Amino acid dipepetide frequency for Angiostrongylus cantonensis (Rat lungworm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.433AlaAla: 5.433 ± 0.054	1.39AlaCys: 1.39 ± 0.022	3.353AlaAsp: 3.353 ± 0.028	4.18AlaGlu: 4.18 ± 0.043	2.959AlaPhe: 2.959 ± 0.035	3.502AlaGly: 3.502 ± 0.035	1.565AlaHis: 1.565 ± 0.021	3.916AlaIle: 3.916 ± 0.038	3.608AlaLys: 3.608 ± 0.037	6.427AlaLeu: 6.427 ± 0.045	1.766AlaMet: 1.766 ± 0.02	2.602AlaAsn: 2.602 ± 0.027	2.924AlaPro: 2.924 ± 0.028	2.365AlaGln: 2.365 ± 0.027	3.705AlaArg: 3.705 ± 0.035	4.829AlaSer: 4.829 ± 0.038	3.592AlaThr: 3.592 ± 0.034	5.193AlaVal: 5.193 ± 0.037	0.657AlaTrp: 0.657 ± 0.013	1.797AlaTyr: 1.797 ± 0.022	0.001AlaXaa: 0.001 ± 0.001
Cys	1.42CysAla: 1.42 ± 0.023	0.634CysCys: 0.634 ± 0.017	1.349CysAsp: 1.349 ± 0.028	1.341CysGlu: 1.341 ± 0.023	1.127CysPhe: 1.127 ± 0.019	1.593CysGly: 1.593 ± 0.025	0.596CysHis: 0.596 ± 0.013	1.23CysIle: 1.23 ± 0.019	1.022CysLys: 1.022 ± 0.019	2.076CysLeu: 2.076 ± 0.023	0.531CysMet: 0.531 ± 0.01	0.916CysAsn: 0.916 ± 0.018	1.16CysPro: 1.16 ± 0.028	0.816CysGln: 0.816 ± 0.018	1.427CysArg: 1.427 ± 0.022	2.035CysSer: 2.035 ± 0.026	1.145CysThr: 1.145 ± 0.018	1.515CysVal: 1.515 ± 0.022	0.261CysTrp: 0.261 ± 0.008	0.666CysTyr: 0.666 ± 0.013	0.001CysXaa: 0.001 ± 0.0
Asp	3.301AspAla: 3.301 ± 0.032	1.114AspCys: 1.114 ± 0.024	3.88AspAsp: 3.88 ± 0.046	4.343AspGlu: 4.343 ± 0.038	2.493AspPhe: 2.493 ± 0.023	3.649AspGly: 3.649 ± 0.038	1.248AspHis: 1.248 ± 0.019	3.193AspIle: 3.193 ± 0.029	2.556AspLys: 2.556 ± 0.027	4.715AspLeu: 4.715 ± 0.038	1.273AspMet: 1.273 ± 0.019	2.002AspAsn: 2.002 ± 0.024	2.243AspPro: 2.243 ± 0.029	1.719AspGln: 1.719 ± 0.019	3.029AspArg: 3.029 ± 0.031	3.928AspSer: 3.928 ± 0.029	2.409AspThr: 2.409 ± 0.024	4.084AspVal: 4.084 ± 0.032	0.669AspTrp: 0.669 ± 0.015	1.728AspTyr: 1.728 ± 0.024	0.001AspXaa: 0.001 ± 0.0
Glu	4.147GluAla: 4.147 ± 0.041	1.367GluCys: 1.367 ± 0.027	3.598GluAsp: 3.598 ± 0.029	5.42GluGlu: 5.42 ± 0.064	2.431GluPhe: 2.431 ± 0.026	2.939GluGly: 2.939 ± 0.028	1.499GluHis: 1.499 ± 0.021	3.591GluIle: 3.591 ± 0.036	4.834GluLys: 4.834 ± 0.062	5.901GluLeu: 5.901 ± 0.049	1.862GluMet: 1.862 ± 0.022	3.052GluAsn: 3.052 ± 0.031	2.17GluPro: 2.17 ± 0.03	2.751GluGln: 2.751 ± 0.028	4.437GluArg: 4.437 ± 0.054	4.091GluSer: 4.091 ± 0.038	3.164GluThr: 3.164 ± 0.031	3.991GluVal: 3.991 ± 0.035	0.882GluTrp: 0.882 ± 0.016	1.882GluTyr: 1.882 ± 0.023	0.001GluXaa: 0.001 ± 0.0
Phe	2.938PheAla: 2.938 ± 0.028	1.199PheCys: 1.199 ± 0.015	2.618PheAsp: 2.618 ± 0.025	2.556PheGlu: 2.556 ± 0.027	2.55PhePhe: 2.55 ± 0.035	2.728PheGly: 2.728 ± 0.029	1.198PheHis: 1.198 ± 0.017	2.69PheIle: 2.69 ± 0.03	2.012PheLys: 2.012 ± 0.022	4.465PheLeu: 4.465 ± 0.042	1.116PheMet: 1.116 ± 0.017	1.891PheAsn: 1.891 ± 0.021	1.923PhePro: 1.923 ± 0.023	1.562PheGln: 1.562 ± 0.021	2.531PheArg: 2.531 ± 0.025	3.738PheSer: 3.738 ± 0.032	2.498PheThr: 2.498 ± 0.027	3.362PheVal: 3.362 ± 0.03	0.523PheTrp: 0.523 ± 0.012	1.753PheTyr: 1.753 ± 0.023	0.002PheXaa: 0.002 ± 0.001
Gly	3.498GlyAla: 3.498 ± 0.04	1.222GlyCys: 1.222 ± 0.021	3.078GlyAsp: 3.078 ± 0.032	3.553GlyGlu: 3.553 ± 0.04	2.573GlyPhe: 2.573 ± 0.028	3.913GlyGly: 3.913 ± 0.062	1.37GlyHis: 1.37 ± 0.021	3.216GlyIle: 3.216 ± 0.031	3.316GlyLys: 3.316 ± 0.034	4.711GlyLeu: 4.711 ± 0.046	1.428GlyMet: 1.428 ± 0.02	2.438GlyAsn: 2.438 ± 0.027	2.355GlyPro: 2.355 ± 0.039	2.017GlyGln: 2.017 ± 0.023	3.667GlyArg: 3.667 ± 0.035	4.272GlySer: 4.272 ± 0.036	3.179GlyThr: 3.179 ± 0.027	4.08GlyVal: 4.08 ± 0.036	0.704GlyTrp: 0.704 ± 0.016	1.91GlyTyr: 1.91 ± 0.028	0.001GlyXaa: 0.001 ± 0.0
His	1.449HisAla: 1.449 ± 0.02	0.661HisCys: 0.661 ± 0.013	1.172HisAsp: 1.172 ± 0.016	1.427HisGlu: 1.427 ± 0.021	1.239HisPhe: 1.239 ± 0.021	1.483HisGly: 1.483 ± 0.021	0.806HisHis: 0.806 ± 0.016	1.455HisIle: 1.455 ± 0.019	1.095HisLys: 1.095 ± 0.015	2.552HisLeu: 2.552 ± 0.027	0.61HisMet: 0.61 ± 0.014	0.957HisAsn: 0.957 ± 0.017	1.354HisPro: 1.354 ± 0.022	0.89HisGln: 0.89 ± 0.015	1.59HisArg: 1.59 ± 0.023	1.951HisSer: 1.951 ± 0.023	1.192HisThr: 1.192 ± 0.019	1.715HisVal: 1.715 ± 0.02	0.338HisTrp: 0.338 ± 0.01	0.879HisTyr: 0.879 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.029IleAla: 4.029 ± 0.031	1.422IleCys: 1.422 ± 0.019	3.363IleAsp: 3.363 ± 0.029	3.513IleGlu: 3.513 ± 0.029	2.676IlePhe: 2.676 ± 0.029	3.567IleGly: 3.567 ± 0.031	1.496IleHis: 1.496 ± 0.021	3.171IleIle: 3.171 ± 0.028	2.648IleLys: 2.648 ± 0.028	5.1IleLeu: 5.1 ± 0.038	1.305IleMet: 1.305 ± 0.019	2.282IleAsn: 2.282 ± 0.025	2.777IlePro: 2.777 ± 0.028	1.954IleGln: 1.954 ± 0.022	3.634IleArg: 3.634 ± 0.032	4.718IleSer: 4.718 ± 0.032	3.211IleThr: 3.211 ± 0.029	4.121IleVal: 4.121 ± 0.038	0.648IleTrp: 0.648 ± 0.012	1.819IleTyr: 1.819 ± 0.024	0.001IleXaa: 0.001 ± 0.0
Lys	3.615LysAla: 3.615 ± 0.034	1.214LysCys: 1.214 ± 0.02	2.805LysAsp: 2.805 ± 0.031	4.126LysGlu: 4.126 ± 0.055	2.146LysPhe: 2.146 ± 0.024	2.601LysGly: 2.601 ± 0.028	1.295LysHis: 1.295 ± 0.019	3.246LysIle: 3.246 ± 0.031	4.347LysLys: 4.347 ± 0.056	4.947LysLeu: 4.947 ± 0.033	1.537LysMet: 1.537 ± 0.021	2.517LysAsn: 2.517 ± 0.026	2.318LysPro: 2.318 ± 0.035	2.184LysGln: 2.184 ± 0.026	3.821LysArg: 3.821 ± 0.035	3.707LysSer: 3.707 ± 0.031	2.965LysThr: 2.965 ± 0.032	3.628LysVal: 3.628 ± 0.031	0.693LysTrp: 0.693 ± 0.013	1.794LysTyr: 1.794 ± 0.022	0.002LysXaa: 0.002 ± 0.001
Leu	6.414LeuAla: 6.414 ± 0.047	2.216LeuCys: 2.216 ± 0.026	4.651LeuAsp: 4.651 ± 0.039	5.718LeuGlu: 5.718 ± 0.047	4.558LeuPhe: 4.558 ± 0.047	4.544LeuGly: 4.544 ± 0.035	2.472LeuHis: 2.472 ± 0.026	5.081LeuIle: 5.081 ± 0.038	5.259LeuLys: 5.259 ± 0.043	9.582LeuLeu: 9.582 ± 0.069	2.421LeuMet: 2.421 ± 0.027	4.06LeuAsn: 4.06 ± 0.035	4.687LeuPro: 4.687 ± 0.043	3.736LeuGln: 3.736 ± 0.03	6.086LeuArg: 6.086 ± 0.04	7.757LeuSer: 7.757 ± 0.049	5.022LeuThr: 5.022 ± 0.037	6.023LeuVal: 6.023 ± 0.04	1.077LeuTrp: 1.077 ± 0.017	2.82LeuTyr: 2.82 ± 0.028	0.001LeuXaa: 0.001 ± 0.001
Met	1.786MetAla: 1.786 ± 0.022	0.554MetCys: 0.554 ± 0.013	1.428MetAsp: 1.428 ± 0.017	1.727MetGlu: 1.727 ± 0.022	1.195MetPhe: 1.195 ± 0.02	1.297MetGly: 1.297 ± 0.019	0.565MetHis: 0.565 ± 0.012	1.386MetIle: 1.386 ± 0.019	1.666MetLys: 1.666 ± 0.023	2.466MetLeu: 2.466 ± 0.028	0.806MetMet: 0.806 ± 0.021	1.279MetAsn: 1.279 ± 0.018	1.122MetPro: 1.122 ± 0.02	0.97MetGln: 0.97 ± 0.015	1.63MetArg: 1.63 ± 0.02	1.952MetSer: 1.952 ± 0.021	1.44MetThr: 1.44 ± 0.019	1.747MetVal: 1.747 ± 0.02	0.314MetTrp: 0.314 ± 0.01	0.689MetTyr: 0.689 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.81AsnAla: 2.81 ± 0.027	0.928AsnCys: 0.928 ± 0.016	2.355AsnAsp: 2.355 ± 0.026	2.917AsnGlu: 2.917 ± 0.03	1.843AsnPhe: 1.843 ± 0.023	2.935AsnGly: 2.935 ± 0.03	1.002AsnHis: 1.002 ± 0.016	2.669AsnIle: 2.669 ± 0.023	2.029AsnLys: 2.029 ± 0.027	3.64AsnLeu: 3.64 ± 0.033	1.144AsnMet: 1.144 ± 0.018	1.758AsnAsn: 1.758 ± 0.025	1.969AsnPro: 1.969 ± 0.025	1.392AsnGln: 1.392 ± 0.018	2.438AsnArg: 2.438 ± 0.027	3.164AsnSer: 3.164 ± 0.031	2.243AsnThr: 2.243 ± 0.022	3.118AsnVal: 3.118 ± 0.03	0.486AsnTrp: 0.486 ± 0.012	1.484AsnTyr: 1.484 ± 0.019	0.001AsnXaa: 0.001 ± 0.0
Pro	2.716ProAla: 2.716 ± 0.029	0.862ProCys: 0.862 ± 0.017	2.29ProAsp: 2.29 ± 0.027	2.728ProGlu: 2.728 ± 0.033	2.161ProPhe: 2.161 ± 0.029	2.91ProGly: 2.91 ± 0.082	1.133ProHis: 1.133 ± 0.019	2.489ProIle: 2.489 ± 0.029	2.288ProLys: 2.288 ± 0.024	4.195ProLeu: 4.195 ± 0.04	1.017ProMet: 1.017 ± 0.017	1.902ProAsn: 1.902 ± 0.021	3.563ProPro: 3.563 ± 0.074	1.764ProGln: 1.764 ± 0.029	2.438ProArg: 2.438 ± 0.027	4.128ProSer: 4.128 ± 0.04	2.81ProThr: 2.81 ± 0.037	3.064ProVal: 3.064 ± 0.031	0.469ProTrp: 0.469 ± 0.012	1.444ProTyr: 1.444 ± 0.022	0.001ProXaa: 0.001 ± 0.0
Gln	2.367GlnAla: 2.367 ± 0.028	0.949GlnCys: 0.949 ± 0.021	1.358GlnAsp: 1.358 ± 0.017	2.045GlnGlu: 2.045 ± 0.026	1.635GlnPhe: 1.635 ± 0.018	1.671GlnGly: 1.671 ± 0.023	1.019GlnHis: 1.019 ± 0.016	2.149GlnIle: 2.149 ± 0.025	2.198GlnLys: 2.198 ± 0.024	4.121GlnLeu: 4.121 ± 0.036	1.163GlnMet: 1.163 ± 0.018	1.6GlnAsn: 1.6 ± 0.022	1.765GlnPro: 1.765 ± 0.027	2.123GlnGln: 2.123 ± 0.052	2.538GlnArg: 2.538 ± 0.025	2.555GlnSer: 2.555 ± 0.027	1.868GlnThr: 1.868 ± 0.024	2.359GlnVal: 2.359 ± 0.025	0.523GlnTrp: 0.523 ± 0.011	1.197GlnTyr: 1.197 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	3.708ArgAla: 3.708 ± 0.034	1.416ArgCys: 1.416 ± 0.024	2.98ArgAsp: 2.98 ± 0.026	3.857ArgGlu: 3.857 ± 0.041	2.806ArgPhe: 2.806 ± 0.029	3.081ArgGly: 3.081 ± 0.033	1.669ArgHis: 1.669 ± 0.02	3.662ArgIle: 3.662 ± 0.032	4.031ArgLys: 4.031 ± 0.038	6.069ArgLeu: 6.069 ± 0.043	1.678ArgMet: 1.678 ± 0.022	2.807ArgAsn: 2.807 ± 0.025	2.601ArgPro: 2.601 ± 0.028	2.503ArgGln: 2.503 ± 0.028	5.029ArgArg: 5.029 ± 0.046	4.642ArgSer: 4.642 ± 0.038	3.304ArgThr: 3.304 ± 0.029	3.629ArgVal: 3.629 ± 0.029	0.751ArgTrp: 0.751 ± 0.014	1.922ArgTyr: 1.922 ± 0.025	0.001ArgXaa: 0.001 ± 0.001
Ser	5.049SerAla: 5.049 ± 0.036	1.717SerCys: 1.717 ± 0.03	4.147SerAsp: 4.147 ± 0.033	4.642SerGlu: 4.642 ± 0.033	3.718SerPhe: 3.718 ± 0.032	4.533SerGly: 4.533 ± 0.032	1.837SerHis: 1.837 ± 0.025	4.401SerIle: 4.401 ± 0.035	3.835SerLys: 3.835 ± 0.031	7.305SerLeu: 7.305 ± 0.043	1.938SerMet: 1.938 ± 0.024	3.182SerAsn: 3.182 ± 0.031	3.7SerPro: 3.7 ± 0.043	2.732SerGln: 2.732 ± 0.031	4.582SerArg: 4.582 ± 0.04	7.68SerSer: 7.68 ± 0.062	4.81SerThr: 4.81 ± 0.037	5.305SerVal: 5.305 ± 0.042	0.849SerTrp: 0.849 ± 0.014	2.261SerTyr: 2.261 ± 0.025	0.001SerXaa: 0.001 ± 0.001
Thr	3.781ThrAla: 3.781 ± 0.035	1.253ThrCys: 1.253 ± 0.022	2.639ThrAsp: 2.639 ± 0.032	3.005ThrGlu: 3.005 ± 0.032	2.416ThrPhe: 2.416 ± 0.027	3.097ThrGly: 3.097 ± 0.03	1.216ThrHis: 1.216 ± 0.019	3.347ThrIle: 3.347 ± 0.031	2.868ThrLys: 2.868 ± 0.029	5.061ThrLeu: 5.061 ± 0.042	1.46ThrMet: 1.46 ± 0.019	2.277ThrAsn: 2.277 ± 0.024	2.769ThrPro: 2.769 ± 0.028	1.764ThrGln: 1.764 ± 0.022	2.912ThrArg: 2.912 ± 0.027	4.564ThrSer: 4.564 ± 0.04	3.592ThrThr: 3.592 ± 0.047	4.165ThrVal: 4.165 ± 0.04	0.619ThrTrp: 0.619 ± 0.016	1.592ThrTyr: 1.592 ± 0.023	0.001ThrXaa: 0.001 ± 0.001
Val	4.663ValAla: 4.663 ± 0.04	1.662ValCys: 1.662 ± 0.022	4.021ValAsp: 4.021 ± 0.035	4.364ValGlu: 4.364 ± 0.039	3.256ValPhe: 3.256 ± 0.033	3.848ValGly: 3.848 ± 0.03	1.734ValHis: 1.734 ± 0.021	4.1ValIle: 4.1 ± 0.035	3.624ValLys: 3.624 ± 0.034	6.729ValLeu: 6.729 ± 0.044	1.741ValMet: 1.741 ± 0.021	2.864ValAsn: 2.864 ± 0.029	3.143ValPro: 3.143 ± 0.033	2.417ValGln: 2.417 ± 0.026	3.89ValArg: 3.89 ± 0.031	5.222ValSer: 5.222 ± 0.042	3.696ValThr: 3.696 ± 0.031	5.525ValVal: 5.525 ± 0.053	0.744ValTrp: 0.744 ± 0.012	2.171ValTyr: 2.171 ± 0.024	0.001ValXaa: 0.001 ± 0.0
Trp	0.668TrpAla: 0.668 ± 0.014	0.255TrpCys: 0.255 ± 0.007	0.599TrpAsp: 0.599 ± 0.013	0.648TrpGlu: 0.648 ± 0.013	0.529TrpPhe: 0.529 ± 0.01	0.527TrpGly: 0.527 ± 0.013	0.277TrpHis: 0.277 ± 0.01	0.764TrpIle: 0.764 ± 0.015	0.762TrpLys: 0.762 ± 0.016	1.151TrpLeu: 1.151 ± 0.018	0.389TrpMet: 0.389 ± 0.011	0.623TrpAsn: 0.623 ± 0.011	0.446TrpPro: 0.446 ± 0.011	0.469TrpGln: 0.469 ± 0.011	0.808TrpArg: 0.808 ± 0.015	0.923TrpSer: 0.923 ± 0.019	0.715TrpThr: 0.715 ± 0.017	0.667TrpVal: 0.667 ± 0.013	0.181TrpTrp: 0.181 ± 0.009	0.382TrpTyr: 0.382 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.969TyrAla: 1.969 ± 0.022	0.825TyrCys: 0.825 ± 0.018	1.894TyrAsp: 1.894 ± 0.024	1.899TyrGlu: 1.899 ± 0.028	1.542TyrPhe: 1.542 ± 0.024	2.083TyrGly: 2.083 ± 0.031	0.82TyrHis: 0.82 ± 0.015	1.696TyrIle: 1.696 ± 0.024	1.51TyrLys: 1.51 ± 0.018	2.969TyrLeu: 2.969 ± 0.029	0.833TyrMet: 0.833 ± 0.015	1.314TyrAsn: 1.314 ± 0.019	1.381TyrPro: 1.381 ± 0.023	1.075TyrGln: 1.075 ± 0.017	1.952TyrArg: 1.952 ± 0.025	2.366TyrSer: 2.366 ± 0.029	1.542TyrThr: 1.542 ± 0.021	2.125TyrVal: 2.125 ± 0.026	0.395TyrTrp: 0.395 ± 0.01	1.21TyrTyr: 1.21 ± 0.021	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.002XaaPhe: 0.002 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.001XaaLys: 0.001 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.002XaaAsn: 0.002 ± 0.001	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.159XaaXaa: 0.159 ± 0.14

Statistics based on 14506 proteins (4143969 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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