp: 2.955 ± 0.07
4.77GluGlu: 4.77 ± 0.103
2.667GluPhe: 2.667 ± 0.052
3.982GluGly: 3.982 ± 0.072
1.029GluHis: 1.029 ± 0.033
5.679GluIle: 5.679 ± 0.089
5.909GluLys: 5.909 ± 0.101
6.128GluLeu: 6.128 ± 0.093
1.929GluMet: 1.929 ± 0.054
3.746GluAsn: 3.746 ± 0.068
1.732GluPro: 1.732 ± 0.053
2.203GluGln: 2.203 ± 0.055
3.485GluArg: 3.485 ± 0.074
4.082GluSer: 4.082 ± 0.073
3.065GluThr: 3.065 ± 0.056
3.925GluVal: 3.925 ± 0.081
0.721GluTrp: 0.721 ± 0.034
2.673GluTyr: 2.673 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
3.177PheAla: 3.177 ± 0.066
0.505PheCys: 0.505 ± 0.024
2.781PheAsp: 2.781 ± 0.06
2.719PheGlu: 2.719 ± 0.055
2.365PhePhe: 2.365 ± 0.056
3.369PheGly: 3.369 ± 0.068
0.695PheHis: 0.695 ± 0.032
3.721PheIle: 3.721 ± 0.066
2.843PheLys: 2.843 ± 0.06
4.121PheLeu: 4.121 ± 0.075
1.273PheMet: 1.273 ± 0.039
2.676PheAsn: 2.676 ± 0.064
1.744PhePro: 1.744 ± 0.048
1.075PheGln: 1.075 ± 0.036
2.234PheArg: 2.234 ± 0.055
3.956PheSer: 3.956 ± 0.091
2.741PheThr: 2.741 ± 0.061
3.012PheVal: 3.012 ± 0.063
0.532PheTrp: 0.532 ± 0.026
1.932PheTyr: 1.932 ± 0.06
0.0PheXaa: 0.0 ± 0.0
Gly
4.521GlyAla: 4.521 ± 0.093
0.835GlyCys: 0.835 ± 0.038
3.359GlyAsp: 3.359 ± 0.068
4.286GlyGlu: 4.286 ± 0.082
3.545GlyPhe: 3.545 ± 0.064
4.805GlyGly: 4.805 ± 0.099
1.101GlyHis: 1.101 ± 0.042
5.794GlyIle: 5.794 ± 0.096
5.587GlyLys: 5.587 ± 0.086
5.813GlyLeu: 5.813 ± 0.09
1.943GlyMet: 1.943 ± 0.053
3.268GlyAsn: 3.268 ± 0.068
1.42GlyPro: 1.42 ± 0.043
1.727GlyGln: 1.727 ± 0.05
2.854GlyArg: 2.854 ± 0.062
4.505GlySer: 4.505 ± 0.091
3.847GlyThr: 3.847 ± 0.08
4.964GlyVal: 4.964 ± 0.086
0.799GlyTrp: 0.799 ± 0.031
3.281GlyTyr: 3.281 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
0.887HisAla: 0.887 ± 0.037
0.207HisCys: 0.207 ± 0.017
0.751HisAsp: 0.751 ± 0.027
0.847HisGlu: 0.847 ± 0.03
0.92HisPhe: 0.92 ± 0.031
0.99HisGly: 0.99 ± 0.036
0.338HisHis: 0.338 ± 0.025
1.348HisIle: 1.348 ± 0.039
1.064HisLys: 1.064 ± 0.038
1.46HisLeu: 1.46 ± 0.045
0.361HisMet: 0.361 ± 0.02
0.875HisAsn: 0.875 ± 0.029
0.845HisPro: 0.845 ± 0.037
0.461HisGln: 0.461 ± 0.028
0.713HisArg: 0.713 ± 0.034
1.073HisSer: 1.073 ± 0.036
0.83HisThr: 0.83 ± 0.032
0.72HisVal: 0.72 ± 0.025
0.142HisTrp: 0.142 ± 0.013
0.768HisTyr: 0.768 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.662IleAla: 5.662 ± 0.095
0.965IleCys: 0.965 ± 0.038
4.849IleAsp: 4.849 ± 0.096
5.245IleGlu: 5.245 ± 0.086
3.627IlePhe: 3.627 ± 0.076
4.924IleGly: 4.924 ± 0.094
1.3IleHis: 1.3 ± 0.039
6.151IleIle: 6.151 ± 0.104
5.619IleLys: 5.619 ± 0.08
7.028IleLeu: 7.028 ± 0.108
1.769IleMet: 1.769 ± 0.047
4.111IleAsn: 4.111 ± 0.082
3.615IlePro: 3.615 ± 0.067
2.072IleGln: 2.072 ± 0.05
3.39IleArg: 3.39 ± 0.067
6.503IleSer: 6.503 ± 0.095
4.462IleThr: 4.462 ± 0.069
4.987IleVal: 4.987 ± 0.086
0.651IleTrp: 0.651 ± 0.03
2.927IleTyr: 2.927 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
4.724LysAla: 4.724 ± 0.09
0.623LysCys: 0.623 ± 0.029
4.082LysAsp: 4.082 ± 0.086
5.96LysGlu: 5.96 ± 0.098
2.799LysPhe: 2.799 ± 0.05
5.014LysGly: 5.014 ± 0.083
1.026LysHis: 1.026 ± 0.035
5.886LysIle: 5.886 ± 0.091
5.27LysLys: 5.27 ± 0.1
5.929LysLeu: 5.929 ± 0.086
2.321LysMet: 2.321 ± 0.054
3.863LysAsn: 3.863 ± 0.077
2.331LysPro: 2.331 ± 0.055
2.065LysGln: 2.065 ± 0.059
3.533LysArg: 3.533 ± 0.067
5.044LysSer: 5.044 ± 0.092
3.451LysThr: 3.451 ± 0.067
4.554LysVal: 4.554 ± 0.086
0.799LysTrp: 0.799 ± 0.028
3.188LysTyr: 3.188 ± 0.065
0.0LysXaa: 0.0 ± 0.0
Leu
6.096LeuAla: 6.096 ± 0.088
1.03LeuCys: 1.03 ± 0.036
4.851LeuAsp: 4.851 ± 0.086
5.499LeuGlu: 5.499 ± 0.101
4.711LeuPhe: 4.711 ± 0.095
5.762LeuGly: 5.762 ± 0.094
1.322LeuHis: 1.322 ± 0.039
6.877LeuIle: 6.877 ± 0.121
7.002LeuLys: 7.002 ± 0.099
8.704LeuLeu: 8.704 ± 0.132
2.347LeuMet: 2.347 ± 0.06
4.599LeuAsn: 4.599 ± 0.076
3.834LeuPro: 3.834 ± 0.07
2.629LeuGln: 2.629 ± 0.064
3.945LeuArg: 3.945 ± 0.08
7.566LeuSer: 7.566 ± 0.104
4.982LeuThr: 4.982 ± 0.077
5.092LeuVal: 5.092 ± 0.082
0.888LeuTrp: 0.888 ± 0.033
3.6LeuTyr: 3.6 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
1.937MetAla: 1.937 ± 0.054
0.188MetCys: 0.188 ± 0.017
1.491MetAsp: 1.491 ± 0.043
1.739MetGlu: 1.739 ± 0.048
1.002MetPhe: 1.002 ± 0.036
1.72MetGly: 1.72 ± 0.044
0.407MetHis: 0.407 ± 0.024
1.894MetIle: 1.894 ± 0.049
2.247MetLys: 2.247 ± 0.048
2.42MetLeu: 2.42 ± 0.057
0.711MetMet: 0.711 ± 0.032
1.564MetAsn: 1.564 ± 0.047
1.071MetPro: 1.071 ± 0.039
0.83MetGln: 0.83 ± 0.028
1.144MetArg: 1.144 ± 0.036
1.768MetSer: 1.768 ± 0.043
1.435MetThr: 1.435 ± 0.045
1.613MetVal: 1.613 ± 0.047
0.203MetTrp: 0.203 ± 0.014
0.79MetTyr: 0.79 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.176AsnAla: 3.176 ± 0.064
0.496AsnCys: 0.496 ± 0.025
2.535AsnAsp: 2.535 ± 0.056
2.937AsnGlu: 2.937 ± 0.067
2.373AsnPhe: 2.373 ± 0.056
3.585AsnGly: 3.585 ± 0.07
0.784AsnHis: 0.784 ± 0.03
4.468AsnIle: 4.468 ± 0.077
3.497AsnLys: 3.497 ± 0.07
4.786AsnLeu: 4.786 ± 0.085
1.377AsnMet: 1.377 ± 0.046
2.87AsnAsn: 2.87 ± 0.073
2.762AsnPro: 2.762 ± 0.062
1.624AsnGln: 1.624 ± 0.048
2.378AsnArg: 2.378 ± 0.057
3.533AsnSer: 3.533 ± 0.078
2.837AsnThr: 2.837 ± 0.065
2.939AsnVal: 2.939 ± 0.071
0.598AsnTrp: 0.598 ± 0.03
2.327AsnTyr: 2.327 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
2.719ProAla: 2.719 ± 0.063
0.308ProCys: 0.308 ± 0.019
2.566ProAsp: 2.566 ± 0.055
3.288ProGlu: 3.288 ± 0.067
1.8ProPhe: 1.8 ± 0.044
2.482ProGly: 2.482 ± 0.058
0.615ProHis: 0.615 ± 0.028
2.249ProIle: 2.249 ± 0.055
2.087ProLys: 2.087 ± 0.057
3.314ProLeu: 3.314 ± 0.068
0.804ProMet: 0.804 ± 0.031
1.445ProAsn: 1.445 ± 0.04
0.839ProPro: 0.839 ± 0.036
1.287ProGln: 1.287 ± 0.041
1.17ProArg: 1.17 ± 0.036
2.439ProSer: 2.439 ± 0.062
1.745ProThr: 1.745 ± 0.048
3.18ProVal: 3.18 ± 0.071
0.329ProTrp: 0.329 ± 0.02
1.556ProTyr: 1.556 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
1.857GlnAla: 1.857 ± 0.053
0.236GlnCys: 0.236 ± 0.018
1.282GlnAsp: 1.282 ± 0.038
1.885GlnGlu: 1.885 ± 0.055
1.311GlnPhe: 1.311 ± 0.045
1.707GlnGly: 1.707 ± 0.051
0.397GlnHis: 0.397 ± 0.021
2.529GlnIle: 2.529 ± 0.055
2.295GlnLys: 2.295 ± 0.06
2.792GlnLeu: 2.792 ± 0.065
0.845GlnMet: 0.845 ± 0.03
1.661GlnAsn: 1.661 ± 0.054
0.99GlnPro: 0.99 ± 0.035
1.059GlnGln: 1.059 ± 0.043
1.353GlnArg: 1.353 ± 0.041
1.796GlnSer: 1.796 ± 0.046
1.608GlnThr: 1.608 ± 0.05
1.723GlnVal: 1.723 ± 0.045
0.319GlnTrp: 0.319 ± 0.019
1.293GlnTyr: 1.293 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
2.639ArgAla: 2.639 ± 0.065
0.432ArgCys: 0.432 ± 0.024
2.347ArgAsp: 2.347 ± 0.052
3.505ArgGlu: 3.505 ± 0.073
2.277ArgPhe: 2.277 ± 0.057
2.64ArgGly: 2.64 ± 0.059
0.778ArgHis: 0.778 ± 0.036
3.644ArgIle: 3.644 ± 0.076
3.197ArgLys: 3.197 ± 0.069
4.006ArgLeu: 4.006 ± 0.074
1.288ArgMet: 1.288 ± 0.04
2.25ArgAsn: 2.25 ± 0.059
1.4ArgPro: 1.4 ± 0.05
1.356ArgGln: 1.356 ± 0.042
2.037ArgArg: 2.037 ± 0.055
2.728ArgSer: 2.728 ± 0.055
2.044ArgThr: 2.044 ± 0.049
2.963ArgVal: 2.963 ± 0.059
0.512ArgTrp: 0.512 ± 0.028
2.068ArgTyr: 2.068 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
4.755SerAla: 4.755 ± 0.087
0.821SerCys: 0.821 ± 0.032
4.029SerAsp: 4.029 ± 0.076
4.35SerGlu: 4.35 ± 0.073
3.653SerPhe: 3.653 ± 0.072
5.655SerGly: 5.655 ± 0.107
1.173SerHis: 1.173 ± 0.039
5.307SerIle: 5.307 ± 0.084
4.497SerLys: 4.497 ± 0.068
7.062SerLeu: 7.062 ± 0.125
1.702SerMet: 1.702 ± 0.039
3.194SerAsn: 3.194 ± 0.061
2.436SerPro: 2.436 ± 0.057
2.129SerGln: 2.129 ± 0.054
2.953SerArg: 2.953 ± 0.068
5.019SerSer: 5.019 ± 0.105
3.533SerThr: 3.533 ± 0.079
5.12SerVal: 5.12 ± 0.089
0.721SerTrp: 0.721 ± 0.033
3.082SerTyr: 3.082 ± 0.073
0.0SerXaa: 0.0 ± 0.0
Thr
3.709ThrAla: 3.709 ± 0.074
0.433ThrCys: 0.433 ± 0.024
2.949ThrAsp: 2.949 ± 0.061
3.168ThrGlu: 3.168 ± 0.07
2.436ThrPhe: 2.436 ± 0.055
4.322ThrGly: 4.322 ± 0.08
0.845ThrHis: 0.845 ± 0.032
4.406ThrIle: 4.406 ± 0.07
3.266ThrLys: 3.266 ± 0.073
5.302ThrLeu: 5.302 ± 0.086
1.11ThrMet: 1.11 ± 0.036
2.639ThrAsn: 2.639 ± 0.062
2.448ThrPro: 2.448 ± 0.052
1.442ThrGln: 1.442 ± 0.041
2.035ThrArg: 2.035 ± 0.05
3.583ThrSer: 3.583 ± 0.073
3.109ThrThr: 3.109 ± 0.076
3.395ThrVal: 3.395 ± 0.068
0.489ThrTrp: 0.489 ± 0.029
2.068ThrTyr: 2.068 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
4.614ValAla: 4.614 ± 0.086
0.713ValCys: 0.713 ± 0.032
3.56ValAsp: 3.56 ± 0.059
4.024ValGlu: 4.024 ± 0.076
2.929ValPhe: 2.929 ± 0.065
3.862ValGly: 3.862 ± 0.078
0.883ValHis: 0.883 ± 0.037
5.095ValIle: 5.095 ± 0.083
4.782ValLys: 4.782 ± 0.09
5.666ValLeu: 5.666 ± 0.09
1.647ValMet: 1.647 ± 0.049
3.299ValAsn: 3.299 ± 0.069
2.322ValPro: 2.322 ± 0.054
1.642ValGln: 1.642 ± 0.043
2.822ValArg: 2.822 ± 0.064
4.729ValSer: 4.729 ± 0.084
3.59ValThr: 3.59 ± 0.075
4.671ValVal: 4.671 ± 0.091
0.641ValTrp: 0.641 ± 0.032
2.571ValTyr: 2.571 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.659TrpAla: 0.659 ± 0.029
0.155TrpCys: 0.155 ± 0.015
0.554TrpAsp: 0.554 ± 0.026
0.654TrpGlu: 0.654 ± 0.033
0.465TrpPhe: 0.465 ± 0.028
0.743TrpGly: 0.743 ± 0.032
0.194TrpHis: 0.194 ± 0.017
0.795TrpIle: 0.795 ± 0.035
0.761TrpLys: 0.761 ± 0.033
0.941TrpLeu: 0.941 ± 0.04
0.325TrpMet: 0.325 ± 0.023
0.611TrpAsn: 0.611 ± 0.025
0.256TrpPro: 0.256 ± 0.018
0.364TrpGln: 0.364 ± 0.021
0.489TrpArg: 0.489 ± 0.025
0.637TrpSer: 0.637 ± 0.029
0.481TrpThr: 0.481 ± 0.027
0.575TrpVal: 0.575 ± 0.027
0.141TrpTrp: 0.141 ± 0.015
0.437TrpTyr: 0.437 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.573TyrAla: 2.573 ± 0.06
0.482TyrCys: 0.482 ± 0.025
2.289TyrAsp: 2.289 ± 0.054
2.213TyrGlu: 2.213 ± 0.056
2.14TyrPhe: 2.14 ± 0.055
2.823TyrGly: 2.823 ± 0.064
0.719TyrHis: 0.719 ± 0.032
3.2TyrIle: 3.2 ± 0.068
3.143TyrLys: 3.143 ± 0.061
3.769TyrLeu: 3.769 ± 0.075
1.054TyrMet: 1.054 ± 0.038
2.597TyrAsn: 2.597 ± 0.075
1.687TyrPro: 1.687 ± 0.052
1.295TyrGln: 1.295 ± 0.044
1.987TyrArg: 1.987 ± 0.052
3.275TyrSer: 3.275 ± 0.074
2.475TyrThr: 2.475 ± 0.062
2.155TyrVal: 2.155 ± 0.053
0.474TyrTrp: 0.474 ± 0.03
2.047TyrTyr: 2.047 ± 0.071
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2289 proteins (808366 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski