Amino acid dipepetide frequency for Pelagerythrobacter marensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.442AlaAla: 18.442 ± 0.212
1.078AlaCys: 1.078 ± 0.041
7.793AlaAsp: 7.793 ± 0.105
8.601AlaGlu: 8.601 ± 0.115
4.405AlaPhe: 4.405 ± 0.078
12.096AlaGly: 12.096 ± 0.171
2.246AlaHis: 2.246 ± 0.065
7.123AlaIle: 7.123 ± 0.105
3.404AlaLys: 3.404 ± 0.079
13.932AlaLeu: 13.932 ± 0.171
3.759AlaMet: 3.759 ± 0.073
3.292AlaAsn: 3.292 ± 0.081
6.378AlaPro: 6.378 ± 0.104
4.651AlaGln: 4.651 ± 0.077
10.199AlaArg: 10.199 ± 0.155
6.368AlaSer: 6.368 ± 0.111
6.164AlaThr: 6.164 ± 0.113
8.485AlaVal: 8.485 ± 0.124
1.661AlaTrp: 1.661 ± 0.057
2.49AlaTyr: 2.49 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
1.02CysAla: 1.02 ± 0.036
0.093CysCys: 0.093 ± 0.011
0.588CysAsp: 0.588 ± 0.029
0.453CysGlu: 0.453 ± 0.02
0.266CysPhe: 0.266 ± 0.02
0.858CysGly: 0.858 ± 0.039
0.199CysHis: 0.199 ± 0.015
0.334CysIle: 0.334 ± 0.018
0.133CysLys: 0.133 ± 0.013
0.629CysLeu: 0.629 ± 0.031
0.121CysMet: 0.121 ± 0.012
0.215CysAsn: 0.215 ± 0.016
0.437CysPro: 0.437 ± 0.023
0.196CysGln: 0.196 ± 0.017
0.539CysArg: 0.539 ± 0.025
0.406CysSer: 0.406 ± 0.026
0.344CysThr: 0.344 ± 0.018
0.511CysVal: 0.511 ± 0.024
0.09CysTrp: 0.09 ± 0.01
0.148CysTyr: 0.148 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
8.049AspAla: 8.049 ± 0.11
0.469AspCys: 0.469 ± 0.023
3.881AspAsp: 3.881 ± 0.081
3.929AspGlu: 3.929 ± 0.078
2.385AspPhe: 2.385 ± 0.061
6.099AspGly: 6.099 ± 0.118
1.313AspHis: 1.313 ± 0.044
2.839AspIle: 2.839 ± 0.058
1.572AspLys: 1.572 ± 0.052
6.107AspLeu: 6.107 ± 0.086
1.538AspMet: 1.538 ± 0.041
1.523AspAsn: 1.523 ± 0.053
4.002AspPro: 4.002 ± 0.062
1.736AspGln: 1.736 ± 0.043
5.38AspArg: 5.38 ± 0.093
2.657AspSer: 2.657 ± 0.058
2.982AspThr: 2.982 ± 0.065
4.083AspVal: 4.083 ± 0.074
1.119AspTrp: 1.119 ± 0.037
1.729AspTyr: 1.729 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
8.2GluAla: 8.2 ± 0.122
0.392GluCys: 0.392 ± 0.022
3.569GluAsp: 3.569 ± 0.063
3.878GluGlu: 3.878 ± 0.085
1.839GluPhe: 1.839 ± 0.05
5.586GluGly: 5.586 ± 0.105
1.198GluHis: 1.198 ± 0.037
3.373GluIle: 3.373 ± 0.07
1.963GluLys: 1.963 ± 0.062
5.565GluLeu: 5.565 ± 0.087
1.591GluMet: 1.591 ± 0.045
1.69GluAsn: 1.69 ± 0.046
2.996GluPro: 2.996 ± 0.061
2.327GluGln: 2.327 ± 0.055
5.796GluArg: 5.796 ± 0.098
2.745GluSer: 2.745 ± 0.053
3.571GluThr: 3.571 ± 0.066
3.99GluVal: 3.99 ± 0.074
0.971GluTrp: 0.971 ± 0.04
1.202GluTyr: 1.202 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
5.123PheAla: 5.123 ± 0.088
0.334PheCys: 0.334 ± 0.021
2.96PheAsp: 2.96 ± 0.054
2.268PheGlu: 2.268 ± 0.06
1.243PhePhe: 1.243 ± 0.045
3.725PheGly: 3.725 ± 0.071
0.663PheHis: 0.663 ± 0.029
1.322PheIle: 1.322 ± 0.042
0.718PheLys: 0.718 ± 0.032
2.9PheLeu: 2.9 ± 0.07
0.72PheMet: 0.72 ± 0.029
0.938PheAsn: 0.938 ± 0.031
1.473PhePro: 1.473 ± 0.051
0.828PheGln: 0.828 ± 0.03
2.293PheArg: 2.293 ± 0.048
1.953PheSer: 1.953 ± 0.049
2.002PheThr: 2.002 ± 0.051
2.705PheVal: 2.705 ± 0.061
0.495PheTrp: 0.495 ± 0.025
0.932PheTyr: 0.932 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
10.528GlyAla: 10.528 ± 0.184
0.823GlyCys: 0.823 ± 0.031
5.667GlyAsp: 5.667 ± 0.106
6.25GlyGlu: 6.25 ± 0.093
3.651GlyPhe: 3.651 ± 0.073
8.531GlyGly: 8.531 ± 0.178
1.793GlyHis: 1.793 ± 0.048
4.321GlyIle: 4.321 ± 0.071
3.055GlyLys: 3.055 ± 0.073
8.45GlyLeu: 8.45 ± 0.1
2.402GlyMet: 2.402 ± 0.06
2.506GlyAsn: 2.506 ± 0.097
3.756GlyPro: 3.756 ± 0.064
3.117GlyGln: 3.117 ± 0.063
6.527GlyArg: 6.527 ± 0.103
5.066GlySer: 5.066 ± 0.119
5.203GlyThr: 5.203 ± 0.131
5.992GlyVal: 5.992 ± 0.112
1.609GlyTrp: 1.609 ± 0.04
2.322GlyTyr: 2.322 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
2.333HisAla: 2.333 ± 0.059
0.226HisCys: 0.226 ± 0.018
1.241HisAsp: 1.241 ± 0.033
1.137HisGlu: 1.137 ± 0.045
0.821HisPhe: 0.821 ± 0.034
1.946HisGly: 1.946 ± 0.058
0.471HisHis: 0.471 ± 0.033
0.741HisIle: 0.741 ± 0.032
0.411HisLys: 0.411 ± 0.023
1.734HisLeu: 1.734 ± 0.052
0.385HisMet: 0.385 ± 0.025
0.444HisAsn: 0.444 ± 0.022
1.232HisPro: 1.232 ± 0.041
0.484HisGln: 0.484 ± 0.026
1.507HisArg: 1.507 ± 0.045
0.923HisSer: 0.923 ± 0.031
0.803HisThr: 0.803 ± 0.036
1.297HisVal: 1.297 ± 0.04
0.338HisTrp: 0.338 ± 0.019
0.512HisTyr: 0.512 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
8.036IleAla: 8.036 ± 0.103
0.413IleCys: 0.413 ± 0.026
3.976IleAsp: 3.976 ± 0.079
3.801IleGlu: 3.801 ± 0.073
1.412IlePhe: 1.412 ± 0.045
5.013IleGly: 5.013 ± 0.113
0.836IleHis: 0.836 ± 0.034
1.554IleIle: 1.554 ± 0.046
1.014IleLys: 1.014 ± 0.038
3.616IleLeu: 3.616 ± 0.073
0.884IleMet: 0.884 ± 0.035
1.267IleAsn: 1.267 ± 0.044
2.186IlePro: 2.186 ± 0.05
0.993IleGln: 0.993 ± 0.027
3.04IleArg: 3.04 ± 0.056
2.362IleSer: 2.362 ± 0.064
2.26IleThr: 2.26 ± 0.056
4.087IleVal: 4.087 ± 0.071
0.564IleTrp: 0.564 ± 0.026
0.983IleTyr: 0.983 ± 0.039
0.0IleXaa: 0.0 ± 0.0
Lys
3.406LysAla: 3.406 ± 0.078
0.14LysCys: 0.14 ± 0.012
1.362LysAsp: 1.362 ± 0.047
1.226LysGlu: 1.226 ± 0.045
0.795LysPhe: 0.795 ± 0.033
2.277LysGly: 2.277 ± 0.052
0.51LysHis: 0.51 ± 0.024
1.262LysIle: 1.262 ± 0.041
1.001LysLys: 1.001 ± 0.051
2.696LysLeu: 2.696 ± 0.069
0.672LysMet: 0.672 ± 0.034
0.655LysAsn: 0.655 ± 0.03
1.544LysPro: 1.544 ± 0.051
0.822LysGln: 0.822 ± 0.038
2.099LysArg: 2.099 ± 0.057
1.33LysSer: 1.33 ± 0.039
1.481LysThr: 1.481 ± 0.048
1.951LysVal: 1.951 ± 0.054
0.383LysTrp: 0.383 ± 0.023
0.556LysTyr: 0.556 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
14.545LeuAla: 14.545 ± 0.186
0.733LeuCys: 0.733 ± 0.03
6.443LeuAsp: 6.443 ± 0.088
5.467LeuGlu: 5.467 ± 0.083
3.396LeuPhe: 3.396 ± 0.071
8.226LeuGly: 8.226 ± 0.114
1.743LeuHis: 1.743 ± 0.048
4.336LeuIle: 4.336 ± 0.088
2.42LeuLys: 2.42 ± 0.068
8.664LeuLeu: 8.664 ± 0.153
2.063LeuMet: 2.063 ± 0.057
2.209LeuAsn: 2.209 ± 0.063
5.375LeuPro: 5.375 ± 0.091
2.506LeuGln: 2.506 ± 0.056
6.901LeuArg: 6.901 ± 0.114
5.581LeuSer: 5.581 ± 0.08
5.183LeuThr: 5.183 ± 0.075
7.196LeuVal: 7.196 ± 0.096
1.098LeuTrp: 1.098 ± 0.042
1.879LeuTyr: 1.879 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
3.243MetAla: 3.243 ± 0.076
0.142MetCys: 0.142 ± 0.012
1.138MetAsp: 1.138 ± 0.04
1.23MetGlu: 1.23 ± 0.042
0.629MetPhe: 0.629 ± 0.028
1.94MetGly: 1.94 ± 0.054
0.444MetHis: 0.444 ± 0.023
1.321MetIle: 1.321 ± 0.044
0.89MetLys: 0.89 ± 0.034
2.431MetLeu: 2.431 ± 0.066
0.564MetMet: 0.564 ± 0.028
0.728MetAsn: 0.728 ± 0.029
1.425MetPro: 1.425 ± 0.045
0.762MetGln: 0.762 ± 0.028
1.812MetArg: 1.812 ± 0.052
1.297MetSer: 1.297 ± 0.041
1.628MetThr: 1.628 ± 0.043
1.547MetVal: 1.547 ± 0.044
0.236MetTrp: 0.236 ± 0.019
0.281MetTyr: 0.281 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.355AsnAla: 3.355 ± 0.078
0.216AsnCys: 0.216 ± 0.016
1.446AsnAsp: 1.446 ± 0.049
1.274AsnGlu: 1.274 ± 0.043
0.937AsnPhe: 0.937 ± 0.036
2.445AsnGly: 2.445 ± 0.092
0.446AsnHis: 0.446 ± 0.023
1.244AsnIle: 1.244 ± 0.053
0.549AsnLys: 0.549 ± 0.027
2.482AsnLeu: 2.482 ± 0.06
0.492AsnMet: 0.492 ± 0.026
0.702AsnAsn: 0.702 ± 0.043
1.766AsnPro: 1.766 ± 0.044
0.734AsnGln: 0.734 ± 0.034
1.908AsnArg: 1.908 ± 0.057
1.276AsnSer: 1.276 ± 0.05
1.224AsnThr: 1.224 ± 0.052
2.007AsnVal: 2.007 ± 0.08
0.406AsnTrp: 0.406 ± 0.025
0.704AsnTyr: 0.704 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
7.092ProAla: 7.092 ± 0.115
0.322ProCys: 0.322 ± 0.02
4.079ProAsp: 4.079 ± 0.075
3.935ProGlu: 3.935 ± 0.065
1.859ProPhe: 1.859 ± 0.046
4.957ProGly: 4.957 ± 0.084
0.959ProHis: 0.959 ± 0.032
2.301ProIle: 2.301 ± 0.056
1.149ProLys: 1.149 ± 0.037
4.804ProLeu: 4.804 ± 0.095
1.059ProMet: 1.059 ± 0.037
1.167ProAsn: 1.167 ± 0.039
2.807ProPro: 2.807 ± 0.098
1.785ProGln: 1.785 ± 0.054
3.177ProArg: 3.177 ± 0.068
2.513ProSer: 2.513 ± 0.061
2.376ProThr: 2.376 ± 0.058
4.166ProVal: 4.166 ± 0.072
0.645ProTrp: 0.645 ± 0.027
1.094ProTyr: 1.094 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
4.198GlnAla: 4.198 ± 0.072
0.194GlnCys: 0.194 ± 0.016
1.579GlnAsp: 1.579 ± 0.043
1.426GlnGlu: 1.426 ± 0.047
1.132GlnPhe: 1.132 ± 0.034
2.649GlnGly: 2.649 ± 0.058
0.581GlnHis: 0.581 ± 0.026
1.735GlnIle: 1.735 ± 0.044
0.776GlnLys: 0.776 ± 0.029
3.003GlnLeu: 3.003 ± 0.059
0.823GlnMet: 0.823 ± 0.032
0.709GlnAsn: 0.709 ± 0.031
1.768GlnPro: 1.768 ± 0.05
1.183GlnGln: 1.183 ± 0.052
2.479GlnArg: 2.479 ± 0.065
1.624GlnSer: 1.624 ± 0.044
1.652GlnThr: 1.652 ± 0.047
2.407GlnVal: 2.407 ± 0.058
0.407GlnTrp: 0.407 ± 0.022
0.704GlnTyr: 0.704 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
8.951ArgAla: 8.951 ± 0.131
0.494ArgCys: 0.494 ± 0.026
4.684ArgAsp: 4.684 ± 0.077
5.182ArgGlu: 5.182 ± 0.099
3.093ArgPhe: 3.093 ± 0.064
5.488ArgGly: 5.488 ± 0.093
1.66ArgHis: 1.66 ± 0.045
4.131ArgIle: 4.131 ± 0.068
2.248ArgLys: 2.248 ± 0.052
8.155ArgLeu: 8.155 ± 0.116
2.053ArgMet: 2.053 ± 0.049
1.903ArgAsn: 1.903 ± 0.046
3.618ArgPro: 3.618 ± 0.08
2.628ArgGln: 2.628 ± 0.066
6.026ArgArg: 6.026 ± 0.103
3.648ArgSer: 3.648 ± 0.068
3.635ArgThr: 3.635 ± 0.07
4.795ArgVal: 4.795 ± 0.088
1.214ArgTrp: 1.214 ± 0.042
1.818ArgTyr: 1.818 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
6.371SerAla: 6.371 ± 0.103
0.351SerCys: 0.351 ± 0.023
3.169SerAsp: 3.169 ± 0.065
2.919SerGlu: 2.919 ± 0.071
1.954SerPhe: 1.954 ± 0.047
5.645SerGly: 5.645 ± 0.114
0.926SerHis: 0.926 ± 0.033
2.321SerIle: 2.321 ± 0.056
1.225SerLys: 1.225 ± 0.045
4.916SerLeu: 4.916 ± 0.081
1.092SerMet: 1.092 ± 0.038
1.29SerAsn: 1.29 ± 0.052
2.72SerPro: 2.72 ± 0.061
1.673SerGln: 1.673 ± 0.048
3.589SerArg: 3.589 ± 0.062
2.657SerSer: 2.657 ± 0.072
2.533SerThr: 2.533 ± 0.074
3.538SerVal: 3.538 ± 0.088
0.686SerTrp: 0.686 ± 0.032
1.308SerTyr: 1.308 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
6.363ThrAla: 6.363 ± 0.104
0.338ThrCys: 0.338 ± 0.022
3.011ThrAsp: 3.011 ± 0.071
2.527ThrGlu: 2.527 ± 0.064
1.979ThrPhe: 1.979 ± 0.046
5.444ThrGly: 5.444 ± 0.115
0.886ThrHis: 0.886 ± 0.037
2.887ThrIle: 2.887 ± 0.06
1.039ThrLys: 1.039 ± 0.038
5.538ThrLeu: 5.538 ± 0.088
1.195ThrMet: 1.195 ± 0.041
1.342ThrAsn: 1.342 ± 0.056
3.103ThrPro: 3.103 ± 0.062
1.382ThrGln: 1.382 ± 0.042
3.623ThrArg: 3.623 ± 0.07
2.478ThrSer: 2.478 ± 0.065
2.654ThrThr: 2.654 ± 0.091
4.265ThrVal: 4.265 ± 0.094
0.588ThrTrp: 0.588 ± 0.03
1.221ThrTyr: 1.221 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
9.443ValAla: 9.443 ± 0.148
0.504ValCys: 0.504 ± 0.025
4.353ValAsp: 4.353 ± 0.077
4.988ValGlu: 4.988 ± 0.078
2.385ValPhe: 2.385 ± 0.05
5.502ValGly: 5.502 ± 0.106
1.267ValHis: 1.267 ± 0.038
3.585ValIle: 3.585 ± 0.063
1.69ValLys: 1.69 ± 0.058
6.572ValLeu: 6.572 ± 0.102
1.575ValMet: 1.575 ± 0.047
1.942ValAsn: 1.942 ± 0.065
3.943ValPro: 3.943 ± 0.079
1.939ValGln: 1.939 ± 0.049
5.12ValArg: 5.12 ± 0.078
3.932ValSer: 3.932 ± 0.075
4.4ValThr: 4.4 ± 0.095
5.335ValVal: 5.335 ± 0.084
0.832ValTrp: 0.832 ± 0.034
1.342ValTyr: 1.342 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
1.347TrpAla: 1.347 ± 0.04
0.098TrpCys: 0.098 ± 0.01
0.751TrpAsp: 0.751 ± 0.029
0.666TrpGlu: 0.666 ± 0.025
0.576TrpPhe: 0.576 ± 0.029
0.958TrpGly: 0.958 ± 0.038
0.345TrpHis: 0.345 ± 0.02
0.709TrpIle: 0.709 ± 0.031
0.425TrpLys: 0.425 ± 0.022
1.745TrpLeu: 1.745 ± 0.05
0.338TrpMet: 0.338 ± 0.023
0.461TrpAsn: 0.461 ± 0.02
0.698TrpPro: 0.698 ± 0.029
0.605TrpGln: 0.605 ± 0.028
1.356TrpArg: 1.356 ± 0.045
0.819TrpSer: 0.819 ± 0.031
0.707TrpThr: 0.707 ± 0.034
0.779TrpVal: 0.779 ± 0.031
0.242TrpTrp: 0.242 ± 0.016
0.274TrpTyr: 0.274 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.521TyrAla: 2.521 ± 0.049
0.216TyrCys: 0.216 ± 0.016
1.706TyrAsp: 1.706 ± 0.089
1.286TyrGlu: 1.286 ± 0.041
0.837TyrPhe: 0.837 ± 0.034
2.185TyrGly: 2.185 ± 0.052
0.497TyrHis: 0.497 ± 0.023
0.858TyrIle: 0.858 ± 0.032
0.485TyrLys: 0.485 ± 0.025
2.026TyrLeu: 2.026 ± 0.058
0.36TyrMet: 0.36 ± 0.02
0.629TyrAsn: 0.629 ± 0.039
1.02TyrPro: 1.02 ± 0.03
0.68TyrGln: 0.68 ± 0.027
2.051TyrArg: 2.051 ± 0.06
1.249TyrSer: 1.249 ± 0.047
1.063TyrThr: 1.063 ± 0.043
1.516TyrVal: 1.516 ± 0.046
0.314TyrTrp: 0.314 ± 0.021
0.638TyrTyr: 0.638 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2659 proteins (874530 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski